|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Endometrial response to conceptus-derived estrogen and interleukin-1β at the time of implantation in pigs显示文摘The establishment of pregnancy is a complex process that requires a well-coordinated interaction between the implanting conceptus and the maternal uterus. In pigs, the conceptus undergoes dramatic morphological and functional changes at the time of implantation and introduces various factors, including estrogens and cytokines,interleukin-1β2(IL1 B2), interferon-γ(IFNG), and IFN-δ(IFND), into the uterine lumen. In response to ovarian steroid hormones and conceptus-derived factors, the uterine endometrium becomes receptive to the implanting conceptus by changing its expression of cell adhesion molecules, secretory activity, and immune response. Conceptus-derived estrogens act as a signal for maternal recognition of pregnancy by changing the direction of prostaglandin(PG) F2αfrom the uterine vasculature to the uterine lumen. Estrogens also induce the expression of many endometrial genes,including genes related to growth factors, the synthesis and transport of PGs, and immunity. IL1 B2, a pro-inflammatory cytokine, is produced by the elongating conceptus. The direct effect of IL1 B2 on endometrial function is not fully understood. IL1 B activates the expression of endometrial genes, including the genes involved in IL1 B signaling and PG synthesis and transport. In addition, estrogen or IL1 B stimulates endometrial expression of IFN signaling molecules,suggesting that estrogen and IL1 B act cooperatively in priming the endometrial function of conceptus-produced IFNG and IFND that, in turn, modulate endometrial immune response during early pregnancy. This review addresses information about maternal-conceptus interactions with respect to endometrial gene expression in response to conceptus-derived factors, focusing on the roles of estrogen and IL1 B during early pregnancy in pigs. | Hakhyun Ka Heewon Seo Yohan Choi Inkyu Yoo Jisoo Han | 2018 | Journal of Animal Science and Biotechnology2018，9，3： | 5 |
| 2 | Interactive classification for pre-integrated volume rendering of high-precision volume data显示文摘 | Heewon K Byeong-Seok S Yeong G S | 2008 | Graphical Models2008，，70： | 1 |
| 3 | Erroneously elevated immature reticulocyte counts in leukemic patients determined using a Sysmex XE-2100 hematology analyzer显示文摘 | Jungwon H Heewon M Whasoon C | 2007 | Ann Hematol2007，86，： | 1 |
| 4 | Characteristics and Outcome of Exertional Heatstroke Patients Complicated by Acute Hepatic Injury显示文摘To the editor,We have read the article titled“Characteristics and Outcome of Exertional Heatstroke Patients Complicated by Acute Hepatic Injury:A Cohort Study”by Ji et al.1 We congratulate the authors for this insightful article.In this letter,we would like to raise several issues about the article to provide constructive criticisms. | Heewon Yang HyukHoon Kim Sangchun Choi | 2021 | Journal of Clinical and Translational Hepatology2021，9，5： | 1 |
| 5 | 25-Year summary of US malpractice claims for diagnostic errors 1986–2010: an analysis from the National Practitioner Data Bank显示文摘 | Ali S Saber Tehrani HeeWon Lee Simon C Mathews Andrew Shore Martin A Makary Peter J Pronovost David E Newman-Toker | 2013 | BMJ Quality & Safety2013，，8： | 1 |
| 6 | An efficient algorthm for the image model technique显示文摘 | Lee Heewon Lee Byung-Ho | 1988 | Applied Acoustics1988，24，2： | 1 |
| 7 | An efficient algorithm for the image model technique 显示文摘 | Heewon Lee Byung-Ho Lee | 1988 | Applied Acoustics1988，，24： | 1 |
| 8 | Raman spectroscopy of sulphur-containing amino acids and their derivatives adsorbed on silver显示文摘 | Heewon Lee Myung Soo Kim Se Won Suh | 1911 | Journal of Raman Spectroscopy1911，22，： | 1 |
| 9 | Erroneously elevated immature reticulocyte counts in leukemic patients deter- mined using a Sysmex XE-2100 hematology analyzer显示文摘 | Jungwon H Heewon M Whasoon C | 2007 | Ann Hematol2007，86，10： | 1 |
| 10 | Pre-implantation exogenous progesterone and pregnancy in sheep.II.Effects on fetalplacental development and nutrient transporters in late pregnancy显示文摘Background:Administration of progesterone(P4)to ewes during the first 9 to 12 days of pregnancy accelerates blastocyst development by day 12 of pregnancy,likely due to P4-induced up-regulation of key genes in uterine epithelia responsible for secretion and transport of components of histotroph into the uterine lumen.This study determined if acceleration of blastocyst development induced by exogenous P4 during the pre-implantation period affects fetal-placental development on day 125 of pregnancy.Suffolk ewes(n=35)were mated to fertile rams and assigned randomly to receive daily intramuscular injections of either corn oil vehicle(CO,n=18)or 25 mg progesterone in CO(P4,n=17)for the first 8 days of pregnancy.All ewes were hysterectomized on day 125 of pregnancy and:1)fetal and placental weights and measurements were recorded;2)endometrial and placental tissues were analyzed for the expression of candidate mRNAs involved in nutrient transport and arginine metabolism;and 3)maternal plasma,fetal plasma,allantoic fluid,and amniotic fluid were analyzed for amino acids,agmatine,polyamines,glucose,and fructose.Results:Treatment of ewes with exogenous P4 did not alter fetal or placental growth,but increased amounts of aspartate and arginine in allantoic fluid and amniotic fluid,respectively.Ewes that received exogenous P4 had greater expression of mRNAs for SLC7A1,SLC7A2,SLC2A1,AGMAT,and ODC1 in endometria,as well as SLC1A4,SLC2A5,SLC2A8 and ODC1 in placentomes.In addition,AZIN2 protein was immunolocalized to uterine luminal and glandular epithelia in P4-treated ewes,whereas AZIN2 localized only to uterine luminal epithelia in CO-treated ewes.Conclusions:This study revealed that exogenous P4 administered in early pregnancy influenced expression of selected genes for nutrient transporters and the expression of a protein involved in polyamine synthesis on day 125 of pregnancy,suggesting a‘programming’effect of P4 on gene expression that affected the composition of nutrients in fetal-placental fluids. | Katherine M.Halloran Emily C.Hoskins Claire Stenhouse Robyn M.Moses Kathrin A.Dunlap M.Carey Satterfield Heewon Seo Gregory A.Johnson Guoyao Wu Fuller W.Bazer | 2021 | Journal of Animal Science and Biotechnology2021，12，3： | 1 |
| 11 | Iterative Semi-Supervised Learning Using Softmax Probability显示文摘For the classification problem in practice,one of the challenging issues is to obtain enough labeled data for training.Moreover,even if such labeled data has been sufficiently accumulated,most datasets often exhibit long-tailed distribution with heavy class imbalance,which results in a biased model towards a majority class.To alleviate such class imbalance,semisupervised learning methods using additional unlabeled data have been considered.However,as a matter of course,the accuracy is much lower than that from supervised learning.In this study,under the assumption that additional unlabeled data is available,we propose the iterative semi-supervised learning algorithms,which iteratively correct the labeling of the extra unlabeled data based on softmax probabilities.The results show that the proposed algorithms provide the accuracy as high as that from the supervised learning.To validate the proposed algorithms,we tested on the two scenarios:with the balanced unlabeled dataset and with the imbalanced unlabeled dataset.Under both scenarios,our proposed semi-supervised learning algorithms provided higher accuracy than previous state-of-the-arts.Code is available at http://gffzz188fe103f8f1460askvf6vkcpnpfx6qop.ffgz.tsg.suse.edu.cn/HeewonChung92/iterative-semi-learning. | Heewon Chung Jinseok Lee | 2022 | Computers, Materials & Continua2022，，9： | 1 |
| 12 | Gastrointestinal tuberculosis is not associated with proton pump inhibitors:A retrospective cohort study显示文摘AIM:To evaluate the effect of proton pump inhibitors(PPIs) on the development of gastrointestinal tuberculosis.METHODS:All patients who were more than 20 years old and who had received a prescription for PPIs among those who visited Seoul National University Hospital from January 1,2005 to December 31,2009 were identified.Due to the low sensitivity of the microbiologic test and the nonspecific pathologic findings,the diagnosis of gastrointestinal tuberculosis was confirmed through the presence of active ulcerations and the responses to anti-tuberculosis medications.The patients were divided into two groups according to treatment duration(group 1:≤ 3 mo;group 2:> 3 mo) and were followed up from the time they took the first prescription of PPIs until their last visit.Logistic regression analysis was used to calculate the relative risks(RR) and 95%CI,adjusting for covariates.RESULTS:Among the 61 834 patients exposed to PPIs(50 534 in group 1;11 300 in group 2),21 patients were diagnosed with PPI-associated gastrointestinal tuberculosis during 124 274 person-years of follow-up.Of 21 patients,the 12 who revealed only scar changes in the colonoscopy were excluded from the statistical analyses.Of those who remained,2 were excluded because they underwent gastrointestinal endoscopy within 4 wk of the first prescription for PPIs.Longer exposure to PPI was associated with a higher mean age(55.0 ± 14.5 in group 1 vs 58.2 ± 13.3 in group 2,P < 0.001) and a higher Charlson co-morbidity index(0.50 ± 0.93 in group 1 vs 0.77 ± 1.14 in group 2,P < 0.001).The true incidence of active gastrointestinal tuberculosis was 0.65 per 1000 person-years in group 1 and 0.03 per 1 000 person-years in group 2.Like the less-than-three-month PPI treatment period in group 1,the over-three-month PPI therapy period in group 2 was not associated with increased risk of acquiring gastrointestinal tuberculosis,after adjusting for age and co-morbidities,whereas the Charlson co-morbidity index was associated with increased risk of acquiring gastrointestinal tuberculosis based on the score [RR:(reference 1) in group 1 vs 1.518 in group 2;95% CI:1.040-2.216,P = 0.03].CONCLUSION:Long-term PPI therapy does not seem to be associated with increased risk of acquiring gastrointestinal tuberculosis,but a higher Charlson comorbidity index is associated with such. | Kyoung Sup Hong Seung Joo Kang Jong Kyoung Choi Ju Han Kim Heewon Seo Suehyun Lee Jae-Woo Jung Hye-Ryun Kang Sang-Heon Cho Joo Sung Kim | 2013 | World Journal of Gastroenterology2013，19，2： | 1 |
| 13 | SARS-CoV-2 Epitopes following Infection and Vaccination Overlap Known Neutralizing Antibody Sites显示文摘Identification of epitopes targeted following virus infection or vaccination can guide vaccine design and development of therapeutic interventions targeting functional sites,but can be laborious.Herein,we employed peptide microarrays to map linear peptide epitopes(LPEs)recognized following SARS-CoV-2 infetion and vaccination.LPEs detected by nonhuman primate(NHP)and patient IgMs after SARS-CoV-2 infection extensively overlapped,localized to functionally important virus regions,and aligned with reported neutralizing antibody binding sies.Similar LPE overlap occurred atfter infection and vaccination,with LPE clusters specifc to each stimulus,where strong and conserved LPEs mapping to sites known or likely to inhibit spike protein function.Vaccine-specifc LPEs tended to map to sites known or likely to be afected by structural changes induced by the proline substitutions in the mRNA vaccine's S protein.Mapping LPEs to regions of known functional importance in this manner may acelerate vaccine evaluation and discovery of targets for sile secific therapeutic interventions. | Li Yang Te Liang Lane M.Pierson Hongye Wang Jesse K.Fletcher Shu Wang Duran Bao Lii Zhang Zhen Huang Wenshu Zheng Xiaomei Zhang Heewon Park Yuwen Li James E.Robinson Amy K.Fechan Christopher J.Lyon Jing Cao Lisa A.Morici Chenzhong Li Chad J.Roy Xiaobo Yu Tony Hu | 2022 | Research2022，，2： | 0 |
| 14 | Quantifying and managing regional greenhouse gas emissions: Waste sector of Daejeon, Korea显示文摘A credible accounting of national and regional inventories for the greenhouse gas(GHG) reduction has emerged as one of the most significant current discussions. This article assessed the regional GHG emissions by three categories of the waste sector in Daejeon Metropolitan City(DMC), Korea,examined the potential for DMC to reduce GHG emission, and discussed the methodology modified from Intergovernmental Panel on Climate Change and Korea national guidelines. During the last five years, DMC's overall GHG emissions were 239 thousand tons CO2 eq./year from eleven public environmental infrastructure facilities, with a population of 1.52 million. Of the three categories, solid waste treatment/disposal contributes 68%, whilst wastewater treatment and others contribute 22% and10% respectively. Among GHG unit emissions per ton of waste treatment, the biggest contributor was waste incineration of 694 kg CO2 eq./ton, followed by waste disposal of 483 kg CO2eq./ton, biological treatment of solid waste of 209 kg CO2 eq./ton, wastewater treatment of 0.241 kg CO2eq./m3, and public water supplies of 0.067 kg CO2 eq./m3. Furthermore, it is suggested that the potential in reducing GHG emissions from landfill process can be as high as 47.5% by increasing landfill gas recovery up to 50%. Therefore, it is apparent that reduction strategies for the main contributors of GHG emissions should take precedence over minor contributors and lead to the best practice for managing GHGs abatement. | Sora Yi Heewon Yang Seung Hoon Lee Kyoung-Jin An | 2014 | Journal of Environmental Sciences2014，26，6： | 0 |
| 15 | 女权主义:从意识、话语到行动——以韩国女权主义运动为例 | HEEWON MIN(闵熙媛) | 2019 | 海外文摘2019，，23： | 0 |
| 16 | Integrins and their potential roles in mammalian pregnancy显示文摘Integrins are a highly complex family of receptors that, when expressed on the surface of cells, can mediate reciprocal cell-to-cell and cell-to-extracellular matrix(ECM) interactions leading to assembly of integrin adhesion complexes(IACs) that initiate many signaling functions both at the membrane and deeper within the cytoplasm to coordinate processes including cell adhesion, migration, proliferation, survival, differentiation, and metabolism. All metazoan organisms possess integrins, and it is generally agreed that integrins were associated with the evolution of multicellularity, being essential for the association of cells with their neighbors and surroundings, during embryonic development and many aspects of cellular and molecular biology. Integrins have important roles in many aspects of embryonic development, normal physiology, and disease processes with a multitude of functions discovered and elucidated for integrins that directly influence many areas of biology and medicine, including mammalian pregnancy, in particular implantation of the blastocyst to the uterine wall, subsequent placentation and conceptus(embryo/fetus and associated placental membranes) development. This review provides a succinct overview of integrin structure, ligand binding, and signaling followed with a concise overview of embryonic development, implantation, and early placentation in pigs, sheep, humans, and mice as an example for rodents. A brief timeline of the initial localization of integrin subunits to the uterine luminal epithelium(LE) and conceptus trophoblast is then presented, followed by sequential summaries of integrin expression and function during gestation in pigs, sheep, humans, and rodents. As appropriate for this journal, summaries of integrin expression and function during gestation in pigs and sheep are in depth, whereas summaries for humans and rodents are brief. Because similar models to those illustrated in Fig. 1, 2, 3, 4, 5 and 6 are present throughout the scientific literature, the illustrations in this manuscript are drafted as Viking imagery for entertainment purposes. | Gregory A.Johnson Robert C.Burghardt Fuller W.Bazer Heewon Seo Joe W.Cain | 2024 | Journal of Animal Science and Biotechnology2024，15，1： | 0 |
| 17 | Dietary supplementation with 0.4%L-arginine between days 14 and 30 of gestation enhances NO and polyamine syntheses and water transport in porcine placentae显示文摘Background:Most embryonic loss in pigs occurs before d 30 of gestation.Dietary supplementation with L-arginine(Arg) during early gestation can enhance the survival and development of conceptuses(embryo/fetus and its extraembryonic membranes) in gilts.However,the underlying mechanisms remain largely unknown.Methods:Between d 14 and 30 of gestation,each gilt was fed daily 2 kg of a corn-and soybean-meal based diet(12% crude protein) supplemented with either 0.4% Arg(as Arg-HCl) or an isonitrogenous amount of L-alanine(Control).There were 10 gilts per treatment group.On d 30 of gestation,gilts were fed either Arg-HCl or L-alanine 30 min before they were hysterectomized,followed by the collection of placentae,embryos,fetal membranes,and fetal fluids.Amniotic and allantoic fluids were analyzed for nitrite and nitrate [NOx;stable oxidation products of nitric oxide(NO)],polyamines,and amino acids.Placentae were analyzed for syntheses of NO and polyamines,water and amino acid transport,concentrations of amino acid-related metabolites,and the expression of angiogenic factors and aquaporins(AQPs).Results:Compared to the control group,Arg supplementation increased(P < 0.05) the number of viable fetuses by 1.9 per litter,the number and diameter of placental blood vessels(+ 25.9% and + 17.0% respectively),embryonic survival(+ 18.5%),total placental weight(+ 36.5%),the total weight of viable fetuses(+ 33.5%),fetal crown-to-rump length(+ 4.7%),and total allantoic and amniotic fluid volumes(+ 44.6% and + 75.5% respectively).Compared to control gilts,Arg supplementation increased(P < 0.05) placental activities of GTP cyclohydrolase-1(+ 33.1%) and ornithine decarboxylase(+ 29.3%);placental syntheses of NO(+ 26.2%) and polyamines(+ 28.9%);placental concentrations of NOx(+ 22.5%),tetrahydrobiopterin(+ 21.1%),polyamines(+ 20.4%),c AMP(+ 27.7%),and c GMP(+ 24.7%);total amounts of NOx(+ 61.7% to + 96.8%),polyamines(+ 60.7% to + 88.7%),amino acids(+ 39% to + 118%),glucose(+ 60.5% to + 62.6%),and fructose(+ 41.4% to + 57.0%) in fetal fluids;and the placental transport of water(+ 33.9%),Arg(+ 78.4%),glutamine(+ 89.9%),and glycine(+ 89.6%).Furthermore,Arg supplementation increased(P < 0.05) placental m RNA levels for angiogenic factors [VEGFA120(+ 117%),VEGFR1(+ 445%),VEGFR2(+ 373%),PGF(+ 197%),and GCH1(+ 126%)] and AQPs [AQP1(+ 280%),AQP3(+ 137%),AQP5(+ 172%),AQP8(+ 165%),and AQP9(+ 127%)].Conclusion:Supplementing 0.4% Arg to a conventional diet for gilts between d 14 and d 30 of gestation enhanced placental NO and polyamine syntheses,angiogenesis,and water and amino acid transport to improve conceptus development and survival. | Cassandra M.Herring Fuller W.Bazer Gregory A.Johnson Heewon Seo Shengdi Hu Mohammed Elmetwally Wenliang He Daniel B.Long Guoyao Wu | 2023 | Journal of Animal Science and Biotechnology2023，14，2： | 0 |
| 18 | Pre-implantation exogenous progesterone and pregnancy in sheep:I.polyamines,nutrient transport,and progestamedins显示文摘Background:Administration of exogenous progesterone(P4)to ewes during the pre-implantation period advances conceptus development and implantation.This study determined effects of exogenous P4 on transport of select nutrients and pathways that enhance conceptus development.Pregnant ewes(n=38)were treated with either 25 mg P4 in 1 mL corn oil(P4,n=18)or 1mL corn oil alone(CO,n=20)from day 1.5 through day 8 of pregnancy and hysterectomized on either day 9 or day 12 of pregnancy.Endometrial expression of genes encoding enzymes for synthesis of polyamines,transporters of glucose,arginine,and glycine,as well as progestamedins was determined by RT-qPCR.Results:On day 12 of pregnancy,conceptuses from P4-treated ewes had elongated while those from CO-treated ewes were spherical.The mRNA expression of AZIN2,an arginine decarboxylase,was lower in endometria of P4-treated than CO-treated ewes on day 9 of pregnancy.Expression of FGF10,a progestamedin,was greater in endometria of CO and P4-treated ewes on day 12 of gestation in addition to P4-treated ewes necropsied on day 9 of gestation.Treatment with P4 down-regulated endometrial expression of amino acid transporter SLC1A4 on day 12 of pregnancy.Conclusions:Results indicated that administration of exogenous P4 during the pre-implantation period advanced the expression of FGF10,which may accelerate proliferation of trophectoderm cells,but also was correlated with decreased expression of glycine and serine transporters and polyamine synthesis enzyme AZIN2.Further research with increased sample sizes may determine how differential expression affects endometrial functions and potentially embryonic loss. | Emily C.Hoskins Katherine M.Halloran Claire Stenhouse Robyn M.Moses Kathrin A.Dunlap Michael C.Satterfield Heewon Seo Gregory A.Johnson Guoyao Wu Fuller W.Bazer | 2021 | Journal of Animal Science and Biotechnology2021，12，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员