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| 1 | The past, current and future trends in DNA vaccine immunisations显示文摘This review focuses on DNA vaccines, denoting the last two decades since the early substantiation of preclinical protection was published in Science in 1993 by Ulmer et al. In spite of being safely administered and easily engineered and manufactured DNA vaccine, it holds the future prospects of immunization by inducing potent cellular immune responses against infectious and non-infectious diseases. It is well documented that injection of DNA plasmid encoding a desired gene of interest can result in the subsequent expression of its products and lead to the induction of an immune response within a host. This is pertinent to prophylactic and therapeutic vaccination approach when the peculiar gene produces a protective epitope from a pathogen. The recent studies demonstrated by a number of research centers showed that these immune responses evoke protective immunity against several infectious diseases and cancers, which provides adequate support for the use of this approach. We attempt in this review to provide an informative and unbiased overview of the general principles and concept of DNA vaccines technology with a summary of a novel approach to the DNA vaccine, present investigations that describe the mechanism(s) of protective immunity provoked by DNA immunization and to highlight the advantages and disadvantages of DNA immunisation. | Sidgi Syed Anwer Abdo Hasson Juma Khalifa Zayid Al-Busaidi Talal Abdulmalek Sallam | 2015 | Asian Pacific Journal of Tropical Biomedicine2015，5，5： | 7 |
| 2 | 真空预压法及真空-堆载联合预压法的室内试验研究显示文摘通过室内试验,研究了试样在模拟的堆载预压、真空预压、真空-堆载联合预压以及各向等压4种情况下土体的固结变形特性。结果表明,在真空预压模拟试验情况下,试样的变形、加固情况等指标与各向等压模拟试验下的情况很接近,即:试样的竖向变形小于堆载预压模拟试验情况下试样的竖向变形,土性改善程度要优于堆载预压的情况。而真空-堆载联合预压模拟情况下,试样的竖向变形大于真空预压的情况,加固效果好于堆载预压的情况,总体上具有更好的加固效果。 | 彭劼 刘汉龙 丰土根 Ali Hasson | 2005 | 岩土力学2005，26，S2： | 7 |
| 3 | 长江流域侵蚀产沙尺度效应的区域分异显示文摘以长江流域水文站点的观测数据为依据,基于一定的分区原则,将整个长江流域分成了8个区域,对所有分区产沙模数的尺度效应进行了深入分析。研究表明,所有分区产沙模数的尺度效应可以概括为三类:产沙模数随流域面积的增大而减小,或先减小后基本保持不变的,主要包括长江中下游干流沿岸区域,岷江主体区域,洞庭湖流域和鄱阳湖流域;产沙模数随流域面积的增大基本保持不变的,包括嘉陵江主体区域和汉江流域;产沙模数随流域面积增大而增大,或先增大后基本保持不变的,包括长江上游干流沿岸的非泥石流区域和乌江流域。不同流域尺度效应的差异主要与流域土地利用方式有关。基于各分区校正方程,将所有站点进行了标准面积为100 km2,1 000 km2,10 000 km2的尺度校正,结果表明,当校正面积为100 km2,侵蚀最强烈的区域主要是岷江流域,其次是鄱阳湖和洞庭湖流域,校正面积为1 000 km2和10 000 km2,产沙模数图变化不显著,但明显区别于校正面积为100km2下的产沙模数图。侵蚀最强烈的区域主要是嘉陵江流域,其次是长江上游干流沿岸的部分区域和汉江流域的部分区域。不同校正面积下产沙模数图的变化,显示了不同流域侵蚀来源的差异。 | 闫云霞 许炯心 Marwan Hasson 廖建华 | 2011 | 山地学报2011，29，2： | 5 |
| 4 | DESTRUCTION OF ANTI-SCALANTS IN RO CONCENTRATES BY ELECTROCHEMICAL OXIDATION显示文摘 | 杨庆峰 马紫峰 HASSON David SEMIAT Raphael | 2004 | 化工学报2004，55，2： | 4 |
| 5 | TM6SF2 E167K variant predicts severe liver fibrosis for human immunodeficiency/hepatitis C virus co-infected patients, and severe steatosis only for a non-3 hepatitis C virus genotype显示文摘AIM To evaluate the impact of the Glu167Lys(E167K) transmembrane 6 superfamily member 2(TM6SF2) variant on the biochemical and morphologic expression of liver lesions in human immunodeficiency virus(HIV)/hepatitis C virus(HCV) co-infected patients.METHODS The study comprised 167 consecutive patients with HIV/HCV coinfection and biopsy-proven chronic hepatitis. A pathologist graded liver fibrosis and necroinflammation using the Ishak scoring system, and steatosis using Kleiner's scoring system. Patients were genotyped for TM6SF2 E167K(rs58542926) by real-time Polymerase chain reaction. The 167 patients, 35 therapy-naive and 132 receiving ART, were prevalently males(73.6%), the median age was 40.7 years and the immunological condition good(median CD4+ cells/mm3 = 505.5).RESULTS The 17 patients with the TM6SF2 E167 K variant, compared with the 150 with TM6SF2-E/E, showed higher AST(P = 0.02) and alanine aminotransferase(P = 0.02) and higher fibrosis score(3.1 ± 2.0 vs 2.3 ± 1.5, P = 0.05). In a multivariate analysis, TM6SF2 E167 K was independently associated with severe fibrosis. The same analysis showed that HCV-genotype 3, present in 42.2% of patients was an independent predictor of severe steatosis. The association of TM6SF2 E167 K with severe steatosis, absent for the whole group of 167 patients, was re-evaluated separately for HCVgenotype 3 and non-3 patients: No factor was independently associated with severe steatosis in the HCV-genotype-3 subgroup, whereas an independent association was observed between severe steatosis and TM6SF2 E167 K in non-3 HCV genotypes. No association between the TM6SF2 E167 K variant and severe liver necroinflammation was observed.CONCLUSION In HIV/HCV coinfection the TM6SF2 E167 K variant is an independent predictor of severe fibrosis, but appears to be independently associated with severe steatosis only for patients with a non-3 HCV genotype. | Caterina Sagnelli Marco Merli Caterina Uberti-Foppa Hamid Hasson Anna Grandone Grazia Cirillo Stefania Salpietro Carmine Minichini Mario Starace Emanuela Messina Patrizia Morelli Emanuele Miraglia Del Giudice Adriano Lazzarin Nicola Coppola Evangelista Sagnelli | 2016 | World Journal of Gastroenterology2016，22，38： | 4 |
| 6 | Antibacterial activity of Lawsonia inermis Linn(Henna) against Pseudomonas aeruginosa显示文摘Objective:To investigate the antibacterial activity of henna(Lawsonia inermis Linn) obtained from different regions of Oman against a wide array of micro-organisms.Methods:fresh henna samples were obtained from different regions of Oman as leaves and seeds,100 g fresh and dry leaves and SO g of fresh and dry seeds were separately soaked in 500 mL of ethanol for three days,respectively,with frequent agitation.The mixture was filtered,and the crude extract was collected.The crude extract was then heated,at 48 ℃ in a water bath to evaporate its liquid content.The dry crude henna extract was then tested for its antibacterial activity using well-diffusion antibiotic susceptibility technique.Henna extracts were investigated for their antibacterial activity at different concentrations against a wide array of different micro-organisms including a laboratory standard bacterial strain of Pseudomonas aeruginosa(NCTC 10662)(A aeruginosa) and eleven fresh clinical isolates of P.aeruginosa obtained from patients attending the Sultan Qaboos University Hospital(SQUH).2-Hydroxy-p-Nathoqinone-Tech(2-HPNT, MW=174.16,C_(10)H_40_3) was included as control(at 50%concentration) along with the henna samples tested.Results:Henna samples demonstrated antibacterial activity against all isolates but the highest susceptibility was against P.aeruginosa with henna samples obtained from Al-sharqyia region.Conclusions:Omani henna from Al-sharqyia region demonstrates high in vitro anti-P. aeruginosa activity compared with many henna samples from different regions of Oman. | Habbal O Hasson SS El-Hag AH Al-Mahrooqi Z Al-Hashmi N Al-Bimani Z MS Al-Balushi Al-Jabri AA | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，3： | 3 |
| 7 | Weed management in rice using allelopathic rice varities in Egypt显示文摘 | Hasson SM Rao AN | 1995 | Nature1995，377，： | 2 |
| 8 | Study of the approximate approaches to the POD based spectral representation method显示文摘The spectral representation method (SRM) is most widely used in simulating the stochastic field.The proper orthogonal decomposition (POD) based SRM is an important form.This paper investigates the approximate approaches to the POD-based SRM in simulating two typical problems,i.e.,the seismic ground motion and wind velocity fields simulations.Then,the accuracy resulting from the power spectral density matrix-based POD method (PSRM) is compared to that of the coherency matrix-based POD method (CPSRM).It is concluded that the CPSRM maintains a much higher accuracy than the PSRM.In the CPSRM,the linear interpolation of eigenvectors and third-order polynomial interpolation of eigenvalues can be accepted to attain high accuracy;the linearly distributed interpolation nodes are effective in the ground motions simulation;however,the exponentially distributed interpolation nodes are effective in the wind velocity simulation. | WU YongXin GAO YuFeng LI DaYong XU ChangJie MAHFOUZ Ali Hasson | 2013 | Science China(Technological Sciences)2013，56，4： | 2 |
| 9 | Differential responses to artificial selection on oviposition site preferences in Drosophila melanogaster and D. simulans显示文摘在植物昆虫相互作用的偏爱表演关系是在进化生态学的一个中央主题。在许多昆虫之中,鸡蛋是脆弱的,幼虫限制了活动性,使一个适当 oviposition 地点的选择成为为女性的最重要的决定之一。我们由人工地为 2 个自然资源,葡萄和植物的一种为偏爱选择在果蝇 melanogaster Meigen 和果蝇 simulans Sturtevant 调查了 oviposition 偏爱的进化。我们的学习的主要发现是 D 的微分回答。melanogaster 和 D。simulans。尽管偏爱在 D 的试验性的人口演变。melanogaster,回答不与政体使用了的选择一致。相反,在 D 的回答。simulans 与期望一致,证明这种有为特点的可选的基因变化。而且,在 D 之间交叉。simulans 分叉的线证明涉及葡萄偏爱的基因因素看起来大部分后退。在摘要,我们的人工的选择学习建议那 D。melanogaster 和 D。simulans 为这个特点拥有不同基因体系结构。 | Eduardo M. Soto Maria I. L. Betti Juan Hurtado Esteban Hasson | 2015 | Insect Science2015，22，6： | 2 |
| 10 | 基于特征正交分解谱表示法插值模拟研究显示文摘在对大跨度结构物进行动力荷载,如地震荷载和风荷载,常需要人工模拟随机场.谱表示法是随机场模拟中广泛运用的方法.基于特征正交分解法的随机场模拟方法是谱表示法的一种重要形式.本文分别以震动场的模拟及风场脉动部分的模拟为例,对比分析了基于功率谱矩阵特征正交分解法与基于相干函数正交分解法的插值模拟的精度,得出基于相干函数特征正交分解法的误差要远小于基于功率谱矩阵特征正交分解法的误差;在基于相干函数特征正交分解法中,可以使用较为简单的线性插值代替三次多项式插值来对特征向量进行插值;对于插值频率点布置型式,建议在地震动模拟时使用线性分布而在风场模拟时使用指数分布. | 吴勇信 高玉峰 李大勇 徐长节 MAHFOUZ Ali Hasson | 2013 | 中国科学:技术科学2013，43，6： | 2 |
| 11 | 反渗透脱盐中CaCO3结垢及阻垢的研究显示文摘采用管式反渗透膜,对反渗透脱盐中的CaCO2结垢与阻垢进行了研究.实验采用全循环操作方式进行.实验结果表明,在阻垢剂存在与不存在两种情况下,结垢随溶液LSI的增加而加重,同时阻垢剂可有效地抑制结垢的进行,膜表面的渗透压随运行时间的进行而减小. | 杨庆峰 马紫峰 阎建民 Hasson David Semiat Raphael | 2003 | 化工进展2003，22，z1： | 2 |
| 12 | Evaluation of anti-resistant activity of Auklandia(Saussurea lappa) root against some human pathogens显示文摘Objective:The antimicrobial activity of the ethanol extract of the Auklandia(Saussurea lappa)root plant was investigated to verify its medicinal use in the treatment of microbial infections.Methods:The antimicrobial activity of the ethanol extract was tested against clinical isolates ofsome multidrug-resistant bacteria using the agar well diffusion method.Commercial antibioticswere used as positive reference standards to determine the sensitivity of the clinical isolates.Results:The extracts showed significant inhibitory activity against clinical isolates of methicillinresistantStaphylococcus aureus,Pseudomonas aeruginosa,Escherichia coli,Klebsiella pneumonia,Extended Spectrum Beta-Lactemase,Acinetobacter baumannii.The minimum inhibitory concentration values obtained using the agar dilution test ranged from 2.0μg/μL-12.0μg/μL.In the contrary the water extract showed no activity at all against the tested isolates.Furthermore,theresults obtained by examining anti-resistant activity of the plant ethanolic extract showed thatat higher concentration of the plant extract(12μg)all tested bacteria isolates were inhibited with variable inhibition zones similar to those obtained when we applied lower extract concentrationusing the well diffusion assay.Conclusion:The results demonstrated that the crude ethanolicextract of the Auklandia(Saussurea lappa)root plant has a wide spectrum of activity suggestingthat it may be useful in the treatment of infections caused by the above clinical isolates(humanpathogens). | Sidgi Syed Anwer Hasson Mohammed Saeed Al-Balushi KhazinaAlharthy JumaZaidAl-Busaidi MunaSulimanAldaihani Mohammed Shafeeq Othman Elias Antony Said Omar Habal Talal Abdullah Sallam Ali Abdullah Aljabri Mohamed AhmedIdris | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，7： | 2 |
| 13 | A new RNA-friendly fixative for the preservation of penaeid shrimp samples for virological detection using eDNA genomie probes显示文摘 | Hasson K W Hasson J Aubert H Redman R M Lightner D V | 1997 | J Virol Methods1997，66，2： | 1 |
| 14 | Removal of organic foulants from feed waters by dynamic membranes 显示文摘 | Altman M Semiat R Hasson D | 1999 | Desalination1999，125，13： | 1 |
| 15 | Removal of organic foulants from feed waters by dynamic membranes 显示文摘 | Marc Altman Raphasel Semiat David Hasson | 1999 | Desalination1999，125，： | 1 |
| 16 | Research guidelines for the Delphi sur- vey technique 显示文摘 | Hasson F Keency S Mc KH | 2002 | J Adv Nuts2002，32，： | 1 |
| 17 | Post-stroke depression and functional independence : a conundrum 显示文摘 | Brown C Hasson H Thyselius V eta| | 2012 | Acta Neurol Seand2012，126，1： | 1 |
| 18 | Nursing staff competence,work strain,stress and satisfaction in elderly care:a comparison of home-based care and nursing homes显示文摘 | Hasson H Arnetz J E | 2008 | J Clin Nurs2008，17，4： | 1 |
| 19 | A modified instrument and method for laparoscopy 显示文摘 | HASSON HM | 1971 | Am J Obstet Gynaecol1971，110，： | 1 |
| 20 | Myo6 facilitates the translocation of endocytic vesicles from cell peripheries显示文摘 | ASCHENBRENNER L LEE T T HASSON T | 2003 | Mol Biol Cell2003，14，7： | 1 |
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