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| 1 | Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population:Role of serine protease inhibitor Kazal 1type and alcohol显示文摘AIM: To test the hypothesis that calcium sensing receptor (CASR) polymorphisms are associated with chronic pancreatitis (CP), and to determine whether serine protease inhibitor Kazal 1type (SPINK1) N34S oralcohol are necessary co-factors in its etiology. METHODS: Initially, 115 subjects with pancreatitis and 66 controls were evaluated, of whom 57 patients and 21 controls were predetermined to carry the high-risk SPINK1 N34S polymorphism. We sequenced CASR gene exons 2, 3, 4, 5 and 7, areas containing the majority of reported polymorphisms and novel mutations. Based on the initial results, we added 223 patients and 239 controls to analyze three common nonsynonymous single nucleotide polymorphisms (SNPs) in exon 7 (A986S, R990G, and Q1011E). RESULTS: The CASR exon 7 R990G polymorphism was signifi cantly associated with CP (OR, 2.01; 95% CI, 1.12-3.59; P = 0.015). The association between CASR R990G and CP was stronger in subjects who reported moderate or heavy alcohol consumption (OR, 3.12; 95% CI, 1.14-9.13; P = 0.018). There was no association between the various CASR genotypes and SPINK1 N34S in pancreatitis. None of the novel CASR polymorphisms reported from Germany and India was detected. CONCLUSION: Our United States-based study confirmed an association of CASR and CP and for the first time demonstrated that CASR R990G is a signifi cant risk factor for CP. We also conclude that the risk of CP with CASR R990G is increased in subjects with moderate to heavy alcohol consumption. | Venkata Muddana Janette Lamb Julia B Greer Beth Elinoff Robert H Hawes Peter B Cotton Michelle A Anderson Randall E Brand Adam Slivka David C Whitcomb | 2008 | World Journal of Gastroenterology2008，14，28： | 7 |
| 2 | Predictors of survival for esophageal cancer patients with and without celiac axis lymphadenopathy: impact of staging endosonography显示文摘 | Mohamad A Eloubeidi Michael B Wallace Brenda J Hoffman Margaret B Leveen Annette Van Velse Robert H Hawes Carolyn E Reed | 2001 | The Annals of Thoracic Surgery2001，，1： | 1 |
| 3 | ADH levels following nonhypotensive hemorrhage in dogs with chronic mireal stenosis显示文摘 | Zehr J E Hawe A Tsakiris A G | 1971 | Am J Physiol1971，221，1： | 1 |
| 4 | Fate and effects of enrofloxacin in aquatic systems under different light conditions 显示文摘 | Knapp C W Cardoza L A Hawes J N | 2005 | Environmental Science & Technology2005，39，23： | 1 |
| 5 | Investigation of the ther-mal performance of a passive solar test-room with wall latent heat storage显示文摘 | Athienitis A K Liu C Hawes D | 1997 | Building and Environment1997，32，5： | 1 |
| 6 | Inheritance of resistance to Fusarium Sulphureum 显示文摘 | Lees A K Brads haw J E | 2001 | Potato Research2001，44，2： | 1 |
| 7 | Standard endoscopy with random biopsies versus narrow hand imaging targeted biopsies in Barrett's esophagus: a prospective, international, randomised controlled trial 显示文摘 | Sharma P Hawes R H Bansal A | 2013 | Gut2013，62，1： | 1 |
| 8 | Investigation of the thermal performance of a passive solar test room with wall latent heat storage 显示文摘 | Athienitis A K Liu C Hawes D W | 1997 | Buliding and Environment1997，32，5： | 1 |
| 9 | The identification of vagi- nal Lactobacillus species and the demographic and microbiologic char- acteristics of women colonized by these species 显示文摘 | ANTONIO M A HAWES S E HILLIER S L | 1999 | J Infect Dis1999，180，6： | 1 |
| 10 | LatePleistocence Raised Beaches of Coastal Estremadura,Central Portugal 显示文摘 | Benedetti M M Haws J A Funk C L | 2009 | Quaternary Science Reviews2009，28，： | 1 |
| 11 | Detection of hypermethylated genes in women with and without cervical neoplasia显示文摘 | Feng Q Balasubramanian A Hawes SE | 2005 | J Natl Cancer Inst2005，97，4： | 1 |
| 12 | Reflectance model for quantifying chlorophyll a in the presence of productivity degradation products 显示文摘 | Carder K L Hawes S K Baker K A | 1991 | Journal of Geophysical Research1991，96，20： | 1 |
| 13 | An in situSolid-State study of the formation and reactivity of trial-kylonium Ions in zeolites显示文摘 | Munson E J Khier A A Haw J F | 1993 | J Phys Chem1993，97，： | 1 |
| 14 | Investigation of the thermal performance of a passive solar test-room with wall latent heat storage显示文摘 | ATHIENITIS A K LIU C HAWES D | 1997 | Build Environ1997，32，： | 1 |
| 15 | Production of gas from water-flood residual oil:gas saturation build-up and relative permeabili-ties显示文摘 | Grattoni C A Hawes R I Dawe R A | 2001 | Petroleum Geoscience2001，7，2： | 1 |
| 16 | Investigation of thethermal performance of a passive solar test-room with walllatent heat storage显示文摘 | Athienitis A K Liu C Hawes D | 1997 | Building and Environment1997，32，5： | 1 |
| 17 | In situ solid-state NMR study of methanol-to-gasoline chemistry in zeolite HZSM-5 显示文摘 | MUNSON E J KHEIR A A LAZO N D HAW J F | 1992 | J Phys Chem1992，96，19： | 1 |
| 18 | Reducing one million child deaths from birth asphyxia- a survey of health systems gaps and priorities显示文摘 | Lawn JE Manandhar A Haws RA | 2007 | Health Res Policy Syst2007，5，： | 1 |
| 19 | Investi-gation of the thermal performance of a passive solar test-roomwith wall latent heatstorage 显示文摘 | Athienitis A K Liu C Hawes D | 2007 | Building Environment2007，32，： | 1 |
| 20 | Serum amyloid P colocalizes with apolipoproteins in human atheroma:functional implications显示文摘 | Stewart C R Haw A 3rd Lopez R | | 0，，10： | 1 |
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