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| 1 | Plasmacytoid dendritic cell deficiency in neonates enhances allergic airway inflammation via reduced production of IFN-α显示文摘Allergic asthma,a chronic inflammatory airway disease associated with type 2 cytokines,often originates in early life.Immune responses at an early age exhibit a Th2 cell bias,but the precise mechanisms remain elusive.Plasmacytoid dendritic cells(pDCs),which play a regulatory role in allergic asthma,were shown to be deficient in neonatal mice.We report here that this pDC deficiency renders neonatal mice more susceptible to severe allergic airway inflammation than adult mice in an OVA-induced experimental asthma model.Adoptive transfer of pDCs or administration of IFN-αto neonatal mice prevented the development of allergic inflammation in wild type but not in IFNAR1−/−mice.Similarly,adult mice developed more severe allergic inflammation when pDCs were depleted.The protective effects of pDCs were mediated by the pDC-/IFN-α-mediated negative regulation of the secretion of epithelial cell-derived CCL20,GM-CSF,and IL-33,which in turn impaired the recruitment of cDC2 and ILC2 cells to the airway.In asthmatic patients,the percentage of pDCs and the level of IFN-αwere lower in children than in adults.These results indicate that impairment of pDC-epithelial cell crosstalk in neonates is a susceptibility factor for the development of allergeninduced allergic airway inflammation. | Min Wu Liuchuang Gao Miao He Hangyu Liu Han Jiang Ketai Shi Runshi Shang Bing Liu Shan Gao Hebin Chen Feili Gong Erwin WGelfand Yafei Huang Junyan Han | 2020 | Cellular & Molecular Immunology2020，17，5： | 3 |
| 2 | Removal of Cadmium Ions from Aqueous Solution by Silicate-incorporated Hydroxyapatite显示文摘这篇文章作为过去常把镉离子从水溶液移开的一种新环境矿物质在 silicate-incorporatedhydroxyapatite 上报导初步的研究。合并硅酸盐的 hydroxyapatite 被一起沉淀准备并且锻烧,并且硅酸盐被磷酸盐的部分替换合并到 hydroxyapatite 的晶体点阵。离子由合并硅酸盐的 hydroxyapatite 移开的镉的数量显著地被提高,它比纯 hydroxya 的高是 76%但是合并硅酸盐的 hydroxyapatite 上的镉离子的吸着行为类似于揭示的纯 hydroxyapatite.Morphological 学习的那硅酸盐加入限制了水晶生长并且增加了 hydroxyapatite 的比面积区域,它赞成提高样品的镉离子吸着能力。进 hydroxyapatite 的硅酸盐的加入似乎是一条有效途径在水的镉离子的移动上改进 hydroxyapatite 的环境性质。 | SHI Hebin ZHONG Hong LIU Yu DENG Jinyang | 2007 | Acta Geologica Sinica(English Edition)2007，81，3： | 2 |
| 3 | Preparation and Characterization of Nucleus/Shell TiO_2/HAP Complex Nanophotocatalyst显示文摘一个快速、更有效的方法被开发准备 nucleus/shelltitania/hydroxyapatite ( TiO /HAP )与 0.1 mol/L HCI 有 beendissolved 的复杂 nanophotocatalyst.Hydroxyapatite ( 5 亩 m )在 nanosized anatasetitania 粉末 byincreasing 的表面上被形成在在水洗澡为的 90 deg C 的解决方案的 pH 值仅仅产生样品的几 hours.Themicrostructure 和形态学被 X-raydiffraction ( XRD )调查,Fourier变换红外线的光谱学(英尺红外)。 | Hongfei LIU Xiaonong CHENG Juan YANG Xuehua YAN Hebin SHI | 2007 | Journal of Materials Science & Technology2007，23，1： | 1 |
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