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| 1 | 急性脊髓损伤患者治疗的临床操作指南:关于MRI基线在临床治疗决策与结果预测中作用的几点建议(英文)显示文摘The objective of this guideline is to outline the role of magnetic resonance imaging(MRI) in clinical decision making and outcome prediction in patients with traumatic spinal cord injury(SCI).Methods A systematic review of the literature was conducted to address key questions related to the use of MRI in patients with traumatic SCI.This review focused on longitudinal studies that controlled for baseline neurologic status.A multidisciplinary Guideline Development Group(GDG) used this information,their clinical expertise,and patient input to develop recommendations on the use of MRI for SCI patients.Based on GRADE(Grading of Recommendation,Assessment,Development and Evaluation),a strong recommendation is worded as ' we recommend,' whereas a weaker recommendation is indicated by 'we suggest.' Results Based on the limited available evidence and the clinical expertise of the GDG,our recommendations were:(1) 'We suggest that MRI be performed in adult patients with acute SCI prior to surgical intervention,when feasible,to facilitate improved clinical decision-making'(quality of evidence,very low) and(2) 'We suggest that MRI should be performed in adult patients in the acute period following SCI,before or after surgical intervention,to improve prediction of neurologic outcome '(quality of evidence,low).Conclusions These guidelines should be implemented into clinical practice to improve outcomes and prognostication for patients with SCI. | Fehlings MG Martin AR Tetreault LA Aarabi B Anderson P Arnold PM Brodke D Burns AS Chiba K Dettori JR Furlan JC Hawryluk G Holly LT Howley S Jeji T Kalsi-Ryan S Kotter M Kurpad S Kwon BK Marino RJ Massicotte E Merli G Middleton JW Nakashima H Nagoshi N Palmieri K Singh A Skelly AC Tsai EC Vaccaro A Wilson JR Yee A Harrop JS | 2017 | 中华神经外科疾病研究杂志2017，16，6： | 8 |
| 2 | Functional characterization of interferon regulatory factor 3a ( IRF-3a), an alternative splice isoform of IRF-3 显示文摘 | Karpova AY Ronco LV Howley PM | 2001 | Mol Cell Biol2001，21，： | 1 |
| 3 | Warts, cancer and ubiquitylation:lessons from the papillomaviruses显示文摘 | Howley PM | 2006 | Trans Am Clin Climatol Assoc2006，117，： | 1 |
| 4 | Inhibition of E2 binding to Brd4 enhances viral genome loss and Phenotypic reve-rsion of bovine papillomavirus-transformed cells显示文摘 | You JX Schweiger MR Howley PM | 2005 | J Virol2005，79，14： | 1 |
| 5 | Ubiquitination of p53 and p21 is differentially affected by ionizing and UV radiation 显示文摘 | Maki CG Howley PM | 1997 | Mol Cell Biol1997，17，1： | 1 |
| 6 | Bromodomain protein 4 mediates the papillomavirus E2 transcriptional activation func-tion显示文摘 | Schweiger MR You J Howley PM | 2006 | J Virol2006，80，9： | 1 |
| 7 | The human papillomaviruses 显示文摘 | Howley PM | 1988 | Am J Med1988，85，1： | 1 |
| 8 | A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18显示文摘 | Huibregtse JM Scheffner M Howley PM | 1991 | EMBO J1991，10，： | 1 |
| 9 | Mutational analysis of cis elements involved in E2 modulation of human papillomavirus type 16 P97 and type 18 PI05 promoters显示文摘 | Romanczuk H Thierry F Howley PM | 1990 | J V irol1990，64，6： | 1 |
| 10 | Role of the human papillomaviruses in human cancer显示文摘 | Howley PM | 1991 | Cancer Res1991，51，18： | 1 |
| 11 | In vivo ubiquitination and proteasome-mediated degradation of p53显示文摘 | Maki CG Huibregse JM Howley PM | 1996 | Cancer Res1996，56，11： | 1 |
| 12 | Physical interaction between specific E2 and Hect E3 enzymes determines functional cooperativity 显示文摘 | Kumar S Kao WH Howley PM | 1997 | J Biol Chem1997，272，13： | 1 |
| 13 | In vivo ubiquitination and proteasome-mediated degradation of p53(1)显示文摘 | Huibregtse JM Howley PM | 1996 | Cancer Res1996，56，11： | 1 |
| 14 | The role of E6AP in the regulation of p53 protein levels in human papillomavirus (HPV)-positive and HPV-negtive cells显示文摘 | Talis AL Huibregtse JM Howley PM | 1998 | J Biol Chem1998，273，11： | 1 |
| 15 | The E6 protein sencoded by HPV 16 and 18 cancomplex p53 invitro显示文摘 | Werness BA Levine AJ Howley PM | 1990 | Science1990，248，： | 1 |
| 16 | Association of hu- man papillomavirus types 16 and 18 E6 protein with p53 显示文摘 | Werness BA Levine A J Howley PM | 1990 | Science1990，248，4951： | 1 |
| 17 | The human E6-AP gene (UBE3A) encodes three potential protein isoforms generated by dif- ferential splicing显示文摘 | Yanmato Y Huibregtse JM Howley PM | 1997 | Genomics1997，41，2： | 1 |
| 18 | The role of E6AP in the regulation of p53 protein levels in human papillomavirus( HPV )- positive and HPV-negative cells 显示文摘 | Talis AL Huibregtse JM Howley PM | 1998 | J Biol Chem1998，273，11： | 1 |
| 19 | The E~6 proteins encoled by HPV~16 and 18 can complex p53 in vitro显示文摘 | Werness BA Levine AJ Howley PM | 1990 | Science1990，248，： | 1 |
| 20 | The bovine papillomavirus E6 oncoprotein interacts with paxillin and disrupts the actin cytoskeleton显示文摘 | Tong X Howley PM | 1997 | Proc Natl Acad Sci USA1997，94，9： | 1 |
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