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| 1 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 2 | An investigation on forced convection boiling of non-azeotropic refrigerant mixtures 显示文摘 | Murata K Hashizume K | 1990 | Heat Transfer Japanese Research1990，19，2： | 1 |
| 3 | Expres-sion of multi-copy flavonoid pathway genes coincides withanthocyanin,flavonol and flavan-3 -ol accumulation of gra-pevine 显示文摘 | Jeong S T Goto-Yamamoto N Hashizume K | 2008 | Vitis2008，47，3： | 1 |
| 4 | Thyroxine suppression therapy inGraves disease显示文摘 | Hashizume K Benker G Reinwein D | 1991 | N Engl J Med1991，324，： | 1 |
| 5 | Solitary fibrous tumor of the adrenal gland with renal cell carcinoma and angiomyolipoma at the same time; a case report] 显示文摘 | Hashizume K Matsumoto S Nakazono S | 2012 | Nihon Hinyokika Gakkai Zasshi2012，103，3： | 1 |
| 6 | Differential in-duction by methyl jasmonate of genes encoding ornithine decar-boxylase and other enzymes involved in nicotine biosynthesis in tobacco cell cultures显示文摘 | Imanishi S Hashizume K Nakakita M | 1998 | Plant Mol Biol1998，38，： | 1 |
| 7 | Fin efficiency of serrated fins显示文摘 | HASHIZUME K MATSUE T | 1999 | Heat Transfer-Asian Research1999，28，6： | 1 |
| 8 | Denaturation of soybean protein by freezing 显示文摘 | Hashizume K Kakiuchi K Koyama E | 1971 | Agricultural and Biological Chemistry1971，35，： | 1 |
| 9 | Polarization behavior of high-alloy OCTG in CO2 environment as affected by chlorides and sulfides显示文摘 | Masamura K Hashizume S Sakai J | 1987 | Corrosion1987，，6： | 1 |
| 10 | Increased endothelial vesicular transport correlates with increased blood-tumor barrier permeability induced by bradykinin and leukotriene C4 显示文摘 | Hashizume K Black K L | 2002 | J Neuropathol Exp Neurol2002，61，8： | 1 |
| 11 | Expression of the flavonoid 3'-hydroxylase and flavonoid 3',5'-hydroxylase genes and flavonoid composition in grape (Vitis vinifera)显示文摘 | JEONG S T GOTO-YAMAMOTO N HASHIZUME K ESAKA M | 2006 | Plant Science2006，170，： | 1 |
| 12 | The development of extrahepatic portal obstruction after undergoing multipie operations for a congenital dilatation of the bile duct:report of a case显示文摘 | Furugaki K Yoshida J Hashizume M | 1998 | Surg Today1998，28，3： | 1 |
| 13 | New insight for management of blunt splenic trauma:significant differences between young and elderly显示文摘 | Tsugawa K Koyanagi N Hashizume M | 2002 | Hepatogast Roenterology2002，49，46： | 1 |
| 14 | Influence'of heating temperature on conformational changes of soybean proteins显示文摘 | Hashizume K Watanabe T | 1979 | Agric Biol Chem1979，43，： | 1 |
| 15 | Nontraumatic paralysis of the posterior interosseous nerve显示文摘 | Nishida K Nanba Y | 1996 | J Bone Joint Surg Br1996，78，5： | 1 |
| 16 | Influence of heating temperature on conformational changes of soybean proteins显示文摘 | Hashizume K Maeda M Watanabe T | 1979 | Agric Biol Chem1979，49，： | 1 |
| 17 | P65 is constitutively activated in human gastric carcinoma tissue 显示文摘 | Sasaki N Morisaki T Hashizume K | 2000 | Clin Cancer Res2000，7，： | 1 |
| 18 | The effect of car- bon dioxide pneumoperitoneum on the partal hemodynamics in a portal-hypertensive rat model 显示文摘 | Tsugawa K Hashizume M Migou S | 1999 | Surg Laparose Endose Percut Tech1999，9，5： | 1 |
| 19 | Regulation of blood-brain tumor barrier permeability by calcium-activated potassium cbannels显示文摘 | Ningaraj NS Rao M Hashizume K et at | 2002 | J Pharmacol Exp Ther2002，301，3： | 1 |
| 20 | Biomechani- cal analysis of the mechanism of elbow fracture dis- locations by compression force 显示文摘 | Wake H Hashizume H Nishida K | 2004 | J Orthop Sci2004，9，1： | 1 |
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