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| 1 | Ovarian cancer stem cells: Can targeted therapy lead to improved progression-free survival?显示文摘Despite significant effort and research funds, epithelial ovarian cancer remains a very deadly disease. There are no effective screening methods that discover early stage disease; the majority of patients are diagnosed with advanced disease. Treatment modalities consist primarily of radical debulking surgery followed by taxane and platinum-based chemotherapy. Newer therapies including limited targeted agents and intraperitoneal delivery of chemotherapeutic drugs have improved disease-free intervals, but failed to yield longlasting cures in most patients. Chemotherapeutic resistance, particularly in the recurrent setting, plagues the disease. Targeting the pathways and mechanisms behind the development of chemoresistance in ovarian cancer could lead to significant improvement in patient outcomes. In many malignancies, including blood and other solid tumors, there is a subgroup of tumor cells, separate from the bulk population, called cancer stem cells(CSCs). These CSCs are thought to be the cause of metastasis, recurrence and resistance. However, todate, ovarian CSCs have been difficult to identify, isolate, and target. It is felt by many investigators that finding a putative ovarian CSC and a chemotherapeutic agent to target it could be the key to a cure for this deadly disease. This review will focus on recent advances in this arena and discuss some of the controversies surrounding the concept. | Christen L Walters Haygood Rebecca C Arend J Michael Straughn Donald J Buchsbaum | 2014 | World Journal of Stem Cells2014，6，4： | 7 |
| 2 | Variability of the mitochondrial control region in populations of the harbour porpoise, Phocoena phocoena, on interoceanic and regional scales 显示文摘 | Rosel P E Dizon A E Haygood M G | 1995 | Can J Fish Aquat Sci1995，52，： | 2 |
| 3 | Phylogenetic relationship among the true porpoise ( Cetacean phocoenidae)显示文摘 | Rosel P E Haygood M G Perrin W F | 1995 | Mol Phyl Evol1995，4，4： | 1 |
| 4 | Variability of the mitochondrial control region in population of the harbour porpoise Phocoena phocoena on interoceanic and regional scales显示文摘 | Rosel P E Dizon A E Haygood M G | 1995 | Canadian Journal of Fisheries and Aquatic Sciences1995，52，6： | 1 |
| 5 | Phylogenetic relationship among the true porpoise(Cetacean phocoenidae)显示文摘 | Rosel P E Haygood M G Perrin W F | 1995 | Mol Phyl Evol1995，4，4： | 1 |
| 6 | C-Type cytochromes andmanganese oxidation in Pseudom onas putida MnB1 显示文摘 | Ron C Bradley M T Haygood M G | 1998 | App l EnvironMicrobiol1998，64，10： | 1 |
| 7 | Phylogenetic Relationships among the True Porpoises (Cetacea:Phocoenidae)显示文摘 | Rosel P E Haygood M G Pervin W F | 1995 | Molecular Phylogenetics and Evolution1995，4，4： | 1 |
| 8 | 'Candidatus Endobugula glebosa,' a specific bacterial symbiont of the marine bryozoan Bugula simplex显示文摘 | Lim G E Haygood M G | | 0，，08： | 1 |
| 9 | A rando-mized,prospective trial of standard Hickman compared with Groshong central venous catheters in pediatric oncology patients显示文摘 | Warner BW Haygood MM Davies SL | 1996 | J Am Coll Surgeons1996，183，2： | 1 |
| 10 | Phylogenetic relation- ship among the true porpoise(Cetacean: Phocoenidae)显示文摘 | Rosel P E Haygood M G Perrin W F | 1995 | Mol Phyl Evol1995，4，4： | 1 |
| 11 | Phylogenetic relationships among the true porpoises (Cetacea: Pho- coenidae)显示文摘 | Rosel P E Haygood M G Perrin W F | 1995 | Mol Biol Evo11995，4，4： | 1 |
| 12 | Enhanced DNA extraction and PCR amplification of mitochondrial genes from museum specimens 显示文摘 | Bentzen P Shedlock A Haygood M | 1997 | Biotechniques1997，22，3： | 1 |
| 13 | Skeletal muscle metastases : a three-part study of a not-so-rare entity显示文摘 | Haygood TM Wong J Lin JC | 2012 | Skeletal Radiol2012，7，： | 1 |
| 14 | Phylogenetic relationships among the true porpoises (Cetacea: Phocoenidae)显示文摘 | ROSEL P E HAYGOOD M G PERRIN W F | 1995 | Molecular Phylogenetics and Evolution1995，4，4： | 1 |
| 15 | Migration of central lines fromthe superior vena cava Io the azygous win显示文摘 | Haygood TM Malhotra K Ng C | 2012 | Clin Radiol2012，67，1： | 1 |
| 16 | Phylogenetic relationships among the true porpoises (Cetacea: Phocoenidae ) 显示文摘 | Rosel P E Haygood M G Perrin W F | 1995 | Molecular Phylogenetics and Evolution1995，4，4： | 1 |
| 17 | PhyIogenetic relationshipsamong the true porpoises(Cetocea:Phocoenidae)显示文摘 | Rosel P E Haygood M G Perrin W F | 1995 | Mol PhylogenetEvol1995，4，4： | 1 |
| 18 | Variability of the mitochon- drial control region in population of the harbour porpoise, Phocoe- na phocoena, on intereceanic and regional scales显示文摘 | Rosel P E Dizon A E Haygood M G | 1995 | Can J Fish Aquat Sci1995，52，： | 1 |
| 19 | Phylogenetic relationship among the true porpoise ( Cetacean: Phocecnidae) 显示文摘 | Rosel P E Haygood M G Perrin W F | 1995 | Molecular Phylogenetics and Evolution1995，4，4： | 1 |
| 20 | Phylogenetic relationship among the true porpoise ( Cetacean: Phocoenidae) 显示文摘 | ROSEL P E HAYGOOD M G PERRIN W F | 1995 | Mol Phyl Evol1995，4，4： | 1 |
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