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| 1 | Protective action of glutamine in rats with severe acute liver failure显示文摘BACKGROUND Severe acute liver failure(SALF) is a rare, but high-mortality, rapidly evolving syndrome that leads to hepatocyte degeneration with impaired liver function.Thioacetamide(TAA) is a known xenobiotic, which promotes the increase of the formation of reactive oxygen species. Erythroid 2-related factor 2(Nrf2) activates the antioxidant protection of cells. Studies have evidenced the involvement of inflammatory mediators in conditions of oxidative stress.AIM To evaluate the antioxidant effects of glutamine on Nrf2 activation and NFκBmediated inflammation in rats with TAA-induced IHAG.METHODS Male Wistar rats(n = 28) were divided into four groups: control,control+glutamine, TAA, and TAA + glutamine. Two TAA doses(400 mg/kg)were administered intraperitoneally, 8 h apart. Glutamine(25 mg/kg) was administered at 30 min, 24 h, and 36 h. At 48 h, blood was collected for liver integrity analysis [aspartate aminotransferase(AST), alanine aminotransferase(ALT), and alkaline phosphatase(ALP)]. The liver was harvested for histology and assessment of oxidative stress [thiobarbituric acid-reactive substances(TBARS), catalase(CAT), glutathione peroxidase(GPx), glutathione S-transferase(GST), glutathione(GSH), Nrf2, Kelch-like ECH-associated protein 1(Keap1),NADPH quinone oxidoreductase1(NQO1), superoxide dismutase(SOD)] and inflammatory process.RESULTS TAA caused disruption of the hepatic parenchyma, with inflammatoryinfiltration, massive necrosis, and ballooning degeneration. Glutamine mitigated this tissue damage, with visible regeneration of hepatic parenchyma; decreased TBARS(P < 0.001), GSH(P < 0.01), IL-1β, IL6, and TNFα levels(P <0.01) in hepatic tissue; and decreased blood levels of AST, ALT, and ALP(P <0.05). In addition, CAT, GPx, and GST activities were restored in the glutamine group(P<0.01, P <0.01, and P <0.001, respectively vs TAA alone). Glutamine increased expression of Nrf2(P < 0.05), NQO1, and SOD(P < 0.01), as well as levels of IL-10(P <0.001), while decreasing expression of Keap1, TLR4, NFκB(P < 0.001), COX-2 and iNOS,(P < 0.01), and reducing NO_2 and NO_3 levels(P < 0.05).CONCLUSION In the TAA experimental model of IHAG, glutamine activated the Nrf2 pathway,thus promoting antioxidant protection, and blunted the NFκB-mediated pathway, reducing inflammation. | Elizangela G Schemitt Renata M Hartmann Josieli R Colares Francielli Licks Jéferson O Salvi Cláudio A Marroni Norma P Marroni | 2019 | World Journal of Hepatology2019，11，3： | 5 |
| 2 | Compared efficacy of preservation solutions on the outcome of liver transplantation:Meta-analysis显示文摘AIM To compare the effects of the four most commonly used preservation solutions on the outcome of liver transplantations.METHODS A systematic literature search was performed using MEDLINE, Scopus, EMBASE and the Cochrane Library databases up to January 31^(st), 2017. The inclusion criteria were comparative, randomized controlled trials(RCTs) for deceased donor liver(DDL) allografts with adult and pediatric donors using the gold standard University of Wisconsin(UW) solution or histidinetryptophan-ketoglutarate(HTK), Celsior(CS) and Institut Georges Lopez(IGL-1) solutions. Fifteen RCTs(1830 livers) were included; the primary outcomes were primary non-function(PNF) and one-year posttransplant graft survival(OGS-1). RESULTS All trials were homogenous with respect to donor and recipient characteristics. There was no statistical difference in the incidence of PNF with the use of UW, HTK, CS and IGL-1(RR = 0.02, 95%CI: 0.01-0.03, P = 0.356). Comparing OGS-1 also failed to reveal any difference between UW, HTK, CS and IGL-1(RR = 0.80, 95%CI: 0.80-0.80, P = 0.369). Two trials demonstrated higher PNF levels for UW in comparison with the HTK group, and individual studies described higher rates of biliary complications where HTK and CS were used compared to the UW and IGL-1 solutions. However, the meta-analysis of the data did not prove a statistically significant difference: the UW, CS, HTK and IGL-1 solutions were associated with nearly equivalent outcomes.CONCLUSION Alternative solutions for UW yield the same degree of safety and effectiveness for the preservation of DDLs, but further well-designed clinical trials are warranted. | Agnes Lilla Szilágyi Péter Mátrai Péter Hegyi Eszter Tuboly Daniella Pécz András Garami Margit Solymár Erika Pétervári Márta Balaskó Gábor Veres László Czopf Bastian Wobbe Dorottya Szabó Juliane Wagner Petra Hartmann | 2018 | World Journal of Gastroenterology2018，24，16： | 5 |
| 3 | Different effects of a CD14 gene polymorphism on disease outcome in patients with alcoholic liver disease and chronic hepatitis C infection显示文摘AIM: Clinical and experimental data suggest that gut-derived endotoxins are an important pathogenic factors for progression of chronic liver disease. Recently, a C-T (-159)polymorphism in the promoter region of the CD14 gene was detected and found to confer increased CD14 expression and to be associated with advanced alcoholic liver damage. Here, we investigated this polymorphism in patients with less advanced alcoholic liver disease (ALD)and chronic hepatitis C virus (HCV) infection.METHODS: CD14 genotyping was performed by PCR-RFLP analysis in (a) 121 HCV patients, (b) 62 patients with alcohol-associated cirrhosis (Alc-Ci), (c) 118 individuals with heavy alcohol abuse without evidence of advanced liver damage (Alc-w/o Ci), and (d) 247 healthy controls.Furthermore, serum levels of soluble CD14 (sCD14) and transaminases were determined.RESULTS: The TT genotype was significantly more frequent in Alc-Ci compared to Alc-w/o Ci or controls (40.3% vs 23.7% or 24.0%, respectively). In Alc-w/o Ci,serum levels of transaminases did not differ significantly between patients with different CD14 genotypes. In HCV patients, TT-homozygotes had significantly higher sCD14 levels and sCD14 serum levels were significantly higher in patients with advanced fibrosis or cirrhosis. However,no association was found between CD14 genotypes and histological staging or grading.CONCLUSION: Considering serum transaminases as surrogate markers for alcoholic liver damage, the CD14 polymorphism seems to exhibit different effects during the course of ALD. Differences in genotype distribution between cirrhotic HCV patients and alcoholics and the known functional impact of this polymorphism on CD14 expression levels further indicate differences in the pathophysiological role of CD14 and CD14-mediated lipopolysaccharides signal transduction with regard to the stage as well as the type of the underlying liver disease. | C Meiler M Mühlbauer M Johann A Hartmann B Schnabl N Wodarz G Schmitz J Schlmerich C Hellerbrand | 2005 | World Journal of Gastroenterology2005，11，38： | 3 |
| 4 | High altitude increases circulating interleukin-6, interleukin-1 receptor antagonist and C-reactive protein显示文摘 | Hartmann G Tschop M Fischer R | 2002 | Cytokine2002，12，3： | 1 |
| 5 | Theoretical evaluation of peek's low 显示文摘 | Hartmann G | 1984 | IEEE Transactions on Industry Applications1984，20，6： | 1 |
| 6 | Regulation of the hepatic multidrug resistance gene expression by endotoxin and inflammatory cytokines in mice显示文摘 | HARTMANN G KIM H PIQUETTE-MILLER M | 2001 | Int Immunopharmacol2001，1，2： | 1 |
| 7 | The influence of mineralising radionecrosis on the dose distribution in interstitial radiation therapy of brain tumours 显示文摘 | HERBOLD G HARTMANN G H LORENZ W J | 1992 | Radiother Oncol1992，25，1： | 1 |
| 8 | Immunogenicity of injectable collagenimplants显示文摘 | Hartmann DJ Charriere G Richard | 1990 | J Dermatol Surg Onco11990，16，： | 1 |
| 9 | Relation between lipoprotein(a) and fibrinogen and serial intravascular ultrasound plaque progression in left main coronary arteries 显示文摘 | Hartmann M von Birgelen C Mintz G S | 2006 | JAm Coil Cardiol2006，48，3： | 1 |
| 10 | Pathway discovery in mantle cell lymphoma by integrated analysis of high-resolution gene expression and copy number profiling 显示文摘 | Hartmann EM Campo E Wright G | 2010 | Blood2010，116，6： | 1 |
| 11 | Mechanisms and therapeutic applications of immune sumulatory CpG DNA显示文摘 | Kneg AM Yi AK Hartmann G | 1999 | Pharmacol Ther1999，84，2： | 1 |
| 12 | High altitude increases circulating interleukin-6,interleukin-1 receptor antagonist and C-reactive protein显示文摘 | Hartmann G Tschop M Fischer R | 2000 | Cytokine2000，12，3： | 1 |
| 13 | Primary ovarian tumors显示文摘 | Davis K P Hartmann L K Keeney G L | 1996 | Gynecol Oncol1996，61，2： | 1 |
| 14 | The value of early enteral nutrition in the prophylaxis of stress ulceration in the severely burned patient显示文摘 | Raff T Germann G Hartmann B | 1997 | Burns1997，23，4： | 1 |
| 15 | Evidence for the identity of human scatter factor and human hepatocyte growth factor显示文摘 | Weider KM Arakaki N Hartmann G | 1991 | Proc Natl Acad Sci USA1991，88，： | 1 |
| 16 | Structure studies of oligonucleotides containing Gquadruplex motifs using AFM显示文摘 | COSTA L T KERKMANN M HARTMANN G | 2004 | Biochem Biophys Res Commun2004，313，4： | 1 |
| 17 | Synthesis of some dialkylsubstituted vinylene carbonates and their photosensitized cycloaddition to ethylene 显示文摘 | Fischler H M Heine H G Hartmann W | 1972 | Tetrahedron Lett1972，17，： | 1 |
| 18 | Asset market linkages in crisis periods 显示文摘 | HARTMANN P STRAETMANS S DE VRIES C G | 2004 | Review of Economics and Statistics2004，86，1： | 1 |
| 19 | High altitude increases circu- lating interleukin-6, interleukin-1 receptor antagonist and C-reac- tive protein显示文摘 | Hartmann G Tschop M Fischer R | 2000 | Cytokine2000，12，3： | 1 |
| 20 | HepatoceIlular carcinoma in southern Germany: epiderniological and clinicopathological characteristics and risk factors显示文摘 | Hellerbrand C Hartmann A Richter G etal | 2001 | Dig Dis2001，19，： | 1 |
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