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| 1 | Changes in myocardial collagen content before and after left ventricular assist device application in dilated cardiomyopathy显示文摘Background The purposes of this study were to confirm the changes in myocardial collagen level after left ventricular assist device (LVAD) support in dilated cardiomyopathy (DCM), find the relation between these changes and prognosis, an d test a practical method to assess the level of myocardial collagen.Methods Left ventricular samples were collected from DCM patients with different prognosis (transplanted group n=8, weaning group n=10) at the time when the LV ADs were implanted and again during cardiac transplantation (n=8). The level of neutral salt soluble collagen (NSC) and acid soluble collagen (ASC) was measured by Sircol collagen assay, and that of total collagen and insoluble collagen (ISC) by quantification of hydroxyproline (Hyp). Serum samples were collected from a portion of these patients (transplanted group, n=6; weaning group n=7) at the time the LVADs were implanted, 1 month after implantation and on explantation. Circulating concentration of carboxy-terminal propeptide of type Ⅰ procollagen (PⅠCP), amino-terminal propeptide of type Ⅰ procollagen (PⅠNP), amino-terminal propeptide of type Ⅲ procollagen (PⅢNP) and type Ⅰ collagen telopeptide (ⅠCTP) were measured by the equilibrium type radioimmunoassay. Results Before LVAD implantation the level of NSC and ISC in th e weaning group was higher but ASC in the transplanted group was lower than in the control s (P<0.05). After LVAD support, the level of total collagen was higher, but ASC was also lower in the transplanted group than in the controls (P<0.05). In comparison of the pre- and po st-LVAD subgroups of the transplanted and weaning groups, all collagen fraction levels before LVAD implantation were lower in the transplanted group than in the weaning group (P<0.05); but this difference disappeared after LVAD support. Comparison of the pre- and post-LVAD subgroups of the transplanted group showed increased le vel of NSC and total collagen after LVAD support. The changes of serum p eptide concentration showed that PⅢNP increased constantly in the transplanted group, but PⅠCP and PⅠNP increased in the weaning group after LVAD implantation. Conclusions The changes in myocardial collagen level as a sign of myocardial interstitial remodeling in DCM are not involved with total collagen b ut invalved with collagen fractions, and they are related to prognosis. The changes of myocardial c ollagen content and serum procollagen peptide after LVAD support can be regarded as an expression of the reverse of maladaptive myocardial interstitial remodeling. | 梁红 Johannes Müller 翁渝国 Gerd Wallukat 付平 林汉生 Sabina Bartel Christoph Knosalla Reinhard Pregla Roland Hetzer | 2004 | Chinese Medical Journal2004，，3： | 3 |
| 2 | 心室辅助装置临床应用现状及进展显示文摘2010年美国心脏学会(AHA)统计数据显示心衰(HF)正成为欧美国家住院、死亡的主要原因之一。我国目前HF患者约400万。随着人类社会老龄化,终末期HF病例持续增长,估计未来20年,超过65岁的HF患者将增加1倍。 | 吴龙 翁渝国 孙宗全 董念国 Hetzer | 2012 | 中华胸心血管外科杂志2012，28，10： | 2 |
| 3 | The Ran GTPase as a marker of chromosome position in spindle formation and nuclear envelope assembly 显示文摘 | HETZER M GRUSS O J MATI'AJ I W | 2002 | Nat Cell Biol2002，4，7： | 1 |
| 4 | County stretches fleet budget with hook-lift hoists显示文摘 | Graham J E Hetzer J C | 1992 | Public Works1992，，9： | 1 |
| 5 | Echocardiographic strain and strain rate imaging clinical application 显示文摘 | Dandel M Hetzer R | 2009 | Cardiol2009，132，： | 1 |
| 6 | An Economic Dis- patch Modelineorporating Wind Power显示文摘 | HETZER J YU D C BHATI'ARAI K | 2008 | IEEE Transac- tions on Power Systems2008，23，2： | 1 |
| 7 | Environment,tourism,culture显示文摘 | Hetzer N.D | | 0，，02： | 1 |
| 8 | Echocardiographic strain and strain rate imaging-clinical applications显示文摘 | Dandel M Hetzer R | 2009 | Int J Cardiol2009，132，1： | 1 |
| 9 | Improvement in survival after mechanical circulatory support with pneumatic pulsatile ventricular assist devices in pediatric patients 显示文摘 | Hetzer R Potapov EV Stiller B | 2006 | Ann Thorac surg2006，82，3： | 1 |
| 10 | An economic dispatch model incorporating wind power显示文摘 | HETZER J YU D C | 2008 | IEEE Transactions on Power Energy Conversion2008，23，2： | 1 |
| 11 | Technology insight:use of ventricular assistdevices in children显示文摘 | Hetzer R Stiller B | 2006 | Nat Clin Pract Card2006，3，7： | 1 |
| 12 | Specific removal of β1-adrenergic autoantibodies from patients with idiopathic dilated cardiomyopathy显示文摘 | Muller J Hetzer R | 2002 | N Engl J Med2002，347，22： | 1 |
| 13 | Echocardiographic strain and strain rate imaging-clinical applications显示文摘 | Dandel M Hetzer R | | 0，，01： | 1 |
| 14 | Echocardiographic strain and strain rate imaging--clinical applications显示文摘 | Dandel M Hetzer R | 2009 | Int J Cardiol2009，132，： | 1 |
| 15 | Small vessel disease after heart transplantation:impact of immunologic and nonimmunologic risk factors显示文摘 | Hiemann NE Wellnhofer E Hetzer R | 2005 | Transpl Int2005，18，8： | 1 |
| 16 | Stapled vs excision hemorrhoidectomy : long- term results of a prospective randomized trial显示文摘 | Hetzer F H Demartines N | 2002 | Areh Surg2002，137，35： | 1 |
| 17 | Preservation of papillary-muscles and chordae during initial valve replacement:possibilities and limitations显示文摘 | Hetzer R Drews T Siniawski H | 1995 | J Heart Valve Dis1995，4，2： | 1 |
| 18 | An economic dispatchmodel incorporating wind power 显示文摘 | Hetzer J Yu D C Bhattarai K | 2008 | IEEE Transactions on Energy Conversion2008，23，2： | 1 |
| 19 | Contrast media radiography in patients with retrosternal irrigation drainage for severe sternal wound infection显示文摘 | Hetzer R | 1999 | Ann Thorac Cardiovasc Surg1999，5，3： | 1 |
| 20 | 查看详情显示文摘 | Hetzer M Chen G J Barner-Kowollik C Stenze M H | | 0，，02： | 1 |
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