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| 1 | Electroacupuncture activates enteric glial cells and protects the gut barrier in hemorrhaged rats显示文摘AIM:To investigate whether electroacupuncture ST36 activates enteric glial cells,and alleviates gut inflammation and barrier dysfunction following hemorrhagic shock.METHODS:Sprague-Dawley rats were subjected to approximately 45% total blood loss and randomly divided into seven groups:(1) sham:cannulation,but no hemorrhage;(2) subjected to hemorrhagic shock(HS);(3) electroacupuncture(EA) ST36 after hemorrhage;(4) vagotomy(VGX)/EA:VGX before hemorrhage,then EA ST36;(5) VGX:VGX before hemorrhage;(6) a-bungarotoxin(BGT)/EA:intraperitoneal injection of a-BGT before hemorrhage,then EA ST36; and(7) a-BGT group:a-BGT injection before hemorrhage.Morphological changes in enteric glial cells(EGCs) were observed by immunofluorescence,and glial fibrillary acidic protein(GFAP; a protein marker of enteric glial activation) was evaluated using reverse transcriptase polymerase chain reaction and western blot analysis.Intestinal cytokine levels,gut permeability to 4-k Da fluorescein isothiocyanate(FITC)-dextran,and the expression and distribution of tight junction protein zona occludens(ZO)-1 were also determined.RESULTS:EGCs were distorted following hemorrhage and showed morphological abnormalities.EA ST36 attenuated the morphological changes in EGCs at 6 h,as compared with the VGX,a-BGT and HS groups.EA ST36 increased GFAP expression to a greater degree than in the other groups.EA ST36 decreased intestinal permeability to FITC-dextran(760.5 ± 96.43 ng/m L vs 2466.7 ± 131.60 ng/m L,P < 0.05) and preserved ZO-1 protein expression and localization at 6 h afterhemorrhage compared with the HS group.However,abdominal VGX and a-BGT treatment weakened or eliminated the effects of EA ST36.EA ST36 reduced tumor necrosis factor-a levels in intestinal homogenates after blood loss,while vagotomy or intraperitoneal injection of a-BGT before EA ST36 abolished its antiinflammatory effects.CONCLUSION:EA ST36 attenuates hemorrhageinduced intestinal inflammatory insult,and protects the intestinal barrier integrity,partly via activation of EGCs. | Sen Hu Zeng-Kai Zhao Rui Liu Hai-Bin Wang Chun-Yu Gu Hong-Min Luo Huan Wang Ming-Hua Du Yi Lv Xian Shi | 2015 | World Journal of Gastroenterology2015，21，5： | 15 |
| 2 | A cyclic nucleotide-gated channel mediates cytoplasmic calcium elevation and disease resistance in rice显示文摘The transient elevation of cytoplasmic calcium is essential for pathogen-associated molecular pattern(PAMP)-triggered immunity(PTI).However,the calcium channels responsible for this process have remained unknown.Here,we show that rice CDSI(CELL DEATH and SUSCEPTIBLE to BLAST 1)encoding OsCNGC9;a cyclic nucleotide-gated channel protein,positively regulates the resistance to rice blast disease.We show that OsCNGC9 mediates PAMP-induced Ca2+influx and that this event is critical for PAMPs-triggered ROS burst and induction of PTI-related defense gene expression.We further show that a PTI related receptor-lih cytoplasmic kinase OsRLCK185 physically interacts with and phosphorylates OsCNGC9 to activate its channel activity.Our results suggest a signaling cascade linking pattern recognition to calcium channel activation,which is required for initiation of PTI and disease resistance in rice. | Jiachang Wang Xi Liu An Zhang Yulong Ren Fuqing Wu Gang Wang Yang Xu Cailin Lei Shanshan Zhu Tian Pan Yongfei Wang Huan Zhang Fan Wang Yan-Qiu Tan Yupeng Wang Xin Jin Sheng Luo Chunlei Zhou Xiao Zhang Jinling Liu Shuai Wang Lingzhi Meng Yihua Wang Xi Chen Qibing Lin Xin Zhang Xiuping Guo Zhijun Cheng Jiulin Wang Yunlu Tian Shijia Liu Ling Jiang Chuanyin Wu Ertao Wang Jian-Min Zhou Yong-Fei Wang Haiyang Wang Jianmin Wan | 2019 | Cell Research2019，29，10： | 13 |
| 3 | LA-ICP-MS Zircon U-Pb Dating of Intermediate-Acidic Intrusive Rocks and Molybdenite Re-Os Dating from the Bangpu Mo (Cu) Deposit, Tibet and its Geological Implication显示文摘The multi-stage intrusions of intermediate-acid magma occur in the Bangpu mining district, the petrogenic ages of which have been identified. The times and sequences of their emplacement have been collated and stipulated in detail in this paper by using the laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) zircon U-Pb dating method. The ages of biotite monzogranite that were formed before mineralization in the southwest of this mining district are 70±1 Ma (mean square of weighted deviates (MSWD) =9.5, n=8) and 60.60±0.31 Ma (MSWD=3.8, n=16), which belong to the late Cretaceous-early Paleocene in age. That means, they are products of an early tectonicmagmatic event of the collision between the Indian and Asian continentals. The ages of ore-bearing monzogranite porphyry and ore-bearing diorite porphyrite are 16.23±0.19 Ma (MSWD=2.0, n=26) and 15.16±0.09 Ma (MSWD=3.9, n=5) separately, which belong to the middle Miocene in age; namely, they are products of the Gangdese post-collision extensional stage when crust-mantle materials melted and mixed as well as magmatic intrusion simultaneously occurred. Some zircons with ages of 203.6±2.2 Ma (MSWD=1.18, n=7) were captured in the ore-bearing diorite porphyrite, which shows that there had been tectono-magmatic events in the late Triassic-early Jurassic. Molybdenum (copper) ore-bodies produced in the monzogranite porphyry and copper (molybdenum) ore-bodies produced in the diorite porphyrite are the main ore types in this ore deposit. The model ages of Re-Os isotopic dating for the 11 molybdenite are 13.97-15.84 Ma, while isochron ages are 14.09±0.49 Ma (MSWD=26). The isochron ages of seven molybdenite from molybdenum (copper) ore with monzogranite porphyry type are 14.11±0.31 Ma (MSWD=5.2). There is great error in the isochron ages of four molybdenite from copper (molybdenum) ore with diorite porphyrite type, and their weighted average model ages of 14.6±1.2 Ma (MSWD=41), which generally represent the mineralization age. The results about the Re-Os isotopic dating of molybdenite in the ore of different types have limited exactly that, the minerlazation age of this ore deposits is about 14.09 Ma, which belongs to the middle Miocene mineralization. The Bangpu deposit has a uniform metallogenic dynamics background with the porphyry type and skarn-type deposits such as Jiama, Qulong and others. | WANG Liqiang CHEN Yuchuan TANG Juxing LU Pengrui LUO Maocheng WANG Huan CHEN Wei LENG Qiufeng | 2012 | Acta Geologica Sinica(English Edition)2012，86，5： | 13 |
| 4 | Calibration of soft sensor by using Just-in-time modeling and Ada Boost learning method显示文摘Soft sensor is an efficacious solution to predict the hard-to-measure target variable by using the process variables.In practical application scenarios, however, the feedback cycle of target variable is usually larger than that of the process variables, which causes the deficiency of prediction errors. Consequently soft sensor cannot be calibrated timely and deteriorates. We proposed a soft sensor calibration method by using Just-in-time modeling and Ada Boost learning method. A moving window consisting of a primary part and a secondary part is constructed.The primary part is made of history data from certain number of constant feedback cycles of target variable and the secondary part includes some coarse target values estimated initially by Just-in-time modeling during the latest feedback cycle of target variable. The data set of the whole moving window is processed by Ada Boost learning method to build an auxiliary estimation model and then target variable values of the latest corresponding feedback cycle are reestimated. Finally the soft sensor model is calibrated by using the reestimated target variable values when the target feedback is unavailable; otherwise using the feedback value. The feasibility and effectiveness of the proposed calibration method is tested and verified through a series of comparative experiments on a pH neutralization facility in our laboratory. | Huan Min Xionglin Luo | 2016 | Chinese Journal of Chemical Engineering2016，24，8： | 11 |
| 5 | Geomicrobial functional groups:A window on the interaction between life and environments显示文摘Microbes are well-known for their great diversity and abundance in modern natural environments.They also are believed to pro-vide critical links among higher organisms and their associated environments.However,the low diversity of morphological fea-tures and structures of ancient microbes preserved in sediments and rocks make them difficult to identify and classify.This diffi-culty greatly hinders the investigation of geomicrobes throughout Earth history.Thus,most previous paleontological studies have focused on faunal and floral fossils.Here,geomicrobial functional groups(GFGs),or a collection of microbes featured in specific ecological,physiological or biogeochemical functions,are suggested to provide a way to overcome the difficulties of ancient mi-crobe investigations.GFGs are known for their great diversity in ecological,physiological and biogeochemical functions.In addi-tion,GFGs may be preserved as the biogeochemical,mineralogical and sedimentological records in sediments and rocks.We reviewed the functions,origins and identification diagnostics of some important GFGs involved in the elemental cycles of carbon,sulfur,nitrogen and iron.GFGs were further discussed with respect to their significant impacts on paleoclimate,sulfur chemistry of ancient seawater,nutritional status of geological environments,and the deposition of Precambrian banded iron formations. | XIE ShuCheng YANG Huan LUO GenMing HUANG XianYu LIU Deng WANG YongBiao GONG YiMing XU Rana | 2012 | Chinese Science Bulletin2012，57，1： | 11 |
| 6 | Interfacial structure design of MXene-based nanomaterials for electrochemical energy storage and conversion显示文摘2D transition metal carbides,carbonitrides,and nitrides known as MXenes possess high electrical conductivity,large redox active surface area,rich surface chemistry,and tunable structures.Benefiting from these exceptional chemical and physical properties,the applications of MXenes for electrochemical energy storage and conversion have attracted increasing research interests around the world.Notably,the electrochemical performances of MXenes are directly dependent on their synthesis conditions,interfacial chemistries and structural configurations.In this review,we summarize the synthesis techniques of MXenes,as well as the recent advances in the interfacial structure design of MXene-based nanomaterials for electrochemical energy storage and conversion applications.Additionally,we provide an in-depth discussion on the relationship between interfacial structure and electrochemical performance from the perspectives of energy storage and electrocatalysis mechanisms.Finally,the challenges and insights for the future research of interfacial structure design of MXenes are outlined. | Jianmin Luo Edward Matios Huan Wang Xinyong Tao Weiyang Li | 2020 | InfoMat2020，2，6： | 10 |
| 7 | Joint contractures in severe burn patients with early rehabilitation intervention in one of the largest burn intensive care unit in China:a descriptive analysis显示文摘Background:Joint contracture is the major clinical complication in burn patients,especially,the severe burn patients.This study aimed to investigate the number and severity of joint contractures in patients with burns affecting greater than or equal to 50%of the total body surface area(TBSA)undergoing early rehabilitation in a burn intensive care unit(BICU).Methods:We analyzed burn patients with burns affecting greater than or equal to 50%of the TBSA admitted to a BICU who received early rehabilitation within 7 days post-injury from January 2011 to December 2015.Demographic and medical information was collected.The range of motion(ROM)of different joints was measured 1 month post-admission.Spearman’s correlation coefficient and logistic regression analysis was used to determine predictors of the presence and severity of contractures.Result:The average affected TBSA of the included burn patients was 67.4%,and the average length of stay in the BICU was 46.2±28.8 days.One hundred and one of 108 burn patients(93.5%)developed at least one joint contracture.The ROM in 67.9%of the affected joints was mildly limited.The majority of contractures in severe burn patients were mild(37.7%)or moderate(33.2%).The wrist was the most commonly affected joint(18.2%),followed by the shoulder,ankle,hip,knee,and elbow.A predictor of the presence of contractures was the length of hospital stay(p=0.049).The severe contracture was related to the area of full-thickness burns,the strict bed rest time,and the duration of rehabilitation in BICU.The length of rehabilitation stay(days)in patients with moderate contracture is 54.5%longer than that in severe contracture(p=0.024)Conclusion:During the long stay in BICU,the length of rehabilitation stay in a BICU could decrease the severity of contractures from severe to moderate in the patients with equal to 50%of the TBSA.Hence,this research reveals the important role of early rehabilitation interventions in severe burn patients. | Jianglin Tan Jian Chen Junyi Zhou Huapei Song Huan Deng Ming Ao Gaoxing Luo Jun Wu | 2019 | Burns & Trauma2019，7，1： | 9 |
| 8 | Progress on the M-type phospholipase A2 receptor in idiopathic membranous nephropathy显示文摘 | Wang Chao Lu Huan Yang Cui Luo Yuezhong | 2014 | Chinese Medical Journal2014，，10： | 9 |
| 9 | A DELLA protein complex controls the arbuscular mycorrhizal symbiosis in plants显示文摘 | Nan Yu Dexian Luo Xiaowei Zhang Junzhong Liu Wanxiao Wang Yue Jin Wentao Dong Jiyun Liu Huan Liu Weibing Yang Longjun Zeng Qun Li Zuhua He Giles E D Oldroyd Ertao Wang | 2014 | Cell Research2014，24，1： | 9 |
| 10 | Fractionated stereotactic radiotherapy with vagina carotica protection technique for local residual nasopharyngeal carcinoma after primary radiotherapy显示文摘 | LIU Feng XIAO Jian-ping XU Ying-jie ZHANG Ye XU Guo-zhen GAO Li YI Jun-lin LUO Jing-wei HUANG Xiao-dong HUAN Fu-kui FANG Hao WAN Bao LI Ye-xiong | 2012 | Chinese Medical Journal2012，，14： | 8 |
| 11 | Oxidation of gaseous elemental mercury in a high voltage discharge reactor显示文摘Effects of the voltage waveform, discharge tooth wheel number and CO2/NO/SO2 concentration in the simulated flue gas on Hg0 oxidation were investigated using a link tooth wheel-cylinder reactor energized by different high voltage power supplies. Negative DC discharge induced more ozone production and a higher Hg0 oxidation efficiency than positive DC discharge and 12 kHz AC discharge. The discharge tooth wheel number had almost no effect on the maximum Hg0 oxidation efficiency. The allowable supplied voltage decreased with the increase of discharge tooth wheel number. CO2 could stabilize the discharge process and increase the maximum voltage for a stable discharge. It has also been found that NO consumed O3 induced by high voltage discharge, thereby decreased Hg0 oxidation efficiency; while SO2 had a slight promoting effect on Hg0 oxidation. | WANG Meiyan, ZHU Tianle, LUO Hongjing, TANG Ping, LI Huan School of Chemistry and Environment, Beihang University, Beijing 100191, China. | 2009 | Journal of Environmental Sciences2009，21，12： | 7 |
| 12 | Superconductivity at 36 K in gadolinium-arsenide oxides GdO_(1-x)F_xFeAs显示文摘In this paper we report the fabrication and superconducting properties of GdO1-xFxFeAs. It was found that when x is equal to 0.17, GdO0.83F0.17FeAs is a su-perconductor with the onset transition temperature Tcon ≈ 36.6 K. Resistivity anomaly near 130 K was observed for all samples up to x = 0.17, and such a phenomenon is similar to that of LaO1-xFxFeAs. Hall coefficient indicates that GdO1-xFxFeAs is conducted by electron-like charge carriers. | CHENG Peng, FANG Lei, YANG Huan, ZHU XiYu, MU Gang, LUO HuiQian, WANG ZhaoSheng & WEN HaiHu National Laboratory for Superconductivity, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China | 2008 | Science China(Physics,Mechanics & Astronomy)2008，51，6： | 6 |
| 13 | SNHG1 functions as an oncogenic lncRNA and promotes osteosarcoma progression by up-regulating S100A6 viamiR-493-5p显示文摘The mechanism behind the aberrant expression of S100A6 in osteosarcoma is seldom reported so far.This study sought to explore the regulatory axis targeting S100A6 involved in osteosarcoma progression.Clinical samples collected from osteosarcoma patients were used to detect the expressions of SNHG1,miR-493-5p,and S100A6 by western bolt analysis and reverse transcription-quantitative polymerase chain reaction(RT-qPCR).The effects of S100A6 on proliferation and osteogenic differentiation were investigated by the CCK-8 assay,colony formation assay,Ethynyl deoxyuridine staining,matrix mineralization assay,and alkaline phosphatase assay.The potential of lncRNAs/miRNAs targeting S100A6 was identified by the bioinformatics approach,and the results were verified by the dual luciferase assay and RNA immunoprecipitation assay.Both in vitro and in vivo rescue experiments were performed to investigate the regulatory relationship between the identified lncRNAs and S100A6.The results showed that S100A6 is highly expressed in osteosarcoma.S100A6 overexpression not only increases the proliferation but also reduces the osteogenic differentiation of osteosarcoma cells,while S1006A silence exerts the opposite effects.Then,SNHG1 is identified to directly interact with miR-493-5p to attenuate miR-493-5p binding to the 3′-untranslated region of S100A6.Notably,S100A6 silence partially rescues the effect of SNHG1 overexpression on proliferation and osteogenic differentiation of osteosarcoma cells.Furthermore,the suppressive role of SNHG1 silence in the growth of osteosarcoma xenograft tumors is countered by S100A6 overexpression.Collectively,this study reveals that S100A6 plays an important role in osteosarcoma progression,and SNHG1 promotes S100A6 expression by competitively sponging miR-493-5p. | Qi Liu Jiaying Luo Huan Wang Lei Zhang Guoxin Jin | 2022 | Acta Biochimica et Biophysica Sinica2022，54，1： | 5 |
| 14 | Monomer reactivity ratios for fluoroacrylate and butyl methacrylate in miniemulsion copolymerizations initiated by potassium persulphate显示文摘有 fluoroacrylate 的丁基 mathacrylate (BMA ) 的 Miniemulsion copolymerization (HFMA, TFMA ) 在 70 ° 被执行;由是采用钾过硫酸盐(KPS ) 的 C 开始者。在低变换层次的共聚物作文被 1 H NMR 系列技术。反应比率被采用 Kellen– 评估; Tudos ( K– ; T )方法,产出明显的反应比率, r BMA = 0.74 , r HFMA = 0.87 并且 r BMA = 0.73 , r TFMA = 0.75 ,分别地,并且 HFMA 和 TFMA 的Q值和电子值被 Alfrey– 计算;普里斯方法。HFMA 和 TFMA 比 BMA 更活跃的结果表演,和跨繁殖的率常数比在这二 copolymerizations 的自我繁殖那大。 | Qing Hua Zhang Zhen Huan Luo Xiao Li Zhan Feng Qiu Chen | 2009 | Chinese Chemical Letters2009，20，4： | 5 |
| 15 | A Polysomnography Study of Kleine-Levin Syndrome in a Single Center显示文摘 | Yan-Wen Luo Huan Yu Lu-Hua Yuan Guo-Xing Zhu | 2016 | Chinese Medical Journal2016，，13： | 5 |
| 16 | Surface morphology and electronic structure in stoichiometric superconductor CaKFe_(4)As_(4) robed by scanning tunneling microscopy/spectroscopy显示文摘CaKFe_(4)As_(4) is a new-type superconductor with a relatively high transition temperature of 35 K among stoichiometric iron-based superconductors. Based on scanning tunneling microscopy/spectroscopy, the surface morphology and electronic structure of CaKFe_(4)As_(4) single crystal were systematically investigated. The cleaved CaKFe_(4)As_(4) showed various morphologies, such as atomically resolved 1×1, 1×2, and √2×√2 lattices. By analyzing the geometrical correlations of these morphologies, the 1×1 and 1×2 lattices were identified as the original and reconstructed As layers, respectively, whereas the √2×√2 lattice was distinguished as the reconstructed alkaline-earth-metal or alkali-metal layer. The superconducting energy gap of 7.3 me V and bosonic mode of 12.7 me V were resolved in the scanning tunneling spectra. In addition, the superconducting energy gaps measured on different terminations were identical and consistent with the values obtained by bulk-sensitive techniques, indicating that the electronic structures of CaKFe_(4)As_(4) were insensitive to the surface reconstructions. Our study clarifies the relationships between complex surface reconstructions and surface terminations and preliminarily presents that there is no obvious effect of surface reconstructions on electronic states. | Xiaodong Yu Zhongxu Wei Zhanyi Zhao Tao Xie Chang Liu Ge He Qihong Chen Lei Shan Huiqian Luo Qing Huan Jie Yuan Kui Jin | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，12： | 5 |
| 17 | Diagnostic accuracy of dynamic contrast-enhanced magnetic resonance imaging for distinguishing pseudoprogression from glioma recurrence:a meta-analysis显示文摘Background:It is crucial to differentiate accurately glioma recurrence and pseudoprogression which have entirely different prognosis and require different treatment strategies.This study aimed to assess the diagnostic accuracy of dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)as a tool for distinguishing glioma recurrence and pseudoprogression.Methods:According to particular criteria of inclusion and exclusion,related studies up to May 1,2019,were thoroughly searched from several databases including PubMed,Embase,Cochrane Library,and Chinese biomedical databases.The quality assessment of diagnostic accuracy studies was applied to evaluate the quality of the included studies.By using the'mada'package in R,the heterogeneity,overall sensitivity,specificity,and diagnostic odds ratio were calculated.Moreover,funnel plots were used to visualize and estimate the publication bias in this study.The area under the summary receiver operating characteristic(SROC)curve was computed to display the diagnostic efficiency of DCE-MRI.Results:In the present meta-analysis,a total of 11 studies covering 616 patients were included.The results showed that the pooled sensitivity,specificity,and diagnostic odds ratio were 0.792(95%confidence interval[CI]0.707-0.857),0.779(95%CI 0.715-0.832),and 16.219(97.5%CI 9.123-28.833),respectively.The value of the area under the SROC curve was 0.846.In addition,the SROC curve showed high sensitivities(>0.6)and low false positive rates(<0.5)from most of the included studies,which suggest that the results of our study were reliable.Furthermore,the funnel plot suggested the existence of publication bias.Conclusions:While the DCE-MRI is not the perfect diagnostic tool for distinguishing glioma recurrence and pseudoprogression,it was capable of improving diagnostic accuracy.Hence,further investigations combining DCE-MRI with other imaging modalities are required to establish an efficient diagnostic method for glioma patients. | Jun Qiu Zhen-Chao Tao Ke-Xue Deng Peng Wang Chuan-Yu Chen Fang Xiao Yi Luo Shu-Ya Yuan Hao Chen Huan Huang | 2021 | Chinese Medical Journal2021，，21： | 5 |
| 18 | Clinical application of a novel sliver nanoparticles biosensor based on localized surface plasmon resonance for detecting the microalbuminuria显示文摘以便基于局部性的表面电浆子回声(LSPR ) 探索 nanobiosensor 的临床的申请,我们使用了我们的 LSPR 生物传感器在这个工作检测 microalbuminuria。裂片 nanoparticles 被使用 nanosphere 平版印刷术制作。反人的白朊抗体被联合方法的胺在传感器表面上使不能调动。在从三个温和 preeclampsia 病人的尿样品的商业白朊和白朊的不同集中根据 LSPR 扑灭系列的山峰被决定。在最佳条件下面,我们的结果证明生物传感器显示了 1 ng/ml 的察觉限制和 1 ng/ml 的宽动态范围到 1 g/ml。而且,三个病人的 microalbuminuria 被我们的生物传感器在一短试金时间以内决定,没有样品纯化。此处建议的这个生物传感器是容易的准备并且能被用于便宜、快速、没有标签、敏感 microalbuminuria 屏蔽。这条途径为开发临床的诊断应用程序提供一个有希望的平台。 | Ting Lai Qiannan Hou Huan Yang Xiangang Luo Mingrong Xi | 2010 | Acta Biochimica et Biophysica Sinica2010，42，11： | 4 |
| 19 | Microarray-based analyses of monocytes from Chinese Uygur patients with Parkinson's disease and cognitive impairment显示文摘Parkinson's disease (PD),a complex neurodegenerative disease,is characterized by the loss of dopamine neurons in the substantia nigra of the midbrain.PD patients have varying degrees of cognitive impairment (CI)1 that we term PD-CI.However,the etiology of these changes remains unexplained.We chose three Uygur male patients with PD-CI and three healthy controls of the same of nationality and sex to explore the pathogenesis of Xinjiang Uygur PD-CI using microarray-based gene expression profiling of monocytes. METHODS Subjects The cases were three Uygur men with PD-CI (sporadic) diagnosed by doctors of the First Affiliated Hospital of Xinjiang Medical University between November 2012 and January 2013.They were 65,72,and 75 years old and were screened using the BrainBank diagnostic criteria (United Kingdom).2 When necessary,diagnosis was confirmed using a head MRI or CT scan.Secondary PD,Parkinson's syndrome,hyperthyroidism and other genetic or neural diseases were excluded.The three healthy individuals in the control group were selected from a survey population about the incidence of PD in Urumqi and were of identical gender and ethnicity as the PD patients,but were not genetically related to the patient group.Their ages were 62,67,and 70 years.These six subjects were used for microarray-based analyzes.We also collected 31 cases of Uygur men with PD-CI (sporadic) and 35 healthy Uygur subjects for qRT-PCR verification of the microarray experiments.To investigate cognitive function,we used Mini-Mental State Examination (MMSE).MMSE scores of junior high school level ≤24 are considered to indicate cognitive disorders.This study was conducted in accordance with the Declaration of Helsinki and with approval from the Ethics Committee of the First Affiliated Hospital of Xinjiang Medical University.Written informed consent was obtained from all participants. | Luo Qin Xia Huan Yang Xinling | 2014 | Chinese Medical Journal2014，，12： | 4 |
| 20 | Maize orthologs of rice GS5 and their transregulator are associated with kernel development显示文摘Genome information from model species such as rice can assist in the cloning of genes in a complex genome,such as maize.Here,we identified a maize ortholog of rice GS5 that contributes to kernel development in maize.The genomewide association analysis of the expression levels of ZmGS5,and 15 of its 26 paralogs,identified a trans-regulator on chromosome 7,which was a BAKi-like gene.This gene that we named as ZmBAK1-7 could regulate the expression of ZmGS5 and three of the paralogs.Candidate-gene association analyses revealed that these five genes were associated with maize kernel development-related traits.Linkage analyses also detected that ZmGSs and ZmBAK1-7 co-localized with mapped QTLs.A transgenic analysis of ZmGS5 in Arabidopsis thaliana L.showed a significant increase in seed weight and cell number,suggesting that ZmGS5 may have a conserved function among different plant species that affects seed development. | Jie Liu Min Deng Huan Guo Sharif Raihan Jingyun Luo Yuancheng Xu Xiaofei Dong Jianbing Yan | 2015 | Journal of Integrative Plant Biology2015，57，11： | 4 |
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