|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Nanopreparations for mitochondria targeting drug delivery system: Current strategies and future prospective显示文摘Mitochondria are a novel and promising therapeutic target for diagnosis, treatment and prevention of a lot of human diseases such as cancer, metabolic diseases and neurodegenerative disease. Owing to the mitochondrial special bilayer structure and highly negative potential nature, therapeutic molecules have multiple difficulties in reaching mitochondria. To overcome multiple barriers for targeting mitochondria, the researchers developed various pharmaceutical preparations such as liposomes, polymeric nanoparticles and inorganic nanoparticles modified by mitochondriotropic moieties like dequalinium (DQA),triphenylphosphonium (TPP), mitochondrial penetrating peptides (MPPs) and mitochondrial protein import machinery that allow specific targeting.The targeted formulations exhibited enhanced pharmacological effect and better therapeutic effect than their untargeted counterpart both in vitro and in vivo. Nanocarriers may be used for bio-therapeutic delivery into specific mitochondria that possess a great potential treatment of mitochondria related diseases. | Zhenjie Wang Weiling Guo Xiao Kuang Shanshan Hou Hongzhuo Liu | 2017 | Asian Journal of Pharmaceutical Sciences2017，12，6： | 10 |
| 2 | Current strategies for drug delivery to the inner ear显示文摘For many years,drug delivery to the inner ear has been a challenge to physicians in the treatment of inner ear disorders.In the past decade,the field of inner ear drug delivery has emerged with the development of new biomaterials and drug delivery technologies to improve the effectiveness of inner ear drug therapy.This paper reviews a number of inner ear drug delivery strategies including systemic,intratympanic,and intracochlear delivery.A focus of this review is the recent advances in intratympanic delivery of medications;approaches utilizing novel biomaterials as well as other recent developments are also discussed.Biotechnology-based approaches,such as gene and stem cell therapy methods are also reviewed.Among the various strategies,local drug delivery approaches including intratympanic and intracochlear drug delivery methods that limit systemic exposure are particularly promising.These inner ear drug delivery systems provide a new opportunity to improve the treatment of inner ear disorders. | Hongzhuo Liu Jinsong Hao Kevin S.Li | 2013 | Acta Pharmaceutica Sinica B2013，3，2： | 3 |
| 3 | Current sustained delivery strategies for the design of local neurotrophic factors in treatment of neurological disorders显示文摘Although therapeutic potential of neurotrophic factors(NTFs)has been well recognized for over two decades,attempts to translate that potential to the clinic have been disappointing,largely due to significant obstacles in delivery,including inadequate protein dose/kinetics released at target sites.Considerable efforts have been made to improve the therapeutic performance of NTFs.This articles reviews recent developments in localized delivery systems of NTFs for the neurological disorders treatments with a main focus on sustained delivery strategies.Different non-covalent binding approaches have been employed to immobilize proteins in hydrogels,microspheres,electrospun nanofibers,and their combined systems,which serve as depots for sustained local release of NTFs.The challenges associated with current NTFs delivery systems and how these systems can be applied to neurological diseases and disorders have been discussed in the review.In conclusion,optimal delivery systems for NTFs will be needed for reliable and meaningful clinical benefits;ideally,delivering a time and dose-controlled release of bioactive multiNTFs at different individual optimal kinetics to achieve multi-functions in target tissues is significant preferred. | Hongzhuo Liu Yanyan Zhou Shichao Chen Meng Bu Jiayu Xin Sanming Li | 2013 | Asian Journal of Pharmaceutical Sciences2013，8，5： | 2 |
| 4 | Triphenylphosphonium-modified mitochondria-targeted paclitaxel nanocrystals for overcoming multidrug resistance显示文摘Mitochondria are currently known as novel targets for treating cancer,especially for tumors displaying multidrug resistance(MDR). This present study aimed to develop a mitochondriatargeted delivery system by using triphenylphosphonium cation(TPP+)-conjugated Brij 98 as the functional stabilizer to modify paclitaxel(PTX) nanocrystals(NCs) against drugresistant cancer cells. Evaluations were performed on 2 D monolayer and 3 D multicellular spheroids(MCs) of MCF-7 cells and MCF-7/ADR cells. In comparison with free PTX and the non-targeted PTX NCs,the targeted PTX NCs showed the strongest cytotoxicity against both2 D MCF-7 and MCF-7/ADR cells,which was correlated with decreased mitochondrial membrane potential. The targeted PTX NCs exhibited deeper penetration on MCF-7 MCs and more significant growth inhibition on both MCF-7 and MCF-7/ADR MCs. The proposed strategy indicated that the TPP+-modified NCs represent a potentially viable approach for targeted chemotherapeutic molecules to mitochondria. This strategy might provide promising therapeutic outcomes to overcome MDR. | Xue Han Ruijuan Su Xiuqing Huang Yingli Wang Xiao Kuang Shuang Zhou Hongzhuo Liu | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，5： | 1 |
| 5 | Prediction of Human Drug Absorption Using Liposome Electrokinetic Chromatography显示文摘 | Yongjun Wang Jin Sun Hongzhuo Liu Yanjiao Wang Zhonggui He | 2007 | Chromatographia (-)2007，，3： | 1 |
| 6 | Effects of Dosing Protocol on Distribution of Propranolol in Periocular Tissues after Topical Ocular Instillation显示文摘 | Hongzhuo Liu Michael B. Yang S. Kevin Li Jinsong Hao | 2014 | Current Eye Research2014，，： | 1 |
| 7 | A novel mitochondria-targeting tetrapeptide for subcellular delivery of nanoparticles显示文摘Mitochondrial dysfunction is associated with the emergence of several neurological and cardiovascular diseases. Hence, mitochondria-targeting delivery strategies are highly significant and critically needed. In this study, we developed a small library of peptides simulating the mitochondria-targeting peptide SS-31, a promising tetra-peptide with antioxidant character, and subsequently evaluated the toxicity, antioxidant ability and mitochondrial delivery of nanoparticles. Among the designed peptides, RF-2 (DArg-Dmt-Arg-Phe-NH2) showed controlled toxicity and excellent protection against gentamicin-induced hair cell damage, as compared with SS-31. More importantly, RF-2-modified PLGA nanoparticles demonstrated high colocalization with mitochondria and comparable specific subcellular accumulation, when compared with SS-31. Taken together, the obtained results supported RF-2 as a mitochondriatargeting peptide with high potential as a targeted carrier. | Yanhui Sun Aiyan Zhan Shuang Zhou Xiao Kuang Hongyan Shen Hongzhuo Liu Youjun Xu | 2019 | Chinese Chemical Letters2019，30，7： | 1 |
| 8 | Exploring the spatio-temporal impacts of farmland reforestation on ecological connectivity using circuit theory:A case study in the agro-pastoral ecotone of North China显示文摘Farmland reforestation can contribute substantially to ecological restoration.Previous studies have extensively examined the ecological effects of farmland reforestation,but few of them have investigated the spatiotemporal responses of broad-scale landscape connectivity to reforestation.By using a typical agro-pastoral ecotone in northern China as a case study,we addressed this issue based on an innovative integration of circuit theory approach and counterfactual analysis.The forest connectivity through multiple dispersal pathways was measured using the circuit theory approach,and its spatiotemporal changes after reforestation were evaluated by counterfactual analysis.The results showed that from 2000–2015,the reforested farmland occupied 2095 km^2,and 12.5% was on steeply sloped land.Farmland reforestation caused a greater increase in ecological connectivity by adding new ecological corridors and stepping stones in scattered forest areas rather than in areas with dense forest distributions.The newly added corridors and stepping stones were fragmented,short and narrow and thus deserve powerful protection.Future reforestation to improve landscape connectivity should highlight pinch point protection and obstacle removal as well as the tradeoff between farmland loss and farmer survival.Our findings are expected to inform the optimization of the Grain for Green policy from the perspective of broad-scale biodiversity conservation. | LIU Xiaojing LIU Dianfeng ZHAO Hongzhuo HE Jianhua LIU Yaolin | 2020 | Journal of Geographical Sciences2020，30，9： | 1 |
| 9 | Effect of raw material variability of glipizide on the in vitro dissolution rate and in vivo bioavailability performance: The importance of particle size显示文摘The objective of this study was to understand the impact of active pharmaceutical ingredients(API) particle size on a re-developed generic product of glipizide and to improve its formulation so that it exhibits bioequivalent to that of the reference listed drug(RLD). Two commercial batches of APIs(API-1 and API-2) with the same polymorphism and one batch of home-made APIs(API-3) with super-small particle size were used in the present study.The in vitro dissolution profiles of the tested formulations were compared with the RLD in a series of dissolution media. Then, the impact of particle size on in vivo absorption was evaluated in Beagle dogs. Compared with the RLD, formulation A with larger API size showed slower dissolution in p H 6.0 and 7.4 medium, resulting bioinequivalent with the RLD. Conversely, formulation B with smaller API size demonstrated similar in vitro dissolution profiles with the RLD and thus exhibited bioequivalent in the present study. Furthermore, formulation C with super small particle size still exhibited identical oral absorption although rapid dissolution was observed in the tested condition. Herein, it indicated that 2–5 μm might be defined as the 'inert size range' of glipizide for ensuring the bioequivalence with the RLD. The results in the present study might help to obtain a better understanding of the variability in raw materials for oral absorption, develop a bioequivalent product and thus post-market quality control. | Chenyao Zhao Chan Jin Hailing Gao Liyuan Wang Hongzhuo Liu Zhonggui He | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员