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| 1 | The Possible Role of Hydrogen Sulfide as an Endogenous Smooth Muscle Relaxant in Synergy with Nitric Oxide显示文摘 | Rumiko Hosoki Norio Matsuki Hideo Kimura | 1997 | Biochemical and Biophysical Research Communications1997，，3： | 3 |
| 2 | Mapping of metastasis suppressor genes for prostate cancer by microcell-mediated chromosome transfer显示文摘Aim: To identify the metastasis suppressor genes for prostate cancer. Methods: A copy of human chromosomes was introduced into the highly metastatic Dunning R-3327 rat prostate cancer cells by the use of microcell-mediated chromosome transfer. Relationships between the size of human chromosomes introduced into microcell hybrid clones and the number of lung metastases produced by the clones were analyzed to determine which part of human chromosomes contained the metastasis suppressor gene (s) for prostate cancer. To determine portions of human chromosomes introduced, G-banding chromosomal analysis, fluorescence in situ hybridization analysis, and polymerase chain reaction analysis were performed. Results: Each of microcell hybrid clones containing human chromosomes 7, 8, 10, 11, 12, or 17 showed decreased ability to metastasize to the lung without any loss of ttmaorigenicity. This demonstrates that these human chromosomes contain metastasis suppressor genes for prostate cancer. Spontaneous deletion of portions of human chromosomes was observed in the human chromosome 7, 10, 11, 12, and 17 studies. In the human chromosome 8 study, irradiated microcell-mediated chromosome transfer was performed to enrich chromosomal ann deletions of human chromosome 8. Molecular and cytogenetic analyses of microcell hybrid clones demonstrated that metastasis suppressor genes on human chromosomes were located on 7q21-22, 7q31.2-32, 8p21-12, 10q11-22, 11p13-11.2, 12p11-q13, 12q24-ter, and 17pter-q23. KAI1 and MKK4/SEKI were identified as metastasis suppressor genes from 11p11.2 and 17p12, respectively. Conclusion: This assay system is useful to identify metastasis suppressor gene (s) for prostate cancer. | Tomohiko ICHIKAWA Shigeru HOSOKI Hiroyoshi SUZUKI Koichiro AKAKURA Tatsuo IGARASHI Yuzo FURUYA Mitsuo OSHIMURA Carrie W.RINKER-SCHAEFFER Naoki NIHEI J.Carl BARRETT John T.ISAACS Haruo ITO | 2000 | Asian Journal of Andrology2000，2，3： | 2 |
| 3 | The possible role of hydrogen sulfide as an endogenous smooth muscle relaxant in synergy with nitric oxide显示文摘 | Hosoki R Matsuki N Kimura H | 1997 | Bioohem Biophys Res Commun1997，237，： | 2 |
| 4 | Complete amino acid sequence and characterization of the reaction mechanism of a glucosamine-induced novel alcohol dehydrogenase from Agrobacterium radiobacter (tumefaciens) 显示文摘 | Iwamoto R Kubota H Hosoki T | 2002 | Arch Biochem Biophys2002，398，2： | 1 |
| 5 | Possibility of classification in some species of Lilium by PCR-RFLP of ribulose-1,5-bisphosphate carboxylase large subunit (rbeL) gene and ribosomal RNA gene 显示文摘 | HARUKI K HOSOKI T NAKO Y | 1997 | J Japan Soc Hort Sci1997，66，： | 1 |
| 6 | Cuhivar selec- tion of tree peony suitable for December flowering 显示文摘 | HOSOKI T HAMADA M KANDO T | 1989 | Bul- letin of the Faculty of Agriculture Shimane University1989，23，： | 1 |
| 7 | Eosinophils promote epithelial to mesenchymal transition of bronchial epithelial cells显示文摘 | YASUKAWA A HOSOKI K TODA M | 2013 | PLoS One2013，8，64： | 1 |
| 8 | Clinical utility of sequential imaging of hepatocellular carcinoma by contrast-enhanced power Doppler ultrasonography显示文摘 | Suzuki Y Fujimoto Y Hosoki Y | 2003 | Eur J Radiol2003，48，： | 1 |
| 9 | The pos-sible role of hydrogen sulfide as an endoge-nous smooth muscle relaxant in synergywith nitric oxide显示文摘 | Hosoki R Matsuki N Kimura H | 1997 | Biochem Biophys KesCommun1997，237，3： | 1 |
| 10 | The possible role of hydrogen sulfide as an endogenous smooth muscle relaxant in synergy with nitric oxide 显示文摘 | Hosoki R Matsuki N Kimura H | 1997 | Biochem Biophys Res Commun1997，237，3： | 1 |
| 11 | Induction of leukemia - specific antibodies by immunotherapy with leukemia - cell - derived heat shock protein 70显示文摘 | Jimbo J Sato K Hosoki T | 2008 | Cancer Sci2008，99，7： | 1 |
| 12 | The possiblerole of hydrogen sulfide as an endogenous smoothmuscle relaxant in synergy with nitric oxide显示文摘 | HOSOKI R MATSUKI N KIMURA H | 1997 | Biochemical and Biophysical Research Communications1997，237，3： | 1 |
| 13 | Visualization of pancreaticobiliary reflux in anomalous pancreaticobiliary junction by secretin-stimulated dynamic magnetic resonance cholangiopancreatography显示文摘 | Hosoki T Hasuike Y Takeda Y | 2004 | Acta Radiol2004，45，4： | 1 |
| 14 | The possible role of hydrogen sulfide as an endogenous smooth muscle relaxant in synergy with nitrie oxide 显示文摘 | Hosoki R Matsuki N Kimura H | 1997 | Biochem Biophys Res Commun1997，237，3： | 1 |
| 15 | Early detection of breakthrough trichosporonosis by serum PCR in a cord blood transplant recipient being prophylactically treated with voriconazole 显示文摘 | Hosoki K Iwamoto S Kumamoto T | 2008 | J Pediatr Hematol Oncol2008，30，12： | 1 |
| 16 | The possible role of hydrogen sulfide as an endogenous smooth muscle relaxant in synergy with nitric oxide显示文摘 | Hosoki R Matsuki N Kimura H | 1997 | Biochem Biophys Res Commun1997，237，： | 1 |
| 17 | Surface modification of MoS2 using an STM 显示文摘 | Hosoki S Hosaka S Hasegawa T | 1992 | Surf Sci1992，60，3： | 1 |
| 18 | The possible role of hydrogen sulfide as an endogenous smooth muscle relaxant in synergy with nitroxide 显示文摘 | Hosoki R Matsuki N Kimura H | 1997 | Biochem Biophys Res Commun1997，237，3： | 1 |
| 19 | Visualization of tumor vessels in HCC: Power Doppler compared with color Doppler and angiography显示文摘 | Hosoki T Mitomo M Chor S | 1997 | Acta Radiol1997，38，3： | 1 |
| 20 | The possible role of hydrogen sulfide as an endogenous smooth muscle relaxant in synergy with nitric oxide显示文摘 | Matsuki N Kimura H | 1997 | Biochem Biophys Res Commun1997，237，3： | 1 |
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