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| 1 | Stability of SARS Coronavirus in Human Specimens and Environment and Its Sensitivity to Heating and UV Irradiation显示文摘The causal agent for SARS is considered as a novel coronavirus that has never been described both in human and animals previously. The stability of SARS coronavirus in human specimens and in environments was studied. Methods Using a SARS coronavirus strain CoV-P9,which was isolated from pharyngeal swab of a probable SARS case in Beijing, its stability in mimic human specimens and in mimic environment including surfaces of commonly used materials or in household conditions, as well as its resistances to temperature and UV irradiation were analyzed. A total of 106 TCID50 viruses were placed in each tested condition, and changes of the viral infectivity in samples after treatments were measured by evaluating cytopathic effect (CPE) in cell line Vero-E6 at 48 h after infectionn. Results The results showed that SARS coronavirus in the testing condition could survive in serum, 1:20 diluted sputum and feces for at least 96 h, whereas it could remain alive in urine for at least 72 h with a low level of infectivity. The survival abilities on the surfaces of eight different materials and in water were quite comparable, revealing reduction of infectivity after 72 to 96 h exposure. Viruses stayed stable at 4℃, at room temperature (20℃) and at 37℃ for at least 2 h without remarkable change in the infectious ability in cells, but were convened to be non-infectious after 90-, 60- and 30-min exposure at 56℃, at 67℃ and at 75℃, respectively. Irradiation of UV for 60 min on the virus in culture medium resulted in the destruction of viral infectivity at an undetectable level. Conclusion The survival ability of SARS coronavirus in human specimens and in environments seems to be relatively strong. Heating and UV irradiation can efficiently eliminate the viral infectivity. | SHU-MING DUAN, XIN-SHENG ZHAO, RUI-FU WEN, JING-JING HUANG, GUO-HUA PI, SU-XIANG ZHANG, JUN HAN, SHENG-LI BI, LI RUAN, XIAO-PING DONGAND SARS RESEARCH TEAMInstitute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention,Ying-Xin Rd. 100, Beijing 100052, China | 2003 | Biomedical and Environmental Sciences2003，16，3： | 29 |
| 2 | The Genome of Medicinal Plant Macleaya cordata Provides New Insights into Benzylisoquinoline Alkaloids Metabolism显示文摘在动物农业和药的抗菌素的 overuse 引起了一系列潜在的威胁到公共健康。Macleaya cordata 是从 Papaveraceae 家庭的药用的植物种,提供为抗菌剂的制造的一个安全资源为家畜喂添加剂。从 M. 的活跃成分 ? cordata 被知道包括 benzylisoquinoline 碱(偏爱) 象 sanguinarine (圣) 和 chelerythrine (CHE ) 那样的 ?,而是他们的新陈代谢的小径还得在这非模型植物被学习。在 M. 的圣和 CHE 的活跃生合成 ? cordata 被喂 13标记 C 的酷氨酸。为了增加,推进卓见,我们 de novo 定序 M 的整个染色体。cordata,第一从 Papaveraceae 家庭被定序。M.? 盖住 378 Mb 的 cordata 染色体与 43.5%being 编码 22,328 预言的编码蛋白质的基因 transposable 元素。作为基础 eudicot 的一个成员, M.? cordata 染色体缺乏 ? 发生在几乎所有 eudicots 的 paleohexaploidy 事件。从 genomics 数据, 16 的一个完全的集合 ? 新陈代谢 ? 为圣和 CHE 生合成的基因被检索,并且 14 项他们的生物化学的活动被验证。这些 genomics 和新陈代谢的数据在 M. 显示出保存 BIA 新陈代谢的小径 ? cordata 并且由庄稼改进或微生物引起的小径重建为圣和 CHE 的未来生产提供知识基础。 | Xiubin Liu Yisong Liu Peng Huang Yongshuo Ma Zhixing Qing Qi Tang Huifen Cao Pi Cheng Yajie Zheng Zejun Yuan Yuan Zhou Jinfeng Liu Zhaoshan Tang Yixiu Zhuo Yancong Zhang Linlan Yu Jialu Huang Peng Yang Qiong Peng dinbo Zhang Wenkai Jiang Zhonghua Zhang Kui Lin Dae-Kyun Ro Xiaoya Chen Xingyao Xiong Yi Shang Sanwen Huang Jianguo Zeng | 2017 | Molecular Plant2017，10，7： | 19 |
| 3 | Investigating the dynamic mechanical behaviors of polyurea through experimentation and modeling显示文摘Polyurea is widely employed as a protective coating in many fields because of its superior ability to improve the anti-blast and anti-impact capability of structures.In this study,the mechanical properties of polyurea XS-350 were investigated via systematic experimentation over a wide range of strain rates(0.001-7000 s^-1)by using an MTS,Instron VHS,and split-Hopkinson bars.The stress-strain behavior of polyurea was obtained for various strain rates,and the effects of strain rate on the primary mechanical properties were analyzed.Additionally,a modified rate-dependent constitutive model is proposed based on the nine-parameter Mooney-Rivlin model.The results show that the stress-strain curves can be divided into three distinct regions:the linear-elastic stage,the highly elastic stage,and an approximate linear region terminating in fracture.The mechanical properties of the polyurea material were found to be highly dependent on the strain rate.Furthermore,a comparison between model predictions and the experimental stress-strain curves demonstrated that the proposed model can characterize the mechanical properties of polyurea over a wide range of strain rates. | Hao Wang Ximin Deng Haijun Wu Aiguo Pi Jinzhu Li Fenglei Huang | 2019 | Defence Technology(防务技术)2019，15，6： | 13 |
| 4 | A COMPARISON OF SOME ELECTRONIC COUNTERMEASURES ON INVERSE SYNTHETIC APERTURE RADAR (ISAR)显示文摘Inverse Synthetic Aperture Radar (ISAR) is an important means for target classification, recognition, identification and many other military applications. A simulation model of ISAR system is established after analyzing the principle of ISAR imaging, and then several ECM (Electronic Counter Measurement) techniques are studied. Simulation experiments are done on the basis of such research. The experimental result of the research can be used for ECM equipment. | Fan Luhong Pi Yiming Huang Shunji Hou Yinming | 2006 | Journal of Electronics(China)2006，23，1： | 9 |
| 5 | Identification and characterization of two morphologically distinct stem cell subpopulations from human urine samples显示文摘Urine-derived stem cells(USCs)have shown potentials for the treatment of skeletal and urological disorders.Based on published literature and our own data,USCs consist of heterogeneous populations of cells.In this paper,we identify and characterize two morphologically distinct subpopulations of USCs from human urine samples,named as spindle-shaped USCs(SS-USCs)and rice-shaped USCs(RS-USCs)respectively.The two subpopulations showed similar clone-forming efficiency,while SS-USCs featured faster proliferation,higher motility,and greater potential for osteogenic and adipogenic differentiation,RS-USCs showed greater potential for chondrogenic differentiation.POU5F1 was strongly expressed in both subpopulations,but MYC was weakly expressed.Both subpopulations showed similar patterns of CD24,CD29,CD34,CD44,CD73,CD90 and CD105 expression,while a higher percentage of RS-USCs were positive for CD133.SS-USCs were positive for VIM,weakly positive for SLC12A1 and UMOD,and negative for KRT18,NPHS1,AQP1 and AQP2,indicating a renal mesenchyme origin;while RSUSCs are positive for VIM,partially positive for KRT18,NPHS1,AQP1,SLC12A1 and UMOD,and negative for AQP2,indicating a nephron tubule origin.The above results can facilitate understanding of the biological characteristics of subpopulations of USCs,and provide a basis for further research and applications of such cells. | An-Jing Chen Jin-Kui Pi Jun-Gen Hu Yi-Zhou Huang Hong-Wei Gao Sheng-Fu Li Jesse Li-Ling Hui-Qi Xie | 2020 | Science China(Life Sciences)2020，63，5： | 7 |
| 6 | Partially hydroxylated ultrathin iridium nanosheets as efficient electrocatalysts for water splitting显示文摘Ultrathin two-dimensional(2D)materials have attracted considerable attention for their unique physicochemical properties and promising applications;however,preparation of freestanding ultrathin 2D noble metal remains a significant challenge.Here,for the first time,we report use of a wet-chemical method to synthesize partially hydroxylated ultrathin Ir nanosheets(ir-NSs)of only five to six atomic layers*thickness.Detailed analysis indicates that the growth confinement effect of carbon monoxide and the partially hydroxylated surface play a critical role in formation of the ultrathin structure.The ultrathin Ir-NSs exhib让excellent performance for both the hydrogen evolution reaction and oxygen evolution reaction in a wide pH range,outperforming the state-of the-art Pt/C and IrO2,respectively.Density-functional theory calculations reveal that the partial hydroxylation not only enhances the surface electron transfer between Ir-sites and intermediate O-species,but also guarantees efficient irdtial activation ofbond cleavage of H-O-H for first-step H2O splitting.This;ultimately,breaks through barriers to full water splitting,with efficient electron transfer essentially maintained. | Zifang Cheng Bolong Huang Yecan Pi Leigang Li Qi Shao Xiaoqing Huang | 2020 | National Science Review2020，7，8： | 4 |
| 7 | Altitude-related shift of relative abundance from insect to sunbird pollination in Elaeagnus umbellata(Elaeagnaceae)显示文摘The evolution of floral traits has been thought to be influenced by local,effective pollinators.However,little attention has been paid to the possibility that altitudinal variation in floral traits could be mediated by local pollinator functional groups,particularly a shift from bees to birds.Plant size,floral traits,pollinators and their pollination roles were investigated in the spring-flowering shrub Elaeagnus umbellata(Elaeagnaceae)at three altitudes(1160,1676,and 2050 m)in Minshan,Sichuan Province,on the northern rim of the Hengduan Mountains,southwest China.Compared to lower altitudes,higher-altitude plants were smaller but the floral tubes were longer,with a larger volume of nectar of lower sugar concentration but with a greater proportion of sucrose.The visitation frequency of bees decreased with altitude,whereas the sunbirds did the opposite.Birds and bees foraged for nectar but not pollen,and birds deposited more pollen grains per visit relative to bees and least were syrphid flies.Excluding birds decreased seed set at high but not at mid-or low altitude.Our study of E.umbellata revealed an association between altitudinal variation in floral traits and a change in the relative abundance of the major pollinators with altitude from majority bees to majority sunbirds.Although abiotic factors also tend to vary with altitude and can affect floral traits,nectar properties of“pro-bird”pollination were observed at high altitude. | Hua-Qiang Pi Qiu-Mei Quan Bo Wu Xiao-Wen Lv Li-Min Shen Shuang-Quan Huang | 2021 | Journal of Systematics and Evolution2021，59，6： | 3 |
| 8 | Near-atomic structure of the inner ring of the Saccharomyces cerevisiae nuclear pore complex显示文摘Nuclear pore complexes(NPCs)mediate bidirectional nucleocytoplasmic transport of substances in eukaryotic cells.However,the accurate molecular arrangement of NPCs remains enigmatic owing to their huge size and highly dynamic nature.Here we determined the structure of the asymmetric unit of the inner ring(IR monomer)at 3.73Åresolution by single-particle cryo-electron microscopy,and created an atomic model of the intact IR consisting of 192 molecules of 8 nucleoporins.In each IR monomer,the Z-shaped Nup188–Nup192 complex in the middle layer is sandwiched by two approximately parallel rhomboidal structures in the inner and outer layers,while Nup188,Nup192 and Nic96 link all subunits to constitute a relatively stable IR monomer.In contrast,the intact IR is assembled by loose and instable interactions between IR monomers.These structures,together with previously reported structural information of IR,reveal two distinct interaction modes between IR monomers and extensive flexible connections in IR assembly,providing a structural basis for the stability and malleability of IR. | Zongqiang Li Shuaijiabin Chen Liang Zhao Guoqiang Huang Xiong Pi Shan Sun Peiyi Wang Sen-Fang Sui | 2022 | Cell Research2022，32，5： | 2 |
| 9 | On the friction effects on rigid-body penetration in concrete and aluminium-alloy targets显示文摘The friction on the projectile shank is usually excluded in the penetration analysis due to the difficulties to measure the pressure and frictional coefficient.In this article,the frictional force on projectile shank is discussed indirectly through the comparison between experimental data and empirical/analytical formulas of the penetration depth for both concrete and aluminium-alloy targets.It is found that the effect of the frictional force along the projectile shank can be further discussed by the afore comparison and discussion and cannot be ignored because of the relatively large effecting area,especially for deep penetration of concrete and aluminium-alloy targets,where the friction will account for more proportion of penetration resistance. | C.G. Chai A.G. Pi Q.M. Li F.L. Huang | 2019 | Defence Technology(防务技术)2019，15，4： | 2 |
| 10 | Origin, Evolution, and Genotyping of Emergent Porcine Epidemic Diarrhea Virus Strains in the United States显示文摘 | Yao-Wei Huang Allan W. Dickerman Pablo Pi?eyro Long Li Li Fang Ross Kiehne Tanja Opriessnig Xiang-Jin Meng | 2013 | mBio2013，，5： | 2 |
| 11 | Crosslinked polyurethane–epoxy hybrid emulsion with core–shell structure显示文摘 | Xiufang Wen Ruilian Mi Ying Huang Jiang Cheng Pihui Pi Zhuoru Yang | 2010 | Journal of Coatings Technology and Research2010，，3： | 2 |
| 12 | Silicon-based inorganic-organic hybrid optoelectronic synaptic devices simulating cross-modal learning显示文摘With advances in Si-based technology infrastructures and the rapid integration of Si-based optoelectronics, Si-based optoelectronic synaptic devices have the potential to greatly facilitate the large-scale deployment of neuromorphic computing. The incorporation of solution-processable polymer semiconductors into Si-based optoelectronics may enable the cost-effective fabrication of optoelectronic synaptic devices.Poly(3-hexylthiophene)(P3HT) is a semiconducting polymer used to manufacture optoelectronic synaptic transistors with P3HT channels and Si gates. The gate dielectric between them consists of a SiO2 layer.Hybrid inorganic-organic Si/P3HT optoelectronic synaptic transistors can mimic synapses when exposed to optical and electrical stimuli. The Si/P3HT synaptic devices can spatiotemporally integrate optical and electrical stimuli to mimic cross-modal learning. | Yayao LI Yue WANG Lei YIN Wen HUANG Wenbing PENG Yiyue ZHU Kun WANG Deren YANG Xiaodong PI | 2021 | Science China(Information Sciences)2021，64，6： | 2 |
| 13 | Tanshinone Ⅱ A protects cardiac myoeytes against oxidative stress-triggered damage and apoptosis显示文摘 | Fu J Huang H Du J Pi R Chen J Liu P | 2007 | Eur J Pharmacol2007，568，13： | 1 |
| 14 | Gas sensing behavior of a single tin dioxide sensor under dynamic temperature modulation显示文摘 | Huang X Meng F Pi Z | 2004 | Sensors Actuators2004，99，23： | 1 |
| 15 | Cucurbitacin Ⅰ suppressed stem-like property and enhanced radiation-induced apoptosis in head and neck squamous carcinoma--derived CD44 (+)ALDH1 (+) cells显示文摘 | Chen YW Chen KH Huang PI | | 0，，11： | 1 |
| 16 | Resveratrol in- duced apoptosis and incrased radiosensitivity in CD133-positive cells derived from a typical teratoid/ rhabdoid tumor 显示文摘 | Kao CL Huang PI Tsai PH | 2009 | Int J Radiat Oncol Biol Phys2009，74，1： | 1 |
| 17 | Analgesic effect of lidocaine patch 5% in the treatment of acute herpes zoster:doule lind and vehicle controlled study显示文摘 | Lin pi Fan SZ Huang CH | 2008 | Reg Anesth Pain Med2008，33，4： | 1 |
| 18 | The global ionospheric asymmetry in total electron content显示文摘 | MENDILLO M HUANG C L PI X Q | 2005 | J Atmos Terr Phys2005，67，： | 1 |
| 19 | Pi J Chronic UVA irradiation of human HaCaT keratinocytes induces malignant transformation associated with acquired apoptotic resistance 显示文摘 | He YY Pi J Huang JL | 2006 | Oncogene2006，25，26： | 1 |
| 20 | The ARGONAUTE10 gene modulates shoot apical meristem maintenance and establishment of leaf polarity by repressing miR165/166 in Arabidopsis 显示文摘 | Liu Q L Yao X Z Pi L M Wang H Cui X F Huang H | 2009 | The Plant Journal2009，1，： | 1 |
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