|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Carbon dioxide accumulation during analgosedated colonoscopy: Comparison of propofol and midazolam显示文摘AIM: To characterize the profiles of alveolar hypoventilation during colonoscopies performed under sedoanalgesia with a combination of alfentanil and either midazolam or propofol. METHODS: Consecutive patients undergoing routine colonoscopy were randomly assigned to sedation with either propofol or midazolam in an open-labeled design using a titration scheme. All patients received 4 μg/kg per body weight alfentanil for analgesia and 3 L of supplemental oxygen. Oxygen saturation (SpO 2 ) was measured by pulse oximetry (POX), and capnography (PcCO 2 ) was continuously measured using a combined dedicated sensor at the ear lobe. Instances of apnea resulting in measures such as stimulation of the patient, a chin lift, a mask maneuver, or withholding of sedation were recorded. PcCO 2 values (as a parameter of sedation-induced hypoventilation) were compared between groups at the following distinct time points: baseline, maximal rise, termination of the procedure and 5 min after termination of the procedure. The number of patients in both study groups who regained baseline PcCO 2 values (± 1.5 mmHg) five minutes after the procedure was determined.RESULTS: A total of 97 patients entered this study. The data from 14 patients were subsequently excluded for clinical procedure-related reasons or for technical problems. Therefore, 83 patients (mean age 62 ± 13 years) were successfully randomized to receive propofol (n = 42) or midazolam (n = 41) for sedation. Most of the patients were classified as American Society of Anesthesiologists (ASA) Ⅱ [16 (38%) in the midazolam group and 15 (32%) in the propofol group] and ASA Ⅲ [14 (33%) and 13 (32%) in the midazolam and propofol groups, respectively]. A mean dose of 5 (4-7) mg of Ⅳ midazolam and 131 (70-260) mg of Ⅳ propofol was used during the procedure in the corresponding study arms. The mean SpO 2 at baseline (%) was 99 ± 1 for the midazolam group and 99 ± 1 for the propofol group. No cases of hypoxemia (SpO 2 < 85%) or apnea were recorded. However, an increase in PcCO 2 that indicated alveolar hypoventilation occurred in both groups after administration of the first drug and was not detected with pulse oximetry alone. The mean interval between the initiation of sedation and the time when the PcCO 2 value increased to more than 2 mmHg was 2.8 ± 1.3 min for midazolam and 2.8 ± 1.1 min for propofol. The mean maximal rise was similar for both drugs: 8.6 ± 3.7 mmHg for midazolam and 7.4 ± 3.2 mmHg for propofol. Five minutes after the end of the procedure, the mean difference from the baseline values was significantly lower for the propofol treatment compared with midazolam (0.9 ± 3.0 mmHg vs 4.3 ± 3.7 mmHg, P = 0.0000169), and significantly more patients in the propofol group had regained their baseline value ± 1.5 mmHg (32 of 41vs 12 of 42,P = 0.0004). CONCLUSION: A significantly higher number of patients sedated with propofol had normalized PcCO 2 values five minutes after sedation when compared with patients sedated with midazolam. | Ludwig T Heuss Shajan Peter Sugandha Christoph Beglinger | 2012 | World Journal of Gastroenterology2012，18，38： | 3 |
| 2 | The AGE/RAGE/NF-κB Pathway May Contribute to the Pathogenesis of Polyneuropathy in Impaired Glucose Tolerance (IGT)显示文摘 | K.-M. Haslbeck E. Schleicher A. Bierhaus P. Nawroth M. Haslbeck B. Neund?rfer D. Heuss | 2005 | Exp Clin Endocrinol Diabetes2005，，05： | 2 |
| 3 | Trained Registered Nurses/Endoscopy Teams Can Administer Propofol Safely for Endoscopy显示文摘 | Douglas K. Rex Ludwig T. Heuss John A. Walker Rong Qi | 2005 | Gastroenterology2005，，5： | 2 |
| 4 | Changing patterns of sedationand monitoring practrice during endoscopy:results of ana tionwide survey in Switzerland显示文摘 | Heuss LT Froehlich F Beglinger C | 2005 | Endosco()2005，1，2： | 1 |
| 5 | Safety of propofol for conscious sedation during endoscopic procedures in high-risk patients-a prospective, controlled study 显示文摘 | HEUSS LT SCHNIEPER P Drewe J | 2003 | Am J Gastroenterol2003，98，： | 1 |
| 6 | The dawning of a new sedative propofol in gastrointestinal endoscopy显示文摘 | Heuss LT Inauen W | 2004 | Digestion2004，69，1： | 1 |
| 7 | Risk stratification and safe administration of propofol by registered nurses supervised by the gastroenterologist: a prospective observational study of more than 2000 cases 显示文摘 | HEUSS LT SCHNIEPER P DREWE J | 2003 | Gastrointest Endosc2003，57，： | 1 |
| 8 | Feasibility of breath monitoring in patients undergoing elective colonoscopy under propofol sedation: A single-center pilot study显示文摘AIM: To determine whether a newly developed respiratory rate monitor can practically and accurately monitor ventilation under propofol sedation in combination with standard monitoring. METHODS: Patients [American Society of Anesthesiologists(ASA) Classification Ⅰ-Ⅲ] scheduled for elective colonoscopy under propofol sedation were monitored with a new device that measures the respiratory rate based on humidity in expired air. Patients with clinically significant cardiac disorders or pulmonary disease and patients requiring emergency procedures were excluded from study participation. All of the patients also received standard monitoring with pulse oximetry. This was a single-center study conducted in a community hospital in Switzerland. After obtaining written informed consent from all subjects, 76 patients(51 females and 25 males) were monitored during colonoscopy under propofol sedation. The primary endpoint was the occurrence of any respiratory event(apnea or hypopnea). Apnea was defined as the cessation of breathing for a minimum of 10 s. Significant apnea was defined as the cessation of breathing for more than 30 s. Hypopnea was defined as a reduction in the respiratory rate below 6/min for a minimum of 10 s. Any cases of significant apnea triggered interventions by the endoscopy team. The interventions included withholding propofol, verbal stimulation of the patients, and increased oxygen supplementation or the chin lift maneuver. A secondary endpoint was the correlation of apnea or hypopnea with hypoxemia(measured as a decrease in SaO2 of at least 5% from baseline or less than 90%). RESULTS: At least one respiratory event was detected in thirty-seven patients(48.7%). In total, there were 73 respiratory events, ranging from one to six events in a single patient. Significant apnea(> 30 s) occurred in five patients(6%). Only one episode of apnea led to a relative SaO2 reduction(from 98% to 93%) after a 50 s lag time. No event requiring assisted ventilation was recorded. Our analysis revealed that the total propofol dose was an independent risk factor for respiratory events(P = 0.01). Artifacts developed with the same frequency with the new device as with conventional pulse oximetry. Compared with pulse oximetry alone, this new monitoring device detected more respiratory events and may provide earlier warning of impending respiratory abnormalities. CONCLUSION: Apnea commonly occurs during endoscopy under sedation and may precede hypoxemia. We recommend this respiration rate monitor as an alternative to capnography to aid in detecting ventilatory problems. | Gurpreet W Anand Ludwig T Heuss | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，3： | 1 |
| 9 | Conscious sedation with propofol in elderly patients: a prospective evaluation显示文摘 | HEUSS LT SCHNIEPER P DREWE J | 2003 | Aliment Pharmacol Ther2003，17，： | 1 |
| 10 | The dawning of a new sedative: propofol in gastrointestinal endoscopy显示文摘 | Heuss LT Inauen W | 2004 | Digestion2004，69，1： | 1 |
| 11 | Neufunde von Dugesia tigrina GIRARD (Turbellaria:Tricladida) im Gebiet des Niederrheins und der unteren Maas显示文摘 | Heuss K | 1971 | Decheniana1971，123，： | 1 |
| 12 | Human papilloma virus DNA: A factor in the pathogenesis of mammary Paget’s disease?显示文摘 | Klaus Czerwenka Friedrich Heuss Josef W. Hosmann Mahmood Manavi Yongxian Lu Darko Jelincic Ernst Kubista | 1996 | Breast Cancer Research and Treatment1996，，1： | 1 |
| 13 | 30 years multiple system atrophy concept: retrospect and overview of multiple system atrophy 显示文摘 | Probst-Cousin S Kayser C Heuss D | 2000 | Fortsehr Neurol Psyehiatr2000，68，1： | 1 |
| 14 | Risk strati?cation and safe administration of propofol by registered nurses supervised by the gastroenterologist:a prospective observational study of more than 2000 cases显示文摘 | Heuss A Schnieper P Drewe J | 2003 | Gastrointest Endosc2003，57，： | 1 |
| 15 | Conscious sedation with propofol in elderly patients: a prospective evaluation 显示文摘 | Heuss LT Schnieper P Drewe J | 2003 | Aliment Pharmacol Ther2003，17，12： | 1 |
| 16 | Retinal dendritic cell recruitment, but not function, was inhibited in MyD88 and TRIF deficient mice显示文摘 | Heuss ND Pierson M J Montaniel KR | 2014 | J Neuroinflammation2014，11，5： | 1 |
| 17 | Risk stratification and safe administration of propofol by registered nurese supervised by tile gastroenterologist: a prospective observational study of more than 2000 cases 显示文摘 | Heuss LT Schnieper P Drewe J | 2003 | Gastrointest Endosc2003，57，6： | 1 |
| 18 | Safety of propofol for conscious sedation during endoscopic procedures in highrisk patients-a prospective,controllee study显示文摘 | Heuss LT Schnieper P Drewe J | 2003 | Am J Gastroenterol2003，98，8： | 1 |
| 19 | Idle sense: An optimal access method for high throughput and fairness in rate diverse wireless LANs显示文摘 | Heusse M Rousseau F Guillier R | 2005 | ACM SICK OMM2005，35，4： | 1 |
| 20 | Idle sense: an optimal access method for high throughput and fairness in rate diverse wireless LANs 显示文摘 | Heusse M Rousseau F Guillier R | 2005 | ACM SIGCOMM Computer Communication Review2005，35，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员