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| 1 | Acute effects of rotavirus and malnutrition on intestinal barrier function in neonatal piglets显示文摘AIM: To investigate the effect of protein-energy malnutrition on intestinal barrier function during rotavirus enteritis in a piglet model.METHODS: Newborn piglets were allotted at day 4 of age to the following treatments:(1) full-strength formula(FSF)/noninfected;(2) FSF/rotavirus infected;(3) half-strength formula(HSF)/noninfected;or(4) HSF/rotavirus infected.After one day of adjustment to the feeding rates,pigs were infected with rotavirus and acute effects on growth and diarrhea were monitored for 3 d and jejunal samples were collected for Ussingchamber analyses.RESULTS: Piglets that were malnourished or infected had lower body weights on days 2 and 3 post-infection(P < 0.05).Three days post-infection,marked diarrhea and weight loss were accompanied by sharp reductions in villus height(59%) and lactase activity(91%) and increased crypt depth(21%) in infected compared with non-infected pigs(P < 0.05).Malnutrition also increased crypt depth(21%) compared to full-fed piglets.Villus:crypt ratio was reduced(67%) with viral infection.There was a trend for reduction in transepithelial electrical resistance with rotavirus infection and malnutrition(P = 0.1).3H-mannitol flux was significantly increased(50%;P < 0.001) in rotavirus-infected piglets compared to non-infected piglets,but there was no effect of nutritional status.Furthermore,rotavirus infection reduced localization of the tight junction protein,occludin,in the cell membrane and increased localization in the cytosol.CONCLUSION: Overall,malnutrition had no additive effects to rotavirus infection on intestinal barrier function at day 3 post-infection in a neonatal piglet model. | Sheila K Jacobi Adam J Moeser Anthony T Blikslager J Marc Rhoads Benjamin A Corl Robert J Harrell Jack Odle | 2013 | World Journal of Gastroenterology2013，19，31： | 4 |
| 2 | Recognition and management of Tillaux fractures in adolescents显示文摘 | Koury S I Stone C K Harrell G | 1999 | J Pediatr Emerg Care1999，15，1： | 1 |
| 3 | A potential approach for decreasing the burst effect of protein from PLGA microspheres显示文摘 | FU K HARRELL R ZINSKI K | 2003 | J Pharm Sci2003，92，8： | 1 |
| 4 | Effect of animal plasma proteins on intestinal damage and recovery of neonatal pigs infected with rotavirus显示文摘 | Corl B A Harrell R J Moon H K | 2007 | J Nutr Bio2007，18，： | 1 |
| 5 | Effect of animal plasma proteins on intestinal damage and recovery of neonatal pigs infected with rotavirus显示文摘 | Corl B A Harrell R J Moon H K | 2007 | The Journal of Nutritional Biochemistry2007，18，12： | 1 |
| 6 | Effect of animal plasma proteins on intestinal dam-age and recovery of neonatal pigs infected with rota-virus 显示文摘 | CORL B A HARRELL R J MOON H K | 2007 | Journal of Nutritional Biochemistry2007，18，： | 1 |
| 7 | A potential approach for decreasingburst effect of protein from PLGA microspheres显示文摘 | Fu K Harrell R Zinski | 2003 | J Pharmaceut Sci2003，92，8： | 1 |
| 8 | Reduction of aerosols produced by ultrasonic sealers 显示文摘 | Harrel S K Bares J B Rivera H F | 1996 | Periodontology1996，67，1： | 1 |
| 9 | Rv3133c/ dosR is a transcription factor that mediates the hypoxic re- sponse of Mycobacterium tuberculosis 显示文摘 | PARK H D GUINN K M HARRELL M I ct al | 2003 | Mol Microbiol2003，48，3： | 1 |
| 10 | A potential approach for decreasing the burst effect of protein from PLGA microspheres显示文摘 | Fu K Harrell R Zinski K | 2003 | J Pharm Sci2003，92，8： | 1 |
| 11 | Successful use of cyclooxygenase- 2 inhibitor in a patient with aspirin - induced asthma显示文摘 | Harrell K Fischer R | 2001 | South Med J2001，94，2： | 1 |
| 12 | Effect of animal plasma proteins on intestinal damage and recovery of neonatal pigs infected with rotavirus显示文摘 | CORL B A HARRELL R J MOON H K | 2007 | Journal of Nutritional Biochemistry2007，18，： | 1 |
| 13 | A po tential approach for decreasing burst effect of protein from PLGA microspheres显示文摘 | Fu K Harrell R Zinski Jaklenec A Frazier J Lotan N | 2003 | J Pharrnaceut Sci2003，92，： | 1 |
| 14 | Synthesis and magnetic properties of self-assembled FeRh nanoparticles显示文摘 | Jia Z Harrell J W Misra R D K | 2008 | Appl Phys Lett2008，93，02： | 1 |
| 15 | Multivariable prognostic models:issues in developing models,evaluating assumptions and adequacy,and measuring and reducing errors显示文摘 | HARRELL F E Jr LEE K L MARK D B | | 0，，04： | 1 |
| 16 | Electrical transport,thermal transport,and elastic properties of M2AlC (M=Ti,Cr,Nb and V)显示文摘 | HETTINGER J D LOFLAND S E FINKEL P MEEHAN T PALMA J HARRELL K GUPTA S GANGULY A EL-RAGHY T BARSOUM M W | 2005 | Physical Review B2005，72，： | 1 |
| 17 | Genetic variability of Bacillus anthracis and related species显示文摘 | Harrell L J Andersen G L Wilson K H | 1995 | J Clin Microbiol1995，33，： | 1 |
| 18 | Effect of animal plasma proteins on intestinal damage and recovery of neonatal pigs infected with rotavirus显示文摘 | Corl B A Harrell R J Moon H K | 2007 | J Nutr Bio2007，18，： | 1 |
| 19 | Reduction of aerosols produced by ultrasonic scalers显示文摘 | HARREL S K BARNES J B RIVERAHIDALGO F | 1996 | Journal of Periodontology1996，67，1： | 1 |
| 20 | Rv3133c/dosR is a transcription factor that mediates the hypoxic response of Mycobacterium tuberculosis显示文摘 | Park H D Guinn K M Harrell M I | 2003 | Mol Microbial2003，48，3： | 1 |
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