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| 1 | Gastric emptying, postprandial blood pressure, glycaemia and splanchnic flow in Parkinson's disease显示文摘AIM: To determine gastric emptying, blood pressure, mesenteric artery blood flow, and blood glucose responses to oral glucose in Parkinson's disease. METHODS: Twenty-one subjects(13 M, 8 F; age 64.2 ± 1.6 years) with mild to moderate Parkinson's disease(Hoehn and Yahr score 1.4 ± 0.1, duration of known disease 6.3 ± 0.9 years) consumed a 75 g glucose drink, labelled with 20 MBq 99mTc-calcium phytate. Gastric emptying was quantified with scintigraphy, blood pressure and heart rate with an automated device, superior mesenteric artery blood flow by Doppler ultrasonography and blood glucose byglucometer for 180 min. Autonomic nerve function was evaluated with cardiovascular reflex tests and upper gastrointestinal symptoms by questionnaire. RESULTS: The mean gastric half-emptying time was 106 ± 9.1 min, gastric emptying was abnormally delayed in 3 subjects(14%). Systolic and diastolic blood pressure fell(P < 0.001) and mesenteric blood flow and blood glucose(P < 0.001 for both) increased, following the drink. Three subjects(14%) had definite autonomic neuropathy and 8(38%) had postprandial hypotension. There were no significant relationships between changes in blood pressure, heart rate or mesenteric artery blood flow with gastric emptying. Gastric emptying was related to the score for autonomic nerve function(R = 0.55, P < 0.01). There was an inverse relationship between the blood glucose at t = 30 min(R =-0.52, P < 0.05), while the blood glucose at t = 180 min was related directly(R = 0.49, P < 0.05), with gastric emptying. CONCLUSION: In mild to moderate Parkinson's disease, gastric emptying is related to autonomic dysfunction and a determinant of the glycaemic response to oral glucose. | Laurence G Trahair Thomas E Kimber Katerina Flabouris Michael Horowitz Karen L Jones | 2016 | World Journal of Gastroenterology2016，22，20： | 5 |
| 2 | Nephropathy in dietary hyperoxaluria:A potentially preventable acute or chronic kidney disease显示文摘Hyperoxaluria can cause not only nephrolithiasis and nephrocalcinosis,but also renal parenchymal disease histologically characterized by deposition of calcium oxalate crystals throughout the renal parenchyma,profound tubular damage and interstitial inflammation and fibrosis.Hyperoxaluric nephropathy presents clinically as acute or chronic renal failure that may progress to endstage renal disease(ESRD).This sequence of events,well recognized in the past in primary and enteric hyperoxalurias,has also been documented in a few cases of dietary hyperoxaluria.Estimates of oxalate intake in patients with chronic dietary hyperoxaluria who developed chronic kidney disease or ESRD were comparable to the reported average oxalate content of the diets of certain populations worldwide,thus raising the question whether dietary hyperoxaluria is a primary cause of ESRD in these regions.Studies addressing this question have the potential of improving population health and should be undertaken,alongside ongoing studies which are yielding fresh insights into the mechanisms of intestinal absorption and renal excretion of oxalate,and into the mechanisms of development of oxalate-induced renal parenchymal disease.Novel preventive and therapeutic strategies for treating all types of hyperoxaluria are expected to develop from these studies. | Robert H Glew Yijuan Sun Bruce L Horowitz Konstantin N Konstantinov Marc Barry Joanna R Fair Larry Massie Antonios H Tzamaloukas | 2014 | World Journal of Nephrology2014，3，4： | 3 |
| 3 | Semiparametric estimation of a proportional hazard model with unobserved heterogeneity显示文摘 | Loel L Horowitz | 1999 | Econmetrica1999，67，5： | 1 |
| 4 | Adaptive emergency braking control with underestimation of friction co- efficient显示文摘 | Yi J Alvarez L Horowitz R | 2002 | IEEE Transactions on Control Systems Technology2002，10，3： | 1 |
| 5 | Hyperoxia inhibits oxidant-induced apoptosis in lung epithelial cells 显示文摘 | Franek WR Horowitz S Stansberry L | 2001 | J Biol Chem2001，276，1： | 1 |
| 6 | Retraction 显示文摘 | Zou Z H Horowitz L F Montmayeur J P | 2008 | Nature2008，452，7183： | 1 |
| 7 | Quality of Life of well-differentiated thyroid carcinoma patients显示文摘 | Dagan T Bedrin L Horowitz Z | 2004 | J Laryngol Otol2004，118，7： | 1 |
| 8 | Repeat microvascular decompression for hemifacial spasm显示文摘 | Engh JA Horowitz M Burkhart L | 2005 | J Neuroi Neurosurg Psychiatry2005，76，11： | 1 |
| 9 | Differen- tial expression and localization of de-novo synthesized endometfiotic haptoglobin in endometrium and endometfiotic lesions 显示文摘 | Sharpe-Timms K L Rieke E A Piva M Horowitz G M | 2000 | Hum Reprod2000，15，10： | 1 |
| 10 | Stress-related genomic responses during the course of heat acclimation and its association with ischemic-reperfusion cross-tolerance显示文摘 | Horowitz M Eli-Berchoer L Wapinski I | 2004 | J Appl Physiol (1985)2004，97，4： | 1 |
| 11 | Is good character good enough? The effects of situational varia- bles on the relationship between integrity and counter- productive work behaviors 显示文摘 | Fine S Horowitz I Weigler H & Basis L | 2010 | Human Resource Man- agement Review2010，20，1： | 1 |
| 12 | Fairness in simple bargaining games显示文摘 | Forsythe R Horowitz J L Savin N E | 1994 | Games and Economic Behavior1994，，6： | 1 |
| 13 | Hepatic undifferentiated(embryonal)sarcoma and rhabdomyosarcoma in children:Results of therapy显示文摘 | Horowitz M E Etcubanas E Webber B L | 1987 | Cancer1987，59，： | 1 |
| 14 | Segmentation of plane curves 显示文摘 | Theodosios P Horowitz S L | 1974 | IEEE Transactions on Computers1974，23，8： | 1 |
| 15 | Picture segmentation by a traversal algorithm 显示文摘 | S L Horowitz T Pavlidis | 1972 | Computer Graphics and Image Processing1972，1，4： | 1 |
| 16 | Relationship between Reproductive Success and Male Plasma Vitellogenin Concentrations in Cunner, Tautogolabrus adspersus显示文摘 | MILLS L J GUTJAHR-GOBELL R E HOROWITZ D B | 2003 | Environmental Health Perspective2003，111，1： | 1 |
| 17 | Syndrome of inappropriate antidiuretic hormone or arginine vasopressin secretion in patients fol- lowing neck dissection 显示文摘 | Zacay G Bedrin L Horowitz Z | 2002 | Laryngoscope2002，112，11： | 1 |
| 18 | Attachment styles among young adults: A test of a four-category model显示文摘 | Bartholomew K Horowitz L M | 1991 | Journal of Personality and Social Psychology1991，61，： | 1 |
| 19 | Bi- directional causality in California' s electricity and natural- gas markets 显示文摘 | Woo C K Olson A Horowitz I Stephen L | 2006 | Energy Policy2006，34，15： | 1 |
| 20 | Prolonged 24 - hour subzero preservation of heterotopieany transplanted rat hearts using antifreeze proteins derived from arotie fish 显示文摘 | Amir G Rubinsky B Horowitz L | 2004 | Annala of Thoracic Surgery2004，77，5： | 1 |
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