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| 1 | Total glucosides of paeony attenuates animal psoriasis induced inflammatory response through inhibiting STAT1 and STAT3 phosphorylation显示文摘OBJECTIVE Psoriasis is an immune system meditated disease,especially T cells.It disturbed many people around the world and hard to therapy.Paeonia lactiflora Pall has been used as a medicine in china for thousands of years.Recent studies has found that the main component of Paeonia lactiflora Pall can alleviates the immune response in many diseases.In this study,we researched the effects and possible mechanisms of total glucosides of paeony(TGP)on animal psoriasis in order to study the therapeutic effects and mechanisms of TGP in 5%propranolol creaminduced psoriasis in guinea pigs and Imiquimod(IMQ)cream-induced psoriasis in mice.METHODS The effect of TGP was evaluated using a psoriasis-like model of guinea pigs and mice.Ear thickness was accessed,and pathology injury was observed by HE staining.The levels of serum IL-1β,IL-6,IL-12,IL-17,IL-23,TNF-α,and IFN-γ,skin IL-17A,IL-22 and orphan nuclear receptor(RORγt)mRNA expression,proliferating cell nuclear antigen(PCNA),total or phosphorylated signal transducers and activators of transcription(STAT1 and STAT3)were determined by ELISA,real time PCR,immu⁃nohistochemical staining,and Western blotting,respectively.RESULTS Compared with model group,TGP treatment decreased the ear thickness,improved pathology of psoriasis,alleviated IMQ-induced keratinocyte proliferation,reduced the inflammatory cytokine,and downregulated IL-17A,IL-22,and RORγt mRNA in mice.Further study indicated that TGP inhibited STAT1 and STAT3 phosphorylation in lesion skins of psoriasis-like mice.CONCLUSION TGP alleviates the symptoms of psoriasis-like guinea pigs and mice,and the possible mechanism may relate to inhibit T helper 17(TH17)cell differentiation and keratinocytes proliferation by inhibiting STAT1 and STAT3 phosphorylation. | LI Bin-bin HE Shu-cheng LIU Rui HUANG Liang-liang LIU Ge WANG Rui-xuan YANG Zhuo-yue LIU Xin-yi LENG Ye LIU Dan YE Cheng-yu LI Yun-man CHEN Yong-jian IN Hong FANG Wei-rong | 2019 | 中国药理学与毒理学杂志2019，33，9： | 21 |
| 2 | Three-dimensional-printed individualized porous implants:A new“implant-bone”interface fusion concept for large bone defect treatment显示文摘Bone defect repairs are based on bone graft fusion or replacement.Current large bone defect treatments are inadequate and lack of reliable technology.Therefore,we aimed to investigate a simple technique using three-dimensional(3D)-printed individualized porous implants without any bone grafts,osteoinductive agents,or surface biofunctionalization to treat large bone defects,and systematically study its long-term therapeutic effects and osseointegration characteristics.Twenty-six patients with large bone defects caused by tumor,infection,or trauma received treatment with individualized porous implants;among them,three typical cases underwent a detailed study.Additionally,a large segmental femur defect sheep model was used to study the osseointegration characteristics.Immediate and long-term biomechanical stability was achieved,and the animal study revealed that the bone grew into the pores with gradual remodeling,resulting in a long-term mechanically stable implant-bone complex.Advantages of 3D-printed microporous implants for the repair of bone defects included 1)that the stabilization devices were immediately designed and constructed to achieve early postoperative mobility,and 2)that osseointegration between the host bone and implants was achieved without bone grafting.Our osseointegration method,in which the“implant-bone”interface fusion concept was used instead of“bone-bone”fusion,subverts the traditional idea of osseointegration. | Teng Zhang Qingguang Wei Hua Zhou Zehao Jing Xiaoguang Liu Yufeng Zheng Hong Cai Feng Wei Liang Jiang Miao Yu Yan Cheng Daoyang Fan Wenhao Zhou Xinhong Lin Huijie Leng Jian Li Xinyu Li Caimei Wang Yun Tian Zhongjun Liu | 2021 | Bioactive Materials2021，6，11： | 9 |
| 3 | Obstetric Outcomes in Chinese Women with Endometriosis: A Retrospective Cohort Study显示文摘 | Hong Lin Jin-Hua Leng Jun-Tao Liu Jing-He Lang | 2015 | Chinese Medical Journal2015，，4： | 9 |
| 4 | Molecular hydrogen isotope analysis of living and fossil plants—Metasequoia as an example显示文摘Molecular hydrogen isotope analysis preformed on modern and fossil plants has made a significant impact on diverse research fields in biology and geology. Using living and fossil Metasequoia as an example, we review the technology of online GC-IRMS that made the molecular analysis of hydrogen isotope possible and discuss critical issues concerning with the studies of molecular dD and its applications. The apparent hydrogen fractionation factors between lipid molecules and source water (ewater–lipid) vary across plant taxonomy and differ among biomolecules and are affected by multiple environmental factors in which precipitation dD values exercise the first order of control. Eco-physiological factors and environmental parameters are also known to influence dD in plants. Molecular hydrogen isotope analysis of chemically stable lipid molecules, such as n-alkanes, finds a wide range of applications in detecting source sediments, reconstruction of paleoclimatic parameters, inference of air-mass trajectory, as well as in petroleum industry and environmental studies. | Hong Yang Qin Leng | 2009 | Progress in Natural Science:Materials International2009，19，8： | 7 |
| 5 | Monitoring and Recognition of Debris Flow Infrasonic Signals显示文摘Low frequency infrasonic waves are emitted during the formation and movement of debris flows, which are detectable in a radius of several kilometers, thereby to serve as the precondition for their remote monitoring.However, false message often arises from the simple mechanics of alarms under the ambient noise interference.To improve the accuracy of infrasound monitoring for early-warning against debris flows, it is necessary to analyze the monitor information to identify in them the infrasonic signals characteristic of debris flows.Therefore, a large amount of debris flow infrasound and ambient noises have been collected from different sources for analysis to sum up their frequency spectra, sound pressures, waveforms, time duration and other correlated characteristics so as to specify the key characteristic parameters for different sound sources in completing the development of the recognition system of debris flow infrasonic signals for identifying their possible existence in the monitor signals.The recognition performance of the system has been verified by simulating tests and long-term in-situ monitoring of debris flows in Jiangjia Gully,Dongchuan, China to be of high accuracy and applicability.The recognition system can provide the local government and residents with accurate precautionary information about debris flows in preparation for disaster mitigation and minimizing the loss of life and property. | LIU Dun-long LENG Xiao-peng WEI Fang-qiang ZHANG Shao-jie HONG Yong | 2015 | Journal of Mountain Science2015，12，4： | 7 |
| 6 | Assessment and Comparison of in vitro Immunoregulatory Activity of Three Astaxanthin Stereoisomers显示文摘In recent years,the immune-modulatory role of all-trans astaxanthin from different pigment sources has been studied.It was reported that all-trans astaxanthin might exist as three stereoisomers,and the composition of all-trans stereoisomers in natural materials differs from that of synthetic products.However,the different biological effects of various all-trans stereoisomers still remain unclear.In the present study,we evaluated the bioactivity of three astaxanthin stereoisomers,(3S,3'S)-trans-,(3R,3'R)-transand meso-trans-astaxanthin,in regulating cell-mediated immune response using mice lymphocytes and peritoneal exudates cells(PECs) systems.After the treatment with three astaxanthin stereoisomers(20 μmol L-1),the lymphocyte proliferation capacity,neutral red phagocytosis of PECs and natural killer(NK) cell cytotoxic activity were comparatively assessed.The results showed that all three astaxanthin stereoisomers significantly promoted lymphocyte proliferation,phagocytic capacity of PECs,and cytotoxic activity of NK cells.Moreover,the(3S,3'S)-trans-astaxanthin exhibited a much higher response than others. | SUN Weihong XING Lihong LIN Hong LENG Kailiang ZHAI Yuxiu LIU Xiaofang | 2016 | Journal of Ocean University of China2016，15，2： | 7 |
| 7 | Alteration of cholinergic and peptidergic neurotransmitters in rat ileum induced by acute stress following transient intestinal infection is mast cell dependent显示文摘背景桅杆房间在急躁的肠症候群(IBS ) 的开发被含有,它与“神经免疫者”的系统的激活被联系。这研究的目的是在改变调查桅杆房间的角色胆碱能并且 peptidergic neurotransmitters 用桅杆房间由尖锐冷限制应力( ACRS )导致了柱子感染( PI )缺乏的老鼠( Ws/Ws )和他们的野类型的控制(+/+) .Methods 短暂肠的感染被开始由由 gavage 给 1500 Trichinella spiralis ( T.S )幼虫。ACRS 在白天 100 PI 被导致 2 个小时。当感染时,终端 ilea 的样品为 H&E 染色,桅杆房间数和激活和评价 IL-1 和 IL-10.Results 作好准备,老鼠的两紧张经历了恢复跟随的一个尖锐传染阶段。组织学的分数与在白天 10 PI 的非感染的控制的那些相比在感染的老鼠是显著地更高的(10 day-PI 对控制:+/+ :2. | LENG Yu-xin WEI Yan-yu CHEN Hong ZHOU Shu-pei YANG Yan-lin DUAN Li-ping | 2010 | Chinese Medical Journal2010，，2： | 6 |
| 8 | Response of larch species to climate changes显示文摘Global warming has changed the distributions of forests of northeastern China.Larix are very important species in this area.Predicting the potential distributions of Larix species and their responses to climate change would attract more and more attention.This paper predicted the potential distributions of three Larix species based on‘climatic-topographic’relationships by logistic regression.The results showed that L.gmelinii is predicted to retreat northwestward by 220 km by 2050 and by 270 km more by 2100;L.olgensis var.changpaiensis is predicted to retreat northwestward by 200 km by 2050 and by 190 to 300 km more by 2100;L.principis-rupprechtii is predicted to retreat northeastward by 200 km by 2050 and by 250 to 400 km more by 2100.This indicated that L.gmelinii could have its optimum latitude moved into Russia,L.olgensis var.changpaiensis could move to the Small Xing’an Mountains and L.principisrupprechtii would move to the middle part of the Great Xing’an Mountains. | Wenfang Leng Hong S.He Hongjuan Liu | 2008 | Journal of Plant Ecology2008，1，3： | 5 |
| 9 | Projected changes in mean and interannual variability of surface water over continental China显示文摘Five General Circulation Model(GCM) climate projections under the RCP8.5 emission scenario were used to drive the Variable Infiltration Capacity(VIC) hydrologic model to investigate the impacts of climate change on hydrologic cycle over continental China in the 21 st century. The bias-corrected climatic variables were generated for the Fifth Assessment Report of the Intergovernmental Panel on Climate Change(IPCC AR5) by the Inter-Sectoral Impact Model Intercomparison Project(ISIMIP). Results showed much larger fractional changes of annual mean Evapotranspiration(ET) per unit warming than the corresponding fractional changes of Precipitation(P) per unit warming across the country, especially for South China, which led to a notable decrease of surface water variability(P-E). Specifically, negative trends for annual mean runoff up to -0.33%/ year and soil moisture trends varying between -0.02% to -0.13%/year were found for most river basins across China. Coincidentally, interannual variability for both runoff and soil moisture exhibited significant positive trends for almost all river basins across China, implying an increase in extremes relative to the mean conditions. Noticeably, the largest positive trends for runoff variability and soil moisture variability, which were up to 0.41%/year and 0.90%/year, both occurred in Southwest China. In addition to the regional contrast, intra-seasonal variation was also large for the runoff mean and runoff variability changes, but small for the soil moisture mean and variability changes. Our results suggest that future climate change could further exacerbate existing water-related risks(e.g., floods and droughts) across China as indicated by the marked decrease of surface water amounts combined with a steady increase of interannual variability throughout the 21 st century. This study highlights the regional contrast and intra-seasonal variations for the projected hydrologic changes and could provide a multi-scale guidance for assessing effective adaptation strategies for China on a river basin, regional, or as a whole. | LENG GuoYong TANG QiuHong HUANG MaoYi HONG Yang Leung L RUBY | 2015 | Science China Earth Sciences2015，58，5： | 4 |
| 10 | Effects of Low Concentrations of Di-(2-ethylhexyl) and Mono-(2-ethylhexyl) Phthalate on Steroidogenesis Pathways and Apoptosis in the Murine Leydig Tumor Cell Line MLTC-1显示文摘这研究的目的是在 vitro 在一根鼠科的 Leydig 肿瘤房间线(MLTC-1 ) 在 steroidogenesis 上评估 DEHP 和 MEHP 的低集中的效果。流动 cytometry 分析的结果表明 apoptotic 房间的比例显著地在暴露以后被增加到 DEHP。所有三基因(P450scc, P450c17,并且 3 ? HSD ) 在学习下面显示出增加的表达式追随者暴露到 DEHP 或 MEHP,尽管一些不足道的禁止的效果出现了在 10 ? mol/L 处理组同样与控制相比。它也被发现那 DEHP 或 MEHP 在特别刺激了 INSL3 mRNA 和蛋白质 0.001 ? mol/L 处理组。睾丸激素分泌物在暴露以后被刺激到 DEHP 或 MEHP。在 MLTC-1 房间的 steroidogenic 酶和 INSL3 的改变可能在雄激素生产上涉及 DEHP/MEHP 的 biphasic 效果。 | CHEN Xi LIU Ya Nan ZHOU Qing Hong LENG Ling CHANG Ying TANG Nai Jun | 2013 | Biomedical and Environmental Sciences2013，26，12： | 4 |
| 11 | Impact of Chronic Stress on Attention Control:Evidence from Behavioral and Event-Related Potential Analyses显示文摘Chronic stress affects brain function,so assessing its hazards is important for mental health.To overcome the limitations of behavioral data,we combined behavioral and event-related potentials(ERPs)in an attention network task.This task allowed us to differentiate between three specific aspects of attention:alerting,orienting,and execution.Forty-one participants under chronic stress and 31 non-stressed participants were enrolled.On the performance level,the chronically stressed group showed a significantly slower task response and lower accuracy.Concerning ERP measures,smaller cue-N1,cueN2,and larger cue-P3 amplitudes were found in the stressed group,indicating that this group was less able to assign attention to effective information,i.e.,they made inefficient use of cues and had difficulty in maintaining alerting.In addition,the stressed group showed larger target-N2 amplitudes,indicating that this group needed to allocate more cognitive resources to deal with the conflict targets task.Subgroup analysis revealed lower target-P3 amplitudes in the stressed than in the non-stressed group.Group differences associated with the attention networks were found at the ERP level.In the stressed group,excessive depletion of resources led to changes in attention control.In this study,we examined the effects of chronic stress on individual executive function from a neurological perspective.The results may benefit the development of interventions to improve executive function in chronically stressed individuals. | Qingjin Liu Yong Liu Xuechen Leng Jinfeng Han Feng Xia Hong Chen | 2020 | Neuroscience Bulletin2020，36，11： | 3 |
| 12 | Hierarchical Micropore/Nanorod Apatite Hybrids In-Situ Grown from 3-D Printed Macroporous Ti6Al4V Implants with Improved Bioactivity and Osseointegration显示文摘The advent of three-dimensional(3-D) printed technique provides great possibility in the fabrication of customized porous titanium(Ti) implant. However, the bioinert property of the printed Ti poses an outstanding problem. Hybrid micro-arc oxidation and hydrothermal(MAO–HT) treatment on porous metals is able to produce multi-scaled hierarchical orthopedic implant, showing great potential for surface modification of 3-D printed implant. In this study, cylindrical porous Ti6Al4V(Ti64) scaffolds with pore size of 640 μm, porosity of 73% were 3-D printed by electron beam melting process, and their surfaces were left untreated or treated by a combined MAO–HT procedure. In vitro bioactivity was tested by immersion in simulated body fluid for different time points. Then, 12 scaffolds in each group were implanted into the femoral condyles of New Zealand rabbit for 8 weeks. Osseointegration was evaluated by qualitative and quantitative histological analysis, and the bone ingrowth features were probed by sequential fluorescent labeling at 3 and 6 weeks post-surgery. Following the MAO–HT treatment, the porous Ti64 scaffold was endowed with multi-scaled micro/nano-topographies and high amounts of Ca P on its surface.The treated scaffold exhibited drastically enhanced apatite forming ability compared with the untreated one. In vivo test revealed significantly that a higher amount of bone ingrowth and bone implant contact at the treated scaffold. The 2 types of scaffolds had different patterns of bone ingrowth: the treated scaffold exhibited a pattern of contact osteogenesis, by which bone formed directly on the treated implant surface, whereas bone formed distal to the implant surface of the untreated scaffold. MAO–HT treatment can significantly enhance the in vitro apatite-inducing ability and in vivo osseointegration capacity of 3-D porous Ti64 scaffold and may provide as a viable approach for the fabrication of bioactive 3-D printed porous implant for orthopedic applications. | Peng Xiu Zhaojun Jia Jia Lv Chuan Yin Hong Cai Chunli Song Huijie Leng Yufeng Zheng Zhongjun Liu Yan Cheng | 2017 | Journal of Materials Science & Technology2017，33，2： | 2 |
| 13 | Surface treatment of 3D printed porous Ti6Al4V implants by ultraviolet photofunctionalization for improved osseointegration显示文摘Three-dimensional(3D)-printed porous Ti6Al4V implants play an important role in the reconstruction of bone defects.However,its osseointegration capacity needs to be further improved,and related methods are inadequate,especially lacking customized surface treatment technology.Consequently,we aimed to design an omnidirectional radiator based on ultraviolet(UV)photofunctionalization for the surface treatment of 3D-printed porous Ti6Al4V implants,and studied its osseointegration promotion effects in vitro and in vivo,while elucidating related mechanisms.Following UV treatment,the porous Ti6Al4V scaffolds exhibited significantly improved hydrophilicity,cytocompatibility,and alkaline phosphatase activity,while preserving their original mechanical properties.The increased osteointegration strength was further proven using a rabbit condyle defect model in vivo,in which UV treatment exhibited a high efficiency in the osteointegration enhancement of porous Ti6Al4V scaffolds by increasing bone ingrowth(BI),the bone-implant contact ratio(BICR),and the mineralized/osteoid bone ratio.The advantages of UV treatment for 3D-printed porous Ti6Al4V implants using the omnidirectional radiator in the study were as follows:1)it can significantly improve the osseointegration capacity of porous titanium implants despite the blocking out of UV rays by the porous structure;2)it can evenly treat the surface of porous implants while preserving their original topography or other morphological features;and 3)it is an easy-to-operate low-cost process,making it worthy of wide clinical application. | Chuan Yin Teng Zhang Qingguang Wei Hong Cai Yan Cheng Yun Tian Huijie Leng Caimei Wang Shiqing Feng Zhongjun Liu | 2022 | Bioactive Materials2022，7，1： | 2 |
| 14 | A New Approach to Reconstruct Paleogene Atmospheric Hydrology at High Latitudes显示文摘通过降水模式的分析的古老的大气的条件的重建是在古气候的学习的一个新奇努力。一条新途径现在为在高北极的 Paleogene 大气的水文学条件的量的重建是可得到的。它基于 1 ) 从在 situ 让步了的加拿大的北极的特别保存的 Paleogene 植物石块的发现易变的 biomolecules;2 ) 能被用于植物材料的小数量的混合物特定的氢同位素分析的发展;并且 3 ) 从实验测量获得的 taxon 特定的明显的氢同位素分别因素。再循环模型的新潮湿被建立在 Paleogene 期间在高北极解释重建的 paleohydrologic 模式。 | Qin Leng Hong Yang | 2009 | Science Foundation in China2009，17，2： | 2 |
| 15 | Debris flows monitoring and localization using infrasonic signals显示文摘Infrasonic waves(frequency ≤ 20 Hz) are generated during the formation and movement of debris flows, traveling in air with a speed far higher than that of the debris-flow movement. Infrasound monitoring and localization of infrasonic waves can serve as warning properties for debris-flows. Based on the characteristics of infrasonic signals, this study presents a three-point array of infrasound sensors as time-synchronous multiple sensors for acquiring signals. In the meantime, the signals are sorted by mutual correlation of signals to figure out their latency, and by means of array coordinating to locate the sound source to realize the monitoring and positioning of a debris-flows hazard. The method has been in situ tested and has been proven to be accurate in monitoring debris-flow occurrences and determining their positions, which is particularly effective for pre-event warning of debris-flow hazards. | LENG Xiao-peng LIU Dun-long WEI Fang-qiang HONG Yong DAI De-fu | 2017 | Journal of Mountain Science2017，14，7： | 2 |
| 16 | A new series of emodin derivatives with bone affinity显示文摘A new series of bone affinity compounds were synthesized by linking emodin with 5-fluorouracil derivatives. Their bone affinities were established by hydroxyapative (HA) affinity experiment in vitro, and their cytostatic effects were shown by the MTT assay. | Hong Chen Ying Wang Ling Leng Mao Sheng Cheng Peng Fei Yu Jing Ze Zhang | 2007 | Chinese Chemical Letters2007，18，2： | 2 |
| 17 | Highly selective and sensitive detection of coralyne based on the binding chemistry of aptamer and graphene oxide显示文摘 | Pu Zhang Yi Wang Fei Leng Zu Hong Xiong Cheng Zhi Huang | 2013 | Talanta2013，，： | 1 |
| 18 | Predicting the distributions of suitable habitat for three larch species under climate warming in Northeastern China a显示文摘 | Wengfang Leng Hong SHe Renchang Bu | 2008 | Forest Ecology and Management2008，2，3： | 1 |
| 19 | Variation of cuticle micromorphology of Metasequoia Glyptostroboides (Txonomic) 显示文摘 | Leng Qin Yang Hong Yang Qun Zhou Jianping | 2001 | Botanical Journal of Linnean Society2001，136，： | 1 |
| 20 | Carbon and hydrogen isotope fractionation under continuous light: implications for paleoenvironmental interpretations of the High Arctic during Paleogene warming显示文摘 | Hong Yang Mark Pagani Derek E. G. Briggs M. A. Equiza Richard Jagels Qin Leng Ben A. LePage | 2009 | Oecologia2009，，3： | 1 |
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