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| 1 | A New Species of the Genus Protobothrops(Squamata:Viperidae:Crotalinae) from the Dabie Mountains,Anhui,China显示文摘During a biological survey in July 2011, a pit viper was collected from the Yaoluoping Nature Reserve in the Dabie Mountains, Anhui, China. The pit viper's the total length measured 836 mm with a dorsal ground color of yellowbrown, decorated by 56 dark-brown transverse bands. The 4thsupralabial squama of the new species is separated from subocular by two squamae, and the tip of tail is orange; this combination of characters distinguish it from other species of the genus Protobothrops. Based on the body proportions, number of squamae, body color pattern, and comparing the data of its life history with those of other species of Protobothrops, we herein describe it as a new species, belonging to the genus of Protobothrops. | Xin HUANG Tao PAN Demin HAN Liang ZHANG Yinxu HOU Lei YU Heming ZHENG Baowei ZHANG | 2012 | Asian Herpetological Research2012，3，3： | 7 |
| 2 | DFOS Applications to Geo-Engineering Monitoring显示文摘Optical fiber sensing technology has developed rapidly since the 1980s with the development of the optical fiber and fiber optical communication technology.It is a new type of sensing technology that uses light as a carrier and optical fiber as a medium to sense and transmit external signals(measurands).Distributed fiber optical sensors(DFOS)can continuously measure the external physical parameters distributed along the geometric path of the optical fiber.Meanwhile,the spatial distribution and change information of the measured physical parameters over time can be obtained.This technology has unmatched advantages over traditional point-wise and electrical measurement monitoring technologies.This paper summarizes the state-of-the-art research of the application of the distributed optical fiber sensing tech no logy in geo-engineering in the past 10 years,mainly including the advantages of DFOS,the challenges in geo-engineering monitoring,related fundamental theoretical issues,sensing performance of the optical sensing cables,distributed optical fiber monitoring system for geo-engineering,and applications of optical fiber sensing technology in geo-engineering. | Bin SHI Dan ZHANG Honghu ZHU Chengcheng ZHANG Kai GU Hongwei SANG Heming HAN Mengya SUN Jie LIU | 2021 | Photonic Sensors2021，11，2： | 3 |
| 3 | Fiber optic monitoring of an anti-slide pile in a retrogressive landslide显示文摘Anti-slide piles are one of the most important reinforcement structures against landslides,and evalu-ating the working conditions is of great significance for landslide mitigation.The widely adopted analytical methods of pile internal forces include cantilever beam method and elastic foundation beam method.However,due to many assumptions involved in calculation,the analytical models cannot be fully applicable to complex site situations,e.g.landslides with multi-sliding surfaces and pile-soil interface separation as discussed herein.In view of this,the combination of distributed fiber optic sensing(DFOS)and strain-internal force conversion methods was proposed to evaluate the working conditions of an anti-sliding pile in a typical retrogressive landslide in the Three Gorges reservoir area,China.Brillouin optical time domain reflectometry(BOTDR)was utilized to monitor the strain distri-bution along the pile.Next,by analyzing the relative deformation between the pile and its adjacent inclinometer,the pile-soil interface separation was profiled.Finally,the internal forces of the anti-slide pile were derived based on the strain-internal force conversion method.According to the ratio of calculated internal forces to the design values,the working conditions of the anti-slide pile could be evaluated.The results demonstrated that the proposed method could reveal the deformation pattern of the anti-slide pile system,and can quantitatively evaluate its working conditions. | Lei Zhang Honghu Zhu Heming Han Bin Shi | 2024 | Journal of Rock Mechanics and Geotechnical Engineering2024，16，1： | 0 |
| 4 | Phenolic rigid organic filler/isotactic polypropylene composites. Ⅲ. Impact resistance property显示文摘A novel phenolic rigid organic filler(KT)was used to modify isotactic polypropylene(iPP).The influence of KT particles on the impact resistance property of PP/KT specimens(with similar interparticles distance,1.8μm)was studied by notched izod impact tests.It was found that the brittle-ductile transition(BDT)of the PP/KT microcomposites took place at the filler content of about 4%,and the impact strength attains the maximum at 5%(with filler particles size of 1.5μm),which is about 2.5 times that of unfilled iPP specimens.The impact fracture morphology was investigated by scanning electron micro-scopy(SEM).For the PP/KT specimens and the high-density polyethylene/KT(HDPE/KT)specimens in ductile fracture mode,many microfibers could be found on the whole impact fracture surface.It was the filler particles that induced the plastic deformation of interparticles ligament and hence improved the capability of iPP matrix on absorbing impact energy dramatically.The determinants on the BDT were further discussed on the basis of stress concentration and debonding resistance.It can be con-cluded that aside from the interparticle distance,the filler particles size also plays an important role in semicrystal-line polymer toughening. | Heming LIN Dongming QI Jian HAN Zhiqi CAI Minghua WU | 2009 | Frontiers of Chemical Science and Engineering2009，3，2： | 0 |
| 5 | Multikinase inhibitor-based immunotherapy doublet for advanced hepatocellular carcinoma:its efficacy still needs to be determined显示文摘The current landscape for advanced hepatocellular carcinoma(HCC)has evolved drastically in recent years,with the ever-increasing development of novel standard first-line therapeutic strategies(e.g.,the combination of atezolizumab and bevacizumab)and the approval of several new agents for second line strategies,such as regorafenib and cabozantinib(1,2).Although a large number of treatment options are available for advanced HCC patients,multikinase inhibitor(MKI)-based immunotherapy doublet has become notably complex,especially after the publication of the COSMIC-312 trial(3).This study evaluated the efficacy and safety of cabozantinib combined with atezolizumab versus sorafenib as the first-line treatment of patients with advanced HCC.Although the primary endpoint of progression-free survival(PFS)was significantly improved with treatment using cabozantinib combined with atezolizumab compared with sorafenib in the COSMIC-312 trial,the overall survival(OS)did not improve,and the response rate was lower than expected(3).Nevertheless,this was a crucial randomized controlled trial(RCT)evaluating the efficacy of MKI-based immunotherapy doublet as the first-line systemic therapy for advanced HCC,paving the way for future investigations to determine the underlying mechanism of these connections.We have several concerns with the interpretation of this study. | Heming Li Xiangjun Hao Tao Han | 2023 | Hepatobiliary Surgery and Nutrition2023，12，3： | 0 |
| 6 | Distribution of Vasoative Intestinal Polypeptide in CranialParasym pathetic Ganglion of the Rat显示文摘Immunoreactivity (IR) for vasoactive intestinal polypeptide (VIP) of cranial parasympathetic ganglia of the rat was observed with indirect immunofluorescent method. It was found that there were VIP IR principal neurons in the ciliary, pterygopalatine, and otic ganglia. The highest positive ratio of VIP IR cells was located in the ciliary ganglia (34.8%), followed by that in the pterygopalatine ganglia(17.0%), and the lowest was found in the otic ganglia (15.4%). VIP IR small intensely fluorescent (SIF) cells and nerve fibers were not observed. Distributive characteristics of neuropeptides and functional significance of VIP in cranial parasympathetic ganglia were discussed. | Wang Heming(王鹤鸣)\ Knyazeva LA\+1 Tong Xinkang(童鑫康) Han Qunying(韩群颖) Fang Shibang(方实邦) | 1999 | The Journal of Biomedical Research1999，23，2： | 0 |
| 7 | Adult-born neurons in critical period maintain hippocampal seizures via local aberrant excitatory circuits显示文摘Temporal lobe epilepsy(TLE),one common type of medically refractory epilepsy,is accompanied with altered adult-born dentate granule cells(abDGCs).However,the causal role of abDGCs in recurrent seizures of TLE is not fully understood.Here,taking advantage of optogenetic and chemogenetic tools to selectively manipulate abDGCs in a reversible manner. | Liying Chen Yingwei Xu Heming Cheng Zhongxia Li Nanxi Lai Menghan Li Yeping Ruan Yang Zheng Fan Fei Cenglin Xu Jiao Ma Shuang Wang Yan Gu Feng Han Zhong Chen Yi Wang | 2023 | Signal Transduction and Targeted Therapy2023，8，7： | 0 |
| 8 | Histamine H1 Receptor in Basal Forebrain Cholinergic Circuit:A Novel Target for the Negative Symptoms of Schizophrenia?显示文摘Schizophrenia is a common and severe mental disorder with a lifetime prevalence of~1%[1]Apart from the typical positive symptoms,such as hallucinations and delusions,which mainly make patients seek medication,60%-70%of patients are tortured by negative symptoms(e.g.apathy and alogia)and cognitive deficits that impose a long-term burden on patients[2]. | Shuangshuang Wu Chenshu Gao Feng Han Heming Cheng | 2022 | Neuroscience Bulletin2022，38，5： | 0 |
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