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| 1 | A randomized open-label trial of on-demand rabeprazole vs ranitidine for patients with non-erosive reflux disease显示文摘AIM:To compare the efficacy of the proton-pump inhibitor,rabeprazole,with that of the H 2-receptor antagonist,ranitidine,as on-demand therapy for relieving symptoms associated with non-erosive reflux disease(NERD).METHODS:This is a single center,prospective,randomized,open-label trial of on-demand therapy with rabeprazole(group A) vs ranitidine(group B) for 4 wk.Eighty-three patients who presented to the American University of Beirut Medical Center with persistent gastroesophageal reflux disease(GERD) symptoms and a normal upper gastrointestinal endoscopy were eligible for the study.Patients in group A(n = 44) were allowed a maximum rabeprazole dose of 20 mg twice daily,while those in group B(n = 39) were allowed a maximum ranitidine dose of 300 mg twice daily.Efficacy was assessed by patient evaluation of global symptom relief,scores of the SF-36 quality of life(QoL) questionnaires,total number of pills used,and number of medication-free days.RESULTS:Among the 83 patients who were enrolled in the study,76 patients(40 in the rabeprazole group and 36 in the ranitidine group) completed the 4-wk trial.Baseline characteristics were comparable between both groups.After 4 wk,there was no significant difference in the subjective global symptom relief between the rabeprazole and the ranitidine groups(71.4% vs 65.4%,respectively;P = 0.9).There were no statistically significant differences between mean cumulative scores of the SF-36 QoL questionnaire for the two study groups(rabeprazole 22.40 ± 27.53 vs ranitidine 17.28 ± 37.06;P = 0.582).There was no significant difference in the mean number of pills used(rabeprazole 35.70 ± 29.75 vs ranitidine 32.86 ± 26.98;P = 0.66).There was also no statistically significant difference in the mean number of medication-free days between both groups.CONCLUSION:Rabeprazole has a comparable efficacy compared to ranitidine when given on-demand for the treatment of NERD.Both medications were associated with improved quality of life. | Abdallah A Kobeissy Jana G Hashash Faek R Jamali Assaad M Skoury Reham Haddad Sarah El-Samad Rami Ladki Rola Aswad Assaad M Soweid | 2012 | World Journal of Gastroenterology2012，18，19： | 4 |
| 2 | Characterisation of Pgal, a putative Candidaalbicans cell wall protein necessary for proper adhesion and bio-film formation显示文摘 | Hashash R Younes S Bahnan W E1 Koussa J Maalouf K’Di-massi H I | 2011 | Mycoses2011，54，： | 1 |
| 3 | Analysis of deep excavation in Boston显示文摘 | WHITTLE A J HASHASH Y M A WHITMAN R V | 1993 | Journal of Geotechnical and Geoenvironmental Engineering ASCE1993，119，1： | 1 |
| 4 | Anal- ysis of deep excavation in boston 显示文摘 | WHITFL A J HASHASH M A WHITMAN R V | 1993 | Journal of Geotechnical Engineering1993，119，1： | 1 |
| 5 | Analysis of deep excavation in Boston显示文摘 | WHITTLE A J HASHASH Y M A WHITMAN R V | 1993 | Journal Geotechnical Engineering ASCE1993，119，1： | 1 |
| 6 | Analysis of a deep excavation in Boston显示文摘 | WHITTLE A J HASHASH Y M A WHITMAN R V | 1993 | Journal of Geotechnical Engineering1993，119，1： | 1 |
| 7 | Analysis of deep excavation in Boston 显示文摘 | Whittle A J Hashash Y M Whitman R V | 1993 | Journal of Gentechnical Engineering ASCE1993，119，1： | 1 |
| 8 | Analysis of deep excavation in Boston显示文摘 | WHITTLE A J HASHASH Y M A WHITMAN R V | 1993 | Journal of Geotechnical Engineering1993，119，1： | 1 |
| 9 | Analysis of deep excavation in Boston显示文摘 | Whittle A Hashash Y Whitman R | 1993 | Journal of Geotechnical Engineering1993，119，1： | 1 |
| 10 | Analysis of Deep Excavation in Boston显示文摘 | Whittle A J Hashash Y M Whitman R V | 1993 | Journal of Geotechnical Engineering ASCE1993，119，1： | 1 |
| 11 | Analysis of Deep Excavation in Boston显示文摘 | Whittle A J Hashash M A Whitman R V | 1993 | Journal of Geotechnical Engineering ASCE1993，119，： | 1 |
| 12 | Analysis of deep excavation in Boston 显示文摘 | Duncan J M Hashash M A Whitman R V | 1993 | Journal of Geotechnical Engineering1993，119，1： | 1 |
| 13 | Analysis of deep excavation in Boston显示文摘 | WHITTLE A J HASHASH Y M A WHITMAN R V | 1993 | Journal of Geotechnical Engineering ASCE1993，119，11： | 1 |
| 14 | A- nalysis of deep excavation in Boston 显示文摘 | WHITTLE A J HASHASH Y M A WHITEMAN R V | 1993 | Journal of Geotechni- cal and Geoenvironmental ASCE1993，119，1： | 1 |
| 15 | Analysis of a deep excavation in Boston显示文摘 | Whittle A J Hashash Y M A Whitman R V | 1993 | Journal of Geotechnical Engineering ASCE1993，119，1： | 1 |
| 16 | Analysis of deep excavation in Bostion 显示文摘 | WHITTLE A J HASHASH Y M A WHITMAN R V | 1993 | Journal of Geotechnical Engineering1993，119，11： | 1 |
| 17 | Analysis of Deep Excavation in Boston显示文摘 | Whittle A J Hashash Y M A Whitman R V | 1993 | Journal of Geotechnical Engineering ASCE1993，119，1： | 1 |
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