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| 1 | Chemoprotective effects of curcumin in esophageal epithelial cells exposed to bile acids显示文摘AIM:To investigate the ability of curcumin to counteract the impact of bile acids on gene expression of esophageal epithelial cells.METHODS:An esophageal epithelial cell line(HET1A)was treated with curcumin in the presence of deoxycholic acid.Cell proliferation and viability assays were used to establish an appropriate dose range for curcumin.The combined and individual effects of curcumin and bile acid on cyclooxygenase-2(COX-2)and superoxide dismutase(SOD-1 and SOD-2)gene expression were also assessed.RESULTS:Curcumin in a dose range of 10-100μmol/L displayed minimal inhibition of HET-1A cell viability.Deoxycholic acid at a concentration of 200μmol/L caused a 2.4-fold increase in COX-2 gene expression compared to vehicle control.The increased expression of COX-2 induced by deoxycholic acid was partially reversed by the addition of curcumin,and curcumin reduced COX-2 expression 3.3-to 1.3-fold.HET-1A cells exposed to bile acid yielded reduced expression of SOD-1 and SOD-2 genes with the exception that high dose deoxycholic acid at 200μmol/L led to a 3-fold increase in SOD-2 expression.The addition of curcumin treatment partially reversed the bile acid-induced reduction in SOD-1 expression at all concentrations of curcumin tested.CONCLUSION:Curcumin reverses bile acid suppression of gene expression of SOD-1.Curcumin is also able to inhibit bile acid induction of COX-2 gene expression. | Matthew R Bower Harini S Aiyer Robert CG Martin Yan Li | 2010 | World Journal of Gastroenterology2010，16，33： | 10 |
| 2 | 公园起作用吗?保护区对土地覆被清理的影响显示文摘本文对来自22个国家49个地点的资料进行了元数据分析,评估了保护区对土地覆被清理的影响。保护区的清理速度明显低于周边地区。而且,从保护伊始,保护区边界内部的清理速度也明显降低。因此,在限制总体土地覆被清理上,保护区显然是有效的。地区间的清理速度有所差异,北美和欧洲大多数保护区的土地覆被变化速度为正,而亚洲保护区的土地覆被清理速度最高。北美和欧洲大多数保护区的参与者相对较少,而亚洲、非洲和拉丁美洲保护区内涉及到的参与者较多,清理的驱动力也较多,说明在这些区域内公园管理所面临的困难增加。相反,国家收入水平和国际自然与自然资源保护联合会的保护分类似乎没有对保护区内土地覆被清理的可能性造成影响。 | Harini Nagendra 王胜(译) | 2008 | AMBIO-人类环境杂志2008，37，5： | 5 |
| 3 | Screening and molecular characterization of Serratia marcescens VITSD2: A strain producing optimum serratiopeptidase显示文摘当前的工作被尝试孤立并且描绘生产 Serratia sp 的 serratiopeptidase。在之中 10 细菌孤立 7 个种类作为 Serratia sp 被识别。从 7 个种类,一个人显示出有势力解朊的活动并且为进一步的研究选择了。基于词法、生物化学、分子的描述,有势力孤立(RH03 ) 作为 Serratia marcescens 被识别(GenBank 就职数字:KC961637 ) 并且种类被指定为 Serratia marcescens VITSD2。serratiopeptidase 的生产在 trypticase 大豆肉汤被执行,酶部分用铵硫酸盐降水和分离被净化。特定的活动被酷蛋白水解作用试金决定并且被发现是为粗略的、猛抛并且渗析的样品的 12.00, 21.33,和 25.40 units/mg。朊酶的分子的重量被 SDS 页决定,是 50 kDa 被发现。生产 serratiopeptidase 的抗菌剂活动对 Pseudomonas aeruginosa MTCC 号码 4676 显示出中等活动(12 公里) 并且 Escherichia coli MTCC 号码 1588 (15 公里) 。 | C. Subathra DEVI Renuka ELIZABETH JOSEPH Harini SARAVANAN S. Jemimah NAINE V. Mohana SRINIVANSAN | 2013 | Frontiers in Biology2013，8，6： | 4 |
| 4 | T cell epitope mimicry between Sj?gren’s syndrome Antigen A (SSA)/Ro60 and oral, gut, skin and vaginal bacteria显示文摘 | Agnieszka Szymula Jacob Rosenthal Barbara M. Szczerba Harini Bagavant Shu Man Fu Umesh S. Deshmukh | 2014 | Clinical Immunology2014，，： | 2 |
| 5 | Marine microbes:invisible nanofactories显示文摘 | Baker S Harini B P Rakshith D | 2013 | J Pharm Res2013，6，3： | 1 |
| 6 | Her-2/neu overex- pression due to polysomy 17 in breast cancer: molecular testing to guide therapeutic options显示文摘 | Sahoo R Babu VC Harini VV | 2011 | Onkologie2011，34，7： | 1 |
| 7 | Growth promotion of maize by phosphate-solubilizing bacteria isolated from composts and macrofauna显示文摘 | B. Hameeda G. Harini O.P. Rupela S.P. Wani Gopal Reddy | 2006 | Microbiological Research2006，，2： | 1 |
| 8 | Classifiers for driver activity monitoring 显示文摘 | Harini Veeraraghavan Nathaniel Bird Stefan Atev | 2007 | Transportation Research Part C: Emerging Technologies2007，1，15： | 1 |
| 9 | Accessibility as a determinant of landscape transformation in western Honduras: linking pattern and process 显示文摘 | Harini Nagendral Jane Southworth Catherine Tucker | 2003 | Landscape Ecology2003，，18： | 1 |
| 10 | Identification of bac- teria in culture negative and polymerase chain reaction (PCR) Positive intraocular specimen from patients with infectious en dopthalmitis显示文摘 | Aarthi P Harini R Sowmiya M | 2011 | Journal of Microbiological Methods2011，85，1： | 1 |
| 11 | Land cover change and landscape fragmentation: comparing the utility of continuous and discrete analyses for a western Honduras region显示文摘 | Jane Southworth Darla Munroe Harini Nagendra | 2004 | Agriculture Ecosystems and Environment2004，101，： | 1 |
| 12 | Growth promotion of maize by phosphate solubilizing bacteria isolated from composts and maerofauna显示文摘 | Hameeda B Harini G Rupela O P | 2008 | Microbiological Research2008，，163： | 1 |
| 13 | Computer vision algorithms for intersection monitoring显示文摘 | Harini Veeraraghavan Osama Masoud Nikolaos P Papanikolopouls | 2003 | IEEE Transactions on Intelligent Transportation Systems2003，4，2： | 1 |
| 14 | Induction of osteoblast differentiation in human adipose derived stem cells by lanthanum ions显示文摘Adipose derived stem cells represent a readily available source of adult stem cells for various biomedical applications. In this study, the proliferation and osteogenic differentiation potential of lanthanum nitrate(La3+) on human adipose derived mesenchymal stem cells(hADSCs) were investigated for the first time and compared with that of dexamethasone(Dex). Our results provided evidence that La3+ at 50 μmol/L concentration promoted proliferation of hADSCs upto 2.4 fold when treated for 21 d in DMEM medium. Treatment of hADSCs with La3+ containing osteogenic induction medium(α-MEM with ascorbic acid and β-glycerophosphate) for 7 d resulted in higher calcium deposition than that in the presence of Dex(0.1 μmol/L) as shown by Alizarin red S and von Kossa staining. Scanning electron micrographs also showed more extracellular matrix mineralization in the presence of La3+. After 7 d of treatment with La3+(10 μmol/L) the expression of RunX2, osteopontin(OP) and osteocalcin(OC) increased 3.4, 5.5 and 2.7 fold respectively. Our results provided evidence that in the presence of La3+ osteogenic differentiation occurred earlier than that in the presence of Dex. | Harini D Indra R Rajaram A Rama Rajaram | 2014 | Journal of Rare Earths2014，32，11： | 1 |
| 15 | Synthesis, Antioxidant and Antimicrobial Activity of Vanillin Derived from Piperidin-4-one Oxime Esters: Preponderant Role of the Phenyl Ester Substituents on the Piperidin-4-one Oxime Core显示文摘 | HARINI S T KUMAR H V RANGASWAMY J | 2012 | Bioorg Meal Chem Lett2012，22，： | 1 |
| 16 | Accessibility as a determinant of landscape transformation in western Honduras:linking pattern and process显示文摘 | Jane S Catherine T | 2003 | Landscape Ecology2003，18，： | 1 |
| 17 | Safety, tolerability, and antibody responses in humans after sequential immunization with a PfCSP DNA vaccine followed by the recombinant protein vaccine RTS,S/AS02A显示文摘 | Judith E Epstein Yupin Charoenvit Kent E Kester Ruobing Wang Rhonda Newcomer Steve Fitzpatrick Thomas L Richie Nadia Tornieporth D.Gray Heppner Chris Ockenhouse Victoria Majam Carolyn Holland Esteban Abot Harini Ganeshan Mara Berzins Trevor Jones C.Nicole | 2004 | Vaccine2004，，13： | 1 |
| 18 | Antihyperglycemic effect of biochanin A, a soy isoflavone, on streptozotocin-diabetic rats 显示文摘 | Harini R Ezhumalai M Pugalendi KV | 2012 | Eur J Pharmacol2012，676，13： | 1 |
| 19 | Land cover change and landscape fragmentation: comparing the utility of continuous and discrete analyses显示文摘 | Jane S Darla M Harini N | 2004 | Agriculture Ecosystems and Environment2004，101，： | 1 |
| 20 | Electro- deposition of Cobalt-chromium AHoy from Trlvalent Chromi- um Solutions 显示文摘 | HARINI Dasarathy CLYDE Riley DWAIN Coble | 1994 | J Electrochem Soc1994，141，7： | 1 |
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