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| 1 | Imbalance between expression of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in invasiveness and metastasis of human gastric carcinoma显示文摘AIM: The expressive balance between matrix metalloproteinase-9 (MMP-9) and its tissue inhibitor of metalloproteinase-1 (TIMP-1) plays a critical role in maintaining the degradation and synthesis of extracellular matrix. Loss of such balance is associated with invasion and metastasis of tumors. This study aimed to determine the expression of MMP-9 and TIMP-1 in gastric carcinoma, and the association of the expressive imbalance between MMP9 and TIMP-1 with the invasion and metastasis and prognosis of gastric carcinoma.METHODS: We used immunohistochemistry to determine the expressions of MMP-9, TTMP-1 and proliferating cell nuclear antigen Ki-67 in the gastric specimens taken from 256 patients with primary gastric carcinoma. The patients were followed-up for up to 96 months.RESULTS: No association between the expression of MMP9 and TIMP-1 and patients' sex and age, tumor size and location of gastric carcinoma was observed. The incidence of the positive expression of MMP-9 in cases with tumors invasion to muscularis propria and visceral peritoneum (70.13% and 69.09%, respectively) was significantly higher than that in cases with tumor invasion only to lamina propria or submucosa (42.50 %, P=0.0162). The positive correlation between MMP-9 expression and the depth of tumor invasion was observed (Pearson correlation coefficient=0.2129,P=0.016). Along with the increase of the metastatic station of lymph nodes, the incidence of the MMP-9 expression was increased by degrees; a positive correlation between them was observed (Pearson correlation coefficient=0.2910,P=0.0001). There was also a significant correlation between MMP-9 expression and the TNM stage in gastric carcinoma (Pearson correlation coefficient=0.3027, P<0.0001). The incidence of MMP-9 expression in stage Ⅱ and Ⅲ/Ⅳ (75.00%and 76.15%, respectively) was significantly higher than those in stage Ⅰ (46.15 %, P<0.0001). A negative correlation between TIMP-1 immunoreactivity and the depth of invasion,status of lymph node metastasis and TNM stage was observed (Pearson correlation coefficient =-0.1688, -0.3556and -0.3004, P=0.023, <0.0001 and <0.0001, respectively).Four types of co-expression of MMP-9 and TIMP-1 were observed; i.e. MMP-9 positive but T IMP-1 negative (n=115),both positive (n=52), both negative (n=62) and MMP-9negative but TIMP-1 positive (n=27). The frequency of serosal invasiveness was significant higher in patients with MMP-9 but without TIMP-1 expression than those with other types of the co-expression (P=0.0303). The incidence of lymph node metastasis was highest in patients with MMP-9but without TIMP-1 expression, and lowest in those with TIMP-1 but without MMP-9 expression (P<0.0001). The survival rate in patients with MMP-9 but without TIMP-1expression was lower than that in those with TIMP-1 but without MMP-9 expression (P=0.0014).CONCLUSION: Our results in gastric carcinoma demonstrated a significant positive association of MMP-9 over-expression with proliferation of tumor cells, the depth of invasiveness,lymph node metastasis and TNM stage, suggesting MMP-9can serve as a molecular marker of tumor invasion and metastasis. We also demonstrate a significant negative relationship of TIMP-1 expression with the depth of invasiveness and lymph node metastasis, which provide a new idea in the tumor biological and genetic treatment.The interaction between MMP-9 and TIMP-1 in the processes of tumor invasion and metastasis is that MMP-9 mainly promotes tumor invasion and metastasis and TIMP-1 inhibits functions of MMP-9. The imbalance between MMP-9 and TIMP-1 expression may suggest the occurrence of tumor invasion and metastasis, predict poor prognosis. For patients with imbalanced MMP-9 and TIMP-1 expression, the optimal treatment scheme needs to be selected. | ShengZhang LiLi Jian-YinLin HuaLin | 2003 | World Journal of Gastroenterology2003，9，5： | 91 |
| 2 | Impact of meteorological factors on the incidence of childhood hand,foot,and mouth disease(HFMD)analyzed by DLNMs-based time series approach显示文摘Background:Hand,foot,and mouth disease(HFMD)has become an emerging infectious disease in China in the last decade.There has been evidence that meteorological factors can influence the HFMD incidence,and understanding the mechanisms can help prevent and control HFMD.Methods:HFMD incidence data and meteorological data in Minhang District,Shanghai were obtained for the period between 2009 and 2015.Distributed lag non-linear models(DLNMs)were utilized to investigate the impact of meteorological factors on HFMD incidence after adjusting for potential confounders of long time trend,weekdays and holidays.Results:There was a non-linear relationship between temperature and HFMD incidence,the RR of 5th percentile compared to the median is 0.836(95%CI:0.671-1.042)and the RR of 95th percentile is 2.225(95%CI:1.774-2.792),and the effect of temperature varied across age groups.HFMD incidence increased with increasing average relative humidity(%)(RR=1.009,95%CI:1.005-1.015)and wind speed(m/s)(RR=1.197,95%CI:1.118-1.282),and with decreasing daily rainfall(mm)(RR=0.992,95%CI:0.987-0.997)and sunshine hours(h)(RR=0.966,95%CI:0.951-0.980).Conclusions:There were significant relationships between meteorological factors and childhood HFMD incidence in Minhang District,Shanghai.This information can help local health agencies develop strategies for the control and prevention of HFMD under specific climatic conditions. | Hongchao Qi Yue Chen Dongli Xu Hualin Su Longwen Zhan Zhiyin Xu Ying Huang Qianshan He Yi Hu Henry Lynn Zhijie Zhang | 2018 | Infectious Diseases of Poverty2018，7，1： | 17 |
| 3 | Transgenic rhesus monkeys carrying the human MCPH1 gene copies show human-like neoteny of brain development显示文摘Brain size and cognitive skills are the most dramatically changed traits in humans during evolution and yet the genetic mechanisms underlying these human-specific changes remain elusive.Here,we successfully generated 11 transgenic rhesus monkeys(8 first-generation and 3 second-generation)carrying human copies of MCPH1,an important gene for brain development and brain evolution.Brain-image and tissue-section analyses indicated an altered pattern of neural-cell differentiation,resulting in a delayed neuronal maturation and neural-fiber myelination of the transgenic monkeys,similar to the known evolutionary change of developmental delay(neoteny)in humans.Further brain-transcriptome and tissue-section analyses of major developmental stages showed a marked human-like expression delay of neuron differentiation and synaptic-signaling genes,providing a molecular explanation for the observed brain-developmental delay of the transgenic monkeys.More importantly,the transgenic monkeys exhibited better short-term memory and shorter reaction time compared with the wild-type controls in the delayed-matching-to-sample task.The presented data represent the first attempt to experimentally interrogate the genetic basis of human brain origin using a transgenic monkey model and it values the use of non-human primates in understanding unique human traits. | Lei Shi Xin Luo Jin Jiang Yongchang chen Cirong Liu Ting Hu Min Li Qiang Lin Yanjiao Li Jun Huang Hong Wang Yuyu Niu Yundi Shi Martin Styner Jianhong Wang Yi Lu Xuejin Sun Hualin Yu Weizhi Ji Bing Su | 2019 | National Science Review2019，6，3： | 12 |
| 4 | Phylogenetic diversity and specificity of bacteria associated with Microcystis aeruginosa and other cyanobacteria显示文摘Interactions between bacteria and cyanobacteria have been suggested to have a potential to influence harmful algal bloom dynamics; however, little information on these interactions has been reported. In this study, the bacterial communities associated with five strains of Microcystis aeruginosa, three species of other Microcystis spp., and four representative species of non-Microcystis cyanobacteria were compared. Bacterial 16S rDNA fragments were amplified and separated by denaturing gradient gel electrophoresis (DGGE) followed by DNA sequence analysis. The similarities among bacterial communities associated with these cyanobacteria were compared to the digitized DGGE profiles using the cluster analyses. The bacterial community structure of all cyanobacterial cultures differed. Cluster analysis showed that the similarity values among M. aeruginosa cultures were higher than those of other cyanobacterial cultures. Sequence analysis of DGGE fragments indicated the presence of bacteria including, Alphaproteobacteria, Betaproteobacteria, Gammaproteobacteria, Bacteroidetes and Actinobacteria in the cyanobacterial cultures. Members of the Sphingomonadales were the prevalent group among the Microcystis-associated bacteria. The results provided further evidence for species-specific associations between cyanoabcteria and heterotrophic bacteria, which are useful for understanding interactions between Microcystis and their associated bacteria. | SHI Limei CAI Yuanfeng YANG Hualin XING Peng LI Pengfu KONG Lingdong KONG Fanxiang | 2009 | Journal of Environmental Sciences2009，21，11： | 11 |
| 5 | Spatiotemporal differences and influencing factors of multiple cropping index in China during 1998-2012显示文摘Raising the level of the multiple cropping index(MCI) plays a critical role in food production of China. Therefore, exploring the spatiotemporal differences and factors of the MCI in China is of important practical significance. This paper examines the trend of multiple cropping index(MCI) changes in China at the national, regional and provincial levels during 1998–2012. Based on the Theil index, this paper explores the spatiotemporal differences of the MCI in China. Additionally, a spatial econometric model is used to identify the determinants of the spatiotemporal differences of the MCI from a behavioral perspective. The results are summarized as follows:(1) From the national perspective, the MCI shows an increasing trend year by year, rising from 120.1% in 1998 to 134.26% in 2012;(2) at the regional level, the northeastern region is the fastest growing area in terms of MCI, whereas the central region is the slowest growing area. The central region has the highest MCI level, whereas the northeastern region is connected to the lowest MCI level;(3) according to the Theil index value, the differences in the MCI show a narrowing trend from 0.11 in 1998 to 0.03 in 2012, which is primarily attributed to the differences among the four regions;(4) the MCI shows differences among China's 31 provinces, and the gap that it shows is great; and(5) the proportion of non-agricultural population has a significant negative effect on the MCI. However, the proportions of non-agricultural industry, agricultural policy, per capita operating arable land area and rural household per capita net income have a significant positive impact on the MCI. Therefore, the following policies are suggested to increase the level of China's cultivated land MCI: transferring rural surplus labor, increasing the farmers' income, accelerating the transfer of the use rights of arable land, developing the scale effect of land use, providing further support and benefits to farmers in less developed regions and major grain-producing areas, and strengthening the role of the national agricultural policy. | XIE Hualin | 2015 | Journal of Geographical Sciences2015，25，11： | 11 |
| 6 | Mechanical Properties of Methane Hydrate-Bearing Interlayered Sediments显示文摘The complex distribution of gas hydrate in sediments makes understanding the mechanical properties of hydrate-bearing sediments a challenging task.The mechanical behaviors of hydrate-bearing interlayered sediments are still poorly known.A series of triaxial shearing tests were conducted to investigate the strength parameters and deformation properties of methane hydrate-bearing interlayered sediments at the effective pressure of 1 MPa.The results indicate that the stress-strain curves of hydrate-bearing interlayered sediments are significantly different from that of hydrate-bearing sediments.The peak strength,Young's modulus,initial yielding modulus,and failure mode are deeply affected by the methane hydrate distribution.The failure behaviors and mechanism of strain softening and hardening patterns of the interlayered specimens are more complicated than those of the integrated specimens.This study compares the different mechanical behaviors between integrated and interlayered specimens containing gas hydrate,which can serve as a reference for the prediction and analysis of the deformation behaviors of natural gas hydrate reservoirs. | DONG Lin LI Yanlong LIU Changling LIAO Hualin CHEN Guoqi CHEN Qiang LIU Lele HU Gaowei | 2019 | Journal of Ocean University of China2019，18，6： | 11 |
| 7 | Influences of working pressure on properties for TiO_2 films deposited by DC pulse magnetron sputtering显示文摘TiO2 films were deposited at room temperature by DC pulse magnetron sputtering system.The crystalline structures,morphological features and photocatalytic activity of TiO2 films were systematically investigated by X-ray diffraction(XRD),atomic force microscopy(AFM) and ultraviolet spectrophotometer,respectively.The results indicated that working pressure was the key deposition parameter in?uencing the TiO2 film phase composition at room temperature,which directly affected its photocatalytic activity.With increasing working pressure,the target self-bias decreases monotonously.Therefore,low temperature TiO2 phase(anatase) could be deposited with high working pressure.The anatase TiO2 films deposited with 1.4 Pa working pressure displayed the highest photocatalytic activity by the decomposition of Methyl Orange solution,which the degradation rate reached the maximum(35%) after irradiation by ultraviolet light for 1 h. | ZHANG Can DING Wanyu WANG Hualin CHAI Weiping JU Dongying | 2009 | Journal of Environmental Sciences2009，21，6： | 11 |
| 8 | Techno-Economic Challenges of Fuel Cell Commercialization显示文摘随着资源稀缺、气候变化加剧以及污染程度上升等问题的凸显,经济增长需要依赖更加环保、高效的生产过程。燃料电池具有高效和环保的特点,是内燃机和锅炉的理想替代品,也是通向绿色工业的途径。然而,作为一种新的能源技术,燃料电池的市场渗透率仍然不高。本文通过研究生命周期和价值链活动,对燃料电池系统进行了技术经济和环境方面的分析。首先,我们研究了燃料电池的发展进程,根据其生命周期活动、价值链活动以及最终用户验收标准确定了下一阶段需要采取的行动。然后,我们统一了解了燃料电池商业化的制度障碍。最终用户的主要验收标准是功能、价格和可靠性,比起其他同类产品,如内燃机和电池,燃料电池需要在这些标准上有所提升,以凸显其竞争优势。燃料电池的维修和保养费用可能会使成本大幅增加并减小可用性(由于可靠性较低),而成本和可用性是最终用户能否接受的主要因素。因此,为了克服可靠性的障碍,燃料电池产业面临着巨大的挑战。本文深入洞察了过去几年燃料电池商业化面临的主要障碍,讨论了燃料电池在未来绿色低碳经济中的潜在关键作用。文中还提出了未来低碳经济的必要性,并指出了相关的研究方向。以燃料电池为配置的绿色能源可以真正作为未来的商业模式。通过采取绿色公众投资、实行政策举措,为经济增长提供一条更加持续的发展道路,鼓励更多的环保产业投资。 | Junyewang Hualin Wang Yi Fan | 2018 | Engineering2018，4，3： | 11 |
| 9 | Quantification of trace amounts of impurities in high purity cobalt by high resolution inductively coupled plasma mass spectrometry显示文摘An analytical method using high resolution inductively coupled plasma mass spectrometry (HR-ICP-MS) for rapid simultaneous determination of 24 elements (Be, Mg, Al, Ti, V, Cr, Mn, Fe, Ni, Cu, Zn, Ga, Ge, As, Se, Mo, Ag, Cd, Sn, Sb, Ba, Pt, Au, and Pb) in high purity cobalt was described. Sample digestions were performed in closed microwave vessels using HNO3 and HCl. The matrix effects because of the presence of excess HCl and Co were evaluated. The usefulness of high mass resolution for overcoming some spectral interference was demonstrated. The optimum conditions for the deter- mination were tested and discussed. The standard addition method was employed for quantitative analysis. The detection limits were 0.016-1.50 μg?g?1, the recovery ratios were 92.2%-111.2%, and the RSD was less than 3.6%. The method was accurate, quick, and convenient. It was applied to the determination of trace impurities in high purity cobalt with satisfactory results. | XIE Hualin HUANG Kelong NIE Xidu TANG Yougen | 2007 | Rare Metals2007，26，3： | 10 |
| 10 | Spatial disparities of regional forest land change based on ESDA and GIS at the county level in Beijing-Tianjin-Hebei area显示文摘福雷斯特土地是必需品和为人的幸存和开发提供强壮的支持的重要自然资源。因此,关于在关于它的特征,规则,和空间模式的县水平的森林陆地变化的研究为地区性的资源保护和社会经济的持续发展是重要的。在这研究,我们选择了 GIS 和 Geoda 软件包裹在 Beijing-Tianjin-Hebei 区域县水平探索森林陆地变化的空间不同,基于探索空间数据的全球、本地的空间自相关分析。结果显示出那:1 ) 在 1985-2000 期间,森林陆地变化的全球空间自相关在学习区域是重要的。全球 Moran 的我价值为全部时间时期是 0.3122 并且显示重要积极空间关联(p < 0.05 ) 。Moran 的我在时间阶段从 0.3084 森林陆地变化减少珍视我到 0.3024 在时间阶段 II;2 ) 森林土地的空间聚类特征变化在 Beijing-Tianjin-Hebei 总体上出现区域。Moran 的我从我上演到时间的时间阶段珍视减少 II,哪个森林陆地变化的空间聚类的趋势在 Beijing-Tianjin-Hebei 区域被削弱的工具;3 ) 我为每个县反映的本地 Moran 的格子地图森林陆地变化的本地空间同质,它意味着关于高价值和低价值的区域的那个空间聚类是特别重要的。有高高度的关联的区域主要位于向北多山的区域。然而,有低低的关联的区域在学习区域的中间被散布。因此,保护策略和具体措施应该在学习区域为每地区性的簇被放在地方[出版摘要] | Hualin XIE Chih-Chun KUNG Yuluan ZHAO | 2012 | Frontiers of Earth Science2012，6，4： | 10 |
| 11 | RNA-binding proteins in neurological diseases显示文摘Emerging studies support that RNA-binding proteins(RBPs)play critical roles in human biology and pathogenesis.RBPs are essential players in RNA processing and metabolism,including pre-mRNA splicing,polyadenylation,transport,surveillance,mRNA localization,mRNA stability control,translational control and editing of various types of RNAs.Aberrant expression of and mutations in RBP genes affect various steps of RNA processing,altering target gene function.RBPs have been associated with various diseases,including neurological diseases.Here,we mainly focus on selected RNA-binding proteins including Nova-1/Nova-2,HuR/HuB/HuC/HuD,TDP-43,Fus,Rbfox1/Rbfox2,QKI and FMRP,discussing their function and roles in human diseases. | ZHOU HuaLin MANGELSDORF Marie LIU JiangHong ZHU Li WU Jane Y | 2014 | Science China(Life Sciences)2014，57，4： | 9 |
| 12 | Spatiotemporal differences and convergence of urban industrial land use efficiency for China's major economic zones显示文摘Based on an SBM model, this paper first analyzes the spatial differences of urban industrial land use efficiency(UILUE) in the six main economic zones of China. Then, we analyze the dynamic changes in the urban industrial land's total factor productivity(UILTFP) by using the Malmquist productivity index approach, and we examine the UILTFP's convergence. The results show that the Pearl River Delta and the Yangtze River Delta have a higher UILUEs but show downward trends in UILTFPs. The other four zones, Beijing-Tianjin-Hebei, Chengdu-Chongqing, Guanzhong-Tianshui and the Central Plains, show poorer UILUEs but have upward trends in UILTFPs. A significant excess supply of industrial land and labor exists in all six zones, and the zones in economically developed areas perform better in industrial output. The results of the convergence test do not support σ-convergence but support conditional β-convergence for all zones. These results indicate that the gaps in the UILTFP of industrial land in all six zones, in fact, do not narrow, and the UILTFPs of cities will converge to their own steady states. The regression results of the influencing factors show that the urbanization rate should be increased in the Pearl River Delta and reduced in Beijing-Tianjin-Hebei. The Yangtze River Delta and Chengdu-Chongqing should pay more attention to the problem of industrial labor surplus, and the Pearl River Delta should reduce the proportion of industrial output. All zones should focus on improving the quality of the industrial economy and the land use intensity. | XIE Hualin WANG Wei | 2015 | Journal of Geographical Sciences2015，25，10： | 8 |
| 13 | AN EQUIVALENT CONTINUUM METHOD OF LATTICE STRUCTURES显示文摘一个相等的连续统方法被开发分析三维的拉长的统治格子材料的有效僵硬。力量 andthree 维的塑料收益表面为相等的连续统被计算。一个让步的模型被提出并且与其它的结果相比当模特儿。床上用品在里面,效果被认为包括格子关节的依从。预言的僵硬和力量在对试验性的数据的好同意,验证在拉长统治格子结构的机械性质的预言的现在的模型。 | Fan Hualin Yang Wei | 2006 | Acta Mechanica Solida Sinica2006，19，2： | 8 |
| 14 | Virus like particle-based vaccines against emerging infectious disease viruses显示文摘Emerging infectious diseases are major threats to human health.Most severe viral disease outbreaks occur in developing regions where health conditions are poor.With increased international travel and business,the possibility of eventually transmitting infectious viruses between different countries is increasing.The most effective approach in preventing viral diseases is vaccination.However,vaccines are not currently available for numerous viral diseases.Viruslike particles(VLPs) are engineered vaccine candidates that have been studied for decades.VLPs are constructed by viral protein expression in various expression systems that promote the selfassembly of proteins into structures resembling virus particles.VLPs have antigenicity similar to that of the native virus,but are non-infectious as they lack key viral genetic material.VLP vaccines have attracted considerable research interest because they offer several advantages over traditional vaccines.Studies have shown that VLP vaccines can stimulate both humoral and cellular immune responses,which may offer effective antiviral protection.Here we review recent developments with VLP-based vaccines for several highly virulent emerging or re-emerging infectious diseases.The infectious agents discussed include RNA viruses from different virus families,such as the Arenaviridae,Bunyaviridae,Caliciviridae,Coronaviridae,Filoviridae,Flaviviridae,Orthomyxoviridae,Paramyxoviridae,and Togaviridae families. | Jinliang Liu Shiyu Dai Manli Wang Zhihong Hu Hualin Wang Fei Deng | 2016 | Virologica Sinica2016，31，4： | 7 |
| 15 | Dual Gabriel theorem with applications显示文摘We introduce the quiver of a bicomodule over a cosemisimple coalgebra. Applying this to the coradical C0 of an arbitrary coalgebra C, we give an alternative definition of the Gabriel quiver of C, and then show that it coincides with the known Ext quiver of C and the link quiver of C. The dual Gabriel theorem for a coalgebra with a separable coradical is obtained, which generalizes the corresponding result for a pointed coalgebra. We also give a new description of C1 = C0 ∧X C0 of any coalgebra C, which can be regarded as a generalization of the first part of the well-known Taft-Wilson Theorem for pointed coalgebras. As applications, we give a characterization of locally finite coalgebras via their Gabriel quivers, and a property of the Gabriel quiver of a quasi-coFrobenius coalgebra. | CHEN Xiaowu, HUANG Hualin & ZHANG Pu Department of Mathematics, University of Science and Technology of China, Hefei 230026, China USTC Shanghai Institute for Advanced Studies, Shanghai 201315, China Mathematical Section, the Abdus Salam ICTP, Strada Costiera 11, Trieste 34014, Italy Department of Mathematics, Shanghai Jiao Tong University, Shanghai 200030, China | 2006 | Science China Mathematics2006，49，1： | 6 |
| 16 | Stabilizing nickel sulfide nanoparticles with an ultrathin carbon layer for improved cycling performance in sodium ion batteries显示文摘Nanostructured 金属硫化物是为钠离子电池的潜在的电极材料;然而,他们典型地由于大体积变化和分泌物产品的溶解受不了很差的骑车的稳定性。此处,我们建议合理材料设计策略让基于硫化物的材料处理这些问题。拿镍硫化物(是的 NiS x ) 一个例子,我们证明它的电气化学的性能能被限制 NiS 在滤的 x nanoparticles 传导性的碳 nanotube 网络,并且与 ultrathin 碳涂层层稳定他们。碳层用作一个物理障碍减轻体积变化和活跃材料的溶解的效果。混合材料展出了一个大可逆特定的能力 > 超过 200 的 500 mAh/g 和优秀骑车稳定性骑车。作为电池阳极材料给 NiS x 的传统地有问题的性质,我们相信这里报导的观察高效反映我们的材料设计策略的有效性。 | Feipeng Zhao Qiufang Gong Brian Traynor Duo Zhang Jiaojiao Li Hualin Ye Fengjiao Chen Na Han Yeyun Wang Xuhui Sun Yanguang Li | 2016 | Nano Research2016，9，10： | 6 |
| 17 | A validated UPLC–MS/MS method for simultaneous determination of imatinib, dasatinib and nilotinib in human plasma显示文摘sensitive, rapid, simple and economical ultra-performance liquid chromatography–tandem mass spectrometric method(UPLC–MS/MS) was developed and validated for simultaneous determination of imatinib,dasatinib and nilotinib in human plasma using gliquidone as internal standard(IS). Liquid-liquid extraction method with ethyl acetate was used for sample pre-treatment. The separation was performed on an Xtimate Phenyl column using isocratic mobile phase consisting of A(aqueous phase: 0.15% formic acid and 0.05% ammonium acetate) and B(organic phase: acetonitrile)(A:B=40:60, v/v). The flow rate was 0.25 mL/min and the total run time was 6 min. The multiple reaction monitoring(MRM) transitions, m/z 494.5→394.5 for imatinib, 488.7→401.5 for dasatinib, 530.7→289.5 for nilotinib and 528.5→403.4 for IS, were chosen to achieve high selectivity in the simultaneous analyses. The method exhibited great improvement in sensitivity and good linearity over the concentration range of 2.6–5250.0 ng/mL for imatinib, 2.0–490.0 ng/mL for dasatinib, and 2.4–4700.0 ng/mL for nilotinib. The method showed acceptable results on sensitivity, specificity,recovery, precision, accuracy and stability tests. This UPLC–MS/MS assay was successfully used for human plasma samples analysis and no significant differences were found in imatinib steady-state trough concentrations among the SLC22A5-1889T > C or SLCO1B3 699G > A genotypes(P > 0.05). This validated method can provide support for clinical therapeutic drug monitoring and pharmacokinetic investigations of these three tyrosine kinase inhibitors(TKIs). | Jing Zeng Hualin Cai Zhiping Jiang Qing Wang Yan Zhu Ping Xu Xielan Zhao | 2017 | Journal of Pharmaceutical Analysis2017，7，6： | 6 |
| 18 | Fabrication and Mechanical Testing of Ultralight Folded Lattice-CoreSandwich Cylinders显示文摘In this research,two novel folded lattice-core sandwich cylinders were designed,manufactured,and tested.The lattice core has periodic zigzag corrugations,whose ridges and valleys are directed axially or circumferentially.Free vibration and axial compression experiments were performed to reveal the fundamental frequency,free vibration modes,bearing capacity,and failure mode of the cylinder.A folded lattice core effectively restricts local buckling by reducing the dimension of the local skin periodic cell,and improves the global buckling resistance by enhancing the shear stiffness of the sandwich core.The cylinders fail at the mode of material failure and possess excellent load-carrying capacity.An axially directed folded sandwich cylinder has greater load-carrying capacity,while a circumferentially directed folded sandwich cylinder has higher fundamental frequencies.These two types of folded lattices provide a selection for engineers when designing a sandwich cylinder requiring strength or vibration.This research also presents a feasible way to fabricate a large-dimensional folded structure and promote its engineering application. | Wanxin Li Qing Zheng Hualin Fan Bin Ji | 2020 | Engineering2020，6，2： | 6 |
| 19 | Is investment-cashflow sensitivity a good measure of financial constraints?显示文摘Since Fazzari et al.(1988),investment-cashflow sensitivity has been one of the most important indicators for testing and measuring the external financial constraints of corporations.This study analyzes the effect of changes in the relative cost of internal and external financing on investment decisions in response to tax changes.China's2004 VAT reform decreased companies' effective tax rates,leading to an increase in operating cashflow.This,in turn,reduced the internal cost of financing and the value of the tax shield and increased the cost of debt financing.This study shows that in the case of the VAT reform,investment-cashflow sensitivity increased significantly,whereas cash holdings-cashflow sensitivity and borrowing-slack sensitivity did not significantly change.We conclude that investment-cashflow sensitivity is not an effective measure of financial constraints under information asymmetry,but cash-cashflow sensitivity and borrowing-slack sensitivity may be useful alternatives. | Hualin Wan Kai Zhu | 2011 | China Journal of Accounting Research2011，，4： | 5 |
| 20 | Exploration and practice of general practitioner responsibility system in an urban community of Shanghai显示文摘Objective:The Minhang district of Shanghai was selected as the subject and its public health management model was investigated.Methods:Minhang became a pilot location for the implementation of the general practitioner responsibility system(GPRS)in 2011.Since then,the management model of public health services in the district has gradually merged with the GPRS through a series of actions:the adjustment of organizations and the coordination mechanism in community public health services,the integration of basic public health services and clinic practice,the establishment of an informationized Internet service platform,comprehensive budgeting management of public health service programs,and performance assessment management of health workers.Results:By the end of 2014,the number of residents who had a contractual relationship with a general practitioner(GP)in Minhang had reached 1.4367 million and all of them had family health records.Compared with 2010,both the rate of maternal management and the rate of children management stayed at high level(≥96%),the rate of hypertension management increased(40.73%vs.28.70%),the rate of blood pressure control increased(82.13%vs.77.51%),the incidence of diabetes decreased(21.93%vs.37.85%),the rate of effective control of blood glucose for dia-betic patients increased(82.43%vs.62.77%),and the rate of child health management increased(99.79%vs.91.54%).Conclusion:The GPRS has helped to create a better community health environment.How-ever,the development of this system is limited by several factors,including the following:the shortage of GPs,most GPs do not have good public health service skills and a correct public health concept,unclear division of different services,and imperfect department coordination. | Yan Wu Yanping Zhao Xiaoxia Huang Junyan Wang Huilin Xu Hualin Su | 2015 | Family Medicine and Community Health2015，3，4： | 5 |
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