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| 1 | Hemostasis in liver transplantation:Pathophysiology,monitoring,and treatment显示文摘Recent findings in the pathophysiology and monitoring of hemostasis in patients with end stage liver disease have major impact on coagulation management during liver transplantation. There is increasing evidence, that the changes in both coagulation factors and platelet count regularly observed in patients with liver cirrhosis cannot be interpreted as a reliable indicator of diffuse bleeding risk. Instead, a differentiated view on hemostasis has led to the concept of a rebalanced coagulation system: While it is important to recognize that procoagulant factors are reduced in liver cirrhosis, it is also evident that synthesis of anticoagulant factors and fibrinolytic proteins produced in the liver is also diminished. Similarly, the decreased platelet count may be counterbalanced by increased platelet aggregability caused by highly active von Willebrand multimeres. The coagulation system is therefor stated to be rebalanced. While under normal 'unstressed' conditions diffuse bleeding is rarely observed, however both diffuse bleeding or thrombus formation may occur when compensation mechanisms are exhausted. While most patients presenting for liver transplantation have severe cirrhosis, liver function and thus production of pro- and anticoagulant factors can be preserved especially in cholestatic liver disease. During liver transplantation, profound changes in the hemostasis system can occur. Surgical bleeding can lead to diffuse bleeding as coagulation factors and platelets are already reduced. Ischemia and tissue trauma can lead to alterations of hemostasis comparable to trauma induced coagulopathy. A further common disturbance often starting with the reperfusion of the transplanted organ is hyperfibrinolysis which can eventually precipitate complete consumption of fibrinogen and an endogenous heparinization by glycocalyx shedding. Moreover, thrombotic events inliver transplantations are not uncommon and contribute to increased mortality. Besides conventional laboratory methods, bed-side monitoring of hemostasis(e.g., thrombelastography, thrombelastometry) is often used during liver transplantation to rapidly diagnose decreases in fibrinogen and platelet count as well as hyperfibrinolysis and to guide treatment with blood products, factor concentrates, and antifibrinolytics. There is also evidence which suggests when algorithms based on bed-side hemostasis monitoring are used a reduction of blood loss, blood product use, and eventual mortality are possible. Notably, the bed-side monitoring of anticoagulant pathways and the thrombotic risk is not possible at time and thus a cautious and restrictive use of blood products is recommended. | Matthias Hartmann Cynthia Szalai Fuat H Saner | 2016 | World Journal of Gastroenterology2016，22，4： | 11 |
| 2 | On the temperature dependence of the fatigue and damage behavior of a particulate reinforced metal matrix composite显示文摘 | Biermann H Kemnitzer M Hartmann O | 2001 | Mater SciEng A2001，319，： | 2 |
| 3 | Swan Hill-A New Ornamental Fruitless Olive for California显示文摘 | Hartmann H T | 1967 | California Agriculture1967，21，1： | 1 |
| 4 | Age-related change in receptor-me-diated and depolarization-induced phosphatidylinositol turno-ver in mouse brain显示文摘 | Hartmann H Muller WE | 1993 | Brain Research1993，622，： | 1 |
| 5 | Regulation of the hepatic multidrug resistance gene expression by endotoxin and inflammatory cytokines in mice显示文摘 | HARTMANN G KIM H PIQUETTE-MILLER M | 2001 | Int Immunopharmacol2001，1，2： | 1 |
| 6 | The influence of mineralising radionecrosis on the dose distribution in interstitial radiation therapy of brain tumours 显示文摘 | HERBOLD G HARTMANN G H LORENZ W J | 1992 | Radiother Oncol1992，25，1： | 1 |
| 7 | Boron is required for the ferricyanide-induced proton release by auxins in suspension-cultured cells of Daucus carota and Lycopersicon esculentum显示文摘 | Goldbach H E Hartmann D Rotzer T | 1990 | Physiol Plant1990，80，： | 1 |
| 8 | Rapid identi- fication of Staphylococcus aureus in blood cuhurgs by a combination of fluorescence in sitn hybridization using peptide nucleic acid probes and flow cytometry 显示文摘 | HARTMANN H STENDER H SCHAFER A | 2005 | J Clin Microbiol2005，43，9： | 1 |
| 9 | Capecitabine plus oxaliplatin as first-line treatment in patients with advanced biliary system adenocareinoma: a prospective multicentre phase II trial显示文摘 | Nehls O Oettle H Hartmann J T | 2010 | Br J cancer2010，98，2： | 1 |
| 10 | Expression of vascular endothelial growth factor and pigment epithelial-derived factor in a rat model of retinopathy of prematurity显示文摘 | Hartmann JS Thompson H Wang H Kanekar S Huang W Budd S J | 2011 | Mol Vis2011，17，： | 1 |
| 11 | A novel, self- expanding, nitinol stent in medically refractory intracranial atherosclerotic stenoses: the Wingspan study显示文摘 | Bose A Hartmann M Henkes H | 2007 | Stroke2007，38，5： | 1 |
| 12 | Food-derived peptides with biological ac- tivity: from research to fuod applications显示文摘 | HARTMANN R MEISE H | 2007 | Curt Opin Bioteeh2007，18，2： | 1 |
| 13 | Digital current controller for a 1 MHz, 10 kW three-phase VIENNA rectifier显示文摘 | Hartmann M Round S Erfl H | 2009 | IEEE Transactions on Industrial Electronics2009，24，11： | 1 |
| 14 | Capecitabine plus oxaliplatin as first-line treatment in patients with advanced biliary system adenocarcinoma: A prospective multicentre phase Ⅱ trial显示文摘 | Nehls O Oettle H Hartmann JT | 2008 | Br J Cancer2008，98，： | 1 |
| 15 | Course and prognostic implications of QT interval and QT interval variability after primary coronary angioplasty in acute myocardial inffarction显示文摘 | Bonnemeier H Hartmann F Wiegand UK | 2001 | J Am Coil Cardiol2001，37，1： | 1 |
| 16 | Cytochemical assessment of phosphopeptides derival from casein as poteintial imgredients for functional food显示文摘 | Hartmann R Meisei H | 2002 | Nahang Food2002，46，： | 1 |
| 17 | High frequency of p53 gene mutations in primary breast cancers in Japanese women;a low-incidece population显示文摘 | Hartmann A Blallszyk H Saitoh S | 1996 | Br J Cancer1996，73，8： | 1 |
| 18 | Contribution of eiliated microprotozoans and dinoflagellates to the diet of three copepod species in the Bay of Biscay显示文摘 | Vincent D Hartmann H J | 2001 | Hydrobiologia2001，443，： | 1 |
| 19 | Food-derived peptides with biological activity: from research to food applications显示文摘 | HARTMANN R MEISEL H | 2007 | Current Opinion in Biotechnology2007，18，2： | 1 |
| 20 | Room temperature ferromagnetism in Mn -doped ZnO films mediated by acceptor de- fects显示文摘 | Xu Q Schmidt H Hartmann L | 2007 | Appl Phys Lett2007，91，09： | 1 |
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