|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 重组脊髓灰质炎病毒用于治疗复发胶质母细胞瘤(英文)显示文摘Background The prognosis of patients with recurrent World Health Organization(WHO)grade IV malignant glioma is dismal,and there is currently no effective therapy.We conducted a dose-finding and toxicity study in this population of patients,evaluating convection-enhanced,intratumoral delivery of the recombinant nonpathogenic polio-rhinovirus chimera(PVSRIPO).PVSRIPO recognizes the poliovirus receptor CD155,which is widely expressed in neoplastic cells of solid tumors and in major components of the tumor microenvironment.Methods We enrolled consecutive adult patients who had recurrent supratentorial WHO grade IV malignant glioma,confirmed on histopathological testing,with measurable disease(contrast-enhancing tumor of≥1 cm and≤5.5 cm in the greatest dimension).The study evaluated seven doses,ranging between 107 and 1010 50%tissue-culture infectious doses(TCID50),first in a dose-escalation phase and then in a dose-expansion phase.Results From May 2012 through May 2017,a total of 61 patients were enrolled and received a dose of PVSRIPO.Dose level-1(5.0×107TCID50)was identified as the phase 2 dose.One dose-limiting toxic effect was observed;a patient in whom dose level 5(1010TCID50)was administered had a grade 4 intracranial hemorrhage immediately after the catheter was removed.To mitigate locoregional inflammation of the infused tumor with prolonged glucocorticoid use,dose level 5 was deescalated to reach the phase 2 dose.In the dose-expansion phase,19%of the patients had a PVSRIPO-related adverse event of grade 3 or higher.Overall survival among the patients who received PVSRIPO reached a plateau of 21%(95%confidence interval,11 to 33)at 24 months that was sustained at 36 months.Conclusions Intratumoral infusion of PVSRIPO in patients with recurrent WHO grade IV malignant glioma confirmed the absence of neurovirulent potential.The survival rate among patients who receivedPVSRIPO immunotherapy was higher at 24 and 36 months than the rate among historical controls. | Desjardins A Gromeier M Herndon JE 2nd Beaubier N Bolognesi DP Friedman AH Friedman HS McSherry F Muscat AM Nair S Peters KB Randazzo D Sampson JH Vlahovic G Harrison WT McLendon RE Ashley D Bigner DD | 2018 | 中华神经外科疾病研究杂志2018，17，4： | 2 |
| 2 | The impact of splenectomy on outcomes after resection of pancreatic adenocarcinoma显示文摘 | Schwarz RE Harrison LE Conlon KC | 1999 | J Am Coil Surg1999，188，5： | 1 |
| 3 | Low acute hypoxic ventilator response and hypoxic depression in acute altitude sickness显示文摘 | Moore LG Harrison GL Mc Cullough RE | 1986 | J Appl Physiol1986，60，4： | 1 |
| 4 | Molecular and functional analysis identifies ALK-1 as the predominant cause of pulmonary hypertension related to hereditary haemorrhagictelangiectasia显示文摘 | Harrison RE Flanagan JA Sankelo M | 2003 | J Med Genet2003，40，12： | 1 |
| 5 | The role of the CD44/ Ezrin complex in cancer metastasis 显示文摘 | Martin TA Harrison G Mansel RE | 2003 | Crit Rev Oncol Hematol2003，46，2： | 1 |
| 6 | Transforming growth factor-beta receptor mutations and pulmonary arterial hypertension in childhood 显示文摘 | Harrison RE Berger R Haworth SG | 2005 | Circulation2005，111，4： | 1 |
| 7 | The role of the CD44/Ezrin complex in cancer metastasis显示文摘 | Martin T A Harrison G Mansel RE | 2003 | Crit Rev Oncol Hematol2003，46，2： | 1 |
| 8 | Dispersion of single wall carbon nanotubes by in situ polymerization under sonication显示文摘 | Park C Ounaies Z Watson KA Crooks RE Smith JJ Lowther SE Connell JW Siochi EJ Harrison JS Clair TLS | 2002 | Chem Phys Lett2002，364，： | 1 |
| 9 | The role of the Cl44/ezrin complex in dancer metastasis显示文摘 | Martin TA Harrison G Mansel RE | 2003 | Crit Rev Oncol Hematol2003，46，2： | 1 |
| 10 | The role of the CD44/ezrin complex in cancer metastasis 显示文摘 | Martin TA Harrison G Mansel RE | 2003 | Crit Rev Oncol Hematol2003，46，2： | 1 |
| 11 | Spatially dependent genetic diversity within and between colonies of wild raspberry (Rubus idaeus) detected using RAPD markers显示文摘 | Graham J Squire GR Marshall B Harrison RE | 1997 | Molecular Ecology1997，6，11： | 1 |
| 12 | Transforming growth factor-beta receptor mutations and pulmonary arterial hypertension in childhood显示文摘 | Harrison RE Berger R Haworth SG | 2005 | Circulation2005，111，43： | 1 |
| 13 | Molecular and functional analysis identifies ALK-1 as the predominant cause of pulmonary hypertension related to hereditary haemorrhagic telangiectasia显示文摘 | Harrison RE Flanagan JA Sankelo M | | 0，，12： | 1 |
| 14 | The role of the CD44/ezrin complex in cancer metastasis显示文摘 | Martin TA Harrison G Mansel RE | 2003 | Crit Rev Oncol Hematol2003，46，2： | 1 |
| 15 | The impact ofsplenectomy on outcomes after resection of pancreatic adenocar-cinoma显示文摘 | Schwarz RE Harrison LE Conlon KC | 1999 | J Am Coll Surg1999，188，5： | 1 |
| 16 | The role of theCD44/ezrin complex in cancer metastasis 显示文摘 | Martin TA Harrison G Mansel RE | 2003 | Crit Rev OncoHematol2003，46，2： | 1 |
| 17 | Therole of te CD44/eztin complex in cancer metastasis显示文摘 | Martin TA Harrison G Mansel RE | 2003 | Crit Rev Oneol Hematol2003，6，： | 1 |
| 18 | Multipractitioner Upledger Cranio- Sacral Therapy: descriptive outcome study 2007 - 2008 显示文摘 | Harrison RE Page JS | 2011 | J Altern Complement Med2011，17，1： | 1 |
| 19 | Molecular and functional analysis identifies ALK-1 as the predominant cause of pulmonary hypertension related to hereditary haemorrhagic telangiectasia显示文摘 | Harrison RE Flanagan JA Sankelo M | 2003 | J Med Genet2003，40，12： | 1 |
| 20 | The role of the CD44/Ezrin complex in cancer metastasis 显示文摘 | MARTIN TA HARRISON G MANSEL RE | 2003 | Crit Rev Oncol Hematol2003，46，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员