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| 1 | Development of early gastric cancer 4 and 5 years after complete remission of Helicobacter pyloriassociated gastric low-grade marginal zone B-cell lymphoma of MALT type显示文摘AIM To report 3 of 120 patients on the German MALT lymphoma trial with H. pYlori-associated gastric MALT Iymphoma who developed early gastric cancer 4 and 5 years, after complete Iymphoma remission following cure of H. pylori infection.PATIENTS AND RESULTS Three patients (two men, 74 and 70 years; one women, 77 years)with H. pylori -associated low-grade MALTlymphoma achieved complete lymphoma remission after being cured. Surveillance endoscopies were performed twice a year in accordance to the protocol. Four years aftercomplete lymphoma remission in two patients,and after 5 years in the other, early gastric adenocarcinoma of the mucosa-type, type Ⅱ a and type Ⅱ c, respectively, was detetcted,which were completely removed by endoscopic mucosa resection. in one patient, the gastric cancer was diagnosed at the same location as the previous. MALT lymphoma, in the other patients it was detected at different sites of the stomach distant from location of the previous MALT lymphoma. The patients were H. pylori negative during the whole follow-up time.CONCLUSION These findings strengthen the importance of regular long-term follow-up endoscopies in patients with complete remission of gastric MALT lymphoma after cure of H.pylori infection. Furthermore, gastric adenocarcinoma may develop despite eradication of H. pylori. | Andrea Morgner Stephan Miehlke Manfred Stolte Andreas Neubauer Birgit Alpen Christian Thiede Hermann Klann Franz-Xaver Hierlmeier Christian Ell Gerhard Ehninger Ekkehard Bayerdorffer | 2001 | World Journal of Gastroenterology2001，7，2： | 28 |
| 2 | 快速检测小反刍兽疫病毒RT-LAMP方法的建立显示文摘本研究采用一步法反转录环介导等温扩增技术(RT-LAMP)建立了一种快速、灵敏、高度特异的检测小反刍兽疫病毒(PPRV)的方法。针对PPRV-N基因保守区域设计4条引物,在Bst大片段聚合酶的作用下,可以实现DNA的梯状等温扩增。优化RT-LAMP的反应体系,并检验其灵敏性、特异性。一步法RT-LAMP检测方法从核酸抽提到检测结果出现仅需70 min,该方法具有良好的特异性,与同属的犬瘟热病毒无交叉反应,灵敏度是RT-PCR的1 000倍,是巢式RT-PCR的100倍。结果证明,RT-LAMP方法可快速、灵敏、特异、经济地检测PPRV,在基层和实验室都具有良好的应用前景。 | 李伟 李刚 范晓娟 张坤 贾风琴 史利军 Hermann Unger | 2009 | 中国预防兽医学报2009，31，5： | 23 |
| 3 | Clinically detected gastroenteropancreatic neuroendocrine tumors are on the rise: Epidemiological changes in Germany显示文摘AIM:To study the epidemiologic changes of gastroenteropancreatic neuroendocrine tumors(GEP-NET)in Germany,we analyzed two time periods 1976-1988 and1998-2006.METHODS:We evaluated epidemiological data of GEP-NET from the former East German National Cancer Registry(DDR Krebsregister,1976-1988)and its successor,the Joint Cancer Registry(GKR,1998-2006),which was founded after German reunification.Due to a particularly substantial database the epidemiological data from the federal states of Mecklenburg-Western Pomerania,Saxony,Brandenburg and Thuringia,covering a population of more than 10.8 million people,were analyzed.Survival probabilities were calculated using life table analysis.In addition,GEP-NET patients were evaluated for one or more second(non-GEP-NET)primary malignancies.RESULTS:A total of 2821 GEP neuroendocrine neoplasms were identified in the two registries.The overall incidence increased significantly between 1976 and2006 from 0.31(per 100.000 inhabitants per year)to2.27 for men and from 0.57 to 2.38 for women.In the later period studied(2004-2006),the small intestine was the most common site.Neuroendocrine(NE)neoplasms of the small intestine showed the largest absolute increase in incidence,while rectal NE neoplasms exhibited the greatest relative increase.Only the incidence of appendiceal NET in women showed little change between 1976 and 2006.Overall survival of patients varied for sex,tumor site and the two periods studied but improved significantly over time.Interestingly,about 20%of the GEP-NET patients developed one or more second malignancies.Their most common location was the gastrointestinal tract.GEP-NET patients without second malignancies fared better than those with one or more of them.CONCLUSION:The number of detected GEP-NET increased about 5-fold in Germany between 1976 and2006.At the same time,their anatomic distribution changed,and the survival of GEP-NET patients improved significantly.Second malignancies are common and influence the overall survival of GEP-NET patients.Thus,GEP-NET warrant our attention as well as intensive research on their tumorigenesis. | Hans Scherübl Brigitte Streller Roland Stabenow Hermann Herbst Michael Hopfner Christoph Schwertner Joachim Steinberg Jan Eick Wanda Ring Krishna Tiwari Soren M Zappe | 2013 | World Journal of Gastroenterology2013，19，47： | 16 |
| 4 | 过敏性疾病家族史与儿童哮喘的相关研究显示文摘目的了解过敏性疾病(过敏性哮喘、过敏性鼻炎和湿疹/神经性皮炎)家族史对儿童哮喘的影响,为儿童哮喘的防治提供依据.方法以2000~2002年德国Wilhelmshaven镇和Delmenhorst镇小学入学儿童为研究对象,采用问卷调查法调查与儿童哮喘有关的因素,采用变量Logistic回归模型和多元Logistic回归模型进行验证.结果3种过敏性疾病家族史对儿童哮喘均有显著影响,尤其是过敏性哮喘家族史影响最大;亲属中,母亲过敏性哮喘对儿童的影响比父亲强,母亲过敏性鼻炎对儿童的影响与父亲接近,父亲湿疹/神经性皮炎对儿童的影响比母亲强;家族中患过敏性疾病的人越多,儿童患哮喘的危险性就越高.在多元Logistic回归模型排除混杂因素后,以上趋势仍存在.结论过敏性疾病家族史对儿童哮喘有显著影响,且不同疾病和不同亲属的影响程度不同. | 许敏兰 Hermann Pohlabeln 陶芳标 | 2005 | 中国学校卫生2005，26，10： | 14 |
| 5 | A SPECTRAL METHOD FOR PANTOGRAPH-TYPE DELAY DIFFERENTIAL EQUATIONS AND ITS CONVERGENCE ANALYSIS显示文摘We propose a novel numerical approach for delay differential equations with vanishingproportional delays based on spectral methods.A Legendre-collocation method is em-ployed to obtain highly accurate numerical approximations to the exact solution.It isproved theoretically and demonstrated numerically that the proposed method convergesexponentially provided that the data in the given pantograph delay differential equationare smooth. | Ishtiaq Ali Hermann Brunner | 2009 | Journal of Computational Mathematics2009，27，2： | 13 |
| 6 | Sedimentation acceleration of remanent iron oxide by magnetic flocculation显示文摘Sedimentation based processes are widely used in industry to separate particles from a liquid phase. Since the advent of the 'Nanoworld' the demand for effective separation technologies has rapidly risen, calling for the development of new separation concepts, one of which lies in hybrid separation using the superposition of a magnetic field for magnetic particles. Possible product portfolio of such separation consists of pigment production, nanomagnetics production for electronics and bio separation. A promising step in that direction is magnetic field enhanced cake filtration, which has by now progressed from batch to continuous operation. In sedimentation processes in a mass force field the settling behaviour of particles strongly depends on physico-chemical properties, concentration and size distribution of the particles. By adjusting the pH, the interparticle forces, in particular the electrostatic repulsion, can be manipulated. For remanent magnetic particles such as magnetite, pre-treatment in a magnetic field could lead to a change of interparticle interactions. By magnetizing the particles apart from van der Waals attraction and electrostatic repulsion, an additional potential is induced, the magnetic attraction, which could easily dominate the other potentials and result in agglomeration in the primary minimum. By sedimentation analysis, a wide spectrum of parameters like pH, magnetic field strength and concentration have been investigated. The results show a strong increase of sedimentation velocity by magnetic flocculation of the raw suspension. This leads to a rise in throughput due to the acceleration of sedimentation kinetics by imparting a non-chemical interaction to the physico-chemical properties in the feed stream of the separation apparatus. | Mathias Stolarski Christian Eichholz Benjamin Fuchs Hermann Nirschl | 2007 | China Particuology2007，5，1： | 12 |
| 7 | Effect of humic substances on the precipitation of calcium phosphate显示文摘For phosphorus (P) recovery from wastewater, the effect of humic substances (HS) on the precipitation of calcium phosphate was studied. Batch experiments of calcium phosphate precipitation were undertaken with synthetic water that contained 20 mg/L phosphate (as P) and 20 mg/L HS (as dissolved organic carbon, DOC) at a constant pH value in the range of 8.0—10.0. The concentration variations of phosphate, calcium (Ca) and HS were measured in the precipitation process; the crystalline state and compositions of the precipitates were analysed by powder X-ray diffraction (XRD) and chemical methods, respectively. It showed that at solution pH 8.0, the precipitation rate and removal efficiency of phosphate were greatly reduced by HS, but at solution pH ≥9.0, the effect of HS was very small. The Ca consumption for the precipitation of phosphate increased when HS was added; HS was also removed from solution with the precipitation of calcium phosphate. At solution pH 8.0 and HS concentrations ≤ 3.5 mg/L, and at pH ≥ 9.0 and HS concentrations ≤ 10 mg/L, the final precipitates were proved to be hydroxyapatite (HAP) by XRD. The increases of solution pH value and initial Ca/P ratio helped reduce the influence of HS on the precipitation of phosphate. | SONG Yong-hui Hermann H. HAHN Erhard HOFFMANN Peter G. WEIDLER | 2006 | Journal of Environmental Sciences2006，18，5： | 11 |
| 8 | 应用中分辨率遥感数据和地理信息系统改进森林材积和生物量评估策略(英文)显示文摘应用遥感技术、地理信息系统和野外观测数据,评估了热带森林环境下地上生物量和木材蓄积量。用于模拟森林属性的这些数据具有地理特异性和高度的不确定性,因此,这方面需要开展更多的研究工作。选取了16个试样地带1460个样地,测定树木胸径及其他用于评估生物量的其他森林属性。本实验在印尼加里曼丹东部的热带雨林开展。应用现有的胸径-生物量公式来评估地上生物量密度。估测值在研究区修正的GIS地图上重叠显示,计算各种地被物的生物量密度。用样品数据子集表达遥感方法来形成地上生物量和材积线性方程模型。皮尔森相关统计检验采用ETM条带反射率、植被指数、图像变化图层、主成分分析条带、缨帽变换、灰度共生矩阵纹理特征和DEM数据作为预报值。在显著的遥感数据中形成了两个线性模型。为了分析每块地被物总的生物量和材积量,对2000年到2003年卫星ETM图进行了预处理、最大似然估计法分类和主体分析过滤。遥感方法获得的结果表明:材积量为(158±16)m3·hm-2,地上生物量为(168±15)t·hm-2;而野外测定和地理信息系统估计的结果分别是材积量为(157±92)m3·hm-2、地上生物量为(167±94)t·hm-2。用多个瞬间ETM数据评估了从2000年到2003年间的生物量丰富度动态,结果发现这一时期总生物量呈略微的下降趋势。遥感技术评估的生物量丰富度低于地理信息系统和野外测定的结果。前一种测定方法估计2000年和2003年总生物量分别是10.47Gt和10.3Gt,而后一种则估计11.9Gt和11.6Gt。还发现,灰度共生矩阵纹理特征与材积量和生物量之间存在较强的相关性。图7表9参43。 | Arief Wijaya Sandi Kusnadi Richard Gloaguen Hermann Heilmeier | 2010 | Journal of Forestry Research2010，21，1： | 10 |
| 9 | 两种具有自动筛选技术的广义有序统计恒虚警检测器及其在多目标环境下的性能显示文摘本文提出两种广义修正的有序统计恒虚警(OS-CFAR)检测器和一种自动筛选技术。对这两种新的OS-CFAR检测器,在Swerling 2型目标假设下我们推出了虚警和检测概率及度量平均判决门限的解析表达式。在均匀背景和强干扰目标情况下,文中分析了它们的检测性能,并把它们与几个以前提出的恒虚警处理器进行了比较。 | 何友 Hermann Rohling | 1994 | 电子科学学刊1994，16，6： | 10 |
| 10 | Stereotactic body radiation therapy for non-small cell lung cancer:A review显示文摘Stereotactic body radiation therapy(SBRT) is the treatment of choice for medically inoperable patients with early stage non-small cell lung cancer(NSCLC). A literature search primarily based on PubMed electronic databases was completed in July 2018. Inclusion and exclusion criteria were determined prior to the search, and only prospective clinical trials were included. Nineteen trials from 2005 to 2018 met the inclusion criteria, reporting the outcomes of 1434 patients with central and peripheral early stage NSCLC. Patient eligibility,prescription dose and delivery, and follow up duration varied widely. Threeyears overall survival ranged from 43% to 95% with loco-regional control of up to 98% at 3 years. Up to 33% of patients failed distantly after SBRT at 3 years. SBRT was generally well tolerated with 10%-30% grade 3-4 toxicities and a few treatment-related deaths. No differences in outcomes were observed between conventionally fractionated radiation therapy and SBRT, central and peripheral lung tumors, or inoperable and operable patients. SBRT remains a reasonable treatment option for medically inoperable and select operable patients with early stage NSCLC. SBRT has shown excellent local and regional control with toxicity rates equivalent to surgery. Decreasing fractionation schedules have been consistently shown to be both safe and effective. Distant failure is common, and chemotherapy may be considered for select patients. However, the survival benefit of additional interventions, such as chemotherapy, for early stage NSCLC treated with SBRT remains unclear. | Kavitha M Prezzano Sung Jun Ma Gregory M Hermann Charlotte I Rivers Jorge A Gomez-Suescun Anurag K Singh | 2019 | World Journal of Clinical Oncology2019，10，1： | 10 |
| 11 | 内皮素-1干预成为高血压治疗新靶点的展望显示文摘内皮素-1(ET-1)引起强烈和持久的血管收缩和血压升高,大量研究表明血浆ET-1水平与很多高血压严重程度高度相关,ET-1参与人类很多类型高血压的发病机制和恶化进展。目前临床高血压治疗并不能很好地改善内皮活性过度增强,这些高浓度的ET-1有强大的血管增殖效应,导致血管壁增厚和心肌肥大,可能是造成高血压恶化和加重的关键原因之一。大量研究证实内皮素受体拮抗剂干扰内皮素信号转导途径,无论是动物实验还是临床试验均可很好地降低血压和改善临床症状。内皮素受体拮抗剂在治疗高血压和改善并发症方面具有很高的开发潜力,有望成为高血压治疗新靶点,现就此做一系统阐述。 | 张瑞 毛露 孙硕 Dirk Hermann 陈艾东 | 2019 | 心血管病学进展2019，40，7： | 9 |
| 12 | 小反刍兽疫病毒N基因重组杆状病毒的构建及间接ELISA抗体检测方法的建立显示文摘本研究旨在建立基于真核表达的小反刍兽疫病毒(PPRV)N蛋白的诊断小反刍兽疫的间接ELISA方法。利用Bac-to-Bac杆状病毒-昆虫表达系统,构建含有PPRV N基因的重组供体质粒pFastBacHTA-N,转化E.coliDH10Bac感受态细胞,得到重组穿梭质粒pBacmid-PPRV-V,转染昆虫细胞Sf21,获得含有PPRV N基因的重组杆状病毒。用重组病毒感染昆虫细胞后,SDS-PAGE鉴定出60ku左右的表达蛋白,Western blot检测该蛋白具有很好的反应原性。以重组Bacmid-PPRV-N蛋白作为包被抗原,建立间接ELISA检测方法。临床检测来自西藏疫区的37份山羊血清和来自青海省非疫区的92份山羊血清,与法国蒙彼利埃农学发展研究国际合作中心(CIRAD-EMVT)提供的竞争ELISA试剂盒相比较,特异性为96.2%,敏感性为100%,二者的符合率达到96.9%。结果表明本研究建立的间接ELISA方法可以很好地用于小反刍兽疫的临床诊断。 | 李伟 李刚 吴晓东 邱文英 张坤 Hermann Unger | 2010 | 畜牧兽医学报2010，41，9： | 9 |
| 13 | Colorectal cancer显示文摘 | Hermann Brenner Matthias Kloor Christian Peter Pox | 2013 | The Lancet2013，，： | 8 |
| 14 | 脑缺血再灌注后免疫损伤分子机制研究进展显示文摘随着分子生物学和分子免疫学的发展逐步深入,大量研究表明,急性炎症反应所造成的免疫损伤在继发性脑损伤中起着越来越重要的作用[1]。脑缺血再灌注后,大量免疫细胞会在损伤部位聚集,大量释放细胞分裂素和氧自由基等物质直接损伤内皮细胞,造成内皮结构和功能的受损,引发血小板聚集和免疫细胞相互作用,导致微血管阻塞,引发损伤[2]。这一过程造成神经元损伤、血脑屏障遭到破坏,脑出血和脑水肿等症状出现. | 付如意 毛露 孙硕 Dirk Hermann(综述) 陈艾东(审校) | 2019 | 中风与神经疾病杂志2019，36，9： | 8 |
| 15 | 应用纳米压痕法测试类金刚石薄膜力学性能的研究显示文摘介绍一种被称为材料机械性质微探针的新型纳米压痕仪 ,藉助于加荷 卸荷过程中压痕对负荷和压入深度 ,即压头位移的敏感关系 ,测试材料的硬度及弹性模量等力学性质。纳米和纳牛顿量级的压头位移与作用力 ,使得测试始终在大多数材料 ,特别是薄膜材料的弹性限度内 ,克服了维氏法、努氏法等传统方法引起压痕边缘模糊或者碎裂的缺点 ,保证了测试的正确性、可靠性和重复性。应用纳米压痕法成功地对具有脆性的类金刚石薄膜的硬度及弹性模量进行了测试和分析。 | 严学俭 I. Hermann | 2003 | 真空电子技术2003，16，3： | 7 |
| 16 | Recent results of laparoscopic surgery in inflammatory bowel disease显示文摘Inflammatory bowel diseases are an ideal indication for the laparoscopic surgical approach as they are basically benign diseases not requiring lymphadenectomy and extended mesenteric excision;well-established surgical procedures are available for the conventional approach.Inflammatory alterations and fragility of the bowel and mesentery,however,may demand a high level of laparoscopic experience.A broad spectrum of operations from the rather easy enterostomy formation for anal Crohn’s disease(CD)to restorative proctocolectomies for ulcerative colitis(UC)may be managed laparoscopically.The current evidence base for the use of laparoscopic techniques in the surgical therapy of inflammatory bowel diseases is presented.CD limited to the terminal ileum has become a common indication for laparoscopic surgical therapy.In severe anal CD, laparoscopic stoma formation is a standard procedure with low morbidity and short operative time.Studies comparing conventional and laparoscopic bowel resections,have found shorter times to first postoperative bowel movements and shorter hospital stays as well as lower complication rates in favour of the laparoscopic approach.Even complicated cases with previous surgery,abscess formation and enteric fistulas may be op-erated on laparoscopically with a low morbidity.In UC, restorative proctocolectomy is the standard procedure in elective surgery.The demanding laparoscopic approach is increasingly used,however,mainly in major centers; its feasibility has been proven in various studies.An increased body mass index and acute inflammation of the bowel may be relative contraindications.Short and longterm outcomes like quality of life seem to be equivalent for open and laparoscopic surgery.Multiple studies have proven that the laparoscopic approach to CD and UC is a safe and successful alternative for selected patients. The appropriate selection criteria are still under investigation.Technical considerations are playing an important role for the complexity of both diseases. | Hermann Kessler Jonas Mudter Werner Hohenberger | 2011 | World Journal of Gastroenterology2011，17，9： | 7 |
| 17 | 6B1细胞的低频弱电磁场效应研究显示文摘以小鼠 6B1骨髓瘤细胞为效应靶细胞 ,采用细胞化学 ( MTT) ,免疫酶标 ( ELISA)等方法 ,研究了低频弱电磁场对 6B1细胞代谢的影响 .结果表明 :( 1 ) 1 m V/ cm的低频电场 ( 1 0~ 1 0 0 Hz)对 6B1细胞的增殖无明显作用 ,而 1 m V/ cm,50 Hz电场对 6B1细胞乙肝表面抗体的分泌有显著促进 ,提示在此条件下电场对 6B1细胞膜的外侧存在某种特异性作用 ;( 2 ) 0 .8m T、3 0 Hz的弱磁场对 6B1细胞的增殖有明显的抑制作用 ,其它频率下则效应不明显 . | 刘曼 王星 周爱华 于海鹰 庞利君 朱明尧 王磊光 Hermann Berg | 2000 | 南开大学学报(自然科学版)2000，33，1： | 7 |
| 18 | 新经济和新计划能否遏制老工业区的衰落?——以德国鲁尔区和多特蒙德市为例显示文摘过去20年间,西欧最大的工业区——著名的德国鲁尔区推行了一项先进的区域和结构改革政策,然而其经济和社会持续衰落的趋势仍然未能扭转。本文试图讨论这项关注新经济部门、新项目以及新公共设施的政策是否能够对未来的就业变化产生影响。 | Hermann Bmer 何晓军 张颖 | 2001 | 国外城市规划2001，16，6： | 5 |
| 19 | Compaction Rate of an Early Permian Volcanic Tuff from Wuda Coalfield, Inner Mongolia显示文摘Compaction rates of sediments or volcaniclastic material are needed to reconstruct original thickness of a bed,which in turn is required to reconstruct subsidence rates,sea-level rise,or in the case of volcaniclastic,the location or direction of the eruption site.The knowledge of compaction rates can also aid in the reconstruction of deformed fossils.The known shape of deformed fossils can allow the determination of the compaction they experienced.Here we report the compaction rate in an early Permian volcanic tuff from Wuda,Inner Mongolia,determined from the deformation of standing tree fern stems of known anatomy.The compaction rate has been found to be 0.56 in this case,indicating that 44% of original thickness remains. | WANG Jun HE Xuezhi Hermann W.PFEFFERKORN WANG Jinrong | 2013 | Acta Geologica Sinica(English Edition)2013，87，5： | 5 |
| 20 | 云南省临沧市临翔区农村居民HIV检测服务利用和感染风险认知情况调查显示文摘目的了解云南临沧市临翔区农村居民对艾滋病病毒(HIV)检测的实际利用情况,以及对感染HIV风险的认知情况,为提高HIV检测服务利用提供基础信息。方法通过随机抽样方法,抽取大众人群进行面对面调查,对调查对象的一般人口统计学特征、HIV检测利用和自身感染风险等信息进行统计分析。结果 2007、2008、2009年,分别有1 153、909和899人参与。结果发现当地大众人群对HIV检测利用低于15%;超过60%的人愿意在医疗机构进行检测;超过50%的人没有意识到自身有感染HIV的风险,缺乏风险意识是影响他们不能主动进行检测的主要原因。结论当地农村居民对自身感染HIV的风险意识不足,影响了他们对HIV检测服务的利用,需对此制订干预措施来提高HIV检测率。 | 刘霞 Michael Hermann 邓邦炎 | 2011 | 中国艾滋病性病2011，17，2： | 5 |
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