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| 1 | Micro and Nanofabrication methods to control cell-substrate interactions and cell behavior: A review from the tissue engineering perspective显示文摘Cell-substrate interactions play a crucial role in the design of better biomaterials and integration ofimplants with the tissues. Adhesion is the binding process of the cells to the substrate through interactionsbetween the surface molecules of the cell membrane and the substrate. There are severalfactors that affect cell adhesion including substrate surface chemistry, topography, and stiffness. Thesefactors physically and chemically guide and influence the adhesion strength, spreading, shape and fate ofthe cell. Recently, technological advances enabled us to precisely engineer the geometry and chemistry ofsubstrate surfaces enabling the control of the interaction cells with the substrate. Some of the mostcommonly used surface engineering methods for eliciting the desired cellular responses on biomaterialsare photolithography, electron beam lithography, microcontact printing, and microfluidics. Thesemethods allow production of nano- and micron level substrate features that can control cell adhesion,migration, differentiation, shape of the cells and the nuclei as well as measurement of the forces involvedin such activities. This review aims to summarize the current techniques and associate these techniqueswith cellular responses in order to emphasize the effect of chemistry, dimensions, density and design ofsurface patterns on cell-substrate interactions. We conclude with future projections in the field of cellsubstrateinteractions in the hope of providing an outlook for the future studies. | Menekse Ermis Ezgi Antmen Vasif Hasirci | 2018 | Bioactive Materials2018，3，3： | 13 |
| 2 | Levels of matrix metalloproteinase-1 and tissue inhibitors of metalloproteinase-1 in gastric cancer显示文摘AIM:To evaluate the levels of preoperative serum matrix metalloproteinase-1 (MMP-1) and tissue inhibitor of metalloproteinase-1 (TIMP-1) in gastric cancer.METHODS:One hundred gastric cancer patients who underwent gastrectomy were enrolled in this study.The serum concentrations of MMP-1 and TIMP-1 in these patients and in fifty healthy controls were determined using an enzyme-linked immunosorbent assay.RESULTS:Higher serum MMP-1 and TIMP-1 levels were observed in patients than in controls (P < 0.001).Serum MMP-1 and TIMP-1 levels were positively associated with morphological appearance,tumor size,depth of wall invasion,lymph node metastasis,liver metastasis,perineural invasion,and pathological stage.They were not significantly associated with age,gender,tumor location,or histological type.CONCLUSION:Increased MMP-1 and TIMP-1 were associated with gastric cancer.Although these markers are not good markers for diagnosis,these markers show in advanced gastric cancer. | Ozgur Kemik Ahu Sarbay Kemik Aziz Sümer Ahmet Cumhur Dulger Mine Adas Huseyin Begenik Ismail Hasirci Ozkan Yilmaz Sevim Purisa Erol Kisli Sefa Tuzun Cetin Kotan | 2011 | World Journal of Gastroenterology2011，17，16： | 10 |
| 3 | Human adipose derived stem cells are superior to human osteoblasts (HOB) in bone tissue engineering on a collagen-fibroin-ELR blend显示文摘The ultrastructure of the bone provides a unique mechanical strength against compressive, torsional andtensional stresses. An elastin-like recombinamer (ELR) with a nucleation sequence for hydroxyapatitewas incorporated into films prepared from a collagen-silk fibroin blend carrying microchannel patternsto stimulate anisotropic osteogenesis. SEM and fluorescence microscopy showed the alignment ofadipose-derived stem cells (ADSCs) and the human osteoblasts (HOBs) on the ridges and in the groovesof microchannel patterned collagen-fibroin-ELR blend films. The Young's modulus and the ultimatetensile strength (UTS) of untreated films were 0.58 ± 0.13 MPa and 0.18 ± 0.05 MPa, respectively. After 28days of cell culture, ADSC seeded film had a Young's modulus of 1.21 ± 0.42 MPa and UTS of0.32 ± 0.15 MPa which were about 3 fold higher than HOB seeded films. The difference in Young'smodulus was statistically significant (p: 0.02). ADSCs attached, proliferated and mineralized better thanthe HOBs. In the light of these results, ADSCs served as a better cell source than HOBs for bone tissueengineering of collagen-fibroin-ELR based constructs used in this study. We have thus shown theenhancement in the tensile mechanical properties of the bone tissue engineered scaffolds by usingADSCs. | Esen Sayin Rosti Hama Rashid JoséCarlos Rodríguez-Cabello Ahmed Elsheikh Erkan Türker Baran Vasif Hasirci | 2017 | Bioactive Materials2017，2，2： | 2 |
| 4 | Thermal and mechanical pro-perties of hydroxyapatite impregnated acrylic bone cements 显示文摘 | K Serbetci F Korkusuz N Hasirci | 2004 | Polymer Testing2004，23，： | 1 |
| 5 | Iron(Ⅲ) ion removal from solution through adsorption on chitosan 显示文摘 | BURKE A YILMAZ E HASIRCI N | 2002 | Journal of Applied Polymer Science2002，84，6： | 1 |
| 6 | Systematically organized nano- pillar arrays reveal differences in adhesion and alignment properties of BMSC and Saos-2 cells 显示文摘 | Ozqelik H Padeste C Hasirci V | 2014 | Colloids Surf B Biointerfaces2014，119，： | 1 |
| 7 | Preparation and characterization of crosslinked gelatin microspheres显示文摘 | Akin H Hasirci N | 1995 | Applied Polymer Sci1995，58，1： | 1 |
| 8 | Nanobiomaterials: a review the existing science and technology and new approaches 显示文摘 | Hasirci V Vrana E Zorlutuna P | 2006 | Journal of Biomaterials Science - Polymer Edition2006，17，11： | 1 |
| 9 | Determination of binary pesticide mixtures by an acetylcholinesterase-choline oxidase biosensor显示文摘 | Kok F N Hasirci V | 2004 | Biosensors and Bioelectronics2004，19，： | 1 |
| 10 | Polyester based nerve guidance conduit design显示文摘 | Yucel D Kose GT Hasirci V | | 0，，： | 1 |
| 11 | Sequential BMP-2/BMP-7 delivery from polyester nanocapsules显示文摘 | Yilgor P Hasirci N Hasirci V | 2010 | J Biomed Mater Res Part A2010，93，2： | 1 |
| 12 | Iron (Ⅲ) ion removal from solution through adsorption on chitosan显示文摘 | BURKE A YILMAZ E HASIRCI N | 2002 | Journal of Applied Polymer Science2002，84，6： | 1 |
| 13 | The role of multiple toll- like receptor signalling cascades on interactions between biome- dical polymers and dendritic cells 显示文摘 | Shokouhi B Coban C Hasirci V | 2010 | Biomaterials2010，31，22： | 1 |
| 14 | Outcome of surgical treatment of intestinal perforation in typhoid fever显示文摘AIM:To represent our clinical experience in the treatment of intestinal perforation arising from typhoid fever.METHODS:The records of 22 surgically-treated patients with typhoid intestinal perforation were evaluated retrospectively.RESULTS:There were 18 males and 4 females,mean age 37 years(range,8-64 years).Presenting symptoms were fever,abdominal pain,diarrhea or constipation.Sixteen cases were subjected to segmental resection and end-to-end anastomosis,while 3 cases received 2-layered primary repair following debridement,one case with multiple perforations received 2-layered primary repair and end ileostomy,one case received segmental resection and end-to-end anastomosis followed by an end ileostomy,and one case received segmental resection and end ileostomy with mucous fistula operation.Postoperative morbidity was seen in 5 cases and mortality was found in one case.CONCLUSION:Intestinal perforation resulting from Salmonella typhi is an important health problem in Eastern and Southeastern Turkey.In management of this illness,early and appropriate surgical intervention is vital. | Aziz Sümer zgür Kemik Ahmet Cumhur Dülger Aydemir Olmez Ismail Hasirci Erol Kisli Vedat Bayrak Gulay Bulut etin Kotan | 2010 | World Journal of Gastroenterology2010，16，33： | 1 |
| 15 | Chitosan‐based wet‐spun scaffolds for bioactive agent delivery显示文摘 | Seniz Ucar Pinar Yilgor Vasif Hasirci Nesrin Hasirci | 2013 | J Appl Polym Sci2013，，5： | 1 |
| 16 | Stability of α-amylase immobilized on poly (methylmethacrylate-a-crylic acid)micros pheres显示文摘 | Aksoy S Tumturk H Hasirci N | 1998 | Journal of Biotechnology1998，，60： | 1 |
| 17 | Controlled Release of Biologically Active Agents for Purposes of Agricultural Crop Management 显示文摘 | Mogul M G Akin H Hasirci N | 1996 | Resour Conserv Recy1996，16，： | 1 |
| 18 | Sequential growth factor delivery from complexed microspheres for bone tissue engineering显示文摘 | Basmanav FB Kose GT Hasirci V | 2008 | Biomaterials2008，29，31： | 1 |
| 19 | Evaluatioachinability of austempered ductile irons in terms of cuttinn of mg forces and surface quality 显示文摘 | Ulvi Seker Hasan Hasirci | 2006 | Journal of Materials Processing Technology2006，，173： | 1 |
| 20 | Labial fusion causing urinary incontinence and recurrent urinary tract infection in a postmenopausal female: a ease report 显示文摘 | Dirim A Hasirci E | 2011 | Int Uronecol J2011，22，： | 1 |
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