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190篇 您的检索式：作者名="Hatton R"

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	题名	作者	年代	出处	被引量
1	Characterization of two rat models of cystic fibrosis—KO and F508del CFTR—Generated by Crispr-Cas9显示文摘Background: Genetically engineered animals are essential for gaining a proper understanding of the disease mechanisms of cystic fibrosis(CF). The rat is a relevant laboratory model for CF because of its zootechnical capacity, size, and airway characteristics, including the presence of submucosal glands.Methods: We describe the generation of a CF rat model(F508 del) homozygous for the p.Phe508 del mutation in the transmembrane conductance regulator(Cftr) gene. This model was compared to new Cftr-/-rats(CFTR KO). Target organs in CF were examined by histological staining of tissue sections and tooth enamel was quantified by micro-computed tomography. The activity of CFTR was evaluated by nasal potential difference(NPD) and short-circuit current measurements. The effect of VX-809 and VX-770 was analyzed on nasal epithelial primary cell cultures from F508 del rats.Results: Both newborn F508 del and Knock out(KO) animals developed intestinal obstruction that could be partly compensated by special diet combined with an osmotic laxative. The two rat models exhibited CF phenotypic anomalies such as vas deferens agenesis and tooth enamel defects. Histology of the intestine, pancreas, liver, and lungs was normal. Absence of CFTR function in KO rats was confirmed ex vivo by short-circuit current measurements on colon mucosae and in vivo by NPD, whereas residual CFTR activity was observed in F508 del rats. Exposure of F508 del CFTR nasal primary cultures to a combination of VX-809 and VX-770 improved CFTR-mediated Cl-transport.Conclusions: The F508 del rats reproduce the phenotypes observed in CFTR KO animals and represent a novel resource to advance the development of CF therapeutics.	Elise Dreano Marc Bacchetta Juliette Simonin Louise Galmiche Claire Usal Lotfi Slimani Jérémy Sadoine Laurent Tesson Ignacio Anegon Jean-Paul Concordet Aurélie Hatton Lucile Vignaud Danielle Tondelier Isabelle Sermet-Gaudelus Marc Chanson Charles-Henry Cottart	2019	Animal Models and Experimental Medicine2019，2，4：	3
2	Interleukin 17-producing CD4+ effector T cells develop via a liesge distinct from The T helper type 1 and lineages显示文摘	Harrington L E Hatton R D Mangan P R	2005	Nat Immunol2005，6，11：	1
3	Interleulein 17-producing CD4+ effector T cells develop via a lineage distinct from the Thelper type 1 and 2 lineages显示文摘	Harrington L E Hatton R D Mangan P R	2005	Nat Immunol2005，6，1：	1
4	Regulatory T cell suppression and anergy are differentially regulated by proinflammatory cytokines produced by TLR-activated dendritic cells 显示文摘	KUBO T HATTON R D OLIVER J	2004	J Immunol2004，173，12：	1
5	Developmental plasticity of Thl7 and Treg cells显示文摘	Lee YK Mukasa R Hatton RD	2009	Curr Opin Immunol2009，21，3：	1
6	The Thl7 family: flexibility fol- lows function显示文摘	Basu R Hatton RD Weaver CT	2013	Immunol Rev2013，252，1：	1
7	Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages显示文摘	Harrington L E Hatton R D Mangan P R	2005	Nat Immunol2005，6，11：	1
8	Interleukin17producing CD4+effector T cells develop via a lineage distinct from the T helper types1and2lineages显示文摘	Harrington L E Hatton R D Mangan P R	2005	Nat Immunol2005，6，11：	1
9	Estimating stand water use of large mountain ash trees and validation of the sap flow measurement technique显示文摘	Vertessy R A Hatton T J Reece P	1997	Tree Physiology1997，17，：	1
10	Transpiration of plantation pinus radiate estimated by the heat pulse method and Bowen Ratio 显示文摘	Hatton T J R A Vertessy	1990	Hydrological Processes1990，4，：	1
11	Integration of sap flow velocity to estimate plant water use显示文摘	Hatton T J Catchpole E A Vertessy R A	1990	Tree Physiology1990，6，2：	1
12	Long-term growth and water balance predictions for a mountain ash (Eucalyptus regnans)forest catchment subject to clear-felling and regeneration显示文摘	Vertessey R A Hatton T J Benyon R J	1996	Tree Physiology1996，16，：	1
13	Developmental plasticity of Thl7 and Treg cells 显示文摘	Lee Y K Mukasa R Hatton R D	2009	Curr Opin Immunol2009，21，3：	1
14	Enhanced hole injection in organic light-emitting diodes using a SAMderivatised ultra-thin gold anode supported on ITO glass显示文摘	Hatton R A Willis M R Chesters M A		0，，01：	1
15	Specific problem associatedwith enteral nutrition in patients with head injury 显示文摘	Rapp R Hatton J Ott L	1993	ClinNutr1993，，：	1
16	Interleukin 17-producing CD4 effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages显示文摘	HARRINGTON L E HATTON R D MANGAN P R	2005	Nat Immunol2005，6，：	1
17	Interleukin 17-producing CD4^+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages显示文摘	Harrington L E Hatton R D Mangan P R	2005	Nat Immunol2005，6，：	1
18	Angiotensin II is generated from angiotensin I by bone cells and stimulates osteoclastic bone resorption in vitro显示文摘	Hatton R Stimpel M Chambers TJ	1997	J Endocrinol1997，152，1：	1
19	Estimating stand water use of large mountain ash trees and validation of the sap flow measurement technique 显示文摘	Vertessy R A Hatton T J Reece P	1997	Tree Physiology1997，17，：	1
20	Intedeu- kinl7 Producing CD4 + ef - fect T cells develop via a lineage distinct from the T helper type 1 and 2 lineag - es 显示文摘	Harrington L E Hatton R D Mangan P R	2005	Nat Immunol2005，6，11：	1

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