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| 1 | FK506对实验性卒中疗效的系统评价和Meta分析显示文摘FK506是治疗急性卒中的一种候选用药。决定一种药物是否可以用于临床试验,应当以全面的、无偏倚的动物实验数据的评估为依据,同时还应考虑到这些数据的局限性。这种评估不但应包括药物疗效,而且也应包括药效在体内的特征和局限性。本研究应用系统评价和Meta分析的方法对FK506在卒中动物模型中保护作用的证据进行评价。总共纳入了29个描述了实验步骤的研究,包括1759只动物。结果显示,FK506疗效的点估计值(结局指标的改善)是31.3%[95%CI(0.272-0.354)]。在采用氯胺酮麻醉和短暂性脑缺血的动物实验中,FK506的疗效更高,在使用大鼠,合并其他疾病的动物及仅以梗死面积为疗效指标的实验中,FK506疗效较低。已发表的实验研究质量均接近临床试验标准,但在高质量的研究中,FK506的疗效较低。FK506在实验性脑卒中的研究中,虽然显示出有明显的疗效,但是应注意由于研究质量和可能的发表偏倚等冈素的影响,FK506的疗效可能被过高估计。 | Malcolm R Macleod Tori O’Collins Laura L Horky David W Howells Geoffrey A Donnan 段建钢 | 2006 | 中国循证医学杂志2006，6，6： | 3 |
| 2 | On the nomenclature, classification, and abstractions of compliant mechanisms显示文摘 | MIDHA A NORTON T W HOWELL L L | 1994 | ASME J of Mechanical Design1994，116，1： | 2 |
| 3 | Thrombolysis of stroke mimics via telestroke显示文摘Background The rate of intravenous tissue plasminogen activator(IVtPA)administered to stroke mimics(SM)occurs in 24%-44%of telestroke series.Methods We reviewed 270 suspected acute ischaemic stroke(AIS)patients who were evaluated by telestroke and received IVtPA from 1 July 2016 to 30 September 2017 at our academic comprehensive stroke centre.Results Among 270 AIS patients who received IVtPA via telestroke,64(23.7%)were diagnosed with SM.Compared with patients who had a stroke,the SM group was younger(mean age 56.4 vs 68.2,p<0.0001),more likely to be female(60.9%vs 45.6%,p=0.0324)and had longer door-to needle times(85.3 vs 69.9,p=0.0008).The most common SM diagnoses were migraine 26(40.6%),conversion disorder 12(18.8%),encephalopathy 7(10.9%)and unmasking(9.4%).Among the SM,migraine and conversion disorder were younger compared with the other subgroups(p<0.001).Functional exam elements were noted more frequently in conversion disorder(66.7%)and migraine(34.6%),but rare in other diagnoses(p=0.006).Among the SM,23(35.9%)had a history of a prior similar episodes,and 15(23.4%)had a history of more than 5 spells.Conclusions In our telestroke programme,23.7%of those administered thrombolysis had a final diagnosis of SM. | Vivien H Lee Ravyn Howell Randheer Yadav Sharon Heaton Karen L Wiles Sushil Lakhani | 2022 | Stroke & Vascular Neurology2022，7，3： | 2 |
| 4 | 美国BYU研究生课程柔顺机构的教学特点显示文摘从课程设置、教学手段和方法等方面阐述了美国BYU研究生课程柔顺机构的教学特点。其在专业课程教学中注重培养研究生科研思维和创新意识的举措值得借鉴。 | 邱丽芳 Larry L Howell | 2011 | 中国冶金教育2011，16，4： | 2 |
| 5 | Limit positions of compliant mechanisms using the pseudo-rigid-body model concept显示文摘 | Midha A Howell L L Norton T W | 2000 | Mechanism and Machine Theory2000，35，： | 2 |
| 6 | Structural acoustics finite element analysis of the aoutomobile passenger compartment: A review of current practice显示文摘 | Nefske N J Wolf J A Jr Howell L J | 1982 | Journal of Sound Vibration1982，80，2： | 1 |
| 7 | Structural-acoustic finite element analysis of the automobile passenger compartment: a review of current practice显示文摘 | NEFSKE D J WOLF J A Jr HOWELL L J | 1982 | J Sound & Vibration1982，80，2： | 1 |
| 8 | Gastroesophageal reflux in infants with wheezing 显示文摘 | Sheikh S Stephen T Howell L Eid N | 1999 | Pediatr Pulmonol1999，28，3： | 1 |
| 9 | Evalution ofequivalent spring stiffness for use in a pseudo--rigid-body model of large-deflection compliant mechanisms显示文摘 | HOWELL L L MIDRA A NORTON T W | 1996 | Transactions of the ASME1996，118，3： | 1 |
| 10 | Symptom burden and performance status in a population-based cohort ofambulatory cancer patients显示文摘 | Barbera L Seow H Howell D | 2010 | Cancer2010，8，5： | 1 |
| 11 | Melanin as an adsorbent for drug residues 显示文摘 | Howells L Godfrey M Saner MJ | 1994 | Analyst1994，119，： | 1 |
| 12 | Spherical lamina emergent mechanisms显示文摘 | Wilding S E Howell L L Magleby S P | 2012 | Mechanism and Machine Theory2012，49，： | 1 |
| 13 | Role of transpiration suppression by evaporation of intercepted water in improving irrigation efficiency显示文摘 | Tolk J A Howell T A Steiner J L | 1995 | Irrigation Science1995，16，： | 1 |
| 14 | Ferric uptake regulator (Fur) mutants of Pseudomonas aeruginosa demonstrate defective siderophore-mediated iron uptake, altered aerobic growth, and decreased superoxide dismutase and catalase activities显示文摘 | Hassett D J Sokol P A Howell M L Ma J F Schweizer H T | 1996 | Journal of Bacteriology1996，178，14： | 1 |
| 15 | Scleromyxedema: a ease clinically and his- tologically responsive to intravenous immunoglobulin 显示文摘 | Caudill L Howell E | 2014 | J Cliu Aesthet Dermatol2014，7，5： | 1 |
| 16 | Seven Strategies for Enabling Faculty Success in Distance Education显示文摘 | Farhad Saba Nathan K Lindsay | 2004 | Internet and Higher Education2004，，7： | 1 |
| 17 | Fully compliant double tensural tristable micromechanisms (DTTM)显示文摘 | CHEN Guimin WILCOX D L HOWELL L L | 2009 | Journal of Micromechanics and Microengineering2009，19，02： | 1 |
| 18 | Relevance of mitogen activated protein kinase (MAPK) and phosphotidylinositol- 3-ki- nase/protein kinase B (PI3K/PKB) pathways to induction of apop- tosis by curcumin in breast cells显示文摘 | Squires MS Hudson EA Howells L | 2003 | Biochem Pharmacol2003，65，3： | 1 |
| 19 | Relevance of mitogen activated protein kinase (MAPK) and phospho-tidylinositol-3-kinase/protein kinase B (PI3K/PKB) pathways to induction of apoptosis by curcumin in breast cells 显示文摘 | SquiresM S Hudson E A Howells L | 2003 | Biochem Pharmacol2003，65，3： | 1 |
| 20 | Summer Olympic Tourist Market-Learning from the Paste显示文摘 | Pyo S Cook R Howell R L | 1988 | Tourism Management1988，，2： | 1 |
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