|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Reduning injection for fever, rash, and ulcers in children with mild hand, foot, and mouth disease: a randomized controlled clinical study显示文摘OBJECTIVE: To assess the efficacy and safety of Reduning injection for fever, rash, and ulcers in children with mild hand, foot, and mouth disease(HFMD). METHODS: A stratified-block randomized, double-blind, parallel-controlled, and multicenter clinical trial was conducted with 360 patients in five hospitals across China: Quanzhou Children's Hospital, Shijiazhuang No. 5 Hospital, Shanghai Public Health Centre, Hunan Provincial Children's Hospital, and Kaifeng Children's Hospital. Patients were randomized into three groups with 120 in each. Group A was treated with Western Medicine, group B with Reduning injection, a Chinese herbal medicine, and group C with both Reduning injection and Western Medicine. Results were compared for treatment efficacy and safety on HFMD. The clinical outcomes were observed as follows: fever and onset time of antifebrile effect(time to bring the body temperature down ≥0.5℃ after medication); cumulative time for fever recovery(body temperature recovering to normal and lasting more than 24 h without medication); cumulative time for rash disappearance(without new rashes or ulcers appearing and the original ones fading away); and cumulative time for mouth ulcer disappearance. RESULTS: For the onset time of the antifebrile effect, there was no statistical difference between groups A and B(P>0.05) and groups B and C(P> 0.05). However, there was a statistical difference between groups A and C(P<0.05), and the effect in group C was the best. For the cumulative time for rash disappearance, there was no statistical difference between groups A and B(P>0.05). There were statistical differences between groups A and C, and groups B and C(P<0.05), and the effect in group C was the best. For the cumulative time for mouth ulcers disappearance, there were no statistical differences among the three groups(P>0.05). CONCLUSION: Reduning injection with Western Medicine for symptomatic treatment is most effective for mild HFMD. No adverse reactions were observed. | Guoliang Zhang Jie Zhao Liyun He Shiyan Yan Ziqiang Zhuo Haojie Zheng Yongping Mu Shuangjie Li Xi Zhang Jihan Huang Xiuhui Li Jianping Liu Hehe Wan Chaoyu Wei Wei Xiao | 2013 | Journal of Traditional Chinese Medicine2013，33，6： | 7 |
| 2 | Biotechnological and food synthetic biology potential of platform strain:Bacillus licheniformis显示文摘Bacillus licheniformis is one of the most characteristic Gram-positive bacteria.Its unique genetic background and safety characteristics make it have important biologic applications in the food industry,including,the biosyn-thesis of high value-added bioproducts,probiotic functions,biological treatment of wastes derived from food production,etc.In this review,these recent advances are summarized and presented systematically for the first time.In addition,we highlight synthetic biology strategies as a potential driver of developing this strain for wider and more efficient application in the food industry.Finally,we present the current challenges faced and provide our unique perspective on relevant future research directions.In summary,this review will provide an illumi-nating and comprehensive perspective that will allow an in-depth understanding of B.licheniformis and promote its more effective development in the food industry. | Hehe He Qianqian Yu Zhongyang Ding Liang Zhang Guiyang Shi Youran Li | 2023 | Synthetic and Systems Biotechnology2023，8，2： | 0 |
| 3 | High-sensitive two-dimensional PbI_(2)photodetector with ultrashort channel显示文摘Photodetectors based on two-dimensional(2D)semiconductors have attracted many research interests owing to their excellent optoelectronic characteristics and application potential for highly integrated applications.However,the unique morphology of 2D materials also restricts the further improvement of the device performance,as the carrier transport is very susceptible to intrinsic and extrinsic environment of the materials.Here,we report the highest responsivity(172 A/W)achieved so far for a PbI_(2)-based photodetector at room temperature,which is an order of magnitude higher than previously reported.Thermal scanning probe lithography(t-SPL)was used to pattern electrodes to realize the ultrashort channel(~60 nm)in the devices.The shortening of the channel length greatly reduces the probability of the photo-generated carriers being scattered during the transport process,which increases the photocurrent density and thus the responsivity.Our work shows that the combination of emerging processing technologies and 2D materials is an effective route to shrink device size and improve device performance. | Kaiyue He Jijie Zhu Zishun Li Zhe Chen Hehe Zhang Chao Liu Xu Zhang Shuo Wang Peiyi Zhao Yu Zhou Shizheng Zhang Yao Yin Xiaorui Zheng Wei Huang Lin Wang | 2023 | Frontiers of physics2023，18，6： | 0 |
| 4 | Forkhead box protein O1(FoxO1)regulates lipids metabolism and cell proliferation mediated by insulin and PI3K-Akt-mTOR pathway in goose primary hepatocytes显示文摘In order to explore the role of forkhead box protein O1(FoxO1)in the lipid metabolism and cell proliferation,goose primary hepatocytes were isolated and incubated with insulin or PI3K-Akt-mTOR pathway dual inhibitor NVPBEZ235,and then transfected with FoxO1 interference plasmid.The related parameters of lipid metabolism and cell proliferation were measured.The results firstly showed that FoxO1 interference increased the intracellular TG and lipids concentration(P<0.05);and increased the proliferative index(PI),cell DNA synthesis,protein expression of Cyclin D1 in goose primary hepatocytes(P<0.05).Secondly,the co-treatment of insulin and FoxO1 interference increased the mRNA level and protein content of Cyclin D1(P<0.05);however,there was no significant difference between the insulin treatment and the co-treatment of insulin and miR-FoxO1 interference in the intracellular TG and lipids concentration and PI(P>0.05).Lastly,the decrease of intracellular TG and lipids concentration and PI induced by NVP-BEZ235 was up-regulated by FoxO1 interference significantly(P<0.05).In summary,FoxO1 could regulate the lipids metabolism and cell proliferation mediated by PI3K-Akt-mTOR signaling pathway in goose primary hepatocytes.Further investigations are required to highlight the potential role of FoxO1 in the lipid metabolism and cell proliferation mediated by insulin in goose primary hepatocyte. | RONGXUE WEI CHUNCHUN HAN FENGJIANG YE SHOUHAI WEI FANG HE HEHE LIU LIANG LI HONGYONG XU SHENQIANG HU XIANYIN ZENG | 2022 | BIOCELL2022，46，1： | 0 |
| 5 | Mechanisms and biotechnological applications of transcription factors显示文摘Transcription factors play an indispensable role in maintaining cellular viability and finely regulating complex internal metabolic networks.These crucial bioactive functions rely on their ability to respond to effectors and concurrently interact with binding sites.Recent advancements have brought innovative insights into the understanding of transcription factors.In this review,we comprehensively summarize the mechanisms by which transcription factors carry out their functions,along with calculation and experimental-based methods employed in their identification.Additionally,we highlight recent achievements in the application of transcription factors in various biotechnological fields,including cell engineering,human health,and biomanufacturing.Finally,the current limitations of research and provide prospects for future investigations are discussed.This review will provide enlightening theoretical guidance for transcription factors engineering. | Hehe He Mingfei Yang Siyu Li Gaoyang Zhang Zhongyang Ding Liang Zhang Guiyang Shi Youran Li | 2023 | Synthetic and Systems Biotechnology2023，8，4： | 0 |
| 6 | Valence modulated nickel oxynitride network as integrated bifunctional electrodes for enhanced energy storage显示文摘As promising electrode materials,transition metal oxides have attracted considerable attention owing to their excellent performance in electrochemical energy storage.However,their poor conductivity and fragile structure limit their practical application.In this study,a binder-free nickel oxide/oxynitride network(NiON WS)bifunctional electrodes with cation multivalent states that exhibit high energy storage performance were synthesized for the first time.The massive active sites,high specific surface areas,and multiple cation valence states of NiON WS were advantageous for electrochemical redox reaction during its application in supercapacitors(1283.5 mF cm^(-2))and lithium-ion batteries(1345.0 mA h g^(-1)).Particularly,the NiON WS based flexible asymmetric SCs exhibit excellent capacitance and energy densities.First-principle calculations were employed to study the mechanism of the electrochemical performance improvement of NiON WS.This study demonstrates the potential of transition metal oxides electrode with high capacity and activity for electrochemical energy storage and conversion. | Shouzhi Wang Hengshuai Li Weidong He Hehe Jiang Yongliang Shao Yongzhong Wu Xiaopeng Hao | 2021 | Journal of Energy Chemistry2021，30，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员