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| 1 | Should antibiotics be administered before arthroscopic knee surgery? A systematic review of the literature显示文摘AIM To explore the current evidence surrounding the administration of prophylactic antibiotics for arthroscopic knee surgery. METHODS Databases were searched from inception through May of 2018 for studies examining prophylactic antibiotic use and efficacy in knee arthroscopy. Studies with patient data were further assessed for types of arthroscopic procedures performed,number of patients in the study,use of antibiotics,and outcomes with the intention of performing a pooled analysis. Data pertaining to 'deep tissue infection' or 'septic arthritis' were included in our analysis. Reported data on superficial infection were not included in our data analysis. For the pooled analysis,a relative risk ratio was calculated and χ~2 tests were used to assess for statistical significance between rates of infection amongst the various patient groups. Post hoc power analyses were performed to compute the statistical power obtained from our sample sizes. Number needed to treat analyses were performed for statistically significant differences by dividing 1 by the difference between the infection rates of the antibiotic and no antibiotic groups. An alpha value of 0.05 was used for our analysis. Study heterogeneity was assessed by Cochrane's Q test as well as calculation of the I^2 value.RESULTS A total of 49682 patients who underwent knee ar-throscopy for a diverse set of procedures across 19 studies met inclusion critera for pooled analysis. For those not undergoing graft procedures,there were 27 cases of post-operative septic arthritis in 34487 patients(0.08%) who received prophylactic antibiotics and 16 cases in 10911(0.15%) who received none [risk ratio(RR) = 0.53,95% confidence interval(CI): 0.29-0.99,P = 0.05]. A sub-group analysis in which bony procedures were excluded was performed which found no significant difference in infection rates between patients that received prophylactic antibiotics and patients that did not(P > 0.05). All anterior cruciate ligament reconstruction studies used prophylactic antibiotics,but two studies investigating the effect of soaking the graft in vancomycin in addition to standard intravenous(IV) prophylaxis were combined for analysis. There were 19 cases in 1095 patients(1.74%) who received IV antibioitics alone and no infections in 2034 patients who received IV antibiotics and had a vancomycin soaked graft(RR = 0.01,95%CI: 0.001-0.229,P < 0.01).CONCLUSION Prophylactic antibiotics are effective in preventing septic arthritis following simple knee arthroscopy. In procedures involving graft implantation,graft soaking reduces the rate of infection. | John Carney Nathanael Heckmann Erik N Mayer Ram K Alluri Carleton Thomas Vangsness George F Hatch Ⅲ Alexander E Weber | 2018 | World Journal of Orthopedics2018，9，11： | 2 |
| 2 | Quantification of basal and stimulated ROS levels as predictors of islet potency and function显示文摘 | AMANN B HANSON M S HATCH E | 2007 | Am J Transplant2007，7，1： | 1 |
| 3 | Reproductive and Hormonal Factors and Risk of Brain Tumor in Adult Females显示文摘 | Hatch E E Linet M S Zhang J Y | 2005 | Int J Cancer2005，114，： | 1 |
| 4 | C3a mediates epithelial-to-mesenchymal transition in proteinuric nephropathy显示文摘 | Tang Z Lu B Hatch E | 2009 | J AmSoc Nephrol2009，20，3： | 1 |
| 5 | Quantification of basal and stimulated ROS levels as predictors of islet potency and function显示文摘 | Amann B Hanson MS Hatch E | 2007 | Am J Transplant2007，7，1： | 1 |
| 6 | The life cycle of eentrioles显示文摘 | Hatch E Steams T | 2010 | Cold Spring Harb Syrup Quant Biol2010，75，： | 1 |
| 7 | Quantifying Surface Water-Groundwater Interactions Using Time Series Analysis of Streambed Thermal Records:Method Development显示文摘 | Hatch C E Fisher A T Revenaugh J S | 2006 | Water Resources Research2006，42，10： | 1 |
| 8 | 显示文摘 | Hatch E Zanotti B | 1999 | Metal Finishing1999，97，3： | 1 |
| 9 | A compact 3D imaging laser radar system using Geiger-mode APD arrays: system and measurements显示文摘 | MARINO R M STEPHENS T HATCH R E | 2003 | SPIE2003，5086，： | 1 |
| 10 | Enteric oxalate elimi- nation is induced and oxalate is normalized in a mouse model of primary hyperoxaluria following intestinal colonization with Ox- alobacter显示文摘 | Hatch M Gjymisbka A Salido E C | 2011 | Am J Physiol Gastrointest Liver Physiol2011，300，3： | 1 |
| 11 | Esthetic preferences of European American,Hispanic American,Japanese,and African judges for soft-tissue profiles显示文摘 | Nomura M Motegi E Hatch JP | | 0，，4： | 1 |
| 12 | Continued follow-up of pregnancy outcomes in diethylstilbestrol-exposed offspring显示文摘 | Kaufman RH Adam E Hatch EE | 2000 | Obstet Gynecol2000，96，4： | 1 |
| 13 | Theories of social honor显示文摘 | Hatch E | 1989 | American Anthropologist1989，91，2： | 1 |
| 14 | C3a mediates epithelial-to- mesenchymal transition in proteinuric nephropathy 显示文摘 | Tang Z Lu B Hatch E | 2009 | J Am Soc Nephrol2009，20，3： | 1 |
| 15 | Childhood exposure to magnetic fields : residential area measurements compared to personal dosimetry 显示文摘 | Friedman DR Hatch E Tarone R | 1996 | Epidemiol1996，7，： | 1 |
| 16 | Quantification of basal and stimulated ROS levels as predictors of islet potency and function显示文摘 | Amann B Hanson MS Hatch E | 2007 | Am J Transplant2007，7，1： | 1 |
| 17 | Mouse A6-positive hepatic oval cells also express several hematopoietic stem cell markers显示文摘 | PETERSEN B E GROSSBARD B HATCH H | 2003 | Hepatology2003，37，： | 1 |
| 18 | Regional fluid flow as a factor in the thermal history of the Illinois basin : Constraints from fluid inclusions and the maturity of Penn- sylvanian coals 显示文摘 | Rowan E L Goldhaber M B Hatch J R | 2002 | AAPG Bulletin2002，86，2： | 1 |
| 19 | Mouse A6 -positive hepatie oval cells also express several hematopoietic stem cell markers 显示文摘 | PETERSEN B E GROSSBARD B HATCH H | 2003 | Hepatology2003，37，3： | 1 |
| 20 | FGF signaling in craniofacial biologicalcontrol and pathological craniofacial development 显示文摘 | Hatch N E | 2010 | Crit Rev Eukaryot Gene Expr2010，20，4： | 1 |
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