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| 1 | Mitochondrial neuronal uncoupling proteins:a target for potential disease-modification in Parkinson’s disease Philip显示文摘This review gives a brief insight into the role of mitochondrial dysfunction and oxidative stress in the converging pathogenic processes involved in Parkinson’s disease(PD).Mitochondria provide cellular energy in the form of ATP via oxidative phosphorylation,but as an integral part of this process,superoxides and other reactive oxygen species are also produced.Excessive free radical production contributes to oxidative stress.Cells have evolved to handle such stress via various endogenous anti-oxidant proteins.One such family of proteins is the mitochondrial uncoupling proteins(UCPs),which are anion carriers located in the mitochondrial inner membrane.There are five known homologues(UCP1 to 5),of which UCP4 and 5 are predominantly expressed in neural cells.In a series of previous publications,we have shown how these neuronal UCPs respond to 1-methyl-4-phenylpyridinium(MPP+;toxic metabolite of MPTP)and dopamine-induced toxicity to alleviate neuronal cell death by preserving ATP levels and mitochondrial membrane potential,and reducing oxidative stress.We also showed how their expression can be influenced by nuclear factor kappa-B(NF-B)signaling pathway specifically in UCP4.Furthermore,we previously reported an interesting link between PD and metabolic processes through the protective effects of leptin(hormone produced by adipocytes)acting via UCP2 against MPP+-induced toxicity.There is increasing evidence that these endogenous neuronal UCPs can play a vital role to protect neurons against various pathogenic stresses including those associated with PD.Their expression,which can be induced,may well be a potential therapeutic target for various drugs to alleviate the harmful effects of pathogenic processes in PD and hence modify the progression of this disease. | WL Ho Jessica WM Ho Hui-Fang Liu Danny HF So Zero HM Tse Koon-Ho Chan David B Ramsden Shu-Leong Ho | 2012 | Translational Neurodegeneration2012，1，1： | 3 |
| 2 | Risk factors for anastomotic leakage after low anterior resection with total mesorectal excision显示文摘 | Law WL Chu KW Ho JW | 2000 | Am J Surg2000，179，2： | 1 |
| 3 | Stabilization of blood meth- ylmalonic acid level in methylmalonie acidemia after liver transplantation显示文摘 | Chen PW Hwu WL Ho MC | 2010 | Pediatr Transplant2010，14，3： | 1 |
| 4 | Self-expanding metallic stent in the treatment of colonic obstruction caused by advanced malignancies显示文摘 | Law WL Chu KW Ho JW | 2000 | Dis Colon Rectum2000，43，11： | 1 |
| 5 | Stabilization of blood methylma- Ionic acid level in methylmalonic aeidemia after liver transplanta- tion显示文摘 | Chen PW Hwu WL Ho MC | 2010 | Pediatr Transplant2010，14，3： | 1 |
| 6 | Hepatic resection of hepa- tocellular carcinoma in cirrhotic livers: is it unjustified in im- paired liver function? 显示文摘 | Wu CC Ho WL Yeh DC | 1996 | Surgery1996，120，1： | 1 |
| 7 | Self-expanding metallic stentin the treatment of colonic obstruction caused by advance malignancies显示文摘 | Law WL Chu K Ho JW | 2000 | Dis Coion Rectum2000，43，11： | 1 |
| 8 | Gastroesophageal reflux dis- ease is a common cause of noneardiac chest pain in a country with a low prevalence of reflux esophagitis显示文摘 | Ho KY Ng WL Kang JY | 1998 | Dig Dis Scl1998，43，9： | 1 |
| 9 | Indications forextraction of permanent teeth in a Nigerian teaching hospital:a16-year follow-up study显示文摘 | Adeyemo WL Oderinu HO Oluseye SB | 2008 | Nig Q J Hosp Med2008，18，3： | 1 |
| 10 | Leakage after resection and intraperitoneal anastomosis for coloreclal malignancy: analysis of risk faetors显示文摘 | Choi HK Law WL Ho JW | 2006 | Dis Colon Rectum2006，49，11： | 1 |
| 11 | Intussusception in Taiwanese children:analysis of incidence,length of hospitalization and hospita| costs in different age groups显示文摘 | Ho WL Yang TW Chi WC | 2010 | Journal of the Formosan Medical Associ ation2010，，06： | 1 |
| 12 | Concomitant splenectomy for hyper -splenic thrombocytopenia in hepatic resection for hepatocellular car -cinoma显示文摘 | Lin MC Wu CC Ho WL | | 0，，26： | 1 |
| 13 | Financial burden of national health insurance for treating patients with transfusion-dependent thalassemia in Taiwan 显示文摘 | Ho WL Lin KH Wang JD | 2006 | Bone Marrow Transplant2006，37，： | 1 |
| 14 | The use of orthographic analogies in learningtoread Chinese显示文摘 | HO C S WONG WL CHAN WS | | 0，，40： | 1 |
| 15 | High serum uric acidas a novel risk factor for type 2 diabetes:response to De-hghan et al显示文摘 | Dai CY Chuang WL Ho CK | 2008 | Diabetes Care2008，31，9： | 1 |
| 16 | Analysis of factors correlated with the development of pseudophakic retinal detachment--a long-term study in a single medical center 显示文摘 | Lin JY Ho WL Get LP Sheu SJ | 2013 | Oraefes Arch Clin Exp Ophthalmol2013，251，2： | 1 |
| 17 | Sub-lethal heat treatmentaffects the tolerance of Cronobacter sakazakii BCRC 13988to various organic acids, simulated gastric juice and bilesolution 显示文摘 | Hsiao WL Ho WL Chou CC | 2010 | International Journal of Food Microbiology2010，144，2： | 1 |
| 18 | Modeling Caco-2 permeability of drugs using immobilized artificial membrane chromatography and physicochemical descriptors显示文摘 | Chan E CY Tan WL Ho PC | 2005 | Chromatogr A2005，1072，2： | 1 |
| 19 | A comparison between single- and double- breath vital capacity inhalation induction with 8% sevoflurane in children显示文摘 | HO KY CHUA WL LIM SS | 2004 | Paediatr Anaesth2004，14，6： | 1 |
| 20 | Preoperative transcatheter arterial chemoembolization for resectable large hepatocellular carcinoma: areappraisal显示文摘 | Wu CC Ho YZ Ho WL | 1995 | Br J Surg1995，82，： | 1 |
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