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| 1 | Endoscopic ultrasound evaluation in the surgical treatment of duodenal and peri-ampullary adenomas显示文摘AIM:To investigate endoscopic ultrasound(EUS) for predicting depth of mucosal invasion and to analyze outcomes following endoscopic and transduodenal resection.METHODS:Records of 111 patients seen at our institution from November 1999 to July 2011 with the postoperative pathological diagnosis of benign ampullary and duodenal adenomas were reviewed.Records of patients who underwent preoperative EUS for diagnostic purposes were identified.The accuracy of EUS in predicting the absence of muscular invasion was assessed by comparing EUS reports to the final surgical pathological results.In addition,the incidence of the post-operative complications over a period of 30 d and the subsequent long-term outcome(recurrence) over a period of 30 mo associated with endoscopic and transduodenal surgical resection was recorded,compared and analyzed.RESULTS:Among 111 patients with benign ampullary and duodenal adenomas,47 underwent preoperative EUS for 29 peri-ampullary lesions and 18 duodenal lesions.In addition,computed tomography was performed in 18 patients,endoscopic retrograde cholangio-pancreatography in 10 patients and esophagogastroduodenoscopy in 22 patients.There were 43 patients with sporadic adenomas and 4 patients with familial adenomatous polyposis(FAP)/other polyposis syndromes.In 38(81%,P < 0.05) patients,EUS reliably identified absence of submucosal and muscularis invasion.In 4 cases,EUS underestimated submucosal invasion that was proven by pathology.In the other 5 patients,EUS predicted muscularis invasion which could not be demonstrated in the resected specimen.EUS predicted tumor muscularis invasion with a specificity of 88% and negative predictive value of 90%(P < 0.05).Types of resection performed included endoscopic resection in 22 cases,partial duodenectomy in 9 cases,transduodenal ampullectomy with sphincteroplasty in 10 cases and pancreaticoduodenectomy in 6 cases.The main post-operative final pathological results included villous adenoma(n = 5),adenoma(n = 8),tubulovillous adenoma(n = 10),tubular adenoma(n = 20) and hyperplastic polyp(n = 2).Among the 47 patients who underwent resection,8(17%,5 of which corresponded to surgical resection) developed post-procedural complications which included retroperitoneal hematoma,intra-abdominal abscess,wound infection,delayed gastric emptying and prolonged ileus.After median followup of 20 mo there were 6 local recurrences(13%,median follow-up = 20 mo) 4 of which were in patients with FAP.CONCLUSION:EUS accurately predicts the depth of mucosal invasion in suspected benign ampullary and duodenal adenomas.These patients can safely undergo endoscopic or local resection. | Lilian C Azih Brett L Broussard Milind A Phadnis Martin J Heslin Mohamad A Eloubeidi Shayam Varadarajulu Juan Pablo Arnoletti | 2013 | World Journal of Gastroenterology2013，19，4： | 13 |
| 2 | Growth hormone and insulin combine to improve whole￣body and skeletal muscle protein kinetics显示文摘 | Wolf RF Heslin MJ Newman E | 1992 | Surgery1992，112，： | 1 |
| 3 | A prospective,randomized trial of early enteral feeding after resetion of upper gastrointestinal malignancy显示文摘 | Heslin MJ Latkaney D Leung D | 1997 | Ann Surg1997，226，： | 1 |
| 4 | Prognostic factors associated with long-term survival for retroperitoneal sarcoma:implications for management显示文摘 | Heslin MJ Lewis JJ Nadter E | 1997 | J Clin Oncol1997，15，8： | 1 |
| 5 | Primary colonic lymphoma显示文摘 | Gonzalez QH Heslin MJ Dávila-Cervantes A | 2008 | Am Surg2008，74，3： | 1 |
| 6 | Intestinal permeability after early postoperative enteral nutrition in patients with upper gastrointestinal malignancy显示文摘 | Hochwald SN Heslin M J | 1999 | JPEN1999，23，2： | 1 |
| 7 | Early postoperative enteral nutrition improves peripheral protein kinetics in uppergastrointestinal cancer patients undergoing complete resection:A randomized trial显示文摘 | Harrison LE Hochwald SN Heslin MJ | 1997 | JPEN1997，21，4： | 1 |
| 8 | Ki67 detected by MIB1 predicts distant metastasis and tumor mortality in primary, high grade extremity soft tissue sarcoma 显示文摘 | Heslin MJ Cordon CC Lewis JJ | 1998 | Cancer1998，83，3： | 1 |
| 9 | Soft tissue sarcoma: preoperative and postoperative imaging for staging 显示文摘 | Tzeng CW Smith JK Heslin MJ | 2007 | Surg Oncol Clin N Am2007，16，2： | 1 |
| 10 | Intestinal permeability after early postoperation enteral nutrition in patients with upper gas- trointestinal malignancy 显示文摘 | Brooks AD Hochwald SN Heslin MJ | 1999 | JPEN1999，23，2： | 1 |
| 11 | Role of matrix metalloproteinase in colorectal carcinogenesis显示文摘 | Heslin MJ Yan J Johnson MR | | 0，，03： | 1 |
| 12 | Role of matrix metalloproteinases in colorectal carcinogenesis显示文摘 | Heslin MJ Yah J Johnson MR | 2001 | Ann Surg2001，233，6： | 1 |
| 13 | Housekeeping gene variability in normal and carcinomatous colorectal and liver tissues:Applications in pharmacogenomic gene expressionstudies显示文摘 | Blanquicett C Johnson M R Heslin M | 2002 | Anal Biochem2002，303，： | 1 |
| 14 | Tumor-associated down- regulation of 15-lipoxygenase-1 is reversed by celecoxib in colorectal cancer显示文摘 | Heslin MJ Hawkins A Boedefeld W | 2005 | Ann Surg2005，241，6： | 1 |
| 15 | Prognostic factors associated with long-term survival for retroperitoneal sarcoma: implications for management显示文摘 | Heslin M J Lewis J J Nadler E | 1997 | J Clin Oncol1997，15，8： | 1 |
| 16 | Appraisal processes,coping,and the regulation of stress-related emotions in a college examination显示文摘 | ABELLA R HESLIN R | 1989 | Basic and Applied Social Psychology1989，10，4： | 1 |
| 17 | Fomannoxin, a phytotoxic metabolite of Fomes annosus:in vitro production, host toxicity and isolation from naturally infected Sitka spruce heartwood显示文摘 | M C Heslin M R Stuart P O Murchu and D MX Donnelly | 1983 | European Journal Forest Pathology1983，，13： | 1 |
| 18 | A prospective ran- domized trial of early feeding after resection of upper gastroin- testinal malignancy显示文摘 | Heslin M J Latkany L Leung D | 1997 | Ann Surg1997，226，4： | 1 |
| 19 | Psychosocial outcomes at three and nine months after good neurological recovery from aneurysmal subarachnoid haemorrhage:predictor and prognosis显示文摘 | Kitchen N Heslin J | 2002 | J Neurol Neurosurg Psychiatry2002，72，： | 1 |
| 20 | Soft tissue sarcoma : preoperative and postoperative imaging for staging显示文摘 | Tzeng CWD Smith JK Heslin MJ | 2007 | Surg Oncol Clin N Am2007，16，2： | 1 |
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