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73篇 您的检索式：作者名="Howdle"

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	题名	作者	年代	出处	被引量
1	Evidence for the involvement of NOD2 in regulating colonic epithelial cell growth and survival显示文摘AIM: To investigate the function of NOD2 in colonic epithelial cells (CEC). METHODS: A combination of in vivo and in vitro analyses of epithelial cell turnover in the presence and absence of a functional NOD2 protein and, in response to enteric Salmonella typhimurium infection, were used. shRNA interference was also used to investigate the consequences of knocking down NOD2 gene expression on the growth and survival of colorectal carcinoma cell lines. RESULTS:In the colonic mucosa the highest levels of NOD2 expression were in proliferating crypt epithelial cells. Muramyl dipeptide (MDP), that is recognized by NOD2, promoted CEC growth in vitro . By contrast,the growth of NOD2-deficient CECs was impaired. In vivo CEC proliferation was also reduced and apoptosis increased in Nod2-/- mice, which were also evident following enteric Salmonella infection. Furthermore, neutralization of NOD2 mRNA expression in human colonic carcinoma cells by shRNA interference resulted in decreased survival due to increased levels of apoptosis. CONCLUSION: These findings are consistent with the involvement of NOD2 protein in promoting CEC growth and survival. Defects in proliferation by CECs in cases of CD may contribute to the underlying pathology of disrupted intestinal homeostasis and excessive inflammation.	Sheena M Cruickshank Louise Wakenshaw John Cardone Peter D Howdle Peter J Murray Simon R Carding	2008	World Journal of Gastroenterology2008，14，38：	3
2	The influence of dispersant concentration on the pore morphology of hydroxyapatite ceramics for bone tissue engineering 显示文摘	Cyster LA Grant DM Howdle SM	2005	Biomaterials2005，26，7：	1
3	The influence of dispersant concentration on the pore morphology of hydroxyapatite ceramics for bone tissue engineering显示文摘	Cyster LA Grant DM Howdle SM	2005	Biomaterials2005，26，7：	1
4	The neurology of liver failure显示文摘	LEWIS M HOWDLE PD	2003	QJM2003，96，：	1
5	Primary small-bowel malig-nancy in the UK and its association with coeliac disease 显示文摘	Howdle PD Jalal PK Holmes GK	2003	Q JMed2003，96，5：	1
6	The neurology of liver failure显示文摘	Lewis M Howdle PD	2003	Q J Med2003，96，9：	1
7	Facile One-Spot Synthesis of Highly Branched Polycaprolactone 显示文摘	Nguyen N T Thurecht K J Howdle S M	2014	Polym Chem2014，5，8：	1
8	The application of supercritical carbon dioxide in polymerization reaction显示文摘	GILES M R HOWDLE S M WINDER R	2000	J Polymer2000，41，18：	1
9	Polyamide/silver antimicrobials: effect of filler types on the silver ion release显示文摘	KUMAR R HOWDLE S MUNSTEDT H	2005	Journal of Biomedical Materials Research Part B: Applied Biomaterials2005，75，：	1
10	Management of patients with non-responsive celiac disease 显示文摘	O'Mahony S Howdle PD 'Losowsky MS	1996	Aliment Pharmacol Ther1996，10，5：	1
11	The effects of intra venous antioxidants in patients with septic shock 显示文摘	Galley HF Howdle PD Walker BE	1997	Free Rad Biol Med1997，23，5：	1
12	The preparation of gold nanoparticle composites using supercritical carbon dioxide显示文摘	Wong B Yoda S Howdle S M	2007	The Journal of Supercritical Fluids2007，42，：	1
13	The neurology of liver failure 显示文摘	Lewis M Howdle PD	2003	QJM2003，96，9：	1
14	Neurologic complications of liver transplantation in adults显示文摘	M. B. Lewis P. D. Howdle	2003	Neurology2003，，9：	1
15	Tin(Ⅱ) ethyl hexanoate catalyzed precipitation polymerization of 8-caprolactone in supercritical carbon dioxide 显示文摘	Barakat D Brown M Howdle S M	2005	Macromolecules2005，38，：	1
16	An in vitro study of coronal microleakage around bonded amalgam coronal-radicular cores in endodontically treated molar teeth显示文摘	Howdle MD Fox K Youngson CC	2002	Quintessence Int2002，33，1：	1
17	An in vitro study of coronal microleakage around bonded amalgam coronal-radicular cores in endodontically treated molar teeth显示文摘	Howdle MD Fox K Youngson CC	2002	Quintessence Int2002，33，1：	1
18	Osteoblast growth on titanium foils coated with hydroxyapatite by pulsed laser ablation显示文摘	M.D Ball S Downes C.A Scotchford E.N Antonov V.N Bagratashvili V.K Popov W.-J Lo D.M Grant S.M Howdle	2001	Biomaterials2001，，4：	1
19	Primary small-bowel ma- lignancy in the UK and its association with coeliac disease 显示文摘	Howdle PD Jalal PK Holmes GK	2003	QJM2003，96，5：	1
20	Supercritical fluid mixing: preparation of thermally sensitive polymer composites containing bioactive materials显示文摘	Howdle S M Watson M S Whitaker M J Popov V K Davies M C Mandel F S Wang J D Shakesheff K M		0，，01：	1

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