3篇
您的检索式：作者名="Hepeng Cheng"
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| 1 | Over-expression of hypoxia-inducible factor 1 alpha increases an-giogenesis of LNCaP cells显示文摘Objective: To evaluate the effect of HIF-1 αover-expression on angiogenesis in human prostate cancer cells. Methods:LNCaP cells(a human prostate cancer cell line) were transfected with the recombinant plasmid pcDNA3.1( -)-HIF-1αwith Lipo-fectamine 2000 system. The positive clones were selected by G418 being further confirmed by Western blot and immunofluores-cence. The expression levels of VEGF, iNOS and Ang-Ⅱ were determined. Results: The expression of HIF-1αin the LNCaP/HIF1αcells was significantly increased in transfected cells, which induced the up-regulation of VEGF, iNOS, whereas Ang-Ⅱexpression remained un- changed. Conclusion: Over-expression of HIF-1αcan induce angiogenesis proteins and may improve theangiogenesis potency of prostate cancer. | Yili Han Dalin He Yong Luo Hepeng Cheng Guangfeng Zhu | 2007 | Journal of Nanjing Medical University2007，21，4： | 2 |
| 2 | Erosion Effect of Molten Steel on Carbon Containing Refractories for Continuous Casting显示文摘The erosion resistance of carbon containingrefractories for continuous casting to molten steel wasinvestigated by means of simulative erosion test and examining used refractories. Decarbonization and reaction between molten steel and decarbonization layer are main erosion process of carbon containingrefractories by molten steel. The reactions between molten steel and oxide in refractories determine thethickness of decarbonization layer. A dense layer formation on the working surface contacting withmolten steel during casting will suppress decarbonization and erosion process. | LI Hongxia YANG Bin LIU Guoqi CHENG Hepeng | 2007 | China's Refractories2007，16，2： | 0 |
| 3 | Injectable hybrid inorganic nanoscaffold as rapid stem cell assembly template for cartilage repair显示文摘Cartilage injuries are o?ten devastating and most cannot be cured because of the intrinsically low regenerative capacity of cartilage tissues. Although stem-cell therapy has shown enormous potential for cartilage repair, the therapeutic outcome has been restricted by low survival rates and poor chondrocyte differentiation in vivo. Here, we report an injectable hybrid inorganic(IHI) nanoscaffold that facilitates fast assembly, enhances survival and regulates chondrogenic differentiation of stem cells. IHI nanoscaffolds that strongly bind to extracellular matrix(ECM) proteins assemble stem cells through synergistic 3 D cell-cell and cell-matrix interactions, creating a favorable physical microenvironment for stem-cell survival and differentiation in vitro and in vivo. Additionally, chondrogenic factors can be loaded into nanoscaffolds with a high capacity, which allows deep, homogenous drug delivery into assembled 3 D stem-cell-derived tissues for effective control over the soluble microenvironment of stem cells. The developed IHI nanoscaffolds that assemble with stem cells are injectable. They also scavenge reactive oxygen species and timely biodegrade for proper integration into injured cartilage tissues. Implantation of stem-cell-assembled IHI nanoscaffolds into injured cartilage results in accelerated tissue regeneration and functional recovery. By establishing our IHI nanoscaffold-templated 3 D stem-cell assembly method, we provide a promising approach to better overcoming the inhibitory microenvironment associated with cartilage injuries and to advance current stem-cell-based tissue engineering. | Shenqiang Wang Letao Yang Bolei Cai Fuwei Liu Yannan Hou Hua Zheng Fang Cheng Hepeng Zhang Le Wang Xiaoyi Wang Qianxin Lv Liang Kong Ki-Bum Lee Qiuyu Zhang | 2022 | National Science Review2022，9，4： | 0 |
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