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| 1 | A randomized open-label trial of on-demand rabeprazole vs ranitidine for patients with non-erosive reflux disease显示文摘AIM:To compare the efficacy of the proton-pump inhibitor,rabeprazole,with that of the H 2-receptor antagonist,ranitidine,as on-demand therapy for relieving symptoms associated with non-erosive reflux disease(NERD).METHODS:This is a single center,prospective,randomized,open-label trial of on-demand therapy with rabeprazole(group A) vs ranitidine(group B) for 4 wk.Eighty-three patients who presented to the American University of Beirut Medical Center with persistent gastroesophageal reflux disease(GERD) symptoms and a normal upper gastrointestinal endoscopy were eligible for the study.Patients in group A(n = 44) were allowed a maximum rabeprazole dose of 20 mg twice daily,while those in group B(n = 39) were allowed a maximum ranitidine dose of 300 mg twice daily.Efficacy was assessed by patient evaluation of global symptom relief,scores of the SF-36 quality of life(QoL) questionnaires,total number of pills used,and number of medication-free days.RESULTS:Among the 83 patients who were enrolled in the study,76 patients(40 in the rabeprazole group and 36 in the ranitidine group) completed the 4-wk trial.Baseline characteristics were comparable between both groups.After 4 wk,there was no significant difference in the subjective global symptom relief between the rabeprazole and the ranitidine groups(71.4% vs 65.4%,respectively;P = 0.9).There were no statistically significant differences between mean cumulative scores of the SF-36 QoL questionnaire for the two study groups(rabeprazole 22.40 ± 27.53 vs ranitidine 17.28 ± 37.06;P = 0.582).There was no significant difference in the mean number of pills used(rabeprazole 35.70 ± 29.75 vs ranitidine 32.86 ± 26.98;P = 0.66).There was also no statistically significant difference in the mean number of medication-free days between both groups.CONCLUSION:Rabeprazole has a comparable efficacy compared to ranitidine when given on-demand for the treatment of NERD.Both medications were associated with improved quality of life. | Abdallah A Kobeissy Jana G Hashash Faek R Jamali Assaad M Skoury Reham Haddad Sarah El-Samad Rami Ladki Rola Aswad Assaad M Soweid | 2012 | World Journal of Gastroenterology2012，18，19： | 4 |
| 2 | Seismic design and analysis of underground structures显示文摘 | Hashash T M A Hook J J Schmidt B Yao J I | 2001 | Tunnelling and Underground Space Technology2001，16，4： | 2 |
| 3 | Some Reaction with Arylidene Malonic Acid and Diethl Arylidene Malonate 显示文摘 | Mohamed M M Hashash M A Kady M Y | 1980 | Rev Roum Chim1980，25，2： | 2 |
| 4 | Mechanisms of load transfer and arching for braced excavation in clay显示文摘 | Hashash Y M A Whittle A J | 2002 | Journal of Geotechnical and Geoenvironmental Engineering ASCE2002，128，3： | 1 |
| 5 | Seismic design and analysis of underground structures 显示文摘 | Hashash Y M A Hook J J Schmidt B | 2001 | Tunnelling and Under- ground Space Technology2001，16，4： | 1 |
| 6 | Seismic Design and Analysis of Underground Structure 显示文摘 | HASHASH Y M A HOOK J SCHMIDT B | 2001 | Tunneling and Underground Space Technology2001，16，4： | 1 |
| 7 | Comparison of two inverse analysis techniques for learning deep excavation response显示文摘 | HASHASH Y M A LEVASSEUR S OSOULI A | 2010 | Computers and Geotechnics2010，37，3： | 1 |
| 8 | Simulation of front end loader bucket-soil interaction显示文摘 | NEZAMI Erfan G HASHASH Youssef M A ZHAO Dawei | 2007 | International Journal for Numerical and Analytical Methods in Geomechanics2007，31，9： | 1 |
| 9 | Generalized strain probing of constitutive models显示文摘 | HASHASH Y M A FU Q w BUTKOUICH J | 2004 | International Journal for Numerical and Analytical Methods in Geomechanics2004，28，： | 1 |
| 10 | Seismic design and analysis of underground structures显示文摘 | HASHASH Y M A HOOK J J SCHMIDT B | | 0，，04： | 1 |
| 11 | Seismic design and analysis of underground structures 显示文摘 | Hashash Y M A Hook J J Schmidt B | 2001 | Tunnelling and Underground Space Technology2001，16，4： | 1 |
| 12 | Seismic design and analysis of underground structures 显示文摘 | Hashash Y M A Hook J J Schmidt B | 2001 | Tunneling and Underground Space Technology2001，16，4： | 1 |
| 13 | Seismic design and analysis of underground structures 显示文摘 | Hashash Y M A Hook J J Schmidt B | 2001 | Tunneling and Underground Space Technology2001，16，4： | 1 |
| 14 | Seismic design and analysis of underground structures显示文摘 | Youssef M A Hashash Jeffrey J Hook Birger Schmidt | 2001 | Tunnelling and Underground Space Technology2001，，16： | 1 |
| 15 | Comparison of two inverse analysis techniques for learning deep excavation response 显示文摘 | Hashash Y M A Levasseur S Osouli A | 2010 | Computers and Geotechnics2010，37，： | 1 |
| 16 | Seismic design and analysis of underground structures 显示文摘 | Hashash Y M A Hook J J Schmidt B | 2001 | Tunneling and Underground Space Technology2001，16，4： | 1 |
| 17 | Simulation of front end loader bucket-soil interaction 显示文摘 | Erfan G Nezami Youssef M A Hashash Dawei Zhao | 2007 | International journal for numerical and analytical methods in geomechanics2007，31，： | 1 |
| 18 | Analysis of deep excavation in Boston显示文摘 | WHITTLE A J HASHASH Y M A WHITMAN R V | 1993 | Journal of Geotechnical and Geoenvironmental Engineering ASCE1993，119，1： | 1 |
| 19 | Ground movement prediction for deep excavations in soft clay 显示文摘 | HASHASH Y M A WHITTLE A J | 1996 | Journal of Geotechnical Engineering ASCE1996，122，6： | 1 |
| 20 | Ground movement prediction for deep excavations in soft day显示文摘 | Hashash M A Whitle A J | 1996 | Journal of Geotechnical Engineering ASCE1996，122，6： | 1 |
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