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| 1 | miR147b:白细胞介素-1β介导的人类星形胶质细胞炎症中的新型关键调节因子显示文摘星形胶质细胞是大脑炎症过程的重要介质,可能在包括癫痫在内的几种神经系统疾病中起重要作用。星形胶质细胞中可生产几种miRNA,是炎症通路的关键调节因子,还可能用作治疗靶标。本研究将探索在体外IL-1β介导的炎症条件下,星形胶质细胞内生成的miRNA及其功能,并在人癫痫脑组织中验证。我们通过测序评估IL-1β刺激的人胎儿星形胶质细胞培养物中的miRNA和mRNA表达。使用miRNA模拟物在细胞培养物中过表达miRNA。使用原位杂交技术检测患有结节性硬化症复合体或颞叶癫痫伴海马硬化患者的切除脑组织中miRNA的表达。我们发现了2种差异表达的miRNA:miR146a和miR147b,它们与免疫/炎症反应相关基因的表达增加有关。既往有研究报道,在星形胶质细胞和结节性硬化复合细胞培养物中使用IL-1β刺激后,miR147b的过表达降低了促炎介质IL-6和COX-2的表达。miR146a和miR147b过表达降低了星形胶质细胞的增殖并促进人神经干细胞的神经元分化。miR147b在致癫痫脑中的星形胶质细胞中表达增加。由于其抗炎和恢复异常星形细胞增殖和促进神经元分化的能力,miR146a和miR147b作为与炎症相关的神经疾病(例如癫痫)的潜在治疗靶标值得进一步研究。 | van Scheppingen J Mills JD Zimmer TS Broekaart DWM Iori V Bongaarts A Anink JJ Iyer AM Korotkov A Jansen FE van Hecke W Spliet WG van Rijen PC Baayen JC Vezzani A van Vliet EA Aronica E 聂昊 | 2018 | 神经损伤与功能重建2018，13，12： | 3 |
| 2 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 3 | Hepatitis B virus - specific cytotoxic T lymphocyte response in patients with acute and chronic hepatitis B virus infections显示文摘 | Van Hecke E Paradijs J Molitor C | 1994 | J Hepatol1994，20，4： | 1 |
| 4 | Distributed Fault- Tolerance for Event Detection Using Heterogeneous Wireless Sensor Networks 显示文摘 | Ould-Ahmed-Vall E Heck Ferri B Riley G | 2012 | Mobile Computing IEEE Transaction on2012，11，12： | 1 |
| 5 | Business network -based value creation in electronic commerce显示文摘 | Kauffman R J Li T Heck E | | 0，，01： | 1 |
| 6 | Solarultraviolet radiation as a trigger of cell signal transduction显示文摘 | HECK D E GERECKE D R VETRANO A M | | 0，，03： | 1 |
| 7 | Cardiovascular magnetic resonance: myocardial perfusion显示文摘 | Nagel E al-Saadi NA Heck E | 2000 | Herz2000，25，： | 1 |
| 8 | AG115, a MADs domain protent expressed in developing embryos显示文摘 | HECK G R PERRY S E NICHOLS K W | 1995 | Plant Cell1995，7，8： | 1 |
| 9 | Yerba mate tea (llexparaguariensis) : a comprehensive review on chemistry, health implications, and technological considerations显示文摘 | HECK C I De MEJIA E G | 2007 | Journal of Food Science2007，72，9： | 1 |
| 10 | Characterization of the oxidase activity in mammalian catalase显示文摘 | VETRANO A M HECK D E MARIANO T M | 2005 | Journal of Biological Chemistry2005，280，35： | 1 |
| 11 | Role of nitric oxidein acetaminophen induced hepatotoxicity in the rat显示文摘 | Gardner C R Heck D E Yang C S | 1998 | Hepa-tology1998，27，3： | 1 |
| 12 | Content validity, construct validity, and reliability of the WHOQOL-Bref in a population of Dutch adult psychiat- ric outpatients 显示文摘 | Trompenaars F J Masthoff E D Van Heck G L | 2005 | De Vries J Qual Life Res2005，14，1： | 1 |
| 13 | The embryo MADS do main factor AGL15 acts post-embryonically Inhibition of perianth senescence and abscission via constitutive expression显示文摘 | Fernandez D E Heck G R Perry S E | 2000 | The plant cell2000，，12： | 1 |
| 14 | Dietary Intake of Methionine, Cysteine, ,and Protein and Urinary Arsenic Excretion in Bangladesh 显示文摘 | Julia E Heck Jeri W | 2009 | Environ Health Perspect2009，1，1： | 1 |
| 15 | Hepatic nitric oxide production following acute endotoxemia in rats in mediatedly increased inducible nitric oxide synthase gene expression显示文摘 | Valle M R Heck D E | 1995 | Hepatology1995，22，1： | 1 |
| 16 | The feasibility of using the Spanish PHQ-9 to screen for depression in primary care in Honduras primary care companion显示文摘 | Wulsin L Somoza E Heck J | 2002 | J Clin Psychiat2002，4，5： | 1 |
| 17 | The restoration of the Mauritius Kestrel Falco punctatus population显示文摘 | JONES C G HECK W LEWIS R E | | 0，，1： | 1 |
| 18 | Body mass index and mortality in 'healther' as compared with 'sicker' hem-odialysis patients显示文摘 | Leaver SF McCullough K Hecking E et a/ | 2001 | Nephrol Dial Transplant2001，16，12： | 1 |
| 19 | Distinct loops in arres- tin differentially regulate ligand binding within the GPCR op sin显示文摘 | Sommer M E Hofmann K P Heck M | 2012 | Nat Commun2012，3，： | 1 |
| 20 | The embryo MADS domain factor AGL15 acts postembryonically: inhibition of perianth senescence and abscission via constitutive expression 显示文摘 | Fernandez D E Heck G R Perry S E | 2000 | Plant Cell2000，12，： | 1 |
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