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| 1 | 小胶质细胞对星形胶质细胞的免疫和神经保护功能的调节作用(英文)显示文摘在中枢神经系统中,小胶质细胞和星形胶质细胞对神经元的发育、功能维持及细胞存活具有重要的作用。但在炎症反应过程中,星形胶质细胞增生的作用及其对神经元的影响目前并不十分清楚。因此,本研究对不同种类的细胞进行培养,给予细菌脂多糖(lipopolysaccharide,LPS)刺激,观察各种细胞的反应。结果显示,星形胶质细胞可以减轻炎症反应的神经元毒性,提示星形胶质细胞增生主要具有神经保护作用。如果去掉上清液中由星形胶质细胞分泌的胶质细胞源性神经营养因子(glial cell line-derived neurotrophic factor,GDNF),这种神经保护作用显著降低。为了研究星形胶质细胞的免疫功能,本研究培养了高浓度的星形胶质细胞,并发现LPS不能诱导肿瘤坏死因子(tumor necrosis factor,TNF)-α及诱导型一氧化氮合酶(inducible nitric oxide synthase,iN OS)/一氧化氮(nitric oxide,NO)(iN OS/NO)释放。但如果在培养的高浓度星形胶质细胞中增加0.5%~1%的小胶质细胞,则可以诱导TNF-α及iN OS/NO的释放。这提示小胶质细胞和星形胶质细胞间的相互作用对于LPS诱导星形胶质细胞释放前炎症因子及GDNF是必须的。我们还发现,小胶质细胞释放的TNF-α可以通过旁分泌作用调节星形胶质细胞的神经保护功能。综上所述,本研究结果提示星形胶质细胞可能不会直接被LPS激活,而是通过与小胶质细胞相互作用被激活,释放神经营养因子,减少因炎症反应激活的小胶质细胞释放的毒性物质对神经元的损害作用。 | Chen SH Oyarzabal EA Sung YF Chu CH Wang Q Chen SL Lu RB Hong JS 唐颖馨 | 2015 | 神经损伤与功能重建2015，10，1： | 9 |
| 2 | Numerical Simulation for Refraction-Diffraction of Waves in Water of Slowly Varying Current and Topography显示文摘A new numerical finite difference iteration method for refraction-diffraction of waves in waterof slowly varying current and topography is developed in this paper.And corresponding theoretical modelincluding the dissipation term is briefly described,together with some analysis and comparison ofcomputational results of the model with measurements in a hydraulic scale model(Berkhoff et al.,1982).An example of practical use of the method is given,showing that the present model is useful to engineeringpractice. | Hong, GW Feng, WB Xia, QY Pan, SH | 1997 | China Ocean Engineering1997，12，4： | 5 |
| 3 | The growth of brain tumors can be suppressed by multiple transplantation of mesenchymal stem cells expressing cytosine deaminase显示文摘Suicide genes have recently emerged as an attractive alternative therapy for the treatment of various types of intractable cancers.The efficacy of suicide gene therapy relies on efficient gene delivery to target tissues and the localized concentration of final geneproducts. | Chang DY Yoo SW Hong Y Kim S Kim SJ Yoon SH Cho KG Paek SH Lee YD Kim SS Suh-Kim H | 2010 | 中国神经肿瘤杂志2010，8，2： | 3 |
| 4 | 房颤相关卒中后的治疗:利伐沙班vs华法林显示文摘心房颤动(a-fib)相关的急性缺血性脑卒中患者,有很高的复发性卒中和颅内出血的风险.本研究比较了非维生素K拮抗剂的口服抗凝血剂(NOAC)--利伐沙班,与剂量调整后的华法林,在轻度房颤相关急性缺血性卒中患者中的疗效和安全性.受试者是患急性缺血性卒中合并非瓣膜性房颤的患者. | 李建华 Hong KS Kwon SU Lee SH | 2017 | 中国康复2017，32，6： | 2 |
| 5 | Sequential caspase-2 and caspase-8 activation is essential for saikosaponin a-induced apoptosis of human colon carcinama cell lines显示文摘 | Kim BM Hong SH | 2010 | Apoptosis2010，，： | 1 |
| 6 | A novel anti-EGFR monoclonal antibody inhibiting tumor cell growth by rec- ognizing different epitopes from cetuximab显示文摘 | Hong KW Kim CG Lee SH | 2010 | J Biotech- nol2010，145，1： | 1 |
| 7 | Decreased pyruvate kinase M2 ac- tivity linked to cisplatin resistance in human gastric carcinoma cell lines显示文摘 | Yoo BC Ku JL Hong SH | 2004 | Int J Cancer2004，，： | 1 |
| 8 | Inflammatory pseudotumour invoMng the skull base: response to steroid and radiation therapy 显示文摘 | Lee DK Cho YS Hong SH | 2006 | Otolaryngol Head Neck Surg2006，135，1： | 1 |
| 9 | Circulating stromal cell derived faetor-1 is predictive of distant metastasis in gastric carcinoma 显示文摘 | Woo IS Hong SH Byun JH | 2008 | Cancer investigation2008，26，： | 1 |
| 10 | Association study of vascular en- dothelial growth factor polymorphisms with the risk of recurrent spon- taneous abortion显示文摘 | Lee HH Hong SH Shin S J | 2010 | Fertil Steril2010，93，4： | 1 |
| 11 | Structure and invitro bioachvity of htania-based films by micro-arc oxidation 显示文摘 | Hong SH Han Y Xu KW | 2003 | Surf Coat Technol2003，168，： | 1 |
| 12 | Anti-invasive activity of sanguinarina through modulation oftight junctions and matrix metalloproteinase activities in MDA-MB-231 human breast carcinoma cells显示文摘 | Choi YH Choi WY Hong SH Kim SO Kim GY Lee WH | 2009 | Chem Biol Interact2009，179，23： | 1 |
| 13 | Effects of dexmedetomidine on inflammatory responses in patients undergoing laparoscopic cholecystectomy显示文摘 | Kang SH Kim YS Hong TH | 2013 | Acta Anaesthesiol Scand2013，57，4： | 1 |
| 14 | Intranasal administration of a flagellin-adjuvanted inactivated influenza vaccine enhances mucosal immune responses to protect mice against lethal infection显示文摘 | Hong SH Byun YH Nguyen CT | | 0，，2： | 1 |
| 15 | Dysplastic nodules of the liver: imaging findings显示文摘 | Choi BI Han JK Hong SH | 1999 | Abdom Imaging1999，24，3： | 1 |
| 16 | Comparisons of norcantharidin cytotoxic effects on oral cancer cells and normal buccal keratino- cytes显示文摘 | Kok SH Hong CY Kuo MY | 2003 | Oral 0ncol2003，39，1： | 1 |
| 17 | Therapeutic potential of inducedneural stem cells for spinal cord injury 显示文摘 | Hong JY Lee SH Lee SC | 2014 | J Biol Chem2014，289，32： | 1 |
| 18 | Minimum 2-year follow-up resuh of degenerative spinal stenosis treated with interspinousu(coflex)显示文摘 | Park SC Yoon SH Hong YP | 2009 | J Korean Neurosurg Soe2009，46，4： | 1 |
| 19 | Neutralization of hepatitis B virus (HBV) by human monoclonal antibody against HBV surface antigen (HBsAg) in chimpanzees显示文摘 | Kim SH Shin YW Hong KW | 2008 | Antiviral Res2008，79，3： | 1 |
| 20 | Red scrotum syndrome:successful treatment with oral doxycycline 显示文摘 | Byun JW Hong WK Han SH | 2012 | Int J Dermatol2012，51，3： | 1 |
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