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| 1 | Technical framework for Internetware: An architecture centric approach显示文摘Being a new software paradigm evolved by the Internet, Internetware brings many challenges to the traditional software methods and techniques. Sponsored by the national basic research program (973), researchers in China have developed an architecture centric technical framework for the definition, incarnation and engineering of Internetware. First of all, a software model for Internetware is defined for what to be, including that Internetware entities should be packaged as components, behaving as agents, interoperating as services, collaborating in a structured and on demand manner, etc. Secondly, a middleware for Internetware is designed and implemented for how to be, including that Internetware entities are incarnated by runtime containers, structured collaborations are enabled by runtime software architecture, Internetware can be managed in a reflective and autonomic manner, etc. Thirdly, an engineering methodology for Internetware is proposed for how to do, including the way to develop Internetware entities and their collaborations by transforming and refining a set of software architectures which cover all the phases of software lifecycle, the way to identify and organize the disordered software assets by domain modeling, etc. | YANG FuQing1,2, Lü Jian3,4 & MEI Hong1,2 1 Key Laboratory of High Confidence Software Technologies (Peking University), Ministry of Education, Beijing 100871, China 2 School of Electronics Engineering and Computer Science, Peking University, Beijing 100871, China 3 State Key Laboratory for Novel Software Technology, Nanjing 210093, China 4 Department of Computer Science and Technology, Nanjing University, Nanjing 210093, China | 2008 | Science in China(Series F)2008，51，6： | 33 |
| 2 | Formation of complexes of Rubisco-Rubisco activase from La^3+, Ce^3+ treatment spinach显示文摘The complex of Rubisco and Rubisco activase from LaCl3-, CeCl3- treated spinach in vivo is induced. SDS-PAGE result shows that the purified proteins from LaCl3-, CeCl3- treated spinach have not only large and small subunits (55 kD, 14.4 kD) of Rubisco, but also two large subunits of 45 kD and 41 kD near the large subunits of Rubisco. Native-PAGE shows that the purified proteins from LaCl3-, CeCl3- treated spinach have not only a band of Rubisco (560 kD), but also a band of about 1100 kD, about twice distant from Rubisco, which might be a complex of Rubisco and Rubisco activase. The purified enzyme activities from LaCl3-, CeCl3-treated spinach are 1.8 and 2.8 times that of the control,the intensities of absorption and fluorescence are sig- nificantly higher than that of the purified Rubisco from the control, and the total sulfhydryl groups and available sulfhydryl groups are 36—39 –SH per mol enzyme, 14—25 –SH per mol enzyme more than those of the purified Rubisco from the control, respectively. The CD spectra show that the secondary structure of the purified enzyme from LaCl3-, CeCl3 -treated spinach is very dif- ferent from the control. The enzyme activities from LaCl3-, CeCl3- treated spinach in vivo are 1.5 and 1.9 times those of the control. | HONG Fashui1, LIU Chao1, ZHENG Lei1, WANG Xuefeng1, WU Kang1, SONG Weiping1, Lü Shipeng1, TAO Ye2 & ZHAO Guiwen3 1. College of Life Sciences, Suzhou Universty, Suzhou 215006, China 2. Synchrotron Radiation Laboratory, Institute of High Energy Physics, The Chinese Academy of Science, Beijing 100039, China 3. Chemical Department, University of Science and Technology of China, Hefei 230026, China | 2005 | Science China Chemistry2005，48，1： | 16 |
| 3 | Primary scientific results of Chang'E-1 lunar mission显示文摘The strategic plan for the development of the unmanned Chinese Lunar Exploration Program is characterized by three distinct stages: 'orbiting around', 'landing on' and 'returning from' the Moon. The first Chinese lunar probe, Chang'E-1, which was successfully launched on October 24th, 2007 at Xichang Satellite Launch Center, and guided to crash on the Moon on March 1st, 2009, at 52.36°E, 1.50°S, in the north of Mare Fecunditatis, is the first step towards the 'orbiting around' stage. The Chang'E-1 mission lasted 495 days, exceeding the expected life-span by about four months. A total of 1.37 TB raw data was received from Chang'E-1. It was then processed into 4 TB scientific data products at various levels. Many scientific results have been obtained by analyzing these data, including especially the 'global lunar image from the first Chinese lunar explora- tion mission'. All scientific goals of Chang'E-1 have been achieved. It provides much useful materials for further advances of lunar sciences and planetary chemistry. Meanwhile, these results will serve as a firm basis for future Chinese lunar missions. | OUYANG ZiYuan1,2, LI ChunLai1, ZOU YongLiao1, ZHANG HongBo1, Lü Chang1, LIU JianZhong1, LIU JianJun1, ZUO Wei1, SU Yan1, WEN WeiBin1, BIAN Wei1, ZHAO BaoChang3, WANG JianYu4, YANG JianFeng3, CHANG Jin5, WANG HuanYu6, ZHANG XiaoHui7, WANG ShiJin7, WANG Min1, REN Xin1, MU LingLi1, KONG DeQing1, WANG XiaoQian1, WANG Fang1, GENG Liang1, ZHANG ZhouBin1, ZHENG Lei1, ZHU XinYing1, ZHENG YongChun1, LI JunDuo1, ZOU XiaoDuan1, XU Chun1, SHI ShuoBiao1, GAO YiFei1 & GAO GuanNan1 1 National Astronomical Observatories, Chinese Academy of Sciences, Beijing 100012, China 2 Institute of Geochemistry, Chinese Academy of Sciences, Guiyang 550002, China 3 Xi’an Institute of Optics and Precision Mechanics, Chinese Academy of Sciences, Xi’an 710119, China 4 Shanghai Institute of Technical Physics, Chinese Academy of Sciences, Shanghai 200083, China 5 Purple Mountain Observatory, Chinese Academy of Sciences, Nanjing 210008, China 6 Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China 7 Center for Space Science and Applied Research, Chinese Academy of Sciences, Beijing 100190, China | 2010 | Science China Earth Sciences2010，53，11： | 11 |
| 4 | Effect of acetyl-L-carnitine on hypersensitivity in acute recurrent caerulein-induced pancreatitis and microglial activation along the brain’s pain circuitry显示文摘BACKGROUND Acute pancreatitis(AP)and recurring AP are serious health care problems causing excruciating pain and potentially lethal outcomes due to sepsis.The validated caerulein-(CAE)induced mouse model of acute/recurring AP produces secondary persistent hypersensitivity and anxiety-like behavioral changes for study.AIM To determine efficacy of acetyl-L-carnitine(ALC)to reduce pain-related behaviors and brain microglial activation along the pain circuitry in CAE-pancreatitis.METHODS Pancreatitis was induced with 6 hly intraperitoneal(i.p.)injections of CAE(50μg/kg),3 d a week for 6 wk in male C57BL/6J mice.Starting in week 4,mice received either vehicle or ALC until experiment’s end.Mechanical hypersensitivity was assessed with von Frey filaments.Heat hypersensitivity was determined with the hotplate test.Anxiety-like behavior was tested in week 6 using elevated plus maze and open field tests.Microglial activation in brain was quantified histologically by immunostaining for ionized calcium-binding adaptor molecule 1(Iba1).RESULTS Mice with CAE-induced pancreatitis had significantly reduced mechanical withdrawal thresholds and heat response latencies,indicating ongoing pain.Treatment with ALC attenuated inflammation-induced hypersensitivity,but hypersensitivity due to abdominal wall injury caused by repeated intraperitoneal injections persisted.Animals with pancreatitis displayed spontaneous anxiety-like behavior in the elevated plus maze compared to controls.Treatment with ALC resulted in increased numbers of rearing activity events,but time spent in“safety”was not changed.After all the abdominal injections,pancreata were translucent if excised at experiment’s end and opaque if excised on the subsequent day,indicative of spontaneous healing.Post mortem histopathological analysis performed on pancreas sections stained with Sirius Red and Fast Green identified wide-spread fibrosis and acinar cell atrophy in sections from mice with CAE-induced pancreatitis that was not rescued by treatment with ALC.Microglial Iba1 immunostaining was significantly increased in hippocampus,thalamus(intralaminar nuclei),hypothalamus,and amygdala of mice with CAE-induced pancreatitis compared to naïve controls but unchanged in the primary somatosensory cortex compared to naïves.CONCLUSION CAE-induced pancreatitis caused increased pain-related behaviors,pancreatic fibrosis,and brain microglial changes.ALC alleviated CAE-induced mechanical and heat hypersensitivity but not abdominal wall injury-induced hypersensitivity caused by the repeated injections. | Sabrina L McIlwrath Marlene E Starr Abigail E High Hiroshi Saito Karin N Westlund | 2021 | World Journal of Gastroenterology2021，27，9： | 2 |
| 5 | EGFR/HER2 inhibitor fective in preclinical lung cancer models显示文摘 | LI D AM BIBW2992 highly ef BROGIO L SHI an irreversible MAMURA T | 2008 | Oncogene2008，27，34： | 1 |
| 6 | leaching through undisturbed soil columns显示文摘 | PLEYSIER J L JUO A S R Leaching of fertilizer ions in a Ultisolfromthe high rainfall tropics | 1981 | Soil Science Society of America Journal1981，45，： | 1 |
| 7 | Angiotensin AT1 receptor glucose-induced epithelial- mesenchymal transition in renal proximal tubular cells显示文摘 | Zhou L Xue H Yuan P et activation mediates high al | 2010 | Clin Exp Pharmacol Physiol2010，37，9： | 1 |
| 8 | WFDC2(HFA):a potential role in the innate immunity of the oral cavity and respiratory tract and the development of adenocarcinomas of the lung显示文摘 | Bingle L Cross SS High AS | 2006 | Respir Res2006，7，1： | 1 |
| 9 | Dependences of ESR line widths and spin-spin relaxation times of single nitrogen defects on the concentration of nitrogen defects in diamond显示文摘 | Wyk J A Van Reynhardt E C High G L | 1997 | J Phys D:Apple Phys1997，30，12： | 1 |
| 10 | WFDC2 (HE4):A potential role in the innate immunity of the oral cavity and respiratory tract and the development of adenocarcinomas of the lung显示文摘 | Bingle L Cross SS High AS | 2006 | Respir Res2006，7，1： | 1 |
| 11 | WFDC2 (HE4) :a potential role in the innate immunity of the oral cavity and respiratory tract and the development of adenocaminomas of the lung显示文摘 | Bingle L Cross SS High AS | 2006 | Respir Res2006，7，1： | 1 |
| 12 | Gene therapy for haemophilia显示文摘 | Murphy S L High K A | 2008 | Br J Haematol2008，140，5： | 1 |
| 13 | Particles in the lower t plains of the unitedstates, Part 2: and deliquescent particles 显示文摘 | Hobbs P V Bowdle D A roposphere over the high Cloud condensation nuclei mate Appl Meteor 1985 RadKe L F | 1985 | Cli- 24(12) :1358- 13691985，24，12： | 1 |
| 14 | Precise determination of optical constants and sample thickness in terahertz time-domain spectroscopy显示文摘 | Duvillaret L Garet F Highly J L | 1999 | Applied Optics1999，38，2： | 1 |
| 15 | evolution equations显示文摘 | Zhang H Q Soliton-like and period form solutions for high dimensional nonlinear | 2003 | Chaos Solitons Fractals2003，17，： | 1 |
| 16 | 显示文摘 | Song Y He Q Li P l Capillary high performance liquid chroma- tography coupled with electrospray ionization mass spectrometry for rapid analysis of pinane monoterpene glycosides in Cortex Moutan | 2008 | J Sep Sci2008，31，1： | 1 |
| 17 | The primary signal in the biological perception of temperature: Pd -catalyzed hydrogenation of membrane liquids the expression of the desA gene in Synechocystie PCC6803显示文摘 | High L | 1993 | Proc Natl Acad Sci USA1993，90，： | 1 |
| 18 | WFDC2 (HE4): a potential role in the innate immunity of the oral cavity and respiratory tract and the development of adenocarcinomas of the lung显示文摘 | Bingle L Cross SS High AS | 2006 | Respir Res2006，7，： | 1 |
| 19 | Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection,Evaluation,And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III)显示文摘 | Expert Panel on Detection eveluation and treatment of High blood cholestero l in adults | 2001 | JAMA2001，285，19： | 1 |
| 20 | Transportation Research Record : Journal of the Transportation Research Board 显示文摘 | Mallick R B Kandhal P S Bradbury R L Asphalt Technology to Incorporate High Using Warm Mix Percentage of Re- claimed Asphalt Pavement Material in Asphalt Mixtures | 2008 | (2051):71 -792008，，2051： | 1 |
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