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| 1 | Lipid accumulation in hepatocytes induces fibrogenic activation of hepatic stellate cells显示文摘尽管有非酒精的脂肪肝疾病是良性的混乱的起始的信仰,纤维变性前进发生在病人的一个重要数字,这现在被认出。而且,肝的脂肪变性在大量其它为肝的纤维变性的前进作为一个风险因素被识别了肝疾病。这里,我们建立了一在里面在肝的星形的房间(HSC ) 上学习肝的类脂化合物累积的效果的 vitro 模型,肝 fibrogenesis 的中央调停人。主要人的 hepatocytes 与浸透的丰满的酸 palmitate 被孵化导致细胞内部的类脂化合物累积。随后,人的 HSC 从 steatotic 或控制 hepatocytes 与调节媒介(厘米) 被孵化。在 hepatocytes 的类脂化合物累积导致了加速了 HSC 的激活和增长的因素的版本,并且提高了他们的抵抗到 apoptosis,大部分经由 PI-3-kinase 小径的激活调停了。而且,从 steatotic hepatocytes 的厘米导致了 profibrogenic 基因 TGF- 尾, metallo-proteinase-1 (TIMP-1 ) 的织物禁止者, TIMP-2 和 matrix-metallo-proteinase-2 的表示,以及在 HSC 的原子因素的魏 B 依赖者 MCP-1 表示。在摘要,我们的在里面 vitro 数据在 vivo 为在肝的脂肪变性和 fibrogenesis 之间的 pathophysiological 连接显示潜在的机制。附此,这研究提供一在 vitro 吸引人学习导致脂肪变性的 fibrogenesis 的分子的机制,并且识别并且测试小说的模型在脂肪肝为 antifibrotic 指向治疗疾病。 | Hella Wobser Christoph Dora Thomas S Weiss Thomas Amann Cornelius Bollheimer Roland Btittner Juergen Schoelmerich Claus Helterbrand | 2009 | Cell Research2009，19，8： | 16 |
| 2 | Expression of inducible nitric oxide synthase and cyclooxygenase-2 in pancreatic adenocarcinoma:Correlation with microvessel density显示文摘AIM: Cydooxygenases (COX) are key enzymes for conversion of arachidonic acid to prostaglandins. Nitric oxide synthase (NOS) is the enzyme responsible for formation of nitric oxide.Both have constitutive and inducible isoforms. The inducible isoforms (iNOS and COX-2) are of great interest as regulators of tumor angiogenesis, tumorigenesis and inflammatory processes. This study was to clarify their role in pancreatic adenocarcinomas.METHODS: We investigated the immunohistochemical iNOS and COX-2 expression in 40 pancreatic ductal adenocarcinomas of different grade and stage. The results were compared with microvessel density and clinicopathological data.RESULTS: Twenty-one (52.5%) of the cases showed iNOS expression, 15 (37.5%) of the cases were positive for COX-2.The immunoreaction was heterogeneously distributed within the tumors. Staining intensity was different between the tumors. No correlation between iNOS and COX-2 expression was seen. There was no relationship with microvessel density.However, iNOS positive tumors developed more often distant metastases and the more malignant tumors showed a higher COX-2 expression. There was no correlation with other clinicopathological data.CONCLUSION: Approximately half of the cases expressed iNOS and COX-2. These two enzymes do not seem to be the key step in angiogenesis or carcinogenesis of pancreatic adenocarcinomas. Due to a low prevalence of COX-2 expression, chemoprevention of pancreatic carcinomas by COX-2 inhibitors can only achieve a limited success. | Hans U.Kasper Hella Wolf Uta Drebber Helmut K.Wolf Michael A.Kern | 2004 | World Journal of Gastroenterology2004，10，13： | 14 |
| 3 | 考虑H_2S脱除的多杂质H_2网络优化显示文摘针对炼油厂H2网络系统的集成优化,考虑废氢流股的净化回用。净化装置不仅包括变压吸附、膜分离,还引入了脱硫单元。建立了相应的状态空间超结构,依据工程经验将超结构进行化简后,建立以最小年度费用为目标,综合考虑H2流量、体积分数,杂质体积分数和压力匹配限制的混整型线性规划。考察了2种规模的改造优化。实例计算表明了该方法的有效性。 | 周利 廖祖维 Tokos Hella 王靖岱 阳永荣 | 2013 | 石油学报(石油加工)2013，29，2： | 5 |
| 4 | Diagnostic delay and associated factors among patients with pulmonary tuberculosis in Dar es Salaam,Tanzania显示文摘Background:Tanzania is among the 30 countries with the highest tuberculosis(TB)burdens.Because TB has a long infectious period,early diagnosis is not only important for reducing transmission,but also for improving treatment outcomes.We assessed diagnostic delay and associated factors among infectious TB patients.Methods:We interviewed new smear-positive adult pulmonary TB patients enrolled in an ongoing TB cohort study in Dar es Salaam,Tanzania,between November 2013 and June 2015.TB patients were interviewed to collect information on socio-demographics,socio-economic status,health-seeking behaviour,and residential geocodes.We categorized diagnostic delay into≤3 or>3 weeks.We used logistic regression models to identify risk factors for diagnostic delay,presented as crude(OR)and adjusted Odds Ratios(aOR).We also assessed association between geographical distance(incremental increase of 500 meters between household and the nearest pharmacy)with binary outcomes.Results:We analysed 513 patients with a median age of 34 years(interquartile range 27-41);353(69%)were men.Overall,444(87%)reported seeking care from health care providers prior to TB diagnosis,of whom 211(48%)sought care>2 times.Only six(1%)visited traditional healers before TB diagnosis.Diagnostic delay was positively associated with absence of chest pain(aOR=7.97,95%confidence intervals[CI]:3.15-20.19;P<0.001),and presence of hemoptysis(aOR=25.37,95%CI:11.15-57.74;P<0.001)and negatively associated with use of medication prior to TB diagnosis(aOR=0.31,95%CI:0.14-0.71;P=0.01).Age,sex,HIV status,education level,household income,and visiting health care facilities(HCFs)were not associated with diagnostic delay.Patients living far from pharmacies were less likely to visit a HCF(incremental increase of distance versus visit to any facility:OR=0.51,95%CI:0.28-0.96;P=0.037).Conclusions:TB diagnostic delay was common in Dar es Salaam,and was more likely among patients without prior use of medication and presenting with hemoptysis.Geographical distance to HCFs may have an impact on health-seeking behaviour.Increasing community awareness of TB signs and symptoms could further reduce diagnostic delays and interrupt TB transmission. | Khadija Said Jerry Hella Grace Mhalu Mary Chiryankubi Edward Masika Thomas Maroa Francis Mhimbira Neema Kapalata Lukas Fenner | 2017 | Infectious Diseases of Poverty2017，6，1： | 4 |
| 5 | Quality of Gastric Ulcer Healing: A New, Emerging Concept显示文摘 | Andrzej Tarnawski Jerzy Stachura William J. Krause Thomas G. Douglass Hella Gergely | 1991 | Journal of Clinical Gastroenterology1991，，： | 2 |
| 6 | A study of sulfur functionalities in fossil fuels using destructive-( ASTM and Py-GC-MS) and non-destructive-( SEM-EDX, XANES and XPS) techniques 显示文摘 | OLIVELLA M A PALACIOS J M VAIRAVAMURTHY A DEL RIO J C De LAS HELLAS F X C | 2002 | Fuel2002，81，4： | 1 |
| 7 | Guidelines for ecological compensation associated with highways 显示文摘 | Ruud Cuperusa Kees J Canters Hellas A Udo de Haes Debra S Friedman | 1999 | Biological Conservation1999，9，： | 1 |
| 8 | Metal Processing with a high power CO2 laser显示文摘 | Locke E V Hella R A | 1974 | IEEE Journal of Quantum Eleetronies1974，10，2： | 1 |
| 9 | Deep penetration welding with high-power CO2lasers显示文摘 | Locke E V Hnag E D Hella R A | 1972 | IEEE Journal of Quantum Electronics1972，8，2： | 1 |
| 10 | Quality of Gastric Ulcer Healing: A New, Emerging Concept显示文摘 | Andrzej Tarnawski Jerzy Stachura William J. Krause Thomas G. Douglass Hella Gergely | 1991 | Journal of Clinical Gastroenterology1991，，： | 1 |
| 11 | ‘Healed’ Experimental Gastric Ulcers Remain Histologically and Ultrastructurally Abnormal显示文摘 | Andrzej Tarnawski Daniel Hollander William J. Krause Wojtek Dabros erzy Stachura Hella Gergely | 1990 | Journal of Clinical Gastroenterology ( Suppl )1990，，1： | 1 |
| 12 | Das Dreigliedrige, zweisprachige Kommunikationssystem Dolmetschen显示文摘 | Kirchhoff Hella | 1976 | La Language et l''Homme1976，，31： | 1 |
| 13 | Social and economic factors af- fecting the adoption of soil and water conservation in West Usambara highlands,Tanzania显示文摘 | Tenge J Graaff D Hella J P | 2004 | Land Degradation and De- velopment2004，，2： | 1 |
| 14 | The toxic potential of an industrial effluent determined with the Saccharomyces cerevisiae -based assay显示文摘 | Marcel Schmitt Georg Gellert Hella Lichtenberg-Fraté | 2005 | Water Research2005，，14： | 1 |
| 15 | A domi- nant mutation in the gene encoding the erythroid tran- scription factor KLFI causes a congenital dyserythro- poietic anemia显示文摘 | ARNAUD L SAISON C HELLAS V | 2010 | Am J Hum Genet2010，87，： | 1 |
| 16 | Deep Penetration Welding with High Power CO2 Laser显示文摘 | LOCKE E HOAG E HELLA R | 1972 | Journal of Quantum Electronics1972，8，2： | 1 |
| 17 | Prevalence of ultrasound-diagnosed non-alcoholic fatty liver disease in a hospital cohort and its association with anthropometric, biochemical and sonographic characteristics 显示文摘 | Georgi K Doris S Hella W | 2010 | Int J Clin Exp Med2010，3，： | 1 |
| 18 | Deep Penetration Welding with High Power CO2 Laser显示文摘 | LOCKE E HOAG E HELLA R | 1972 | Welding Journal1972，51，5： | 1 |
| 19 | Nonste- roidal anti- inflammatory drugs and upper gastrointesti- nal bleeding, identifying high risk groups by excess risk estimates显示文摘 | Hellas J Lauritsen J Villeolsen HD | 1995 | Scand J Gastroenterol1995，30，5： | 1 |
| 20 | Carcinoma of the nasal cavity and paranasal sinuses in Denmark 1995-2004 显示文摘 | CHRISTIAN THORUP LARS SEBBESEN HELLA DANO | 2010 | Acta Oncologica2010，49，： | 1 |
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