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| 1 | Prevalence of Malnutrition and Frailty in Elderly Cancer Patients and Resulting Impact on Primary Treatment Recommendations in Colorectal and Breast Cancer显示文摘Objectives To estimate the prevalence of malnutrition in elderly cancer patients and its association with frailty and primary cancer treatment recommendations in patients with the two most prevalent cancers(colorectal cancer,CRC and breast cancer,BC)in the Centre-Val de Loire region of France.Methods The entire cohort of 704 patients aged 75 years or older presenting with cancer who underwent comprehensive geriatric assessment(CGA)between 2014 and 2017 was included.Nutritional status,frailty(defined by the Balducci classification system based on CGA parameters and comorbidity),and pathological criteria were analyzed in terms of the cancer treatment recommendations suggested by geriatricians both in the whole cohort and in those with CRC and BC.Results In the whole group of 704 patients(84.3+/-4.8 years),the prevalence of malnutrition was 62.9%,and was higher in CRC than in BC patients(71.1%vs 55.4%,P<0.01).In a multivariate analysis,malnutrition and frailty(as determined by the Balducci classification system)were independently related in CRC patients(OR:7.28,95%CI,1.58~34.03;P=0.012)and were unrelated to metastasis[odds ratio(OR):1.34,95%CI,0.56~3.18;P=0.5].By contrast,malnutrition in BC patients was related exclusively to the extent of metastasis(OR:3.52,95%CI,1.50~8.24;P=0.002).It was also demonstrated that geriatricians had a greater tendency to suggest only palliative care to CRC patients presenting with malnutrition(15.4%vs 2.7%,P=0.006)than to BC patients(9.8%vs 5.4%,NS).Conclusion Malnutrition in elderly cancer patients is prevalent,especially in those with colorectal cancer,where malnutrition is frailty-related and may strongly impact on cancer treatment strategies. | Vittoria Balzano Véronique Dardaine Giraud Carine Sauger Carole Lefebvre Patrick Heitzmann Thierry Lecomtef Étienne Dorvalg | 2020 | Journal of Nutritional Oncology2020，5，4： | 2 |
| 2 | No potassium, no acid: K~ channels and gastric acid secretion 显示文摘 | Heitzmann D Warth R | 2007 | Physiology2007，22，5： | 1 |
| 3 | Invalidation of TASK1 potassium channels disrupts adrenal gland zonation and mineralocorticoid homeostasis显示文摘 | Heitzmann D Derand R Jungbauer S | | 0，，1： | 1 |
| 4 | Modelling and Control of a Jet Mill Plant显示文摘 | Goeren H J C Heitzmann D A Moolenaar J A C Scarlett B | 2000 | Powder Technology2000，108，： | 1 |
| 5 | The correction of high myopia using the excimer laser显示文摘 | Heitzmann J Binder PS Kassar BS | 1993 | Arch Ophthalmol1993，111，： | 1 |
| 6 | Assessment of methods for measuring social support 显示文摘 | Heitzmann C A Kaplan R M | 1988 | Health Psychology1988，7，1： | 1 |
| 7 | Excimer laser effects on human corneal endothelium显示文摘 | Lambert RW Anderson JA Heitzmann J | 1996 | Arch Ophthalmo-logy1996，4，： | 1 |
| 8 | Assessing self-efficacy for coping with dancer:Development and psychometric analysis of the brief version of the cancer behavior inventory(CBI-B)显示文摘 | Heitzmann CA Merluzzi1 TV Jean-Pierre P | 2001 | Psychooncology2001，10，3： | 1 |
| 9 | Spermatophore formarion in the white shrimp, Penaeus vannamei boone 1931 : dependence on the intermoult cycle显示文摘 | Heitzmann J C Diter A AQUACOP | 1993 | Aquaeulture1993，116，： | 1 |
| 10 | Modelling and control of a jet mill plant显示文摘 | GOMMEREN H J C HEITZMANN D A MOOLENAAR J A C | 2000 | Powder Technol2000，108，： | 1 |
| 11 | Modelling and control of a jet mill plant 显示文摘 | Gommeren H J C Heitzmann D A Moolenaar A C | 2000 | Powder Technology2000，108，： | 1 |
| 12 | Invalidation of TASKI potassium channels disrupts adrenal gland zonation and mineralocorticoid homeostasis 显示文摘 | Heitzmann D Derand R Jungbauer S et el | 2008 | EMBO J2008，27，： | 1 |
| 13 | Effect of constant and variable domain glycosylation on pharmacokinetics of therapeutic antibodies in mice显示文摘 | Millward T A Heitzmann M Bill K | 2008 | Biologicals2008，36，1： | 1 |
| 14 | The correction of high myopia using the exeimer laser显示文摘 | Heitzmann J Binder PS Kassar BS | 1993 | Arch Ophthalmal1993，111，12： | 1 |
| 15 | Invalida- tion of TASK1 potassium channels disrupts adrenal gland zonation and mineraloeorticoid homeostasis 显示文摘 | Heitzmann D Derand R Jungbauer S | 2008 | EMBO J2008，27，1： | 1 |
| 16 | Spermatophore formation in the white shrimp,Penaeus vannamei Boone 1931:dependence on the intermoult cycle显示文摘 | Heitzmann J C Diter A | 1993 | Aquac1993，116，： | 1 |
| 17 | Invalidation o TASK1 potassium channels disrupts adrenal gland zonation and mineralocorticoid homeostasis显示文摘 | Heitzmann D Derand R Jungbauer S | 2008 | EMBO J2008，27，1： | 1 |
| 18 | The Influence of Botulinum Toxin A Injections into the Calf Muscles on Genu Recurvatum in Children With Cerebral Palsy显示文摘 | Matthias C. M. Klotz Sebastian I. Wolf Daniel Heitzmann Simone Gantz Frank Braatz Thomas Dreher | 2013 | Clinical Orthopaedics and Related Research?2013，，： | 1 |
| 19 | The use of azimuthal intensity variations in diffraction patterns for particle shape characterization显示文摘 | Heffels C Heitzmann D Hirleman E D | 1994 | Part Part Syst Charact1994，，11： | 1 |
| 20 | The correction of high myopia using the excimer laser显示文摘 | Heitzmann J Binder PS kassar BS | 1993 | Arch Ophthalmol1993，111，12： | 1 |
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