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| 1 | Acute effects of rotavirus and malnutrition on intestinal barrier function in neonatal piglets显示文摘AIM: To investigate the effect of protein-energy malnutrition on intestinal barrier function during rotavirus enteritis in a piglet model.METHODS: Newborn piglets were allotted at day 4 of age to the following treatments:(1) full-strength formula(FSF)/noninfected;(2) FSF/rotavirus infected;(3) half-strength formula(HSF)/noninfected;or(4) HSF/rotavirus infected.After one day of adjustment to the feeding rates,pigs were infected with rotavirus and acute effects on growth and diarrhea were monitored for 3 d and jejunal samples were collected for Ussingchamber analyses.RESULTS: Piglets that were malnourished or infected had lower body weights on days 2 and 3 post-infection(P < 0.05).Three days post-infection,marked diarrhea and weight loss were accompanied by sharp reductions in villus height(59%) and lactase activity(91%) and increased crypt depth(21%) in infected compared with non-infected pigs(P < 0.05).Malnutrition also increased crypt depth(21%) compared to full-fed piglets.Villus:crypt ratio was reduced(67%) with viral infection.There was a trend for reduction in transepithelial electrical resistance with rotavirus infection and malnutrition(P = 0.1).3H-mannitol flux was significantly increased(50%;P < 0.001) in rotavirus-infected piglets compared to non-infected piglets,but there was no effect of nutritional status.Furthermore,rotavirus infection reduced localization of the tight junction protein,occludin,in the cell membrane and increased localization in the cytosol.CONCLUSION: Overall,malnutrition had no additive effects to rotavirus infection on intestinal barrier function at day 3 post-infection in a neonatal piglet model. | Sheila K Jacobi Adam J Moeser Anthony T Blikslager J Marc Rhoads Benjamin A Corl Robert J Harrell Jack Odle | 2013 | World Journal of Gastroenterology2013，19，31： | 4 |
| 2 | Comnmnication networks - the hidden organizational clum 显示文摘 | HARRELL A T | 1976 | The Personal Administrator1976，21，6： | 1 |
| 3 | An end-effector for robotic removal of citrus from the tree显示文摘 | Pool T A Harrell R C | 1991 | Transactions of the ASAE1991，34，2： | 1 |
| 4 | Rice seeding and nitrogen rate effects on yield and yield components of two rice cultivars 显示文摘 | Bond J A Walker T W Ottis B V Harrell D | 2008 | Agronomy Journal2008，100，2： | 1 |
| 5 | Blunt popliteal artery trauma:a challenging injury显示文摘 | HARRELL D J SPAIN D A BERGAMINI T M | 1997 | Am Surg1997，63，3： | 1 |
| 6 | Electrical transport,thermal transport,and elastic properties of M2AlC (M=Ti,Cr,Nb and V)显示文摘 | HETTINGER J D LOFLAND S E FINKEL P MEEHAN T PALMA J HARRELL K GUPTA S GANGULY A EL-RAGHY T BARSOUM M W | 2005 | Physical Review B2005，72，： | 1 |
| 7 | Communication networks - the hidden organizational chart 显示文摘 | HARRELL A T | 1976 | The Personal Administrator1976，21，6： | 1 |
| 8 | An end-effector for robotic removal of citrus from the tree显示文摘 | Pool T A Harrell R C | 1991 | Transactions of the ASAE1991，34，2： | 1 |
| 9 | Energy sources in laparascopy显示文摘 | HARRELL A G KERCHER K W HENIFORD B T | 2004 | Surg Innov2004，11，3： | 1 |
| 10 | An end-effector for robotic removal of citrus from the tree显示文摘 | Pool T A Harrell R C | 1991 | Transactions of the ASAE1991，34，2： | 1 |
| 11 | The Florida robotic grove-lab 显示文摘 | Harrell R C Adsit P D Pool T A | 1990 | Transactions of the ASAE1990，33，2： | 1 |
| 12 | The flotida robotic grove-lab显示文摘 | Harrell R C Adsit P D Pool T A | 1990 | Trans of the ASAE1990，3，2： | 1 |
| 13 | An end-effector for robotic removal of cirus from the tree显示文摘 | Pool T A Harrell R C | 1991 | Transacions of the ASAE1991，34，2： | 1 |
| 14 | Rotavi- ral enteritis stimulates ribosomal p70 s6 kinase and increases intestinal protein synthesis in neonatal pigs 显示文摘 | Cori B M Rhoads R J Harrell A T | 2005 | FASEB2005，19，： | 1 |
| 15 | Rotaviral enteritis stimulates ribosomal p70 s6 kinase and increases intestinal protein synthesis in neonatal pigs显示文摘 | Cori B M Rhoads R J Harrell A T | 2005 | Faseb Journal2005，19，： | 1 |
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