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| 1 | 板蓝根低极性流分的分离及其免疫活性显示文摘目的 :进行板蓝根低极性流分及其亚流分的分离 ,并研究其免疫活性。方法 :用快速低压干柱柱层析从板蓝根中分离出一个低极性流分及其一组亚流分 ;用化学发光法检测其对人多形核细胞化学发光的影响。结果 :板蓝根低极性流分具有双向免疫活性 ,在低浓度时具有激活作用 ,在高浓度时具有抑制作用 ;而亚流分的免疫活性并未因其纯度的提高而相应提高。结论 :板蓝根低极性流分及其亚流分含有抗炎成分。 | 秦箐 贺海平 Soren Brogger Christensen Hasse Bonde Rasmussen Arsalan Kharazmi 陈鸣 | 2001 | 中国临床药学杂志2001，10，1： | 30 |
| 2 | 黄芩提取物抗卵巢癌的体外活性研究显示文摘目的 :研究从黄芩中提取获得的化合物黄芩黄酮 A抑制卵巢癌 A2 780细胞生长及对常用抗肿瘤药的体外增效作用。方法 :MTT法测定黄芩黄酮 A的细胞毒作用及与多种抗癌药物作用后对卵巢癌 A2 780细胞的抑制作用 ,集落形成实验观察药物的诱导分化作用 ,PCR- EL ISA试剂盒测定细胞端粒酶活性。结果 :黄芩黄酮 A能抑制 A2 780细胞的增殖 ,其 IC5 0 为 2 0 0 mg/ L,同时黄芩黄酮 A与丝裂霉素 (MMC)、阿霉素 (ADM)、氟尿嘧啶(5 - Fu)、卡铂、羟基喜树碱合用具有相加或协同作用 ,可降低端粒酶活性的表达。结论 :黄芩黄酮 A具有体外抗肿瘤活性 ,对多种化疗药物具有增效作用。 | 秦箐 侯华新 黎丹戎 邱莉 吴华慧 梁永红 Soren Brogger Christensen Hasse Bonde Rasmussen | 2000 | 肿瘤研究与临床2000，12，3： | 13 |
| 3 | 板蓝根高级不饱和脂肪组酸的体外抗人肝癌BEL-7402细胞活性显示文摘目的 :研究板蓝根高级不饱和脂肪组酸体外抗人肝癌BEL 74 0 2细胞的活性。方法 :MTT法测定细胞毒作用 ,集落形成实验观察药物对肝癌细胞增殖的抑制作用 ,PCR ELISA试剂盒测定细胞的端粒酶活性。结果 :板蓝根高级不饱和脂肪组酸能抑制BEL 74 0 2细胞的增殖 ,其IC50 为 0 6mg·mL-1,有促使肿瘤细胞向正常细胞逆转的趋势 ,可降低端粒酶活性的表达。结论 | 侯华新 秦箐 黎丹戎 唐东平 邱莉 吴华慧 Soren BroggerChristensen Hasse Bonde Rasmussen | 2002 | 中国临床药学杂志2002，11，1： | 10 |
| 4 | 永磁导轨上组合与单块YBCO的悬浮力关系研究显示文摘受现有块材尺寸与性能的限制 ,实际应用中总是将许多超导块组合以满足实际需求 .因此 ,研究组合样品与单个样品悬浮力之间的关系对设计磁悬浮系统具有实际意义 .本文研究了永磁导轨上组合样品与单块样品悬浮力之间的关系 .组合样品由 3块矩形融熔织构YBCO块材组成 ,实验分两种方式进行 ,即组合样品平行于永磁导轨和垂直于永磁导轨两种情况 .两种情况的实验结果均表明 ,组合样品的悬浮力与单个样品悬浮力的总和相当 ,平行时的最大悬浮力偏差为 1 4 .0N ,垂直时的最大悬浮力偏差为 4.9N .30mm悬浮间距内的最大悬浮力偏差百分比不超过 6% .因此 ,我们可以根据单个样品的悬浮力来估算各种组合情况时的悬浮力 . | 任仲友 Oliver de Hass 王晓融 宋宏海 王兴志 郑珺 王素玉 王家素 | 2003 | 低温物理学报2003，25，A01： | 7 |
| 5 | Intervention to increase physical activity in irritable bowel syndrome shows long-term positive effects显示文摘AIM: To assess the long-term effects of physical activity on irritable bowel syndrome(IBS) symptoms and on quality of life, fatigue, depression and anxiety.METHODS: Seventy-six patients from a previous randomized controlled interventional study on increased physical activity in IBS were asked to participate in this long-term follow-up study. The included patients attended one visit in which they filled out questionnaires and they underwent a submaximal cycle ergometer test. The primary end point was the change in the IBS Severity Scoring System(IBS-SSS) at baseline, i.e., before the intervention and at follow-up. The secondary endpoints were changes in quality of life, fatigue, depression and anxiety.RESULTS: A total of 39 [32 women, median age 45(28-61) years] patients were included in this followup. Median follow-up time was 5.2(range: 3.8-6.2) years. The IBS symptoms were improved compared with baseline [IBS-SSS: 276(169-360) vs 218(82-328), P = 0.001]. This was also true for the majority of the dimensions of psychological symptoms such as disease specific quality of life, fatigue, depression and anxiety. The reported time of physical activity during the week before the visit had increased from 3.2(0.0-10.0) h at baseline to 5.2(0.0-15.0) h at follow-up, P = 0.019. The most common activities reported were walking, aerobics and cycling. There was no significant difference in the oxygen uptake 31.8(19.7-45.8) m L per min per kg at baseline vs 34.6(19.0-54.6) m L/min per kg at follow-up.CONCLUSION: An intervention to increase physical activity has positive long-term effects on IBS symptoms and psychological symptoms. | Elisabet Johannesson Gisela Ringstrom Hasse Abrahamsson Riadh Sadik | 2015 | World Journal of Gastroenterology2015，21，2： | 6 |
| 6 | 南极冬季威德尔海冰脊的表面形态显示文摘基于2006年南极威德尔海冬季科学考察期间由机载激光测高仪测得的海冰上表面高度数据,以脊高和脊距的理论与实测概率密度的相对误差之和为性能指标,以切断高度为控制变量建立优化模型。结果表明,W'80型分布和对数正态分布分别与实测脊高和脊距分布吻合较好;最优切断高度为0.62 m。进而从海冰表面起伏中确定出冰脊。利用k均值聚类算法以冰脊强度(Ri)为标准将剖面分为3类(Ri≤0.01,0.010.026)。对应各类剖面分别有:平均脊高为0.99 m,1.12 m和1.17 m;平均脊距为232 m,54 m和31 m。利用数学模型估算并分析了多脊冰平均厚度、有效厚度,帆横截面积及冰脊所占面积,这些参数值均随冰脊强度增大而增大。 | 谭冰 李志军 卢鹏 HASS Christian NICOLAUS Marcel | 2012 | 水科学进展2012，23，1： | 5 |
| 7 | 急性心肌梗死桥血管病变急诊介入治疗的临床研究显示文摘目的评价梗死相关血管为静脉桥血管(SVBG)的急性心肌梗死(AMI)患者,进行急诊直接经皮冠状动脉介入治疗(PCI)的有效性及安全性。方法对≥70岁(213例)与<70岁(96例)两组AMI患者介入治疗的临床效果和不良事件进行比较。分析SVBG有效再通比例、住院期间死亡比例及短期临床预后。结果两组患者PCI的技术成功比例、急性再闭塞比例均未见显著差异。但在≥70岁组,PCI后发生慢血流和无血流现象明显为多、住院期间绝对死亡数为多(20vs4)。死亡病例分析显示,90%的死亡病例出现在发生慢血流无血流现象的病例;多次心肌梗死、SVBG连通优势冠状动脉血管、以及连通惟一剩存的SVBG时,发生无血流慢血流后,死亡危险较高。结论老年AMI患者的SVBG病变急诊介入治疗有明确的效果和高的技术成功率。 | 王禹 Hasse KK 盖鲁粤 杨庭树 沈洪 计达 陈练 孙志军 任艺红 | 2005 | 中华老年心脑血管病杂志2005，7，3： | 4 |
| 8 | Identification of osteopontin as the most consistently over-expressed gene in intrahepatic cholangiocarcinoma: Detection by oligonucleotide microarray and real-time PCR analysis显示文摘AIM: To investigate the molecular pathways involved in human cholangiocarcinogenesis by gene expression profiling. METHODS: Oligonucleotide arrays (Affymetrix U133A) were used to establish a specific gene expression profile of intrahepatic CCC in comparison to corresponding non- malignant liver tissue. To validate the expression values of the most overexpressed genes, RT-PCR experiments were performed. RESULTS: Five hundred and fifty-two statistically differentially expressed genes/ESTs (221 probes significantly up-regulated, 331 probes down-regulated; P < 0.05; fold change > 2; ≥ 70%) were identified. Using these data and two-dimensional cluster analysis,a specific gene expression profile was obtained allowing fast and reproducible differentiation of CCC, which was confirmed by supervised neuronal network modelling. The most consistently overexpressed gene (median fold change 33.5, significantly overexpressed in 100%) encoded osteopontin. Furthermore, an association of various genes with the histopathological grading could be demonstrated. CONCLUSION: A highly specific gene expression profile for intrahepatic CCC was identified, allowing for its fast and reproducible discrimination against non- malignant liver tissue and other liver masses. The most overexpressed gene in intrahepatic CCC was the gene encoding osteopontin. These data may lead to a better understanding of human cholangiocarcinogenesis. | Holger G Hass Oliver Nehls Juergen Jobst Andrea Frilling Ulrich Vogel Stephan Kaiser | 2008 | World Journal of Gastroenterology2008，14，16： | 4 |
| 9 | 中药板蓝根两个高极性流分的分离及其活性的研究显示文摘 | 秦箐 贺海平 Soren Brogger Christensen Hasse Bonde Rasmussen Arsalan Kharazmi 陈鸣 | 2001 | 中国药理学通报2001，17，6： | 3 |
| 10 | A characterization of polymethylmethacrylate bone cement显示文摘 | Hass SS Brauer GM Dickson G | 1975 | J Bone Joint Surg1975，57，4： | 3 |
| 11 | Long-term effects of hypnotherapy in patients with refractory irritable bowel syndrome显示文摘 | Perjohan Lindfors Peter Unge Henry Nyhlin Brjánn Ljótsson Einar S. Bj?rnsson Hasse Abrahamsson Magnus Simrén | 2012 | Scandinavian Journal of Gastroenterology2012，，4： | 2 |
| 12 | S3-Leitlinie Kolorektales Karzinom Version 1.0 - Juni 2013 AWMF-Registernummer: 021/007OL显示文摘 | C. Pox S. Aretz S. Bischoff U. Graeven M. Hass P. Heu?ner W. Hohenberger A. Holstege J. Hübner F. Kolligs M. Kreis P. Lux J. Ockenga R. Porschen S. Post N. Rahner A. Reinacher-Schick J. Riemann R. Sauer A. Sieg W. Scheppach W. Schmitt H. Schmoll K. Schulm | 2013 | Z Gastroenterol2013，，08： | 2 |
| 13 | Navier-Stokes Airfoil Computations with Transition Prediction Including Transitional Flow Regions 显示文摘 | Hans W S Hasse W | 2000 | AIAA Journal2000，38，11： | 1 |
| 14 | Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand 显示文摘 | de Sauvage FJ Hass PE Spencer SD | 1994 | Nature1994，369，： | 1 |
| 15 | Cadmium- induced 8-hydroxydeoxyguanosine formation, DNA strand breaks and antioxidant enzyme activities ha lymphoblastoid cells 显示文摘 | Mikhailova M V Littlefield N A Hass B S | 1997 | Cancer Letters1997，115，2： | 1 |
| 16 | Methionine loading test is necessary for detection d hyperhomocysteinemia显示文摘 | Van-der Griend R Hass FJ Dunm M | 1998 | J Lab Clin Med1998，132，： | 1 |
| 17 | Ways to get water: Rainwater utilization or long-distance water supply? A holistic assessment显示文摘 | Herrmann T Hasse K | 1997 | Water Science and Technology1997，36，89： | 1 |
| 18 | Hepatic-portal venous gas in acute colonic diverticulitis 显示文摘 | Zielke A Hasse C Nies C | 1998 | Surg Endosc1998，12，3： | 1 |
| 19 | Vacuum-assisted fascial closure for patients with abdominal trauma 显示文摘 | Stone PA Hass SM Flaherty SK | 2004 | J Trauma2004，57，5： | 1 |
| 20 | MRP3,a new multidrug teansporter显示文摘 | Koll M Van der Linden M de Hass M | 1999 | Proc Am Assoc Cancer Res1999，40，： | 1 |
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