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| 1 | Current updates on laboratory techniques for the diagnosis of male reproductive failure显示文摘导致不孕的男繁殖失败的发生,是否由于推迟的做家长,环境问题,基因因素,药,等等,在全世界正在增加。男 subfertility 的诊断和预后成为了挑战。当基本精液评价被执行许多年了时,很多研究询问传统的精液特征的价值。这是部分由于不适当的方法和标准化,为优秀保证的技术要求的有限知识,和一个精液评价能提供临床的信息的不完全的理解。当前执行精液和内分泌的评价表演伟人可变性的实验室。世界健康组织() 精液的评估的手册是在许多年在这个领域的进一步的开发帮助了的 andrology 和生育力评估的核心。这些包括精液,对精子计数的评价,活动性,活力,形态学,和精子和精液样品的功能的方面的物理外观。这些测试也由于氧化应力包括男内分泌的侧面,精液的生物化学的评估,在浆液的 antisperm 抗体的察觉,电脑辅助的精子分析(房屋) 的使用,精子 DNA 正直,和它的损坏。帮助繁殖技术(例如, IVF, ICSI ) 显示出大成功,但是是太昂贵的。与更新的技术在这块地里推进开发,广泛的火车 / 说明能改进精确性和还原剂可变性,因此维持如此的评估的质量和标准。有迫切需要标准化了训练中心并且为繁殖成功在 mens 健康的这个区域增加了了解。 | Suresh C Sikka Wayne JG Hellstrom | 2016 | Asian Journal of Andrology2016，18，3： | 9 |
| 2 | 男性迟发性性腺功能减退症的检查、治疗和监测:国际男科学会(ISA)、国际老年男性研究会(ISSAM)、欧洲泌尿外科学会(EAU)、欧洲泌尿外科学院(EAA)和美国男科学会(ASA)联合推荐显示文摘简介
人口学资料明确显示:老年人口占总人口的百分率正逐年增加。当前,有关老年男性雄激素缺乏的问题逐渐成为令人感兴趣、但又充满争议的世界性话题。已经有横向和纵向的研究资料表明,随着年龄增大,成年男子的雄激素水平逐渐降低, | Wang C Nieschlage E Swerdloff R Behre HM Hellstrom WJ Gooren LJ Kaufman JM Legros JJ Lunenfeld B Morales A Morley JE Schulman C Thompson IM Weidner W Wu FCW 伍学焱(翻译) | 2011 | 国际生殖健康/计划生育杂志2011，30，1： | 8 |
| 3 | Stem cell therapy for the treatment of Leydig cell dysfunction in primary hypogonadism显示文摘The production of testosterone occurs within the Leydig cells of the testes. When production fails at this level from either congenital, acquired, or systemic disorders,the result is primary hypogonadism. While numerous testosterone formulations have been developed, none are yet fully capable of replicating the physiological patterns of testosterone secretion. Multiple stem cell therapies to restore androgenic function of the testes are under investigation. Leydig cells derived from bone marrow, adipose tissue, umbilical cord, and the testes have shown promise for future therapy for primary hypogonadism. In particular, the discovery and utilization of a group of progenitor stem cells within the testes, known as stem Leydig cells(SLCs), has led not only to a better understanding of testicular development, but of treatment as well. When combining this with an understanding of the mechanisms that lead to Leydig cell dysfunction, researchers and physicians will be able to develop stem cell therapies that target the specific step in the steroidogenic process that is deficient. The current preclinical studies highlight the complex nature of regenerating this steroidogenic process and the problems remain unresolved. In summary, there appears to be two current directions for stem cell therapy in male primary hypogonadism. The first method involves differentiating adult Leydig cells from stem cells of various origins from bone marrow, adipose, or embryonic sources. The second method involves isolating, identifying, and transplanting stem Leydig cells into testicular tissue. Theoretically, in-vivo re-activation of SLCs in men with primary hypogonadism due to age would be another alternative method to treat hypogonadism while eliminating the need for transplantation. | Taylor C Peak Nora M Haney William Wang Kenneth J DeLay Wayne J Hellstrom | 2016 | World Journal of Stem Cells2016，8，10： | 5 |
| 4 | Further geological and palaeoanthropological investigations at the Maludong hominin site, Yunnan Province, Southwest China显示文摘Three-dimensional mapping and section work undertaken by us in 2008 have identified 11 stratigraphic units at Maludong site.AMS radiocarbon dating of charcoal established an accurate and internally consistent age profile for the sequence of 17.8±0.2 ka to 13.2±0.1 ka.Archaeomagnetic analysis showed changes in externally derived pedogenically enhanced material consistent with a warming in climate between the cold period of Henrich Event 1 and the B lling-Aller d interstadial.Human remains recovered during the 1989 excavation were derived from a deposit dating to this interstadial,or between 14.3±0.3 ka and 13.5±0.1 ka.Anthropogenic features,including burnt rocks,baked sediment and thick charcoal and ash layers,were identified and examined through archaeomagnetic analysis.Two monkey fossils are described here,one of them being reassigned from Macaca robustus to M.aff.M.assamensis.They confirm the young age of the site and also show signs of anthropogenic alteration in the form of burning.Additional human cranial remains are reported for the first time and new data are provided for some specimens described previously.A range of new features is identified that strengthen the affinities of the Maludong remains to archaic humans.The presence of this globally unique mosaic of archaic and modern features raises important questions about human evolutionary history in East Asia during the Late Upper Pleistocene. | JI XuePing CURNOE Darren BAO ZhenDe HERRIES Andy I R FINK David ZHU YunSheng HELLSTROM John LUO Yun TACON Paul S C | 2013 | Chinese Science Bulletin2013，58，35： | 3 |
| 5 | Improvements in 230Th dating, 230Th and 254U half-life values, and U Th isotopic measurements by multi--collector inductively coupled plasma mass spectroscopy 显示文摘 | Cheng H Edwards R L Shen C C Po Asrnerom Y Woodhed J Hellstrom J Wang Y Kon6 X Spotl C Wang X Alexander Jr E C | 2013 | Earth and Planetary Science Letters2013，3713，72： | 1 |
| 6 | Amplitude integrated EEG 3 and 6 hours after birth in full term neonates with hypoxicisehaemic encephalopathy 显示文摘 | Toet M C Hellstrom Westas L Groenendaal F | 1999 | Arch Dis Child Fetal Neonatal Ed1999，81，1： | 1 |
| 7 | Low IGF-I suppresses VEGF-survival signaling in retinal endothelial cells:direct correlation with clinical retinopathy of prematurity显示文摘 | Hellstrom A Perruzzi C Ju M | | 0，，： | 1 |
| 8 | Multi proxy constraints on the climatic significance of trace element records from a New Zealand speleothem 显示文摘 | Hellstrom J C McCulloch M T | 2000 | Earth Planetary Science Letters2000，179，2： | 1 |
| 9 | Multi-proxy constraints on the climatic significance of trace element records from a New Zealand speleothem 显示文摘 | Hellstrom J C McCulloch M T | 2000 | Earth and Planetary Science Letters2000，179，2： | 1 |
| 10 | Role of PDGF-B and PDGFR-beta in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse 显示文摘 | Hellstrom M Kalen M Lindahl P Abramsson A Betsholtz C | 1999 | Development1999，126，14： | 1 |
| 11 | Quality of care in relation to a critical pathway from the staff' s perspective 显示文摘 | FURAKER C HELLSTROM MUHLI U WALLDAL E | 2004 | J Nurs Manag2004，12，5： | 1 |
| 12 | Transcription profiling of platelet-derived growth factor-B-deficient mouse embryos identifies RGS5as a novel marker for pericytes and vascular smooth muscle cells 显示文摘 | Bondjers C Kalen M Hellstrom M Scheidl SJ Abramsson A Renner Q Lindahl P Cho H Kehl J Betssholtz C | 2003 | Am J Pathol2003，162，3： | 1 |
| 13 | Low IGF-I suppresses VEGF-survival signaling in retinal en- dothelial cells: direct correlation with clinical retinopathy of prematurity 显示文摘 | Hellstrom A Perruzzi C Ju M Engstrom E Hard AL Liu JL et a/ | 2001 | Proc Natl Acad Sci USA2001，98，10： | 1 |
| 14 | Subjective future as a mediating factor in the relation between pain,pain-related distress and depression 显示文摘 | Hellstrom C Jansson B Carlsson SG | 1999 | Eur J Pain1999，3，3： | 1 |
| 15 | Frequent gain of the human telomerase gene TERC at 3q26 in cervical ad 显示文摘 | ANDERSSON S WALLIN K L HELLSTROM A C | 2006 | British Journal of Cancer2006，95，3： | 1 |
| 16 | Longi- tudinal postnatal weight measurements for the prediction of ret- inopathy of prematurity 显示文摘 | Wu C Vanderveen DK Hellstrom A Lofqvist C Smith LE | 2010 | Arch Ophthalmol2010，128，4： | 1 |
| 17 | Psychoneuroendocrinology显示文摘 | Jokinen J Chatzittofis A Hellstrom C Nordstrom P Uvnas-Moberg K Asberg M | 2012 | 37(4):4822012，37，4： | 1 |
| 18 | Low IGF-I suppresses VEGF-survival signaling in retinal endothelial cells: direct correlation with clinical retinopathy of prematurity 显示文摘 | Hellstrom A Perruzzi C Ju M | 2001 | Proc Natl Acad Sci USA2001，98，10： | 1 |
| 19 | Im- portance of early postnatal weight gain for normal retinal angio- genesis in very preterm infants: a multicenter study analyzing weight velocity deviations for the prediction of retinopathy of prematurity 显示文摘 | Wu C Lofqvist C Smith LE Vander Veen DK Hellstrom A | 2012 | Arch Ophthalmol2012，130，8： | 1 |
| 20 | Human papillomavirus infection, centrosome aberration, and genetic stability in cervical lesions显示文摘 | SKYLDBERG B FUJIOKA K HELLSTROM A C | 2001 | Mod Pat Hol2001，14，4： | 1 |
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