|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Treatment strategies using adefovir dipivoxil for individuals with lamivudine-resistant chronic hepatitis B显示文摘AIM:To investigate retrospectively the long-term efficacy of various treatment strategies using adefovir dipivoxil(adefovir) in patients with lamivudine-resistant chronic hepatitis B.METHODS:We included 154 consecutive patients in two treatment groups:the 'add-on' group(n = 79),in which adefovir was added to ongoing lamivudine treatment due to lamivudine resistance,and the 'switch/combination' group(n = 75),in which lamivudine was first switched to adefovir and then re-added later as needed.The 'switch/combination' group was then divided into two subgroups depending on whether participants followed(group A,n = 30) or violated(group B,n = 45) a proposed treatment strategy that determined whether to add lamivudine based on the serum hepatitis B virus(HBV) DNA levels(< 60 IU/mL or not) after 6 mo of treatment(roadmap concept).RESULTS:The cumulative probability of virologic response(HBV DNA < 60 IU/mL) was higher in group A than in the 'add-on' group and in group B(P < 0.001).In contrast,the cumulative probability of virologic breakthrough was lower in the 'add-on' group than in group B(P = 0.002).Furthermore,the risk of virologic breakthrough in the multivariate analysis was significantly lower in the 'add-on' group than in group A(hazard ratio = 0.096;95%CI,0.015-0.629;P = 0.015).CONCLUSION:The selective combination of adefovir with lamivudine based upon early treatment responses increased the odds of virologic breakthrough relative to the use of uniform combination therapy from the beginning of treatment. | Tae Jung Yun Jin Yong Jung Chang Ha Kim Soon Ho Um Hyonggin An Yeon Seok Seo Jin Dong Kim Hyung Joon Yim Bora Keum Yong Sik Kim Yoon Tae Jeen Hong Sik Lee Hoon Jai Chun Chang Duck Kim Ho Sang Ryu | 2012 | World Journal of Gastroenterology2012，18，47： | 19 |
| 2 | Clinical analysis of risk factors contributing to recurrence of pterygium after excision and graft surgery显示文摘AIM: To find the risk factors related to the reproliferation of the pterygial tissue after excision and graft surgery.METHODS: Charts of 130 eyes of 130 patients who had pterygial excision from March 2006 to April 2011 were reviewed. Preoperative pterygium morphology, surgical methods, and adjunctive treatments were statistically analyzed for their relationship with recurrence.RESULTS: During the follow-up period, recurrence was observed in 20 eyes(15.4%). None of the preoperative morphologic features were affected the rate of the recurrence. However, an age <40y [P =0.085, odds ratio(OR) 3.609, 95% confidence interval(CI) 0.838-15.540]and amniotic membrane graft instead of conjunctival autograft(P =0.002, OR 9.093, 95% CI 2.316-35.698) were statistically significant risk factors for recurrence.Multivariate analysis revealed that intraoperative mitomycin C(MMC)(P =0.072, OR 0.298, 95% CI 0.080-1.115)decreased the rate of recurrence. CONCLUSION: Younger age is a risk factor for reproliferation of pterygial tissue after excision and amniotic membrane transplantation(AMT) are less effective in preventing recurrence of pterygium after excision based on the comparison between conjunctival autograft and AMT. Intraoperative MMC application and conjunctival autograft reduce recurrence. | Sang Won Ha Joon Ho Park Im Hee Shin Hong Kyun Kim | 2015 | International Journal of Ophthalmology(English edition)2015，8，3： | 13 |
| 3 | Clinical significance of loss of heterozygosity for M6P/IGF2R in patients with primary hepatocellular carcinoma显示文摘AIM:To investigate the relationship between loss of heterozygosity (LOH) for mannose 6-phosphate/insulin- like growth factor 2 receptor (M6P/IGF2R) and the outcomes for primary HCC patients treated with partial hepatectomy. METHODS: The LOH for M6P/IGF2R in primary HCC patients was assessed using six different gene-specific nucleotide polymorphisms. The patients studied were enrolled to undergo partial hepatectomy. RESULTS: M6P/IGF2R was found to be polymorphic in 73.3% (22/30) of the patients, and of these patients, 50.0% (11/22) had tumors showing LOH in M6P/IGF2R. Loss of heterozygosity in M6P/IGF2R was associated with significant reductions in the two year overall survival rate (24.9% vs 65.5%; P = 0.04) and the disease-free survival rate (17.8% vs 59.3%; P = 0.03). CONCLUSION: These results show M6P/IGF2R LOH predicts poor clinical outcomes in surgically resected primary HCC patients. | Hong Seok Jang Ki Mun Kang Byung Ock Choi Gyu Young Chai Soon Chan Hong Woo Song Ha Randy L Jirtle | 2008 | World Journal of Gastroenterology2008，14，9： | 12 |
| 4 | Anti-inflammatory and Antimicrobial Effects of Anthocyanin Extracted from Black Soybean on Chronic Bacterial Prostatitis Rat Model显示文摘Objective: To investigated the anti-inflammatory and antimicrobial effects of anthocyanins extracted from black soybean on the chronic bacterial prostatitis(CBP) rat model.Methods: The SpragueDawley rats were divided into 4 groups,including control,ciprofloxacin,anthocyanins and anthocyanins with ciprofloxacin groups(n=8 in each group).Then,drip infusion of bacterial suspension(Escherichia coli Z17O_2:K_1:H^-) into Sprague-Dawley rats was conducted to induce CBP.In 4 weeks,results of prostate tissue,urine culture,and histological analysis on the prostate were analyzed for each group.Results: The use of ciprofloxacin,anthocyanins,and anthocyanins with ciprofloxacin showed statistically significant decreases in bacterial growth and improvements in the reduction of prostatic inflammation compared with the control group(P<0.05).The anthocyanins with ciprofloxacin group showed a statistically significant decrease in bacterial growth and improvement in prostatic inflammation compared with the ciprofloxacin group(P<0.05).Conclusions: These results suggest that anthocyanins may have anti-inflammatory and antimicrobial effects,as well as a synergistic effect with ciprofloxacin.Therefore,we suggest that the combination of anthocyanins and ciprofloxacin may be effective in treating CBP to obtain a higher rate of treatment success. | Byung Il Yoon Woong Jin Bae Yong Sun Choi Su Jin Kim U Syn Ha Sung-Hoo Hong Dong Wan Sohn Sae Woong Kim | 2018 | Chinese Journal of Integrative Medicine2018，24，8： | 11 |
| 5 | Pretreated Glehnia littoralis Extract Prevents Neuronal Death Following Transient Global Cerebral Ischemia through Increases of Superoxide Dismutase 1 and Brain-derived Neurotrophic Factor Expressions in the Gerbil Hippocampal Cornu Ammonis 1 Area显示文摘 | Joon Ha Park Tae-Kveono Lee Bing-Chun Yan Bich-Na Shin Ji Hyeon Ahn In Hye Kim Jeong Hwi Cho Jae-Chul Lee In Koo Hwang Jong Dai Kim Seongkweon Hong Young Joo Lee Moo-Ho Woll Il Jun Kang | 2017 | Chinese Medical Journal2017，，15： | 10 |
| 6 | Graphene-based catalysts for electrochemical carbon dioxide reduction显示文摘Electrochemical carbon dioxide(CO2)reduction is considered to be an efficient strategy to produce usable fuels and overcome the concerns regarding global warming.For this purpose,an efficient,earth abundant,and a low cost catalyst has to be designed.It has been found that graphene-based materials could be promising candidates for CO2 conversion because of their unique physical,mechanical,and electronic properties.In addition,the surface of graphenebased materials can be modified by using different strategies,including doping,defect engineering,producing composite structures,and wrapping shapes.In this review,the fundamentals of electrochemical CO2 reduction and recent progress of graphene-based catalysts are investigated.Furthermore,recent studies on graphene-based materials for CO2 reduction are summarized. | Amirhossein Hasani Mahider Asmare Teklagne Ha Huu Do Sung Hyun Hong Quyet Van Le Sang Hyun Ahn Soo Young Kim | 2020 | Carbon Energy2020，2，2： | 7 |
| 7 | 精索静脉曲张诱导的大鼠不育模型中E—cadherin和α—catenin在的表达显示文摘评价精索静脉曲张诱导的不育发展过程中E—cadhering和α-catenin的作用。本文分析了E—cadherin/α—catenin的表达与临床/病理参数之间的关联。取30只10周龄雄性大鼠,将左肾静脉结扎后致精索静脉曲张模型,作为实验组。取30只大鼠腹部切开处理作为对照组,取10只大鼠未做处理,作为基线组。分别记录各组大鼠4周和8周后的左睾丸的重量,血清中活性氧(ROS),睾酮,促黄体激索(LH),促卵泡激素(FSH)和生精小管的退行性改变。采用免疫组织化学法OHC)染色色Westernblot法分析E—cadherin和α—catenin的表达。与对照组和基线组相比,8周后实验组ROS增加(两组均P〈0.001)。此外,与对照组相比,478(P=0.013)和8周(P=0.032)后实验组的FSH显著增加。所有实验组中大鼠生精小管发生退行性改变的比例增加。免疫组织化学染色法的结果表明,4周和8周的实验组中E—cadherin和α-catenin的表达有所下降。Westernblot法的实验结果与免疫组化法的实验结果相近。E—eadherin和α—catenin的表达与ROS和生精小管的退行性改变是密切相关的。实验结果表明,血睾屏障(BTB)的损伤与精索静脉曲张诱导的男性不育有相关性,ROS可能会损坏血睾屏障。 | Hong Koo Ha Hyun Jun Park Nam Cheol Park | 2011 | Asian Journal of Andrology2011，13，3： | 5 |
| 8 | Neuroprotection of Chrysanthemum indicum Linne against cerebral ischemia/reperfusion injury by anti-inflammatory effect in gerbils显示文摘In this study, we tried to verify the neuroprotective effect of Chrysanthemum indicum Linne(CIL) extract, which has been used as a botanical drug in East Asia, against ischemic damage and to explore the underlying mechanism involving the anti-inflammatory approach. A gerbil was given CIL extract for 7 consecutive days followed by bilateral carotid artery occlusion to make a cerebral ischemia/reperfusion model. Then, we found that CIL extracts protected pyramidal neurons in the hippocampal CA1 region(CA1) from ischemic damage using neuronal nucleus immunohistochemistry and Fluoro-Jade B histofluorescence. Accordingly, interleukin-13 immunoreactivities in the CA1 pyramidal neurons of CIL-pretreated animals were maintained or increased after cerebral ischemia/reperfusion. These findings indicate that the pre-treatment of CIL can attenuate neuronal damage/death in the brain after cerebral ischemia/reperfusion via an anti-inflammatory approach. | Ki-YeonYoo In Hye Kim Jeong-Hwi Cho li Hyeon Ahn Joon Ha Park Jae-Chul Lee Hyun-Jin Tae Dae Won Kim Jong-Dai Kim Seongkweon Hong Moo-Ho Won il Jun Kang | 2016 | Neural Regeneration Research2016，11，2： | 4 |
| 9 | Treatment for gastric ‘indefinite for neoplasm/dysplasia' lesions based on predictive factors显示文摘BACKGROUND Gastric ‘indefinite for neoplasm/dysplasia'(IFND) is a borderline lesion that is difficult to diagnose as either regenerative or neoplastic. There is a need for guidance in the identification of a subset of patients, who have an IFND lesion with a higher risk of malignant potential, to enable risk stratification and optimal management.AIM To determine the clinical and pathologic factors for the accurate diagnosis of gastric IFND lesions.METHODS In total, 461 gastric lesions diagnosed via biopsy as IFND lesions were retrospectively evaluated. Endoscopic resection(n = 134), surgery(n = 22), and follow-up endoscopic biopsy(n = 305) were performed to confirm the diagnosis.The time interval from initial biopsy to cancer diagnosis was measured, and diagnostic delays were categorized as > 2 wk, > 2 mo, > 6 mo, and > 1 year. The IFND lesions presenting as regenerating atypia(60%) or atypical epithelia(40%)at initial biopsy were adenocarcinomas in 22.6%, adenomas in 8.9%, and gastritis in 68.5% of the cases.RESULTS Four clinical factors [age ≥ 60 years(2.445, 95%CI: 1.305-4.580, P = 0.005),endoscopic size ≥ 10 mm(3.519, 95%CI: 1.891-6.548, P < 0.001), single lesion(5.702, 95%CI: 2.212-14.696, P < 0.001), and spontaneous bleeding(4.056, 95%CI:1.792-9.180, P = 0.001)], and two pathologic factors [atypical epithelium(25.575,95%CI: 11.537-56.695, P < 0.001], and repeated IFND diagnosis [6.022, 95%CI:1.822-19.909, P = 0.003)] were independent risk factors for gastric cancer. With two or more clinical factors, the sensitivity and specificity for carcinoma were91.3% and 54.9%, respectively. Ten undifferentiated carcinomas were initially diagnosed as IFND. In the subgroup analysis, fold change(5.594, 95%CI: 1.458-21.462, P = 0.012) predicted undifferentiated or invasive carcinoma in the submucosal layers or deeper. Diagnostic delays shorter than 1 year were not associated with worse prognoses. Extremely well-differentiated adenocarcinomas accounted for half of the repeated IFND cases and resulted in low diagnostic accuracy even on retrospective blinded review.CONCLUSION More than two clinical and pathologic factors each had significant cut-off values for gastric carcinoma diagnosis; in such cases, endoscopic resection should be considered. | Mi Jung Kwon Ho Suk Kang Hyeon Tae Kim Jin Woo Choo Bo Hyun Lee Sung Eun Hong Kun Ha Park Dong Min Jung Hyun Lim Jae Seung Soh Sung Hoon Moon Jong Hyeok Kim Hye-Rim Park Soo Kee Min Jin won Seo Ji-Young Choe | 2019 | World Journal of Gastroenterology2019，25，4： | 4 |
| 10 | Computed tomography findings for predicting severe acute hepatitis with prolonged cholestasis显示文摘AIM: To evaluate the significance of computed tomography (CT) findings in relation to liver chemistry and the clinical course of acute hepatitis. METHODS: Four hundred and twelve patients with acute hepatitis who underwent enhanced CT scanning were enrolled retrospectively. Imaging findings were analyzed for the following variables: gallbladder wall thickness (GWT), arterial heterogeneity, periportal tracking, number and maximum size of lymph nodes, presence of ascites, and size of spleen. The serum levels of alanine aminotransferase, alkaline phosphatase, bilirubin, albumin, and prothrombin time were measured on the day of admission and CT scan, and laboratory data were evaluated every 2-4 d for all subjects during hospitalization. RESULTS: The mean age of patients was 34.4 years, and the most common cause of hepatitis was hepatitis A virus (77.4%). The mean GWT was 5.2 mm. The number of patients who had findings of arterial heterogeneity, periportal tracking, lymph node enlargement > 7 mm, and ascites was 294 (80.1%), 348 (84.7%), 346 (84.5%), and 56 (13.6%), respectively. On multivariate logistic regression, male gender [odds ratio (OR) = 2.569, 95%CI: 1.477-4.469, P = 0.001], toxic hepatitis (OR = 3.531, 95%CI: 1.444-8.635, P = 0.006), level of albumin (OR = 2.154, 95%CI: 1.279-3.629, P = 0.004), and GWT (OR = 1.061, 95%CI: 1.015-1.110, P = 0.009) were independent predictive factors for severe hepatitis. The level of bilirubin (OR = 1.628, 95%CI: 1.331-1.991, P < 0.001) and GWT (OR = 1.172, 95%CI: 1.024-1.342,P = 0.021) were independent factors for prolonged cholestasis in multivariate analysis. CONCLUSION: In patients with acute hepatitis, GWT on CT scan was an independent predictor of severe hepatitis and prolonged cholestasis. | Sang Jung Park Jin Dong Kim Yeon Seok Seo Beom Jin Park Min Ju Kim Soon Ho Um Chang Ha Kim Hyung Joon Yim Soon Koo Baik Jin Yong Jung Bora Keum Yoon Tae Jeen Hong Sik Lee Hoon Jai Chun Chang Duck Kim Ho Sang Ryu | 2013 | World Journal of Gastroenterology2013，19，16： | 4 |
| 11 | Magnifying endoscopy of gastric epithelial dysplasia based on the morphologic characteristics显示文摘AIM:To investigate the difference in magnifying endoscopic findings of gastric epithelial dysplasias(GEDs)according to the morphologic characteristics.METHODS:This study included 46 GED lesions in 45patients who underwent magnifying endoscopy using narrow band imaging(ME-NBI)before endoscopic resection.During ME-NBI,the microvascular and microsurface(MS)patterns and the presence of light blue crest(LBC)and white opaque substance were investigated.GEDs were categorized as adenomatous,foveolar,and hybrid types,and their mucin phenotype was evaluated.RESULTS:Of the 46 lesions,27(59%)were categorized as adenomatous,15(32%)as hybrid,and the remaining 4(9%)as foveolar.All adenomatous GEDs showed the round pit and/or tubular MS patterns,all foveolar GEDs showed the papillary pattern,and hybrid GEDs showed mixed patterns(P<0.001).LBC was more frequently observed in adenomatous GEDs than in hybrid or foveolar GEDs(52%,33%,0%,respectively),although this difference was not significant(P=0.127).The papillary MS pattern was associated with MUC5AC and MUC6 expression,and the round pit and/or tubular MS patterns were associated with CD10expression.CONCLUSION:The MS pattern in ME-NBI findings is useful for predicting the morphologic category and mucin phenotype of GEDs,and ME-NBI findings may guide decisions regarding GED treatment. | Hwa Mi Kang Gwang Ha Kim Do Youn Park Hong Ryeol Cheong Dong Hoon Baek Bong Eun Lee Geun Am Song | 2014 | World Journal of Gastroenterology2014，20，42： | 4 |
| 12 | Computation and field experiment validation of greenhouse energy load using building energy simulation model显示文摘Greenhouse Building Energy Simulation(BES)models were developed to estimate the energy load using TRNSYS(ver.16,University of Wisconsin,USA),a commercial BES program.Validation was conducted based on data recorded during field experiments.The BES greenhouse modeling is reliable,as validation showed 5.2%and 5.5%compared with two field experiments,respectively.As the next step,the heating characteristics of the greenhouses were analyzed to predict the maximum and annual total heating loads based on the greenhouse types and target locations in the Republic of Korea using the validated greenhouse model.The BES-computed results indicated that the annual heating load was greatly affected by the local climate conditions of the target region.The annual heating load of greenhouses located in Chuncheon,the northernmost region,was 44.6%higher than greenhouses in Jeju,the southernmost area among the studied regions.The regression models for prediction of maximum heating load of Venlo type greenhouse and widespan type greenhouse were developed based on the BES computed results to easily predict maximum heating load at field and they explained nearly 95%and 80%of the variance in the data set used,respectively,with the predictor variables.Then a BES model of geothermal energy system was additionally designed and incorporated into the BES greenhouse model.The feasibility of the geothermal energy system for greenhouse was estimated through economic analysis. | Taehwan Ha In-bok Lee Kyeong-seok Kwon Se-Woon Hong | 2015 | International Journal of Agricultural and Biological Engineering2015，8，6： | 4 |
| 13 | Prediction of effluent concentration in a wastewater treatment plant using machine learning models显示文摘Of growing amount of food waste, the integrated food waste and waste water treatment was regarded as one of the efficient modeling method. However, the load of food waste to the conventional waste treatment process might lead to the high concentration of total nitrogen(T-N) impact on the effluent water quality. The objective of this study is to establish two machine learning models—artificial neural networks(ANNs) and support vector machines(SVMs), in order to predict 1-day interval T-N concentration of effluent from a wastewater treatment plant in Ulsan, Korea. Daily water quality data and meteorological data were used and the performance of both models was evaluated in terms of the coefficient of determination(R^2), Nash–Sutcliff efficiency(NSE), relative efficiency criteria(d rel). Additionally, Latin-Hypercube one-factor-at-a-time(LH-OAT) and a pattern search algorithm were applied to sensitivity analysis and model parameter optimization, respectively. Results showed that both models could be effectively applied to the 1-day interval prediction of T-N concentration of effluent. SVM model showed a higher prediction accuracy in the training stage and similar result in the validation stage.However, the sensitivity analysis demonstrated that the ANN model was a superior model for 1-day interval T-N concentration prediction in terms of the cause-and-effect relationship between T-N concentration and modeling input values to integrated food waste and waste water treatment. This study suggested the efficient and robust nonlinear time-series modeling method for an early prediction of the water quality of integrated food waste and waste water treatment process. | Hong Guo Kwanho Jeong Jiyeon Lim Jeongwon Jo Young Mo Kim Jong-pyo Park Joon Ha Kim Kyung Hwa Cho | 2015 | Journal of Environmental Sciences2015，27，6： | 4 |
| 14 | Effects of traditional Chinese herbal medicine San-HuangXie-Xin-Tang on gastrointestinal motility in mice显示文摘AIM: To investigate the effects of San-Huang-Xie-XinTang(SHXXT), a herbal product used in traditional Chinese medicine, on gastrointestinal(GI) motility in mice.METHODS: The in vivo effects of SHXXT on GI motility were investigated by measuring the intestinal transit rates(ITRs) using Evans blue in normal mice and in mice with experimentally induced GI motility dysfunction(GMD).RESULTS: In normal ICR mice, ITRs were significantly and dose-dependently increased by SHXXT(0.1-1 g/kg). GMD was induced by injecting acetic acid or streptozotocin intraperitoneally. The ITRs of GMD mice were significantly reduced compared to normal mice, and these reductions were significantly and dose-dependently inhibited by SHXXT(0.1-1 g/kg).CONCLUSION: These results suggest that SHXXT is a novel candidate for the development of a prokinetic agent that may prevent or alleviate GMD. | Min Woo Hwang Tae Seok Ahn Noo Ri Hong Han-Sol Jeong Myeong Ho Jung Ki-Tae Ha Byung Joo Kim | 2015 | World Journal of Gastroenterology2015，21，4： | 3 |
| 15 | Study on SCR De NO_x mechanism through in situ electrical conductivity measurements on V_2O_5-WO_3/TiO_2 catalysts显示文摘V2O5-WO3/TiO2 catalysts were prepared by impregnation method and in situ electrical conductivity measurements were carried out to investigate the reaction mechanism for ammonia SCR (selective catalytic reduction) of NOx. The electrical conductivity change with ammonia supply and the increase of electrical conductivity were mainly caused by reduction of the labile surface oxygen. The electrical conductivity change of catalysts shows close relationship with the conversion rate of NOx. Variation of conversion rate in atmosphere without gaseous oxygen also supports that the labile lattice oxygen is indispensable in the initial stage of the de NOx reaction. These results suggest that the liable lattice oxygen acts decisive role in the de NOx mechanism. They also support that De NOx reaction occurs through the Eley-Rideal type mechanism. The amount of labile oxygen can be estimated from the measurement of electrical conductivity change for catalysts with ammonia supply. | HA Heon Phil JUNG Soon Hyo LEE Jun Yub HONG Sung Ho | 2006 | Rare Metals2006，25，z2： | 3 |
| 16 | Benidipine has effects similar to losartan on the central blood pressure and arterial stiffness in mild to moderate essential hypertension显示文摘 | Sang-Hyun Ihm Hui-Kyung Jeon Shung Chull Chae Do-Sun Lim Kee-Sik Kim Dong-Ju Choi Jong-Won Ha Dong-Soo Kim Kye Hun Kim Myeong-Chan Cho Sang Hong Baek | 2013 | Chinese Medical Journal2013，，11： | 3 |
| 17 | Do microRNA 96, 145 and 221 expressions really aid in Lhe prognosis of prostate carcinoma?显示文摘MicroRNAs (米尔) 是被报导了正在答应诊断工具的小 noncoding RNA。我们使用了量的即时反向的抄写 PCR (RT-qPCR ) 分析在前列腺肿瘤的表示 miRNAs 取样决定它的预示的价值的差别。从 2007 ~ 2009,肿瘤纸巾从 73 个激进的前列腺切除术标本被获得。差别表示了 miR-96, -145 和 -221 被 TaqMan RT-qPCR 用所有 73 纸巾验证。预示的价值用 Kaplan-Meier 和考克斯回归分析以生物化学的复发被估计。为我们的耐心的队,吝啬的年龄是 64.7 年(50-76 年) ,吝啬的前列腺特定的抗原(PSA ) 是 7.5 ng ml −1 。在后续时期期间(平均数, 19.4 个月) , 73 中的 14 个(19.2 %) 病人们发展了生物化学的复发。miR-96, -145 和 -221 的表示与对方一起强烈相关,但是在 miRNA 表示和 clinicopathologic 参数之间没有关联。用木头等级测试的 Kaplan-Meier 幸存曲线与病理学的舞台显示出减少的生物化学的没有复发的间隔(P< 0.001 ) 。另外,有超过 8 的格利森分数的病人, 6 与格利森一起与那些相比得分,在 Kaplan-Meier 分析(P=0.001 ) 显示出减少的生物化学的没有复发的间隔。然而, miR-96, -145 和 -221 的表示没用考克斯在 Kaplan-Meier 幸存曲线或由 multivariate 分析与生物化学的复发间隔相关比例的危险回归模型也。在结论,我们没观察在 miR-96, -145 和 -221 和 clinicopathologic 参数的表达式之间的重要关联。为了在临床的实践作为一个诊断工具利用 miRNA,更多的研究被需要理解 miRNA 机制,识别 miRNA 目标,并且进一步描绘 miRNA,工作。 | Sung Gu Kang Young Ran Ha Seo Jin Kim Seok Ho Kang Hong Seok Park Jeong Gu Lee Jun Cheon | 2012 | Asian Journal of Andrology2012，14，5： | 2 |
| 18 | Comparison of Hepatic Venous Pressure Gradient and Two Models of End-stage Liver Disease for Predicting the Survival in Patients With Decompensated Liver Cirrhosis显示文摘 | Ki Tae Suk Chang Hoon Kim Seung Ha Park Ho Taik Sung Jong Young Choi Kwang Hyub Han So Hyung Hong Dae Yong Kim Jai Hoon Yoon Yeon Soo Kim Gwang Ho Baik Jin Bong Kim Dong Joon Kim | 2012 | Journal of Clinical Gastroenterology2012，，10： | 2 |
| 19 | Oenanthe Javanica Extract Protects Against Experimentally Induced Ischemic Neuronal Damage via its Antioxidant Effects显示文摘 | Joon Ha Park Jeong Hwi Cho In Hye Kim Ji Hyeon Ahn Jae-Chul Lee Bai Hui Chen Bich-Na Shin Hyun-Jin Tae Ki-Yeon Yoo SeongKweon Hong II Jun Kang Moo-Ho Won Jong-Dai Kim | 2015 | Chinese Medical Journal2015，，21： | 2 |
| 20 | Activation of immediate-early response gene c-Fos protein in the rat paralimbic cortices after myocardial infarction显示文摘c-Fos is a good biological marker for detecting the pathogenesis of central nervous system disorders. Few studies are reported on the change in myocardial infarction-induced c-Fos expression in the paralimbic regions. Thus, in this study, we investigated the changes in c-Fos expression in the rat cingulate and piriform cortices after myocardial infarction. Neuronal degeneration in cingulate and piriform cortices after myocardial infarction was detected using cresyl violet staining, Neu N immunohistochemistry and Fluoro-Jade B histofluorescence staining. c-Fos-immunoreactive cells were observed in cingulate and piriform cortices at 3 days after myocardial infarction and peaked at 7 and 14 days after myocardial infarction. But they were hardly observed at 56 days after myocardial infarction. The chronological change of c-Fos expression determined by western blot analysis was basically the same as that of c-Fos immunoreactivity. These results indicate that myocardial infarction can cause the chronological change of immediate-early response gene c-Fos protein expression, which might be associated with the neural activity induced by myocardial infarction. | Ji Yun Ahn Hyun-Jin Tae Jeong-Hwi Cho In Hye Kim Ji Hyeon Ahn Joon Ha Park Dong Won Kim Jun Hwi Cho Moo-Ho Won Seongkweon Hong Jae-Chul Lee Jeong Yeol Seo | 2015 | Neural Regeneration Research2015，10，8： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员