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| 1 | Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres显示文摘BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic tract.There is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be defined.AIM To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of MiNEN.METHODS Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European centres.Patient data were retrospectively collected from medical records.Pathological samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of MiNEN.Tumour responses to systemic treatment were assessed according to the Response Evaluation Criteria in Solid Tumours 1.1.Kaplan-Meier analysis was applied to estimate survival outcomes.Associations between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).RESULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 years.Males:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases analysed.Most distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine component.Ninety-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of origin.Chemotherapy was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal proportion.In localised cases,median recurrence free survival(RFS);14.0 months(95%CI:9.2-24.4),and median overall survival(OS):28.6 months(95%CI:18.3-41.1).On univariate analysis,receipt of perioperative treatment(vs surgery alone)did not improve RFS(P=0.375),or OS(P=0.240).In advanced cases,median progression free survival(PFS);5.6 months(95%CI:4.4-7.4),and median OS;9.0 months(95%CI:5.2-13.4).On univariate analysis,receipt of palliative active treatment(vs best supportive care)prolonged PFS and OS(both,P<0.001).CONCLUSION MiNEN is most commonly driven by a poorly differentiated neuroendocrine component,and has poor prognosis.Advances in its biological understanding are needed to identify effective treatments and improve patient outcomes. | Melissa Frizziero Xin Wang Bipasha Chakrabarty Alexa Childs Tu V Luong Thomas Walter Mohid S Khan Meleri Morgan Adam Christian Mona Elshafie Tahir Shah Annamaria Minicozzi Wasat Mansoor Tim Meyer Angela Lamarca Richard A Hubner Juan W Valle Mairéad G McNamara | 2019 | World Journal of Gastroenterology2019，25，39： | 13 |
| 2 | Single-Molecule Identification by Spectrally and Time-Resolved Fluorescence Detection 显示文摘 | Prummer M Hubner C G Sick B | 2000 | Anal Chem2000，72，3： | 2 |
| 3 | Gadoliniumlabeled liposomes: targeted MR contrast agents for the liver and spleen显示文摘 | KABALKA G BUONOCORE E HUBNER K | 1987 | Radiology1987，163，1： | 1 |
| 4 | Derivation of oocytes from embryonic stem cells显示文摘 | Hubner K Fuhrmann G ChristensonL K | 2003 | Science2003，300，： | 1 |
| 5 | Correlations between Charpy energy and crack initiation parameters of the J integral concept显示文摘 | HUBNER P PUSCH G | 2002 | European Structural Integrity Society2002，30，： | 1 |
| 6 | Self-concept:Validation of construct interpretations显示文摘 | HUBNER J J STANTON G C | 1976 | Reviewof Educational Research1976，，46： | 1 |
| 7 | In situ methodology for studying N-mineralization in soils using anion exchange resins 显示文摘 | HUBNER C REDL G WURST F | 1991 | Soil Biology and Biochemistry1991，23，： | 1 |
| 8 | Self-concept: Validation of construct interpretations显示文摘 | Shavclson R J Hubner J J and Stanton G C | 1976 | Review of Educational Research1976，46，3： | 1 |
| 9 | Derivation ofoocytes from mouse embryonic stem cells显示文摘 | Hubner K Fuhrmann G Christenson LK | 2003 | Science2003，300，5623： | 1 |
| 10 | Regulation of Vascular Endothelial Growth Factor Expression in Cultured Keratinocytes显示文摘 | Frank S Hubner G Breier G | 1995 | J Biol Chem1995，270，12： | 1 |
| 11 | Single-molecule identification by spectrally and time-resolved fluorescence detection显示文摘 | Prummer M Hubner C G Sick B | 2000 | Anal Chem2000，72，： | 1 |
| 12 | The three sorCS genes are differentially expressed and regulated by synaptic activity显示文摘 | Hermey G Plath N Hubner C A | 2004 | J Neuro- chem2004，88，6： | 1 |
| 13 | Self-concept:Validation of construct interpretation显示文摘 | Hubner J J & STANTON G C | 1976 | Review of Educational Research1976，46，： | 1 |
| 14 | Derivation of oocytes from mouse embryonic stem cells显示文摘 | Hubner K Fuhrmann G Scholer HR | 2003 | Science2003，300，： | 1 |
| 15 | Derivation of oocytes from mouse embryonic stem cells显示文摘 | Hubner K Fuhrmann G Christenson L K | 2003 | Science2003，300，： | 1 |
| 16 | Practical methods for measuring and managing operational risk in the financial sector: A clinical study 显示文摘 | Chapelle A Crama Y Hubner G Peters J | 2008 | Journal of Banking & Finance2008，32，6： | 1 |
| 17 | Regulation of vascular growth factor expression in cultured keratinocytes显示文摘 | Hubner G Breier G | 1995 | J Biol Chem1995，270，12： | 1 |
| 18 | Derivation of oocytes from mouse embryonic stem cells 显示文摘 | Hubner K Fuhrrnann G Christenson LK | 2003 | Science2003，300，： | 1 |
| 19 | Derivation of Oocytes from mouse embryonic stem cells显示文摘 | Hubner K Fuhrmann G Christenson LK | 2003 | Science2003，300，5623： | 1 |
| 20 | Derivation of oocytes from embryonic stem cells显示文摘 | Hubner K Fuhrmann G Christenson LK | 2003 | Science2003，300，： | 1 |
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