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| 1 | Randomized trial in malignant biliary obstruction:Plastic vs partially covered metal stents显示文摘AIM:To compare efficacy and complications of par-tially covered self-expandable metal stent(pcSEMS)to plastic stent(PS)in patients treated for malignant,infrahilar biliary obstruction.METHODS:Multicenter prospective randomized clinical trial with treatment allocation to a pcWallstent(SEMS)or a 10 French PS.Palliative patients aged≥18,for infrahilar malignant biliary obstruction and a Karnofsky performance scale index>60%from 6 participating North American university centers.Primary endpoint was time to stent failure,with secondary outcomes of death,adverse events,Karnofsky performance score and short-form-36 scale administered on a three-monthly basis for up to 2 years.Survival analyses were performed for stent failure and death,with Cox proportional hazards regression models to determine significant predictive characteristics.RESULTS:Eighty-five patients were accrued over 37mo,42 were randomized to the SEMS group and 83patients were available for analyses.Time to stent failure was 385.3±52.5 d in the SEMS and 153.3±19.8 d in the PS group,P=0.006.Time to death did not differ between groups(192.3±23.4 d for SEMS vs211.5±28.0 d for PS,P=0.70).The only significant predictor was treatment allocation,relating to the time to stent failure(P=0.01).Amongst other measured outcomes,only cholangitis differed,being more common in the PS group(4.9%vs 24.5%,P=0.029).The small number of patients in follow-up limits longitudinal assessments of performance and quality of life.From an initially planned 120 patients,only 85 patients were recruited.CONCLUSION:Partially covered SEMS result in a longer duration till stent failure without increased complication rates,yet without accompanying measurable benefits in survival,performance,or quality of life. | Peter L Moses Khalid M AlNaamani Alan N Barkun Stuart R Gordon Roger D Mitty M Stanley Branch Thomas E Kowalski Myriam Martel Viviane Adam | 2013 | World Journal of Gastroenterology2013，19，46： | 6 |
| 2 | Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial显示文摘 | Paul Y Kwo Eric J Lawitz Jonathan McCone Eugene R Schiff John M Vierling David Pound Mitchell N Davis Joseph S Galati Stuart C Gordon Natarajan Ravendhran Lorenzo Rossaro Frank H Anderson Ira M Jacobson Raymond Rubin Kenneth Koury Lisa D Pedicone Clifford | 2010 | The Lancet2010，，9742： | 3 |
| 3 | Tensile Testing of EP-823 and HT-9 After Irradiation in STIP Ⅱ 显示文摘 | Maloy Stuart A Romero T James M R | 2006 | Journal of Nuclear Materials2006，356，123： | 1 |
| 4 | Embrittlement of Irradiated Ferritic/Martensitic Steels in the Absence of Irra diation Hardening 显示文摘 | Maloy Stuart A Romero T James M R | 2008 | Journal of Nuclear Materials2008，377，3： | 1 |
| 5 | Exponential mean- square stability of numerical solutions to stochastic differ- ential equations 显示文摘 | Higham D J Mao X R Stuart A M | 2003 | LMS Journal of Computation and Mathematics2003，6，： | 1 |
| 6 | Assessing DBP yield:Uniform formation conditions显示文摘 | R Scott Summers Stuart M Hooper Hiba M Shukairy | 1996 | American Water Works Association Journal1996，88，6： | 1 |
| 7 | Steroid hormone influence on brain calbindin-D28k in male prepubertal and ovariectomized rats显示文摘 | Stuart E B Thompson J M Rhees R W | 2001 | Developmental Brain Research2001，129，2： | 1 |
| 8 | Novel drying process using forced aeration through a porous biomass matrix 显示文摘 | Frei K M Cameron D Stuart P R | 2004 | Drying Technology2004，22，5： | 1 |
| 9 | Rival penalized competitive learning (RPCL) : a topology-determining algorithm for analyzing gene expression data 显示文摘 | NAIR T M ZHENG C L FINK J L STUART R O GRIBSKOV M | 2003 | Computational Biology and Chemistry2003，27，6： | 1 |
| 10 | Assessment of eccentric exercise-induced muscle damage of the elbow flexors by tensiomyography 显示文摘 | Angus M Hunter Stuart D R Galloway Iain J S | 2012 | Journal of Electromyography and Kinesiology2012，22，3： | 1 |
| 11 | Nonionic bolaamphiphiles and Gemini surfactants based on carbohydrates显示文摘 | Pestman J M Terpstra K R Stuart M C A | 1997 | Langmuir1997，13，25： | 1 |
| 12 | Role of epigailocatcchin gallate (EGCG) in the treatment of breast and prostste cancer显示文摘 | STUART E C SCANDLYN M J ROSENGREN R J | 2006 | Life Sci2006，79，25： | 1 |
| 13 | Resolving mantle and crustal contributions to ancient hydrothermal fluids: He-Ar isotopes in fluid inclusions from Dae Hwa W-Mo mineraliza- tion, South Korea显示文摘 | Stuart F M Burnard P G Taylor R P | 1995 | Geoehimiea et Cosmochimica Acta1995，59，22： | 1 |
| 14 | Long-term outcome for arthroscopic repair of partial articular-sided supraspinatus tendon avulsion显示文摘 | Stuart K D Karzel R P Ganjianpour M | 2013 | Arthroscopy2013，29，5： | 1 |
| 15 | Loss of P53 function through PAX-mediated transcriptional repression显示文摘 | Haffner R Oren M | 1995 | EMBOJ1995，14，22： | 1 |
| 16 | Helium isotopes as tracers of trapped hydrothermal fluids in ocean floor sulfides 显示文摘 | Stuart F M Turner G Duckworth R C | 1994 | Geology1994，22，： | 1 |
| 17 | Wormlike micellar and vesicular phases in aqueous solutions of single-tailed surfac- rants with aromatic counterions 显示文摘 | Buwalda T R Stuart M C A Engberts J B F N | 2000 | Langmuir2000，16，： | 1 |
| 18 | Resonance raman crosssections and vibronic analysis of rhodamine 6G from broadband stimulated Raman spectroscopy显示文摘 | SHIM S STUART C M MATHIES R A | 2008 | Chem Phys Chem2008，9，5： | 1 |
| 19 | Helium and sulfur isotopes in sulfides from the Middle Valley, northem Juan de Fuca Ridge显示文摘 | Stuart F M Duckwolth R Tunler G | 1994 | Proceedings of ODP Scientific Result1994，139，： | 1 |
| 20 | Runge-Kutta methods for dissipative and gradient dynamical systems显示文摘 | HUMPHRIES A R STUART A M | 1994 | SIAM J Numer Anal1994，31，： | 1 |
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