|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Incidence and mortality of female breast cancer in the AsiaPacific region显示文摘Objective: To provide an overview of the incidence and mortality of female breast cancer for countries in the Asia-Pacific region.Methods: Statistical information about breast cancer was obtained from publicly available cancer registry and mortality databases(such as GLOBOCAN), and supplemented with data requested from individual cancer registries. Rates were directly age-standardised to the Segi World Standard population and trends were analysed using joinpoint models.Results: Breast cancer was the most common type of cancer among females in the region, accounting for 18% of all cases in 2012, and was the fourth most common cause of cancer-related deaths(9%). Although incidence rates remain much higher in New Zealand and Australia, rapid rises in recent years were observed in several Asian countries. Large increases in breast cancer mortality rates also occurred in many areas, particularly Malaysia and Thailand, in contrast to stabilising trends in Hong Kong and Singapore, while decreases have been recorded in Australia and New Zealand. Mortality trends tended to be more favourable for women aged under 50 compared to those who were 50 years or older. Conclusion: It is anticipated that incidence rates of breast cancer in developing countries throughout the Asia-Pacific region will continue to increase. Early detection and access to optimal treatment are the keys to reducing breast cancerrelated mortality, but cultural and economic obstacles persist. Consequently, the challenge is to customise breast cancer control initiatives to the particular needs of each country to ensure the best possible outcomes. | Danny R.Youlden Susanna M.Cramb Cheng Har Yip Peter D.Baade | 2014 | Cancer Biology & Medicine2014，11，2： | 35 |
| 2 | Cdx1和Cdx2基因表达异常与先天性结肠性肠炎的关系显示文摘目的 结肠炎是先天性巨结肠患儿常见的并发症,组织学研究表明巨结肠性肠炎患儿肠粘膜内的内分泌细胞减少和粘膜内分泌型 IgA不足。而Cdx1和Cdx2基因调控结肠粘膜上皮细胞的分化和增殖,本研究的目的是明确Cdx1和Cdx2基因表达与先天性巨结肠性肠炎之间的关系。方法 采用半定量RT-PCR反应和原位杂交方法,11例先天性巨结肠患儿(年龄1~30个月,4例合并结肠炎)的无神经节细胞段、移行段和扩张段的手术切除标本为病例组,12例年龄相符(1~30个月)的非巨结肠患儿的远端结肠标本为对照组,观察Cdx1和Cdx2基因在其中的表达情况。结果Cdx1和Cdx2基因在对比组和先天性巨结肠的结肠粘膜上皮细胞均有表达,但是此二基因在先天性巨结肠性肠炎患儿的标本中表达明显减弱。结论 本研究结果表明Cdx1和Cdx2基因表达减弱与先天性巨结肠性肠炎的病因密切相关。 | 李龙 Vincent Lui Mai Har Sham 谭广 | 2003 | 中华小儿外科杂志2003，24，5： | 9 |
| 3 | 苏州河的功能定位与综合整治目标显示文摘苏州河水“变清”,是上海人民长期以来的一个美好愿望。根据市委、市府确定的苏州河环境综合整治目标,该文论述了苏州河环境综合整治总体规划方案的基本思想,提出苏州河的功能定位要从实际出发,并全面考虑迈向21世纪的上海城市发展需要,使苏州河综合整治成为上海环境建设的标志性工程。 | ( Headquarter of Suzhou Creek Environmental Comprehensive Harness, Shanghai 200080 ) | 1997 | 上海环境科学1997，16，1： | 6 |
| 4 | 从定期安全性更新报告过渡到定期受益-风险评价报告:初步经验和挑战显示文摘人用药品注册技术要求国际协调会议(ICH)提供了定期安全性更新报告指南(PSUR,ICH E2C(R1))和新的定期受益-风险评价报告指南(PBRER,ICH E2C(R2))。PBRER由PSUR演变而来,实现了从比较传统的获批后药物警戒定期总结报告到现代定期受益-风险评价总结报告的转变,根据累积信息对批准上市产品做出最新的受益-风险评价。通过总结ICH E2C PSUR指南和PBRER指南的主要区别,介绍了某跨国制药公司在由编写PSUR改为编写PBRER的转变过程中所积累的初步经验及其遇到的挑战,讨论了中国在推进药物警戒系统的背景下实行PBRER的可能性。 | 张晓兰 Lester REICH 梁冰 Donald PUCCIO Craig HAR TFORD | 2014 | 中国药物警戒2014，11，4： | 3 |
| 5 | Accommodation of China's Industrial Heritage in Urban Conservation Practices (I) | Peter G. Rowe Har Ye Kan | 2012 | China City Planning Review2012，21，1： | 3 |
| 6 | Security of a key agreement protocol based on chaotic maps显示文摘 | Har S | 2008 | Chaos Solitons Fract2008，38，： | 1 |
| 7 | Netzhautablusung bei kindem und jundenlichen显示文摘 | LAATIKAINEN L TARKANEN A HAR JU H | 1984 | Klin Monatsbl Augenheilkd1984，185，1： | 1 |
| 8 | Complications of total thyroidectomy for carcinoma显示文摘 | Thompson NW Harness JK | 1970 | Surg Gynecol Obstet1970，131，5： | 1 |
| 9 | Development of a predictive model for aggressive lymphoma: the international NHL prognostic fac- tors project显示文摘 | Skipp M Harring D Anderson J | 1993 | N Engl J Med1993，329，14： | 1 |
| 10 | Comment on diffraction loss of rooftop-to-street in COST 231-walfischikegami model显示文摘 | HAR D WATSON A M CHADNEY A G | 1999 | IEEE Transaction on Vehicular Communications Technology1999，48，5： | 1 |
| 11 | Metallographic methods for revealing the multiphase microstructure of TRIP-assisted steels显示文摘 | Girault E Jacques P Har let P | 1998 | Materials Characteristic1998，40，： | 1 |
| 12 | Assessment by quantitive ultrasonometry of the effects of hormone replacement therapy on bone mss显示文摘 | Hadji P Hars O Schuler M | 2000 | Am J Obstet Gyneeol2000，182，： | 1 |
| 13 | Malignant fibrous histiocytomas ofthe head and neck 显示文摘 | Simph B Shaha A Har EIG | 1993 | J Craniomaxillofac Surg1993，21，： | 1 |
| 14 | Sporadic heterozygous frameshift mutation of HESXI causing pituitary and optic nerve hypoplasia and combined pituitary hormone deficiency in a Japanese parient显示文摘 | Tajirna T Har torri T Nakajima T | 2003 | J Clin Endocrinol Metab2003，88，1： | 1 |
| 15 | 1,2,3-Triazole as a safer and practical substitute for cyanide in the bruylants reaction for the synthesis of tertiary amines containing tertiary alkyl or aryl groups 显示文摘 | Prashad M Liu Yugang Har D | 2005 | Tetrahedron Lett2005，46，33： | 1 |
| 16 | al,Testosterone increases end estradiol decreases middle cerebra artery occlnsion lesion size in male rats显示文摘 | Har K T Zhang Y Q Rajknmar G et | 1998 | Brain Res1998，796，12： | 1 |
| 17 | Blastocyst stage embryo transfer in patients who failed to conceive in three or more day 2-3embryo trasfer cycles:a prospective,randomized study显示文摘 | Levitas E Lunenfeld E Har Vardi I | 2004 | Fertil Steil2004，81，3： | 1 |
| 18 | Working for Free? Motivations of Participating in Open Source Projects显示文摘 | Hars A Ou S | 2002 | International Journal of E - Commerce2002，6，3： | 1 |
| 19 | Sympto matic biliary tract disease in the elderly patient显示文摘 | Sstrodel WE Talama SE | 1986 | Ann Surg1986，52，4： | 1 |
| 20 | Polymorphism of FGFR4 GlyS8BArgdoes not confer an increased risk to breast cancer development显示文摘 | Naidu R Har YC Taib NA | 2009 | Oncol Res2009，18，23： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员