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| 1 | Hierarchical design of FeCo-based microchains for enhanced microwave absorption in C band显示文摘Microwave absorbing materials(MAMs)has been intensively investigated in order to meet the requirement of electromagnetic radiation control,especially in S and C band.In this work,FeCo-based magnetic MAMs are hydrothermally synthesized via a magnetic-field-induced process.The composition and morphology of the MAMs are capable of being adjusted simultaneously by the atomic ratio of Fe2+to Co2+in the precursor.The hierarchical magnetic microchain,which has a core–shell structure of twodimensional FexCo1−xOOH nanosheets anchored vertically on the surface of a one-dimensional(1D)Co microchain,shows significantly enhanced microwave absorption in C band,resulting in a reflection loss(RL)of lower than−20 dB at frequencies ranging from 4.4 to 8.0 GHz under a suitable matching thickness.The magnetic coupling of Co microcrystals and the double-loss mechanisms out of the core-shell structure are considered to promote the microwave attenuation capability.The hierarchical design of 1D magnetic MAMs provides a feasible strategy to solve the electromagnetic pollution in C band. | Yixuan Han Mukun He Jinwen Hu Panbo Liu Zhongwu Liu Zhonglei Ma Wenbo Ju Junwei Gu | 2023 | Nano Research2023，16，1： | 12 |
| 2 | Two-Stage Resource Allocation Scheme for Three-Tier Ultra-Dense Network显示文摘In 5 G Ultra-dense Network(UDN), resource allocation is an efficient method to manage inter-small-cell interference. In this paper, a two-stage resource allocation scheme is proposed to supervise interference and resource allocation while establishing a realistic scenario of three-tier heterogeneous network architecture. The scheme consists of two stages: in stage I, a two-level sub-channel allocation algorithm and a power control method based on the logarithmic function are applied to allocate resource for Macrocell and Picocells, guaranteeing the minimum system capacity by considering the power limitation and interference coordination; in stage II, an interference management approach based on K-means clustering is introduced to divide Femtocells into different clusters. Then, a prior sub-channel allocation algorithm is employed for Femtocells in diverse clusters to mitigate the interference and promote system performance. Simulation results show that the proposed scheme contributes to the enhancement of system throughput and spectrum efficiency while ensuring the system energy efficiency. | Junwei Huang Pengguang Zhou Kai Luo Zhiming Yang Gongcheng He | 2017 | China Communications2017，14，10： | 5 |
| 3 | Abrogation of USP7 is an alternative strategy to downregulate PD-L1 and sensitize gastric cancer cells to T cells killing显示文摘Targeting immune checkpoints such as programmed cell death protein 1(PD-1)and programmed death ligand-1(PD-L1)have been approved for treating melanoma,gastric cancer(GC)and bladder cancer with clinical benefit.Nevertheless,many patients failed to respond to anti-PD-1/PD-L1 treatment,so it is necessary to seek an alternative strategy for traditional PD-1/PD-L1 targeting immunotherapy.Here with the data from The Cancer Genome Atlas(TCGA)and our in-house tissue library,PD-L1 expression was found to be positively correlated with the expression of ubiquitin-specific processing protease 7(USP7)in GC.Furthermore,USP7 directly interacted with PD-L1 in order to stabilize it,Gastric cancer;Immunosuppression;Cancer biologywhile abrogation of USP7 attenuated PD-L1/PD-1 interaction and sensitized cancer cells to T cell killing in vitro and in vivo.Besides,USP7 inhibitor suppressed GC cells proliferation by stabilizing P53 in vitro and in vivo.Collectively,our findings indicate that in addition to inhibiting cancer cells proliferation,USP7 inhibitor can also downregulate PD-L1 expression to enhance anti-tumor immune response simultaneously.Hence,these data posit USP7 inhibitor as an anti-proliferation agent as well as a novel therapeutic agent in PD-L1/PD-1 blockade strategy that can promote the immune response of the tumor. | Zhiru Wang Wenting Kang Ouwen Li Fengyu Qi Junwei Wang Yinghua You Pengxing He Zhenhe Suo Yichao Zheng Hong-Min Liu | 2021 | Acta Pharmaceutica Sinica B2021，11，3： | 5 |
| 4 | PEPT1-mediated prodrug strategy for oral delivery of peramivir显示文摘Peramivir was a novel and highly potent neuraminidase(NA) inhibitor for the treatment of influenza A and B. However, it exhibited a very low oral bioavailability(only 3%) due to the high polarity(log P of-1.4) and the low membrane permeability across the intestine. To utilize the PEPT1-mediated prodrug strategy to improve the oral absorption and develop the oral alternative, seven amino acid ester prodrugs and seven amino acid amide prodrugs have been synthesized. The permeability of these prodrugs across Caco-2 cells were screened. Peramivr-(CH_2)_2-l-Val and Peramivir-l-Ile were of the highest permeability in ester prodrugs and amide prodrugs, respectively, and then they were selected for further studies. Glycylsarcosine(gly-sar) uptake by Caco-2 could be inbihited by Peramivir-(CH_2)_2-l-Val and Peramivir-l-Ile in a concentration-dependent manner, and the IC 50 was 1.34 ± 0.31 m M and 1.78 ± 0.48 m M, respectively. The direct uptake of Peramivir-(CH_2)_2-l-Val and Peramivirl-Ile in MDCK-PEPT1 cells were significantly higher than in MDCK mock cells, and could be markedly inhibited by gly-sar. The uptake of Peramivir-(CH_2)_2-l-Val and Peramivir-l-Ile(0.01 to 50 m M) in MDCK-hPEPT1 cells conformed to Michaelis–Menten Equation. The oral bioavailability of peramivir was 65.3% and 37.3% after the oral administration of Peramivir-(CH_2)_2-l-Val and Peramivir-l-Ile to rats, respectively. The oral absorption and bioactivation of Peramivir-(CH_2)_2-l-Val was rapid and extensive, and no Peramivir-(CH_2)_2-l-Val was found in plasma. Because the amide bond was relatively stable, Peramivir-l-Ile could not be totally converted to the parent drug in vivo. Peramivir-(CH_2)_2-l-Val with good oral profiles and rapid bioactivation might be a promising prodrug for the further clinic development. The present study also corroborated the idea that the PEPT1-mediated prodrug approach has enormous promise for improving the oral absorption of poorly absorbed drug. | Yongbing Sun Wei Gan Mingdao Lei Wei Jiang Meng Cheng Junwei He Qi Sun Wan Liu Lvjiang Hu Yi Jin | 2018 | Asian Journal of Pharmaceutical Sciences2018，13，6： | 4 |
| 5 | Simultaneously optimizing pore morphology and enhancing mechanical properties of Al-Si alloy composite foams by graphene nanosheets显示文摘The integrity and regularity of pore morphology play an important role in determining the mechanical properties of the metallic foam materials.The conventional methods on refining pore morphology are mainly focused on the optimization of fabrication techniques,however,they are usually inconvenient and complicated.Recently,incorporating nano reinforcement is considered to be a suitable way to fabricate metallic composite foams accompanied by optimized pore morphology and enhanced mechanical properties.In this work,through a facile and rapid powder metallurgy foaming method,the aluminum-silicon(Al-Si)alloy composite foams reinforced by graphene nanosheets(GNSs)are successfully fabricated.The microstructure analyses reveal that,for the Al-Si alloy foams incorporating the GNSs(GNSs/Al-Si composite foams),the pore size is transformed to be smaller,the pore size distributions become more homogeneous and the pore shape is also refined to a regular and roundish state.Meanwhile,the shape of Si precipitates is found transforming from an irregular long strip(length of~20μm,width of~5μm)to a fine particle state(diameter of~5μm).Moreover,the compressive testing results show that,the 0.4wt%GNSs/Al-Si composite foams own the optimal compression stress of 11.7±0.5 MPa,plateau stress of 10.0±1.0 MPa and energy absorption capacity of 6.8±0.7 MJ/m^(3),which have improvement of 58.1%,53.8%and 51.1%in comparison with the Al-Si alloy foams counterpart,respectively.The present findings may pave a new way for developing new generation of metallic composite foams that with stable microstructure and excellent mechanical performance. | Weiting Li Xudong Yang Kunming Yang Chunnian He Junwei Sha Chunsheng Shi Yunhui Mei Jiajun Li Naiqin Zhao | 2022 | Journal of Materials Science & Technology2022，，6： | 3 |
| 6 | Nano-polycrystalline diamond formation under ultra-high pressure显示文摘 | Chao Xu Duanwei He Haikuo Wang Junwei Guan Chunmei Liu Fang Peng Wendan Wang Zili Kou Kai He Xiaozhi Yan Yan Bi Lei Liu Fengjiao Li Bo Hui | 2013 | International Journal of Refractory Metals and Hard Materials2013，，： | 2 |
| 7 | Nano-polycrystalline diamond formation under ultra-high pres- sure显示文摘 | Chao Xu Duanwei He Haikuo Wang Junwei Guan | 2013 | Journal of Refractory Metals and Hard Materials2013，36，2013： | 1 |
| 8 | A robust activequeue management scheme for network congestion control显示文摘 | Zhou Chuan He Junwei Chen Qingwei | 2013 | Computers and Electrical Engineering2013，39，2： | 1 |
| 9 | Energy Sharing and Frequency Regulation in Energy Network via Mixed H_(2)/H_(∞) Control with Markovian Jump显示文摘In this paper,the problem of mixed optimization for energy sharing and frequency regulation in a typical energy network scenario where energy routers(ERs)interconnected AC microgrids(MGs)is investigated.Continuous-time Markov chains are introduced to describe the switching paths in the power dynamics of MGs.Such that the modelling of considered energy network system could be closer to the real-world engineering practice.Advanced parameter estimation techniques are integrated into the proposed method to achieve better modelling accuracy and controlling performance.Based on the parameters of MG power dynamics,the mixed H_(2)/H_(∞) controllers are obtained via stochastic control theory.The feasibility and efficacy of the proposed approach are evaluated in numerical examples. | Haochen Hua Yuchao Qin Zicheng He Liuying Li Junwei Cao | 2021 | CSEE Journal of Power and Energy Systems2021，7，6： | 1 |
| 10 | Preparation of Lead-free Base Glaze Suitable for Pearlescent Pigments by Low-temperature Solid-phase Reaction with Alkali Waste显示文摘A lead-free base glaze suitable for pearlescent pigments was prepared by a low-temperature solid-phase reaction with alkali waste.Tests were performed to evaluate the effects of the sintering conditions and alkali waste composition on the prepared base glaze and pearlescent glaze.The experimental results show that partially replacing SiO_(2) with B_(2)O_(3) effectively reduced the sintering temperature and time to form a glass network,but the network structure becomes disconnected as the B_(2)O_(3) content increases.An amorphous base glaze was obtained when soda ash was replaced with a small amount of alkali waste,but increasing the addition of NaCl further was adverse to base glaze formation by resulting in crystallization of the base glaze and a decrease in the bridging oxygen content.The pearlescent pigment was thermally stable in the glaze at 750℃,while higher temperatures caused the crystalline phase of NaAlSiO_(4) to appear and adhere to the surface of pigment granules,which degraded the pearlescent effect of the glaze. | 饶黎 HUANG Kang FU Qiong WANG Junwei DAI Li ZHAO Na LI Xiangjun HE Yong ZHOU Yi 陈艳林 | 2022 | Journal of Wuhan University of Technology(Materials Science)2022，37，6： | 1 |
| 11 | Si-Assisted Solidification Path and Microstructure Control of 7075 Aluminum Alloy with Improved Mechanical Properties by Selective Laser Melting显示文摘The construction and application of traditional high-strength 7075 aluminum alloy(Al7075) through selective laser melting(SLM) are currently restricted by the serious hot cracking phenomenon. To address this critical issue, in this study, Si is employed to assist the SLM printing of high-strength Al7075. The laser energy density during SLM is optimized, and the eff ects of Si element on solidification path, relative density, microstructure and mechanical properties of Al7075 alloy are studied systematically. With the modified solidification path, laser energy density, and the dense microstructure with refined grain size and semi-continuous precipitates network at grain boundaries, which consists of fine Si, β-MgSi, Q-phase and θ-AlCu, the hot cracking phenomenon and mechanical properties are eff ectively improved. As a result, the tensile strength of the SLM-processed Si-modified Al7075 can reach 486 ± 3 MPa, with a high relative density of ~ 99.4%, a yield strength of 291 ± 8 MPa, fracture elongation of(6.4 ± 0.4)% and hardness of 162 ± 2(HV) at the laser energy density of 112.5 J/mm~3. The main strengthening mechanism with Si modification is demonstrated to be the synergetic enhancement of grain refinement, solution strengthening, load transfer, and dislocation strengthening. This work will inspire more new design of high-strength alloys through SLM. | Junwei Sha Meixian Li Lizhuang Yang Xudong Rong Bowen Pu Dongdong Zhao Simi Sui Xiang Zhang Chunnian He Jianglin Lan Naiqin Zhao | 2022 | Acta Metallurgica Sinica(English Letters)2022，35，9： | 1 |
| 12 | Hybrid Recommendation Based on Graph Embedding显示文摘In recent years,online reservation systems of country hotel have become increasingly popular in rural areas.How to accurately recommend the houses of country hotel to the users is an urgent problem to be solved.Aiming at the problem of cold start and data sparseness in recommendation,a Hybrid Recommendation method based on Graph Embedding(HRGE)is proposed.First,three types of network are built,including user-user network based on user tag,househouse network based on house tag,and user-user network based on user behavior.Then,by using the method of graph embedding,three types of network are respectively embedded into low-dimensional vectors to obtain the characterization vectors of nodes.Finally,these characterization vectors are used to make a hybrid recommendation.The datasets in this paper are derived from the Country Hotel Reservation System in Guizhou Province.The experimental results show that,compared with traditional recommendation algorithms,the comprehensive evaluation index(F1)of the HRGE is improved by 20% and the Mean Average Precision(MAP)is increased by 11%. | Cheng Zeng Haifeng Zhang Junwei Ren Chaodong Wen Peng He | 2021 | China Communications2021，18，11： | 1 |
| 13 | Quantitative measurements of pressure gradients for the pyrophyllite and magnesium oxide pressure-transmitting mediums to 8?GPa in a large-volume cubic cell显示文摘 | Haikuo Wang Duanwei He Xiaozhi Yan Chao Xu Junwei Guan Ning Tan Wendan Wang | 2011 | High Pressure Research2011，，4： | 1 |
| 14 | Real-time state estimation for spatial six-degree-of-freedom linearly actuated parallel robots显示文摘 | YANG Chifu HE Jingfeng HAN Junwei | 2009 | Mechatronics2009，19，： | 1 |
| 15 | Preventive Effects and Mechanisms of Rhein on Renal Interstitial Fibrosis in Obstructive Nephropathy显示文摘 | Dongyuan He Li Lee Junwei Yang | 2011 | Biol Pharm Bull2011，34，8： | 1 |
| 16 | Image edge detection method based on the direction feature of fuzzy entropy显示文摘 | He Chun Lu Jun Han Junwei | 2010 | ICNC2010，，10： | 1 |
| 17 | Prediction of cognitive scores by joint use of movie-watching fMRI connectivity and eye tracking via Attention-CensNet显示文摘Background:Brain functional connectivity under the naturalistic paradigm has been shown to be better at predicting individual behaviors than other brain states,such as rest and doing tasks.Nevertheless,the state-of-the-art methods have found it difcult to achieve desirable results from movie watching paradigm functional magnetic resonance imaging(mfMRI)-induced brain functional connectivity,especially when there are fewer datasets.Incorporating other physical measurements into the prediction method may enhance accuracy.Eye tracking,becoming popular due to its portability and lower expense,can provide abundant behavioral features related to the output of human's cognition,and thus might supplement the mfMRI in observing participants'subconscious behaviors.However,there are very few studies on how to effectively integrate the multimodal information to strengthen the performance by a unified framework.objective:A fusion approach with mfMRI and eye tracking,based on convolution with edge-node switching in graph neural networks(CensNet),is proposed in this article.Methods:In this graph model,participants are designated as nodes,mfMRI derived functional connectivity as node features,and different eye-tracking features are used to compute similarity between participants to construct heterogeneous graph edges.By taking multiple graphs as different channels,we introduce squeeze-and-excitation attention module to CensNet(A-CensNet)to integrate graph embeddings from multiple channels into one.Results:The proposed model outperforms those using a single modality and single channel,and state-of-the-art methods.Conclusions:The results indicate that brain functional activities and eye behaviors might complement each other in interpreting trait-like phenotypes. | Jiaxing Gao Lin Zhao Tianyang Zhong Changhe Li Zhibin He Yaonei Wei Shu Zhang Lei Guo Tianming Liu Junwei Han Xi Jiang Tuo Zhang | 2023 | Psychoradiology2023，3，1： | 0 |
| 18 | Development of an indirect immunofluorescence assay for PCV3 antibody detection based on capsid protein显示文摘Porcine circovirus type 3(PCV3)is a novel porcine circovirus associated with porcine dermatitis and nephritis syndrome(PDNS),reproductive failure,and multisystemic inflammation.Capsid protein(Cap)encoded by PCV3 ORF2 gene has been identified as an immunogenic protein.Currently,there is no immunofluorescence assay(IFA)available for serological diagnosis.Here,the N-terminal 33 amino acids of Cap protein were predicted to serve as a PCV3 nuclear localization signal(NLS).Two types of recombinant plasmids were constructed for recombinant protein expression in 5f9 cells by using a baculovirus expression system:plasmid rvBac-Pc for full-length Cap protein expression and rvBac-Sc for Cap protein expression with a honeybee melittin signal peptide in place of the predicted NLS sequence.Expression of the nuclear localization sequences was further analyzed by IFA.Strong and specific fluorescence signals were observed in the nucleus of rvBac-Pc-transfected cells and in the cytoplasm of rvBac-Sc-transfected cells.No cross-reactivity was observed with porcine circovirus type 2,porcine pseudorabies virus,classical swine fever virus,or porcine reproductive and respiratory syndrome virus.In summary,we developed two fluorescence detection modes for Cap protein that can be used to detect PCV3 antibodies.This method is suitable for the diagnosis and epidemiological investigation of PCV3.This study provides a reliable detection method for monitoring PCV3 antibody level in pigs in the future. | Lun Yao Chang Li Junwei Wang Yufang Cheng Ahmed H.Ghonaim Qi Sun Xuexiang Yu Weijie Niu Shengxian Fan Qigai He | 2021 | Animal Diseases2021，1，2： | 0 |
| 19 | Discrete element modeling and verification of the simulation parameters for chopped hybrid Broussonetia papyrifera stems显示文摘In this study,the discrete element software EDEM was applied to establish a simulation model of non-uniform-sized particle units for Broussonetia papyrifera stalks,which aimed to address the low utilization rate of existing Broussonetia papyrifera harvesting machinery,the significant variation between the simulated model of Broussonetia papyrifera stalks and their actual appearance,as well as the absence of contact parameter calibration.Through a combination of the free-fall collision method,inclined plane sliding method,and inclined plane rolling method,numerical simulation was conducted to analyze the pattern of variations in contact parameters between Broussonetia papyrifera stalks and the steel material of the machinery.Accordingly,these parameters were calibrated.The results showed that the coefficient of restitution between Broussonetia papyrifera stalks and steel materials was 0.321,the static friction factor was 0.589,and the rolling friction factor was 0.078.With the parameters of contact between Broussonetia papyrifera stalks as variables and the experimentally measured pile angle as the objective of optimization,the steepest ascent experiment and the three-factor five-level rotation combination experiment were conducted.In this way,a second-order response model was constructed to analyze the relationship between the contact parameters and the pile angle.Through the optimization analysis of experimental data,it was determined that the coefficient of restitution between Broussonetia papyrifera stalks was 0.21,the static friction factor was 0.24,and the rolling friction factor was 0.03.Furthermore,the calibration results were validated through experimentation to show that the relative error between the obtained pile angle under the context of optimal parameter combination and the actual one was 4.11%.In addition,the relative error of mass flow rate in spiral transport was within a reasonable range,this study lays a foundation both theoretically and statistically for the simulation of contact parameters for Broussonetia papyrifera stalk harvesting processing,mechanical harvesting,and so on. | Caiwang Peng Junwei Chen Xi He Songlin Sun Yulong Yin Zhong Chen | 2024 | International Journal of Agricultural and Biological Engineering2024，17，1： | 0 |
| 20 | Manipulating mechanical properties of graphene/Al composites by an in-situ synthesized hybrid reinforcement strategy显示文摘The structural deterioration caused by the relatively weak out-of-plane bending stiffness and the chemically-active edge area of graphene limits its outperformance in strengthening for Al matrix composites(AMCs).Introducing one-dimensional(1D)carbon nanotubes(CNTs)to graphene/metal system is one of the promised strategies to complement the weakness of 2D graphene and make full use of the outstanding intrinsic properties of the both reinforcements.To date,such synergistic strengthening and toughening mechanisms are largely unknown.In this study,AMCs reinforced by a novel hybrid reinforcement,i.e.,graphene nanosheets decorated with Cu nanoparticles and CNTs(Cu@GNS-CNTs),are fabricated by an in-situ synthesis method.The combined contrast experiments validated that the organically integrated reinforcing structure promotes the intrinsic load bearing capacity of GNS and the strain hardening capability of the Al matrix simultaneously.As a result,the composites achieved excellent tensile strength and uniform elongation with almost no loss.The strengthening mechanism originated primarily from the hybrid reinforcement exhibits superior load-transfer,fracture inhibition and dislocation storage capability by controlling the interface reaction to construct an effective interface structure without damaging the reinforcement.Our work identifies a promising structural modification strategy for 2D materials and provides mechanistic insights into the synergistic strengthening effect of graphene/CNTs hybrid reinforcement. | Lizhuang Yang Bowen Pu Xiang Zhang Junwei Sha Chunnian He Naiqin Zhao | 2022 | Journal of Materials Science & Technology2022，，28： | 0 |
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