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| 1 | FAIR Principles:Interpretations and Implementation Considerations显示文摘The FAIR principles have been widely cited,endorsed and adopted by a broad range of stakeholders since their publication in 2016.By intention,the 15 FAIR guiding principles do not dictate specific technological implementations,but provide guidance for improving Findability,Accessibility,Interoperability and Reusability of digital resources.This has likely contributed to the broad adoption of the FAIR principles,because individual stakeholder communities can implement their own FAIR solutions.However,it has also resulted in inconsistent interpretations that carry the risk of leading to incompatible implementations.Thus,while the FAIR principles are formulated on a high level and may be interpreted and implemented in different ways,for true interoperability we need to support convergence in implementation choices that are widely accessible and(re)-usable.We introduce the concept of FAIR implementation considerations to assist accelerated global participation and convergence towards accessible,robust,widespread and consistent FAIR implementations.Any self-identified stakeholder community may either choose to reuse solutions from existing implementations,or when they spot a gap,accept the challenge to create the needed solution,which,ideally,can be used again by other communities in the future.Here,we provide interpretations and implementation considerations(choices and challenges)for each FAIR principle. | Annika Jacobsen Ricardo de Miranda Azevedo Nick Juty Dominique Batista Simon Coles Ronald Cornet Melanie Courtot Merce Crosas Michel Dumontier Chris T.Evelo Carole Goble Giancarlo Guizzardi Karsten Kryger Hansen Ali Hasnain Kristina Hettne Jaap Heringa Rob W.W.Hooft Melanie Imming Keith G.Jeffery Rajaram Kaliyaperumal Martijn GKersloot Christine R.Kirkpatrick Tobias Kuhn Ignasi Labastida Barbara Magagna PeterMcQuilton Natalie Meyers Annalisa Montesanti Mirjam van Reisen Philippe Rocca-Serra Robert Pergl Susanna-Assunta Sansone Luiz Olavo Bonino da Silva Santos Juliane Schneider George Strawn Mark Thompson Andra Waagmeester Tobias Weigel Mark D.Wilkinson Egon L.Willighagen Peter Wittenburg Marco Roos Barend Mons Erik Schultes | 2020 | Data Intelligence2020，2，1： | 26 |
| 2 | A simple and fast secondary structure prediction method using hidden neural networks 显示文摘 | LIN Kuang SIMOSSIS A V TAYLOR W R HERINGA J | 2005 | Bioinformatics2005，21，2： | 1 |
| 3 | T-COFFEE:a novel method for fast and accurate multiple sequence alignment显示文摘 | Notredame C Heringa J Higgins | 2000 | J Mol Biol2000，302，： | 1 |
| 4 | Use of the Threshold of Toxicological Concern (TTC) approach for deriving target values for drinking water contaminants显示文摘 | MONS M N HERINGA M B VAN GENDEREN J | 2013 | Water Research2013，47，4： | 1 |
| 5 | SnapDRAGON: a method to delineate protein structural domains from sequence data 显示文摘 | George RA Heringa J | 2002 | J Mol Biol2002，316，3： | 1 |
| 6 | An analysis of protein domain linkers: their classification and role in protein folding显示文摘 | George R A Heringa J | 2002 | Protein Eng2002，15，11： | 1 |
| 7 | T-Coffeee:A novel method for fast and accurate multiple sequence alignment显示文摘 | Notredame C Higgins DG Heringa J | 2000 | Journal of molecular biology2000，302，1： | 1 |
| 8 | Raloxifene pharmacokinetics in males with normal and impaired renal function显示文摘 | Czock D Keller F Heringa M | 2005 | Br J Clin Pharmacol2005，59，4： | 1 |
| 9 | The do- sing determines mutagenicity of hydrophobic com- pounds in the Ames II assay with metabolic transfor- mation: Passive dosing versus solvent spiking 显示文摘 | Smith K E C Heringa M B Uytewaal M | 2013 | Mu- tation Research/Genetic Toxicology and Environmental Mutagenesis2013，750，12： | 1 |
| 10 | Missed drug therapy alerts as a consequence of incomplete electronic patient records in dutch community pharmacies显示文摘 | Floor-Schreudering A Heringa M Buurma H | 2013 | Ann Pharmacother2013，47，10： | 1 |
| 11 | Gate-drain charge analysis for switching in power trench MOSFETs 显示文摘 | HUETING R J E HIJZEN E A HERINGA A | 2004 | IEEE Transactions on Electron Devices2004，51，8： | 1 |
| 12 | A novel method for fast and accurate multiple sequence alignment显示文摘 | Notredame C Higgins DG Heringa J T-Coffee | 2000 | J Mol Biol2000，302，1： | 1 |
| 13 | Avalanche Injection and Near Avalanche Injection of Charge Carriers into SiO2 显示文摘 | Verway J F Heringa A | 1977 | IEEE Trans Electron Devices1977，24，5： | 1 |
| 14 | Measurement of free concentrations using negligible depletion-solid phase microextraction (nd-SPME) 显示文摘 | Heringa M B Hermens J L M | 2003 | TrA C - Trends in Analytical Chemistry2003，22，9： | 1 |
| 15 | T-COFFEE: a novel method for fast and accurate multiple sequence alignment 显示文摘 | Nortred C Higgins DG Heringa J | 2000 | J Mol Biol2000，302，1： | 1 |
| 16 | Detection of multiple hormonal activities in wastewater effluents and surface wa- ter, using a panel of steroid receptor CALUX bioassays显示文摘 | Van der Linden SC Heringa MB Man HY | 2008 | Envi- ron Sci Techol2008，42，15： | 1 |
| 17 | Cerebral cortical microinfarcts at 7Tesla MRI in patients with early Alzheimer's disease显示文摘 | van Veluw SJ Heringa SM Kuijf H J | 2014 | J Alzheimer''s Disease2014，39，1： | 1 |
| 18 | Detection of multiple hormonal activities in wastewater effluents and surface water,using a panel of steroid receptor CALUX bioassays显示文摘 | Van der Linden SC Heringa MB Man HY | | 0，，15： | 1 |
| 19 | T-Coffee: A novel method for fast and accurate multiple sequence alignment显示文摘 | NOTREDAME C HIGGINS D G HERINGA J | 2000 | J Mol Biol2000，302，1： | 1 |
| 20 | Cerebral cortical microinfarcts at 7Tesla MRI in patients with early Alzheimer' s disease显示文摘 | van Veluw S J Heringa SM Kuijf H J | 2014 | J Alzheimers Dis2014，39，： | 1 |
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