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106篇 您的检索式：作者名="Hubens"

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	题名	作者	年代	出处	被引量
1	Tumor Antigen Specific Activation of Primary Human T-Cells Expressing a Virally Encoded Chimeric T-Cell Receptor Specific for p185HER2显示文摘We have developed and tested chimeric T-cell receptors (TCR) specific for p185HER2. In these experiments, retroviral vectors expressing the N29γ or N29ζ receptors were constructed in pRET6. Amphotropic viral producer cells were established in the GALV-based PG13 packaging cell line. Ficoll purified human peripheral blood lymphocytes (PBL) were virally transduced using an optimized protocol incorporating activation with immobilized anti-CD3/anti-CD28 monoclonal anti- bodies, followed by viral infection in the presence of fibronectin fragment CH296. Transduced cells were co-cultured with human tumor cell lines that overexpress (SK-OV-3) or underexpress (MCF7) p185HER2 to assay for antigen specific im- mune responses. Both CM+ and CD8+ T-cells transduced with the N29γ or N29ζ chTCR demonstrated HER2-specific anti- gen responses, as determined by release of Th1 like cytokines, and cellular cytotoxicity assays. Our results support the fea- sibility of adoptive immunotherapy with genetically modified T-cells expressing a chTCR specific for p185HER2.	杨建民 Michael S FRIEDMAN Christopher M REYNOLDS Marianne T HUBEN Lee WILKE Jennifer FULLER 李桥 Zelig ESHHAR James J MULE Kevin T MCDONAGH	2004	Journal of Microbiology and Immunology2004，2，4：	5
2	In vivo anti-tumor activity of murine hematopoietic stem cells expressing a p185HER2-specific chimeric T-cell receptor gene显示文摘We have confirmed efficient anti-tumor activities of the peripheral lymphocytes transduced with a p185HER2-specific chimeric T-cell receptor gene both in murine and in human in our previous studies. To further test the feasibility of chimeric T-cell receptor in a bone marrow transplantation model, we first, made two murine tumor cell lines: MT901 and MCA-205, to express human p185HER2 by retroviral gene transduction. Murine bone marrow cells were retrovirally transduced to express the chimeric T-cell receptor and gene-modified bone marrow cells were transplanted into lethally irradiated mouse. Six months post transplantation, p185HER2-positive tumor cells:MT-901/HER2 or MCA-205/ HER2 was subcutaneously or intravenously injected to make mouse models simulating primary breast cancer or pulmonary metastasis. The in vivo anti-tumor effects were monitored by the size of the subcutaneous tumor or counting the tumor nodules in the lungs after India ink staining. The size of the subcutaneous tumor was significantly inhibited and the number of pulmonary nodules were significantly decreased in mouse recipients transplanted with chimeric T-cell receptor modified bone marrow cells compared with the control group. Our results suggest the efficient in vivo anti-tumor activities of chimeric T-cell receptor gene modified bone marrow cells.	JIAN MIN YANG MICHAEL S FRIEDMAN MARIANNE T HUBEN JENNIFER FULLER QIAO LI ALFRED E CHANG JAMES J MULE KEVIN T MCDONAGH	2006	Journal of Microbiology and Immunology2006，4，2：	3
3	Laparoscopic treatment of nonparasitic liver cysts: adequate selection of patients and surgical technique显示文摘	Gigot J F Legrand M Hubens G	1996	World J Surg1996，20，：	1
4	Roux-en-Y gastric bypass procedure performed with the da Vinci robot system: is it worth it? 显示文摘	Hubens G Balliu L Ruppert M	2008	Surg Endosc2008，22，7：	1
5	Future prospects of agricultural irrigation technologies显示文摘	Hubener R	1999	Zeitschrift Fur Be wasserungs-wirttschaft1999，34，2：	1
6	Tumor markers in bladder cancer显示文摘	Huben RP	1984	Urol-ogy1984，23，3：	1
7	Tumor grade and stage as prognostic variable in upper tract urothelial tumors显示文摘	Huben R P Mounzer A M Murphy G P	1988	Cancer1988，62，9：	1
8	Quantitative competitive PCR for the detection of genetically modified organisms in food显示文摘	Philipp Hubener and Edgar Studer	1999	Food contro1999，10，：	1
9	Vasectomy and pros- tate cancer risk显示文摘	Mettlin C Natarajan N Huben R	1990	AM J Epidemiol1990，132，6：	1
10	Ischemia and reactive oxygen species in sympathetic hyperactivity states:a vicious cycle that can be interrupted by renal denervation?显示文摘	Hubens LE Verloop WL Joles JA	2013	Curr Hypertens Rep2013，15，4：	1
11	Malignant phyllodes tumor of prostate显示文摘	Lopez-Behran A Graeta JF Huben R	1990	Urology1990，35，2：	1
12	Differential contributions of dopaminergic D( 1 ) - and D(2) - like receptors to to cognitive function in rhesus monkeys显示文摘	Von Huben SN Davis SA Lay CC	2006	Psychopharmacology (Berl)2006，188，4：	1
13	The influence of a pneumoperitoneum on the peritoneal implantation of free intraperitoneal colon cancer cells显示文摘	G. Hubens M. Pauwels A. Hubens P. Vermeulen E. Marck E. Eyskens	1996	Surgical Endoscopy1996，，8：	1
14	Roux-en-Y gastric bypass as a re-do procedure for failed restrictive gastric surgery 显示文摘	Van Dessel E Hubens G Ruppert M	2008	Surg Endosc2008，22，：	1
15	Laparoscopic treatment of nonparasitic liver cysts : adequate selection of patients and surgi- cal technique 显示文摘	Gigot JF Legrand M Hubens G	1996	World J Surg1996，20，5：	1
16	Laparoscopic treatment of nonparasitic liver cysts:adequate selection of patients and surgical technique显示文摘	Gigot JF Legrand M Hubens G	1996	World J Surg1996，20，5：	1
17	Laparoscopic treatment of nonparasitic liver cysts:adequate selection of patients and syrgical technique显示文摘	Legrand M ralld M Hubens G	1996	World J surg1996，20，1：	1
18	Port site metastases: where are we at the beginning of the 21st century? 显示文摘	Hubens G	2002	Acta Chir Belg2002，102，4：	1
19	Laparoscopie treatment of nonparasitic liver cysts : adequate selection of patients and surgical technique 显示文摘	Gigot JF Legrand M Hubens G	1996	World J Surg1996，20，：	1
20	Critical-period plasticity in the visual cortex显示文摘	LEVELT C N HUBENER M		0，，：	1

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