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| 1 | Axial strain enhances osteotomy repair with a concomitant increase in connexin43 expression显示文摘The mechanical environment is known to influence fracture healing. We speculated that connexin43(Cx43) gap junctions, which impact skeletal homeostasis, fracture healing and the osteogenic response to mechanical load,may play a role in mediating the response of the healing bone to mechanical strain. Here, we used an established rat fracture model, which uses a 2 mm osteotomy gap stabilized by an external fixator, to examine the impact of various cyclical axial loading protocols(2%, 10%, and 30% strain) on osteotomy healing. We examined the presence of Cx43 in the osteotomy-healing environment and assessed how mechanical strain modulates Cx43 expression patterns in the callus. We demonstrated that increased cyclical axial strain results in increased radiographic and histologic bone formation. In addition, we show by immunohistochemistry that Cx43 is abundantly expressed in the healing callus, with the expression most robust in samples exposed to increased cyclical axial strain. These data are consistent with the concept that an increase in Cx43 expression by mechanical load may be part of the mechanisms by which mechanical forces enhances fracture healing. | Rishi R Gupta Hyunchul Kim Yu-Kwan Chan Carla Hebert Leah Gitajn David J Yoo Robert V O’Toole Adam H Hsieh Joseph P Stains | 2015 | Bone Research2015，3，2： | 2 |
| 2 | Ten species in one:DNA barcoding reveals cryptic species in the Neotropical skipper butterfly Astraptes fulgerator显示文摘 | HEBERT P D N PENTON E H BURNS J M | 2004 | Proc Natl Acad Sci2004，101，14： | 1 |
| 3 | Identification of Birds through DNA Barcodes显示文摘 | Hebert P D N Stoeckle M Y Zemlak T S | 2004 | PLoS Biology2004，2，10： | 1 |
| 4 | The campaign to DNA barcode all fishes,FISH-BOL显示文摘 | WARD R D HANNER R HEBERT P D N | 2009 | Journal of Fish Biology2009，74，2： | 1 |
| 5 | Biological identifications through DNA barcodes显示文摘 | HEBERT P D CYWINSKA A BALL S L | 2003 | Proceeding of Royal Society of London B2003，270，： | 1 |
| 6 | Barcoding animal life : cytechmme c oxidase subunit 1 divergences among closely related species 显示文摘 | Hebert P D N Ratnasingham S de Waard J R | 2003 | Proceedings of the Royal Society of London B : Biolocal Sciences2003，270，1： | 1 |
| 7 | Identification of birds through DNA barcodes显示文摘 | HEBERT P D N STOECKLE M Y ZEMLAK T S | 2004 | PLoS Biol2004，2，： | 1 |
| 8 | Identifying spiders through DNA barcodes显示文摘 | Barrett R D H Hebert P D N | 2005 | Canada Journal of Zoology2005，83，3： | 1 |
| 9 | Blacl/white differences in very low birth weight neonatal mortality rates among New York City hospitals显示文摘 | Howell EA Hebert P Chatterjee S | | 0，，03： | 1 |
| 10 | The promise of DNA barcoding for taxon- omy显示文摘 | Hebert P D N Gregory T R | 2005 | Systematic Biology2005，54，5： | 1 |
| 11 | Biological identifications through DNA barcodes显示文摘 | Hebert P D N Cywinska A Ball S L E A | 2003 | Preceedings:biological sciences2003，270，： | 1 |
| 12 | Identiffcarion of birds through DNA barcodes显示文摘 | Hebert P D N Stoeckle M Y Zemlak T S | 2004 | Plos Biol2004，2，： | 1 |
| 13 | Biological identifications through DNA barcodes显示文摘 | HEBERT P D N CYWINSKA A BALL S L | 2003 | Proceedings of the Royal Socie ty B-Biological Sciences2003，270，： | 1 |
| 14 | Genome organization of the Kres- se strain of porcine parvovirus: Identification of the allotropic de- terminant and comparison with those of NADL-2 andfield isolates 显示文摘 | Bergeron J Hebert B Tijssen P | 1996 | Virol1996，70，： | 1 |
| 15 | BOLD:The barcode of life data system显示文摘 | RATNASINGHAM S HEBERT P D N | 2007 | Molecular ecology notes2007，7，3： | 1 |
| 16 | Biological identification through DNA barcodes 显示文摘 | Hebert P D Cywinska A Ball S L | 2003 | Proc Biol Sci2003，270，： | 1 |
| 17 | Identification of birds through DNA barcodes显示文摘 | Hebert P D N Stoeckle M Y Zemlak T S | 2004 | PLos Biol2004，2，10： | 1 |
| 18 | Autonomous vehicle navigation utilizing electrostatic potential fields and fuzzy logic显示文摘 | Tsourveloudis Nikos C Valavanis Kimon P Hebert Timothy | 2001 | IEEE Transactions on Robtics and Automation2001，17，4： | 1 |
| 19 | Migraine and subsequent risk of stroke in the Physician's Health Study显示文摘 | Buring J E Hebert P Romero J | 1995 | Arch Neurol1995，52，2： | 1 |
| 20 | Vasopressin versus epinephrine for inhospital cardiac arrest:a randomized controlled trial显示文摘 | STIELL I G HEBERT P C WELLS G A | 2001 | Lancet2001，358，9276： | 1 |
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